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| 1 | HBV vaccine efficacy and detection and genotyping of vaccineé asymptomatic breakthrough HBV infection in Egypt显示文摘AIM:To evaluate the impact of mass vaccination against the hepatitis B virus (HBV) in Egypt,and to search for vaccinee asymptomatic breakthrough HBV infection and its genotype.METHODS:Seven hundred serum samples from vaccinated children and adults (aged 2-47 years) were used for quantitative and qualitative detection of HBsAb by ELISA.Three hundred and sixty serum samples representing undetectable or low or high HBsAb were screened for markers of active HBV infection (HBsAg,HBcAb (IgG) and HBeAb by ELISA,plus HBsAg by AxSYM) and HBV-DNA genotyping by nested multiplex PCR and by DNA sequencing.RESULTS:It was found that 65% of children aged 2-4 years,and 20.5% aged 4-13 years,as well as 45% adults were good responders to HBV vaccination mounting protective level HBsAb.Poor responders were 28%,59.5% and 34%,and non-responders were 7%,20% and 21% respectively,in the three studied groups.Markers of asymptomatic HBV infections were HBsAg detected by ELISA in 2.5% vs 11.39% by AxSYM.Other markers were HBcAb (IgG) in 1.38%,HBeAb in 0.83%,and HBV-DNA in 7.8%.All had HBV genotype E infection.CONCLUSION:It is concluded that HBV vaccine is efficient in controlling HBV infection among children and adults.The vaccine breakthrough infection was by HBV genotype E.A booster dose of vaccine is recommended,probably four years after initial vaccination. | Eman AE Abushady Magda MA Gameel John D Klena Salwa F Ahmed Kouka SE Abdel-wahab Sanya M Fahmy | 2011 | World Journal of Hepatology2011，3，6： | 5 |
| 2 | Scintigraphy in laryngopharyngeal and gastroesophageal reflux disease:A definitive diagnostic test?显示文摘AIM: To investigate the utility of scintigraphic studies in predicting response to laparoscopic fundoplication(LF) for chronic laryngopharyngeal reflux symptoms.METHODS: Patients with upper aero-digestive symptoms that remained undiagnosed after a period of 2 mo were studied with conventional p H and manometric studies. Patients mainly complained of cough, sore throat, dysphonia and globus. These patients were imaged after ingestion of 99m-technetium diethylene triamine pentaacetic acid. Studies were quantified with time activity curves over the pharynx, upper and lower oesophagus and background. Late studies of the lungs were obtained for aspiration. Patients underwent LF with post-operative review at 3 mo after surgery.RESULTS: Thirty four patients(20 F, 14 M) with an average age of 57 years and average duration of symptoms of 4.8 years were studied. Twenty four hour p H and manometry studies were abnormal in all patients. On scintigraphy, 27/34 patients demonstrated pharyngeal contamination and a rising or flat pharyngeal curve. Lung aspiration was evident in 50% of patients. There was evidence of pulmonary aspiration in 17 of 34 patients in the delayed study(50%). Pharyngeal contamination was found in 27 patients. All patients with aspiration showed pharyngeal contamination. In the 17 patients with aspiration, graphical time activity curve showed rising activity in the pharynx in 9 patients and a flat curve in 8 patients. In those 17 patients without pulmonary aspiration, 29%(5 patients) had either a rising or flat pharyngeal graph. A rising or flat curve predicted aspiration with a positive predictive value of 77% and a negative predictive valueof 100%. Over 90% of patients reported a satisfactory symptomatic response to LF with an acceptable sideeffect profile. CONCLUSION: Scintigraphic reflux studies offer a good screening tool for pharyngeal contamination and aspiration in patients with gastroesophageal reflux disease. | Gregory L Falk John Beattie Alvin Ing SE Falk Michael Magee Leticia Burton Hans Van der Wall | 2015 | World Journal of Gastroenterology2015，21，12： | 2 |
| 3 | Social Support and Personal Models of Diabetes as Predictors of Self-Care and Well-Being:A Longitudinal Study of Adolescents With Diabetes显示文摘 | Skinner TC John M Hampson SE | 2000 | Journal of Pediatric Psychology2000，25，： | 1 |
| 4 | Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4-The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)显示文摘 | St John SE Tomar S Stauffer S R | 2015 | Bioorg Med Chem2015，23，17： | 1 |
| 5 | 接受最佳治疗的高危血管病患者中C反应蛋白对脂蛋白(a)相关心血管病风险的影响显示文摘脂蛋白(a)是动脉粥样硬化性心血管病的遗传致病危险因素,但目前还不清楚哪些动脉粥样硬化性心血管病患者从脂蛋白(a)降低中受益最大。在二级预防中炎症是否会调节与脂蛋白(a)相关的心血管病风险也未知。该文旨在确定在接受最佳治疗的高危心血管病患者中,脂蛋白(a)相关的心血管病风险是否受到全身炎症的调节。 | 周卫(译) 刘莉(摘/审校) Puri R Nissen SE Arsenault BJ St John J Riesmeyer JS Ruotolo G McErlean E Menon V Cho L Wolski K Lincoff AM Nicholls SJ | 2020 | 中华高血压杂志2020，28，11： | 1 |
| 6 | Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle–mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response显示文摘 | Ivan Grskovic Anna Kutsch Christian Frie Gergely Groma Jacek Stermann Ursula Schl?tzer‐Schrehardt Anja Niehoff Stephen E Moss Sabrina Rosenbaum Ernst P?schl Markus Chmielewski Gunter Rappl Hinrich Abken John F Bateman Kathryn SE Cheah Mats Paulsson Bent B | 2012 | J Bone Miner Res2012，，11： | 1 |
| 7 | An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach显示文摘 | Sung Kim Do Hoon Lim Jeeyun Lee Won Ki Kang John S. MacDonald Chan Hyung Park Se Hoon Park Se-Hoon Lee Kihyun Kim Joon Oh Park Won Seog Kim Chul Won Jung Young Suk Park Young-Hyuck Im Tae Sung Sohn Jae Hyung Noh Jin Seok Heo Yong Il Kim Chul Keun Park Keu | 2005 | International Journal of Radiation Oncology Biology Physics2005，，5： | 1 |
| 8 | Long-term results of idiopathic blepharospasm with botulinum toxin injections显示文摘 | John SE | 1987 | Br J Ophthalmol1987，71，： | 1 |
| 9 | Social support and Personal models of diabetes as Predictors of self-care and well-being:a longitudinal study of adolescents with diabetes显示文摘 | Skinner TC John M Ham Pson SE | | 0，，04： | 1 |
| 10 | Effect of a self-etch primer adhesive on the shearbond strength of orthodontic brackets显示文摘 | Bishara SE Leigh V John F | 2001 | Am J Orthod Dentofacial Orthop2001，119，6： | 1 |
| 11 | Long-term results of idiopathic blepharospa sm with botulinum toxin injections显示文摘 | John SE | 1987 | Br J Ophthal- mo11987，71，： | 1 |
| 12 | Social support and personal models of diabetes as predictors of self-care and well-being:a longitudinal study of adolescents with diabetes显示文摘 | Skinner TC John M Hampson SE | 2004 | J Pediatr Psychol2004，25，4： | 1 |
| 13 | Social support and personal models of diabetes as predictors of self - care and well - being: A longitudinal study of adolescents with diabetes显示文摘 | Skinner TC John M Hampson SE | 2004 | Society of Pedi- atric Psychology2004，25，4： | 1 |
| 14 | Long-term results of idiopathic blepharospasm with botulinum toxin injections显示文摘 | John SE | 2007 | Br J Ophthalmol2007，71，： | 1 |
| 15 | Social support and personal models of diabetes as predictors of self-care and well-being:a longitudinal study of adolescents with diabetes显示文摘 | Skinner TC John M Hampson SE | | 0，，04： | 1 |
| 16 | Social support and personal models of diabetes as predictors of self-care and well-being: a longitudinal study of adolescents with diabetes显示文摘 | Skinner TC John M Hampeon SE | 2000 | J Pediatr Psychol2000，25，4： | 1 |
| 17 | Human Fetal Hippocampal Development II : the Neuronal Cytoskeleton显示文摘 | Amold SE John QT | 1996 | J Comp Neurol1996，367，2： | 1 |
| 18 | The Tei index-a role in the diagnosis of heart failure显示文摘 | St John Sutton M Wiegers SE | 2000 | Eur Heart J2000，21，22： | 1 |
| 19 | The assessment of school engagement: examining dimensionality and measurement in variance by gender and race/ethnicity显示文摘 | Wang MT John BW Jacquelynne SE | 2011 | J School Psychol2011，49，： | 1 |
| 20 | Social support and personal models of diabetes as predictors of self - care and well - being : A longitudinal study of adolescents with diabetes 显示文摘 | Skinner TC John M Hampson SE | 2000 | J Pediatr Psychol2000，25，4： | 1 |
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