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| 1 | Role of nanoparticle-mediated immunogenic cell death in cancer immunotherapy显示文摘An essential concept of cancer immunotherapy is that immunogenic cell death(ICD),characterized by the release of tumor-associated antigens(TAAs)and tumor-specific antigens(TSAs)like neoantigens,danger-associated molecular patterns(DAMPs),and pro-inflammatory cytokines,facilitates the presentation of TAAs and TSAs to adaptive immune cells,eliciting an emerging or reinstating a pre-existing anti-cancer immune response. | Yajie Sun Xiangru Feng Chao Wan Jonathan F.Lovell Honglin Jin Jianxun Ding | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，2： | 5 |
| 2 | Matching algorithms for three-stagebufferless Clos network switches 显示文摘 | H Jonathan Chao Zhigang Jing Soung Y Liew | 2003 | IEEE Communication Magazine2003，41，10： | 1 |
| 3 | Selected loss of tolerance evidenced by Crohn’s disease–associated immune responses to auto- and microbial antigens显示文摘 | Carol J. Landers Offer Cohavy Rajeev Misra Huiying Yang Ying–Chao Lin Jonathan Braun Stephan R. Targan | 2002 | Gastroenterology2002，，： | 1 |
| 4 | Next Generation Routers显示文摘 | Jonathan Chao | 2002 | Proceedings of The IEEE2002，90，9： | 1 |
| 5 | Matching Algorithms for Three - stage Bufferless Clos Network Switches显示文摘 | Jonathan H Chao Jing Zhigang Soung Y Liew | 2003 | IEEE Communications Magazine2003，41，： | 1 |
| 6 | A high-speed PacketScore DDoS defense system显示文摘 | Paulo E Ayres Huizhong Sun Jonathan Chao H | 2006 | The IEEE Journal on Selected Areas in Communications2006，，： | 1 |
| 7 | Traumatic Injuries to the Portal Vein: Case Study显示文摘 | Jonathan Pearl Alexander Chao Susan Kennedy Bikram Paul Peter Rhee | 2004 | The Journal of Trauma: Injury Infection and Critical Care2004，，4： | 1 |
| 8 | Renal Cell Carcinoma With Retroperitoneal Lymph Nodes: Role of Lymph Node Dissection显示文摘 | ALLAN J. PANTUCK AMNON ZISMAN FREDRICK DOREY DEBBY H. CHAO KEN-ryu HAN JONATHAN SAID BARBARA J. GITLITZ ROBERT A. FIGLIN ARIE S. BELLDEGRUN | 2003 | The Journal of Urology2003，，： | 1 |
| 9 | Robotic-assisted cholecystectomy: Current status and future application显示文摘Robotic-assisted cholecystectomy(RC)is increasingly common.However,its exact role remains unde-fined,with multiport conventional laparoscopic cholecystectomy(LC)being regarded as the established gold standard.This review aims to provide an overview of the evidence for RC and to define its current and future role.A literature search was performed on the PubMed and Medline databases to identify relevant articles published between 1994 and February 2022.The evidence obtained was summarised in a narrative style.Greater emphasis was placed on recent 10-year articles and studies of higher meth-odological quality.RC is noninferior to LC.The robotic platform facilitates the application of minimally invasive surgery in a way conventional laparoscopy cannot.LC remains appropriate for the majority of patients requiring cholecystectomy.The advantages of RC include inherent technical benefits,facilitating the learning of new surgical technology and its potential to reduce the risk of open conversion and bile leakage in certain populations(Mirizzi syndrome,complicated calculous disease,chronic liver disease and possibly malignancy).It also has increasing applicability to related biliary surgery.The limitations include cost,loss of tactile feedback and the learning curve associated with initial implementation.Future applications of robotic surgical systems include utilisation in difficult cholecystectomy,cases of biliary malignancy,telerobotic surgery and telementoring. | Simran Chandhok Phillip Chao Jonathan Koea Sanket Srinivasa | 2022 | Laparoscopic, Endoscopic and Robotic Surgery2022，5，3： | 1 |
| 10 | A High-Speed PaeketSeore DDoS Defense System 显示文摘 | Paulo E Ayres Huizhong Sun Jonathan Chao H | 2006 | IEEE Journal on Selected Areas in Communications2006，，06： | 1 |
| 11 | Next generation routers 显示文摘 | Jonathan Chao H | 2002 | IEEE2002，90，9： | 1 |
| 12 | PetaStar: a petabit photonic packet switch显示文摘 | H Jonathan Chao Kungli Deng Zhigang Jing | 2003 | IEEE Journal on Selected Areas in Communicalions2003，21，7： | 1 |
| 13 | Hepatitis B and liver cancer knowledge and practices among healthcare and public health professionals in china:a cross-sectional study显示文摘 | Jonathan Chao Ellen T Chang Samuel KS So | 2010 | BMC Public Health2010，10，3： | 1 |
| 14 | Targeted Micellar Phthalocyanine for Lymph Node Metastasis Homing and Photothermal Therapy in an Orthotopic Colorectal Tumor Model显示文摘Tumor lymph node(LN)metastasis seriously affects the treatment prognosis.Studies have shown that nanoparticles with size of sub-50 nm can directly penetrate into LN metastases after intravenous administration.Here,we speculate through introducing targeting capacity,the nanoparticle accumulation in LN metastases would be further enhanced for improved local treatment such as photothermal therapy.Trastuzumabtargeted micelles(<50 nm)were formulated using a unique surfactantstripping approach that yielded concentrated phthalocyanines with strong near-infrared absorption.Targeted micellar phthalocyanine(T-MP)was an effective photothermal transducer and ablated HT-29 cells in vitro.A HER2-expressing colorectal cancer cell line(HT-29)was used to establish an orthotopic mouse model that developed metastatic disease in mesenteric sentinel LN.T-MP accumulated more in the LN metastases compared to the micelles conjugated with control IgG.Following surgical resection of the primary tumor,minimally invasive photothermal treatment of the metastatic LN with T-MP,but not the control micelles,extended mouse survival.Our findings demonstrate for the first time that targeted small-sized nanoparticles have potential to enable superior paradigms for dealing with LN metastases. | Hai‑Yi Feng Yihang Yuan Yunpeng Zhang Hai‑Jun Liu Xiao Dong Si‑Cong Yang Xue‑Liang Liu Xing Lai Mao‑Hua Zhu Jue Wang Qin Lu Quanjun Lin Hong‑Zhuan Chen Jonathan F.Lovell Peng Sun Chao Fang | 2021 | Nano-Micro Letters2021，13，11： | 1 |
| 15 | PetaStar: a petabit photonic packet switch显示文摘 | H Jonathan Chao Deng Kung-li Jing Zhi-gang | 2003 | IEEE Journal on Selected Areas In Communications2003，21，7： | 1 |
| 16 | Matching algorithms for three-stage bufferless clos network switches 显示文摘 | H Jonathan Chao Jing Zhi-gang Soung Y Liew | 2003 | IEEE Communications Magazine2003，41，10： | 1 |
| 17 | Secretions from hypochlorous acid-treated tumor cells delivered in a melittin hydrogel potentiate cancer immunotherapy显示文摘Autologous tumor cells and cell-derived secretions(CDS)can induce antitumor immune responses.The conditions in which cells are cultured and treated impact CDS,and cellular insults alter their composition and function.In this study,we generated CDS from tumor cells exposed to normal culture conditions,hypoxia,cisplatin,radiotherapy,photodynamic therapy,or hypochlorous acid(HOCl).In vitro HOCl-CDS showed the strongest stimulatory effects on dendritic cells and macrophages compared to CDS generated by hypoxia,cisplatin,radiotherapy or photodynamic therapy.To improve HOCl-CDS activity at the tumor site,we loaded HOCl-CDS into a melittin-encapsulated hydrogel scaffold.When injected intratumorally,the HOCl-CDS hydrogel promoted tumor cell death,cytotoxic T lymphocyte infiltration,and tumor-associated macrophage reprogramming towards an M1 phenotype.The hydrogel inhibited tumor growth and prolonged the survival of mice bearing B16-F10 melanoma.Furthermore,hydrogel-delivered HOCl-CDS augmented the antitumor effects of immune checkpoint blockade.These results underscore the importance of the CDS generation method and delivery approach for improving cancer immunotherapy. | Yuhan Zhou Ting Ye Chengzhi Ye Chao Wan Siyue Yuan Yushuai Liu Tianyu Li Fagang Jiang Jonathan F.Lovell Honglin Jin Jing Chen | 2022 | Bioactive Materials2022，7，3： | 0 |
| 18 | Silicon-integrated nonlinear Ⅲ-Ⅴ photonics显示文摘Mainstream silicon photonic integrated circuits are based on compact and low-loss silicon-on-insulator(SOI)waveguide platforms. However, monolithic SOI-based photonics provides only a limited number of functional device types. Here, to extend the on-chip capabilities, we propose a general heterogeneous integration approach to embed highly nonlinear Ⅲ-Ⅴ(Al Ga As) photonics into the SOI platform. We develop low-loss AlGaAs-on-SOI photonic circuits with integrated Si waveguides and showcase sub-milliwatt-threshold(-25 mW) Kerr frequency comb generation in ultrahigh-QAlGaAs microrings(Q over 10^(6)) at the telecom bands. Our demonstration complements existing mature Si photonics technology with efficient nonlinear functionalities provided by Ⅲ-Ⅴ and propels conventional Si photonics into emerging nonlinear photonic applications towards fully chip-based nonlinear engines. | Weiqiang Xie Chao Xiang Lin Chang Warren Jin Jonathan Peters John E.Bowers | 2022 | Photonics Research2022，10，2： | 0 |
| 19 | Machine learning accelerated carbon neutrality research using big data-from predictive models to interatomic potentials显示文摘Carbon neutrality has been proposed as a solution for the current severe energy and climate crisis caused by the overuse of fossil fuels, and machine learning(ML) has exhibited excellent performance in accelerating related research owing to its powerful capacity for big data processing. This review presents a detailed overview of ML accelerated carbon neutrality research with a focus on energy management, screening of novel energy materials, and ML interatomic potentials(MLIPs), with illustrations of two selected MLIP algorithms: moment tensor potential(MTP) and neural equivariant interatomic potential(NequIP). We conclude by outlining the important role of ML in accelerating the achievement of carbon neutrality from global-scale energy management, unprecedented screening of advanced energy materials in massive chemical space, to the revolution of atomicscale simulations of MLIPs, which has the bright prospect of applications. | WU LingJun XU ZhenMing WANG ZiXuan CHEN ZiJian HUANG ZhiChao PENG Chao PEI XiangDong LI XiangGuo MAILOA Jonathan P HSIEH Chang-Yu WU Tao YU Xue-Feng ZHAO HaiTao | 2022 | Science China(Technological Sciences)2022，65，10： | 0 |
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