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| 1 | In Vivo Phosphorylation Site Mapping and Functional Characterization of Arabidopsis Phototropin 1显示文摘Phototropins (phot1 和 phot2 ) 是控制优化植物的光合的效率的回答的一个范围的蓝光的受体 kinases。察觉到的光被二个黄素绑定主题调停,作为 LOV1 和 LOV2 知道,在蛋白质的 N 终端区域以内定位了。经由 LOV2 的 Photoexcitation 导致 C 终端 kinase 领域并且因而的激活受体 autophosphorylation。然而,为 Arabidopsis phototropins 的 in-vivo phosphorylation 地点的知识在阐明正在缺乏并且阻碍了进步受体 phosphorylation 的功能的意义。我们从 Arabidopsis 净化了 phot1 并且由液体层析双人脚踏车团 spectrometry 识别了受体 phosphorylation 的 in-vivo 地点。导出 Arabidopsis 的 phot1 作为色基绑黄素 mononucleotide 并且是在 LOV2 (Ser58, Ser85, Ser350,和 Ser410 ) 在上游的定位的四个主要地点的 phosphorylated。不过,结构功能分析显示 phot1 的生物活动能被归因于包括蛋白质的 LOV2-kinase 区域的一个模块化的单位。因此,包括这里识别的受体 phosphorylation 的地点, LOV2 在上游的肽区域不看起来为受体发信号重要。由对比,这些区域可能为最大化是必要的有气孔的性能和 phot1 的可能导致光的本地化。 | Stuart Sullivan Catriona E. Thomson Douglas J. Lamont Matthew A. Jones John M. Christie | 2008 | Molecular Plant2008，1，1： | 11 |
| 2 | Intraoperative cardiac arrest during anesthesia: a retrospective study of 218 274 anesthetics undergoing non-cardiac surgery in a US teaching hospital显示文摘背景耐心的安全更被获得了在最近的 years.The 作者的注意考察了在在匹兹堡大学医学中心经历在1989年1月和2001年12月之间的 noncardiac 外科的操作房间里有心脏的拘捕的病人,学习的 USA.The 主要目的是决定 intraoperative 的发生心脏的拘捕,识别心脏的拘捕的可能的原因并且由匹兹堡大学与赞同探索顺从的 modifications.Methods | AN Jian-xiong Li-Ming Zhang Erin A. Sullivan GUO Qu-lian John E Williams | 2011 | Chinese Medical Journal2011，，2： | 9 |
| 3 | Myosin XI Is Required for Actin-Associated Movement of Plastid Stromules显示文摘Stromules 是从质体和偶尔相连的单个质体的表面延长的高度有活力的充满基质的小管,允许在互连的质体之间的复杂生物分子的运动。有细胞骨架汇编的禁止者的实验在 stromule 运动显示了一个基于肌动朊的系统的参与。然而,与系统联系的马达蛋白质没被识别。这里,我们肌浆球蛋白 XI 在烟草涉及 stromules 的形成和运动的现在的直接证据离开。2,3-butanedione 2-monoxime 的申请,肌浆球蛋白 ATPase 活动的一个禁止者,从烟草叶导致了 stromules 的损失表皮的细胞。在 Nicotiana benthamiana 的叶子的肌浆球蛋白 XI 的短暂 RNA 干扰也从表皮的房间导致了 stromules 的损失,没有为肌动朊或肌浆球蛋白 VIII 的抄本上的任何效果。在烟草叶的一个标注 GFP 的肌浆球蛋白 XI 尾巴领域的短暂表示表皮的房间证明对叶绿体,以及到线粒体和其它局部性的熔化蛋白质包细胞器。我们的调查结果作为涉及 stromules 的形成和运动的关键蛋白质识别肌浆球蛋白 XI。 | Senthil Kumar A. Natesan James A. Sullivan John C. Gray | 2009 | Molecular Plant2009，2，6： | 6 |
| 4 | Development and optimization of thermal contrast amplification lateral flow immunoassays for ultrasensitive HIV p24 protein detection显示文摘Detection of human immunodeficiency virus(HIV)p24 protein at a single pg/ml concentration in point-of-care(POC)settings is important because it can facilitate acute HIV infection diagnosis with a detection sensitivity approaching that of laboratory-based assays.However,the limit of detection(LOD)of lateral flow immunoassays(LFAs),the most prominent POC diagnostic platform,falls short of that of laboratory protein detection methods such as enzyme-linked immunosorbent assay(ELISA).Here,we report the development and optimization of a thermal contrast amplification(TCA)LFA that will allow ultrasensitive detection of 8 pg/ml p24 protein spiked into human serum at POC,approaching the LOD of a laboratory test.To achieve this aim,we pursued several innovations as follows:(a)defining a new quantitative figure of merit for LFA design based on the specific to nonspecific binding ratio(BR);(b)using different sizes and shapes of gold nanoparticles(GNPs)in the systematic optimization of TCA LFA designs;and(c)exploring new laser wavelengths and power regimes for TCA LFA designs.First,we optimized the blocking buffer for the membrane and running buffer by quantitatively measuring the BR using a TCA reader.The TCA reader interprets the thermal signal(i.e.,temperature)of GNPs within the membrane when irradiated by a laser at the plasmon resonance wavelength of the particle.This process results in higher detection and quantitation of GNPs than in traditional visual detection(i.e.,color intensity).Further,we investigated the effect of laser power(30,100,200 mW),GNP size and shape(30 and 100 nm gold spheres,150 nm gold-silica shells),and laser wavelength(532,800 nm).Applying these innovations to a new TCA LFA design,we demonstrated that 100nm spheres with a 100 mW 532 nm laser provided the best performance(i.e.,LOD=8pg/ml).This LOD is significantly better than that of the current colorimetric LFA and is in the range of the laboratory-based p24 ELISA.In summary,this TCA LFA for p24 protein shows promise for detecting acute HIV infection in POC settings. | Li Zhan Timothy Granade Yilin Liu Xierong Wei Ae Youngpairoj Vickie Sullivan Jeff Johnson John Bischof | 2020 | Microsystems & Nanoengineering2020，6，1： | 3 |
| 5 | Management of Thyroid Dysfunction during Pregnancy and Postpartum: An Endocrine Society Clinical Practice Guideline显示文摘 | Leslie De Groot Marcos Abalovich Erik K. Alexander Nobuyuki Amino Linda Barbour Rhoda H. Cobin Creswell J. Eastman John H. Lazarus Dominique Luton Susan J. Mandel Jorge Mestman Joanne Rovet Scott Sullivan | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，8： | 2 |
| 6 | Risk factor management and depression post-stroke: The value of an integrated model of care显示文摘 | Jacques Joubert Chris Reid Lynette Joubert David Barton Denise Ruth David Jackson John O’. Sullivan Stephen M. Davis | 2005 | Journal of Clinical Neuroscience2005，，1： | 2 |
| 7 | Spine surgery may cause more spinal epidural hematomas than spinal puncture显示文摘 | AN Jian-xiong FANG Qi-wu Erin A. Sullivan John P. Williams | 2013 | Chinese Medical Journal2013，，2： | 2 |
| 8 | Impact of Premorbid Undernutrition on Outcome in Stroke Patients显示文摘 | James P. Davis Andrew A. Wong Philip J. Schluter Robert D. Henderson John D. O’Sullivan Stephen J. Read | 2004 | Stroke: Journal of the American Heart Association2004，，8： | 2 |
| 9 | Number and Size of Lymph Nodes Recovered From Dukes B Rectal Cancers: Correlation with Prognosis and Histologic Antitumor Immune Response显示文摘 | John Murphy M.B. Marc Pocard M.D. Jeremy R. Jass M.D. F.R.C.Path. Gerald C. O'Sullivan M.Ch. F.R.C.S.I. Garry Lee M.B. F.R.C.Path. Ian C. Talbot M.D. F.R.C.Path | 2007 | Diseases of the Colon & Rectum2007，，10： | 1 |
| 10 | Walking Distances to and from Light-Rail Transit Stations显示文摘 | Sean O' Sullivan John Morrall | 1996 | Transportation Research Record: Journal of the Transportation Research Board1996，，1538： | 1 |
| 11 | Using desktop GIS for the investigation of accessibility by public transport: an isochrone approach显示文摘 | David O’Sullivan Alastair Morrison John Shearer | 2000 | International Journal of Geographical Information Science2000，，1： | 1 |
| 12 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 13 | Association of Contemporary Sensitive Troponin I Levels at Baseline and Change at 1 Year With Long-Term Coronary Events Following Myocardial Infarction or Unstable Angina显示文摘 | Harvey D. White Andrew Tonkin John Simes Ralph Stewart Kristy Mann Peter Thompson David Colquhoun Malcolm West Paul Nestel David Sullivan Anthony C. Keech David Hunt Stefan Blankenberg | 2014 | Journal of the American College of Cardiology2014，，4： | 1 |
| 14 | Extending the Boundaries of the Primary Arterial Switch Operation in Patients With Transposition of the Great Arteries and Intact Ventricular Septum显示文摘 | Nicholas Kang Marc R. de Leval Martin Elliott Victor Tsang Ergin Kocyildirim Igor Sehic John Foran Ian Sullivan | 2004 | Circulation ( Suppl)2004，，11： | 1 |
| 15 | Blood Transfusion and Infection After Cardiac Surgery显示文摘 | Keith A. Horvath Michael A. Acker Helena Chang Emilia Bagiella Peter K. Smith Alexander Iribarne Irving L. Kron Pamela Lackner Michael Argenziano Deborah D. Ascheim Annetine C. Gelijns Robert E. Michler Danielle Van Patten John D. Puskas Karen O’Sullivan | 2013 | The Annals of Thoracic Surgery2013，，6： | 1 |
| 16 | Simulation of Packed bed Reactors Using Lattice Boltzmann Methods 显示文摘 | Sullivan S P Sani F M Johns M L | 2005 | Chemical Engineering Science2005，60，： | 1 |
| 17 | Influence of HLA gene polymorphisms on susceptibility and outcome post infection with the SARS-CoV virus显示文摘Dear Editor,Severe Acute Respiratory Syndrome(SARS)has beendescribed as the first pandemic of the 21st century andbetween November 2002 and July 2003,over 8000 peo-ple were infected with the SARS-associated coronavirus(SARS-CoV).Polymorphisms in the human leukocyteantigen(HLA)system have been shown to influencesusceptibility to SARS-CoV but here we were unable | Fang Fang Yuan Zlatibor Velickovic Lesley J Ashton Wayne B Dyer Andrew F Geczy Heather Dunckley Garry W Lynch John S Sullivan | 2014 | Virologica Sinica2014，29，2： | 1 |
| 18 | Pressure measurements on the impingement surface of sonic and sub-sonic jets impinging onto a flat plate at inclined angles 显示文摘 | Jim Crafton Campbell Carter John Sullivan | 2006 | Experiments in Fluids2006，44，5： | 1 |
| 19 | Enalapril attenuates angiotensin II-induced atherosclerosis and vascular inflammation显示文摘 | Valdeci da Cunha Doris M. Tham Baby Martin-McNulty Gary Deng Jerrick J. Ho Dennis W. Wilson John C. Rutledge Ronald Vergona Mark E. Sullivan Yi-Xin (Jim) Wang | 2004 | Atherosclerosis2004，，1： | 1 |
| 20 | Walking distances to and from light-rail transit stations显示文摘 | Sean O'Sullivan John Morrall | 1996 | Transportation Research Record1996，，1583： | 1 |
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