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| 1 | Diabetic neuropathic pain:Physiopathology and treatment显示文摘Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes,which affects over 90% of the diabetic patients.Although pain is one of the main symptoms of diabetic neuropathy,its pathophysiological mechanisms are not yet fully known.It is widely accepted that the toxic effects of hyperglycemia play an important role in the development of this complication,but several other hypotheses have been postulated.The management of diabetic neuropathic pain consists basically in excluding other causes of painful peripheral neuropathy,improving glycemic control as a prophylactic therapy and using medications to alleviate pain.First line drugs for pain relief include anticonvulsants,such as pregabalin and gabapentin and antidepressants,especial y those that act to inhibit the reuptake of serotonin and noradrenaline.In addition,there is experimental and clinical evidence that opioids can be helpful in pain control,mainly if associated with first line drugs.Other agents,including for topical application,such as capsaicin cream and lidocaine patches,have also been proposed to be useful as adjuvants in the control of diabetic neuropathic pain,but the clinical evidence is insufficient to support their use.In conclusion,a better understanding of the mechanisms underlying diabetic neuropathic pain will contribute to the search of new therapies,but also to the improvement of the guidelines to optimize pain control with the drugs currently available. | Anne K Schreiber Carina FM Nones Renata C Reis Juliana G Chichorro Joice M Cunha | 2015 | World Journal of Diabetes2015，6，3： | 34 |
| 2 | Stroke survivors' evalua- tions of a stroke Workbook--based intervention designed to in- crease perceived control over recovery显示文摘 | Joice S Jorhnson M Bonetti D | 2012 | Health Education Journal2012，71，： | 1 |
| 3 | Corrosion inhibition by the cafleine 显示文摘 | Rajendran S Joice M | 2004 | CorrosSci2004，22，8： | 1 |
| 4 | Dechlorination of choloro-organics by a white-rot fungus显示文摘 | Huynh V B Chang H M Joice T W | 1985 | TappiJ1985，68，： | 1 |
| 5 | Antibiotic resistance pattern of motile aeromonads from farm raised fresh water fish 显示文摘 | Hatha M Vivekanandhan A A Julie Joice G | 2005 | International Journal of Food Microbiology2005，98，2： | 1 |
| 6 | PSMA-targeted stably linked ' dendrimer-glutamate urea-methothotre' as a prostate cancer therapeutic 显示文摘 | Huang B Otis J Joice M | 2014 | Biomacromolecules2014，15，3： | 1 |
| 7 | Anti biotic resistance pattern of motile aeromonads from farm raised fresh water fish显示文摘 | HATHA M VIVEKANANDHANA A JOICE G | 2005 | Int J Food Microbiol2005，98，2： | 1 |
| 8 | RNAi evidence that GDF9 mediates oocyte regulation of cumulus expansion in mice显示文摘 | GUI L M JOICE I M | 2005 | Biol Reprod2005，72，： | 1 |
| 9 | PSMA-targeted stably linked ' dendrimer-glutamate urea-methotrexate' as a prostate cancer therapeutic 显示文摘 | Huang B Otis J Joice M Kotlyar A Thomas T P | 2014 | Biomacromolecules2014，15，： | 1 |
| 10 | Influence of surface roughness on interdiffusion processes in InGaP/Ge het- eroepitaxial thin films显示文摘 | Joice P Sophia Attolini G Bosi M | 2015 | Journal of Solid State Science and Technology2015，4，3： | 1 |
| 11 | Chondrogenic potential of mesenchymal stem cells from horses using a magnetic 3D cell culture system显示文摘BACKGROUND Mesenchymal stem cells(MSCs)represent a promising therapy for the treatment of equine joint diseases,studied due to their possible immunomodulatory characteristics and regenerative capacity.However,the source of most suitable MSCs for producing cartilage for regenerative processes in conjunction with biomaterials for an enhanced function is yet to be established.AIM To compare the chondrogenicity of MSCs derived from synovial fluid,bone marrow,and adipose tissue of horses,using the aggrecan synthesis.METHODS MSCs from ten horses were cultured,phenotypic characterization was done with antibodies CD90,CD44 and CD34 and were differentiated into chondrocytes.The 3D cell culture system in which biocompatible nanoparticles consisting of gold,iron oxide,and poly-L-lysine were added to the cells,and they were forced by magnets to form one microspheroid.The microspheroids were exposed to a commercial culture medium for 4 d,7 d,14 d,and 21 d.Proteoglycan extraction was performed,and aggrecan was quantified by enzyme-linked immunosorbent assay.Keratan sulfate and aggrecan in the microspheroids were identified and localized by immunofluorescence.RESULTS All cultured cells showed fibroblast-like appearance,the ability to adhere to the plastic surface,and were positive for CD44 and CD90,thus confirming the characteristics and morphology of MSCs.The soluble protein concentrations were higher in the microspheroids derived from adipose tissue.The aggrecan concentration and the ratio of aggrecan to soluble proteins were higher in microspheroids derived from synovial fluid than in those derived from bone marrow,thereby showing chondrogenic superiority.Microspheroids from all sources expressed aggrecan and keratan sulfate when observed using confocal immunofluorescence microscopy.All sources of MSCs can synthesize aggrecan,however,MSCs from synovial fluid and adipose tissue have demonstrated better biocompatibility in a 3D environment,thus suggesting chondrogenic superiority.CONCLUSION All sources of MSCs produce hyaline cartilage;however,the use of synovial liquid or adipose tissue should be recommended when it is intended for use with biomaterials or scaffolds. | Joice Fülber Fernanda R Agreste Sarah R T Seidel Eric D P Sotelo Ângela P Barbosa Yara M Michelacci Raquel Y A Baccarin | 2021 | World Journal of Stem Cells2021，13，6： | 0 |
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