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| 1 | Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors显示文摘 | Jing Liao Zhao Wu Ying Wang Lu Cheng Chun Cui Yuan Gao Taotao Chen Lingjun Rao Siye Chen Nannan Jia Huiming Dai Shunmei Xin Jiuhong Kang Gang Pei Lei Xiao | 2008 | Cell Research2008，18，5： | 61 |
| 2 | A highly active oxygen evolution electrocatalyst: Ultrathin CoNi double hydroxide/CoO nanosheets synthesized via interface-directed assembly显示文摘成本效率、稳定的氧进化 electrocatalyst 为改进精力存储和变换效率是必要的。此处, 2D nanosheets 与随机 cross-linked CoNi 分层的双氢氧化物(LDH ) 并且小咕咕叫 nanocrystals 被设计并且综合经由在在空中的 situ 减小和 interfacedirected 汇编。CoNi LDH/CoO nanosheets 的形成被归因于界面的紧张驾驶的含水的 metaloxide 簇的强壮的挤出。获得了松开、多孔的 nanosheets 由于众多的缺点的存在展出了低 crystallinity。由于在金属 3d 和 O 2p 之间的轨道的杂交, orbitals,和电子在在场的 CoNi LDH 通过 NiOCo,很多个公司和 Ni 原子在金属原子之间转一个高 +3 原子价。在氧进化反应(OER ) 的高密度的这些唯一的特征结果活跃地点,改进与的亲密关系哦 和催化剂,并且为离子吸附和运输导致一个大可存取的表面区域和可渗透的隧道。因此,产生 nanosheets 向 OER 展出了高催化的活动。CoNi LDH/CoO 在碱的媒介展示了 1.48 V 的一个低发作潜力,并且在 10 妈据獥漠 ? 楬桧 ?L 潳灲楴湯漠 ? 桴 ? 的当前的密度要求了仅仅 300 mV 的过电位 ?? 潢瑴浯摥琠慲獮業瑴湡散吗?? | Jun Wu Zhiyu Ren Shichao Du Lingjun Kong Bowen Liu Wang Xi Jiaqing Zhu Honggang Fu | 2016 | Nano Research2016，9，3： | 25 |
| 3 | Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3inflammasome activation in LPS-induced vascular injury显示文摘The loss of endothelial connective integrity and endothelial barrier dysfunction can lead to increased vascular injury, which is related to the activation of endothelial inflammasomes. There are evidences that low concentrations of aspirin can effectively prevent cardiovascular diseases. We hypothesized that low-dose aspirin could ameliorate endothelial injury by inhibiting the activation of NLRP3 inflammasomes and ultimately prevent cardiovascular diseases. Microvascular endothelial cells were stimulated by lipopolysaccharide(2 μg/mL) and administrated by 0.1–2 mmol/L aspirin. The wild type mice were stimulated with LPS(100 μg/kg/day), and 1 h later treated with aspirin(12.5, 62.5, or125 mg/kg/day) and dexamethasone(0.0182 mg/kg/day) for 7 days. Plasma and heart were harvested for measurement of ELISA and immunofluorescence analyses. We found that aspirin could inhibit NLRP3 inflammasome formation and activation in vitro in dose-dependent manner and has correlation between the NLRP3 inflammasome and the ROS/TXNIP pathway. We also found that low-concentration aspirin could inhibit the formation and activation of NLRP3 inflammasome and restore the expression of theendothelial tight junction protein zonula occludens-1/2(ZO1/2). We assume that aspirin can ameliorate the endothelial layer dysfunction by suppressing the activation of NLRP3 inflammasome. | Xing Zhou Yanjiao Wu Lifeng Ye Yunting Wang Kaimin Zhang Lingjun Wang Yi Huang Lei Wang Shaoxiang Xian Yang Zhang Yang Chen | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 13 |
| 4 | B-doped and La_(4)NiLiO_(8)-coated Ni-rich cathode with enhanced structural and interfacial stability for lithium-ion batteries显示文摘Ni-rich layered oxides are considered promising cathodes for advanced lithium-ion batteries(LIBs)in the future,owing to their high capacity and low cost.However,the issues on structural and interfacial stability of Ni-rich cathodes still pose substantial obstacles in the practical application of advanced LIBs.Here,we employ a one-step method to synthesize a B-doped and La_(4)NiLiO_(8)-coated LiNi_(0.82)5Co_(0.115)Mn_(0.06)O_(2)(BL-1)cathode with reliable structure and interface,for the first time.The La_(4)NiLiO_(8)coating layer can prevent cathodes from electrolyte assault and facilitate Li+diffusion kinetics.Moreover,B-doping can effectively restrain the pernicious H_(2)-H_(3) phase transition and adjust the orientation of primary particles to a radial alignment,which is obstructive to the arise of microcracks induced by the change of anisotropic volume.Specifically,when tested in pouch cells,the BL-1 cathode exhibits outstanding capacity retention of 93.49%after 500 cycles at 1 C.This dual-modification strategy dramatically enhances the stability of the structure and interface for Ni-rich cathode materials,consequently accelerating the commercialization process of high-energy–density LIBs. | Lingjun Li Lizhi Fu Miao Li Chu Wang Zixiang Zhao Shangchen Xie Haichen Lin Xianwen Wu Haodong Liu Li Zhang Qiaobao Zhang Lei Tan | 2022 | Journal of Energy Chemistry2022，31，8： | 10 |
| 5 | Interconnected 1D Co3O4 nanowires on reduced graphene oxide for enzymeless H2O2 detection显示文摘无酶的氢过氧化物(H < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 有高敏感和优秀选择的 2 ) 察觉为临床的诊断是合乎需要的。此处,一个维的公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 nanowires 成功地经由一个简单热水的过程和随后的热处理在减少的 graphene 氧化物(rGO ) 上被构造了。这些公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 nanowires,由小 nanoparticles 集合了,与对方一起被交叉并且在 rGO 上使一只蜘蛛成为像网的结构。公司的形成 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 个 -rGO 混血儿被归因于 DDA 的指导结构、抛锚的角色并且分别地去。产生结构为事散开拥有丰富的活跃地点,电子的面向的传播,和未受阻碍的小径,它资助公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 有优秀 electrocatalytic 性能的 4 个 -rGO 混血儿。作为结果,获得的公司<潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”> 4 个 -rGO 混血儿能为 H 用作有效电气化学的催化剂<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”> 2 氧化和高度敏感察觉。在生理的条件下面, H 的氧化电流<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”> 2 与 1.14 妈的敏感从 0.015~0.675 公里关于它的集中线性地变化?????????????? | Lingjun Kong Zhiyu Ren Nannan Zheng Shichao Du Jun Wu Jingling Tang Honggang Fu | 2015 | Nano Research2015，8，2： | 7 |
| 6 | Derivation and characterization of human embryonic stem cell lines from the Chinese population显示文摘人的胚胎的干细胞(hESCs ) 无止境地装自我更新并且在人的身体区分进所有房间类型。因此,他们在再生药,人的发展生物学和药发现是珍贵的。很多根 hESC 线从中国人口被导出,但是他们限制了为研究目的是可得到的。这里,我们报导线从中国起源的人的胚囊导出的二 hESC 的推导和描述。这些 hESCs 快车碱的磷酸酶和 hESC 特定的标记,包括的 Oct4, Nanog, SSEA-3, SSEA-4, TRA-1-60 和 TRA-1-81。他们也有 telomerase 活动和正常 karyotypes 的高水平。这些房间能在 vitro 形成胚胎植物或动物身体并且能被 teratoma 形成在 vivo 区分进所有三细菌层。最新确定的 hESCs 将为研究目的被散布。从中国人口的 hESC 线的可获得性将从不同的种族组在 hESCs 在差别上便于研究。 | Zhao Wu Hui Li Lingjun Rao Lixiaz iHe Lei Bao Jing Liao Chun Cui Zhenyu Zuo Qiao Li Huimin Dai Lei Qian Qing Tian Lei Xiao Xiao junTan | 2011 | Journal of Genetics and Genomics2011，38，1： | 3 |
| 7 | Impact of pre-oxidation on the formation of byproducts in algae-laden water disinfection:Insights from fluorescent and molecular weight显示文摘Pre-oxidation has been reported to be an effective way to remove algal cells in water, but the released algal organic matter (AOM) could be oxidized and lead to the increment in disinfection by-product (DBP) formation. The relationship between pre-oxidation and AOM-derived DBP formation needs to be approached more precisely. This study compared the impact of four pre-oxidants, ozone (O), chlorine dioxide (ClO), potassium permanganate(KMnO) and sodium hypochlorite (NaClO), on the formation of nitrogenous (N-) and carbonaceous (C-) DBPs in AOM chlorination. The characterization (fluorescent properties,molecular weight distribution and amino acids concentration) on AOM samples showed that the characterization properties variations after pre-oxidation were highly dependent on the oxidizing ability of oxidants. The disinfection experiments showed that Oincreased DBP formation most significantly, which was consistent with the result of characterization properties variations. Then canonical correspondent analysis (CCA) and Pearson’s correlation analysis were conducted based on the characterization data and DBP formation. CCA indicated that C-DBPs formation was highly dependent on fluorescent data. The formation of haloacetic acids (HAAs) had a positive correlation with aromatic protein-like component while trichloromethane (TCM) had a positive correlation with fulvic acid-like component.Pearson’s correlation analysis showed that low molecular weight fractions were favorable to form N-DBPs. Therefore, characterization data could provide the advantages in the control of DBP formation, which further revealed that KMnOand ClOwere better options for removing algal cells as well as limiting DBP formation. | Da Sheng Lingjun Bu Shumin Zhu Yangtao Wu Jue Wang Nan Li Shiqing Zhou | 2022 | Journal of Environmental Sciences2022，34，7： | 2 |
| 8 | Epoxidation of Butadiene over Nickel Modifi ed TS-1 Catalyst显示文摘 | Wu Mei Chou Lingjun Song Huanling | 2012 | Catal Lett2012，142，5： | 1 |
| 9 | Preparation of synthetic rutile and metal-doped LiFePO 4 from ilmenite显示文摘 | Ling Wu Xinhai Li Zhixing Wang Xiaojuan Wang Lingjun Li Jie Fang Feixiang Wu Huajun Guo | 2010 | Powder Technology2010，，： | 1 |
| 10 | dentification of mutations in patients with acquired pure red cell aplasia显示文摘 | Xinchao Zhang Yi Shi Lingjun Song Chang Shen Qi Cai Zhou Zhang Jun Wu Guohui FU Weiwei Shen | 2018 | Acta Biochimica et Biophysica Sinica2018，50，7： | 1 |
| 11 | Cathepsin B inhibitors block multiple radiation-induced side effects in C. elegans显示文摘Dear Editor,Radiotherapy(RT)is one of the major treatments for cancer patients,but its application in cancer therapy has been limited due to deleterious side effects caused by radiation,1 which include dry mouth,fatigue,nausea,skin irritation,low blood cell counts,and infertility.These side effects,also called radiation-induced bystander effects(RIBE),are caused by factors released from irradiated cells or tissues,which can act either short-or long-range to impact nearby or distant unexposed cells and tissues to induce genomic instability,stress response,and altered cell proliferation or death.2 RIBE thus is a critical factor in determining the efficacy and success of RT in cancer treatment and a major safety concern to people with occupational exposure to radiation,such as aircrew members,medical workers,and laboratory researchers.1,2 There is no effective way to prevent adverse side effects caused by radiation and RT.This has been a longstanding medical issue that demands an urgent solution1. | Lingjun Zheng Xiaoqi Wu Shanshan Li Bin Liu Ding Xue | 2019 | Cell Research2019，29，12： | 1 |
| 12 | Insight into the mechanisms of trichloronitromethane formation by vacuum ultraviolet: QSAR model and FTICR-MS analysis显示文摘Vacuum ultraviolet(VUV) photolysis is recognized as an environmental-friendly treatment process. Nitrate(NO-3) and natural organic matter(NOM) are widely present in water source.We investigated trichloronitromethane(TCNM) formation during chlorination after VUV photolysis, because TCNM is an unregulated highly toxic disinfection byproduct. In this study:(1) we found reactive nitrogen species that is generated under VUV photolysis of NO-3react with organic matter to form nitrogen-containing compounds and subsequently form TCNM during chlorination;(2) we found the mere presence of 0.1 mmol/L NO-3can result in the formation of up to 63.96 μg/L TCNM;(3) we found the changes in pH(6.0-8.0), chloride(1-4 mmol/L), and bicarbonate(1-4 mmol/L) cannot effectively diminish TCNM formation;and,(4) we established the quantitative structure-activity relationship(QSAR) model,which indicated a linear relationship between TCNM formation and the Hammett constant(σ) of model compounds;and,(5) we characterized TCNM precursors in water matrix after VUV photolysis and found 1161 much more nitrogen-containing compounds with higher aromaticity were generated. Overall, this study indicates more attention should be paid to reducing the formation risk of TCNM when applying VUV photolysis process at scale. | Xiaojun Chen Yangtao Wu Weiqiu Zhang Lingjun Bu Shumin Zhu Da Sheng Shiqing Zhou John C.Crittenden | 2023 | Journal of Environmental Sciences2023，，3： | 0 |
| 13 | High EMI shielding effectiveness and superhydrophobic properties based on step-wise asymmetric structure constructed by one-step method显示文摘It is of significance to prepare biodegradable electromagnetic interference(EMI)shielding materials with high EMI shielding effectiveness(SE)in order to solve electromagnetic and environmental pollution problems.In this paper,environmentally friendly EMI shielding silver nanowires(AgNWs)/poly(L-lactic acid)(PLLA)/poly(D-lactic acid)(PDLA)/ferroferric oxide(Fe_(3)O_(4))composites with step-wise asymmetric structures were prepared by a facile one-step non-solvent-induced phase separation method.The conductive AgNW network was constructed at a low mass fraction of 5 wt.%on the surface of stereo-complexed crystalline poly(lactic acid)(SC-PLA)film(1.08×10^(4) S/m).Moreover,magnetic Fe_(3)O_(4)is mainly distributed in the skeleton of porous SC-PLA film.Due to the synergistic effect of AgNWs and Fe_(3)O_(4),the EMI SE of SC-PLA films reaches up to 50.3 dB.Interestingly,SC-PLA film modified with triethoxy-1H,1H,2H,2H-tridecafluoro-n-octylsilane(TTO)demonstrates an outstanding water contact angle of about 150.2°compared with the pure PLLA film(134.7°),stemming from the synergistic effect of denser SC-PLA nano-protrusions and low-surface-energy TTO.Thus,we successfully fabricated the high EMI shielding SC-PLA film with wonderful superhydrophobicity,which extends the application performance and service life of portable electronics in moist environments. | Kang Yan Changmei Wu Lan Xie Lingjun Zeng Yi Jiang Zhiqiang Jiang Guojun Chang Bai Xue Qiang Zheng | 2023 | Nano Research2023，16，7： | 0 |
| 14 | Production of aromatic hydrocarbons by co-cracking of bio-oil and ethanol over Ga_(2)O_(3)/HZSM-5 catalysts显示文摘The catalytic cracking of bio-oil is important to produce aromatic hydrocarbons,which can partially replace gasoline or diesel to greatly reduce carbon emissions from transportation.To further promote the formation of aromatic hydrocarbons,this work studied the effects of the preparation method and the acid strength of Ga_(2)O_(3)/HZSM-5 on catalytic cracking of the bio-oil distilled fraction systematically.The preparation method of Ga_(2)O_(3)/HZSM-5 had an important effect on its catalytic activity:the Ga_(2)O_(3)/HZSM-5 prepared by physical mixing showed the low dispersion of active phases and poor pore structure,resulting in its insufficient activity and severe coke deposition;the Ga_(2)O_(3)/HZSM-5 prepared by precipitation exhibited the higher activity,while many polycyclic aromatic hydrocarbons unfavorable for the subsequent utilization were in the oil phase;the Ga_(2)O_(3)/HZSM-5 prepared by impregnation showed the highest activity and 35.5%(mass)selectivity of the oil phase,including 80.3%monocyclic aromatic hydrocarbons and 12.0%polycyclic aromatic hydrocarbons.The Brønsted acidity of Ga_(2)O_(3)/HZSM-5 decreased with Si/Al ratio,leading to the decline in reactant conversion,oil phase selectivity and quality.Meanwhile,the polymerization between monocyclic aromatic hydrocarbons and oxygenates was promoted to produce many polycyclic aromatic hydrocarbons and even coke,causing catalyst deactivation. | Xing Zhang Jingfeng Wu Junhao Chen Liang Lu Lingjun Zhu Shurong Wang | 2022 | Chinese Journal of Chemical Engineering2022，35，6： | 0 |
| 15 | 在体细胞重编程早期瞬时激活的线粒体炫对Nanog的调控显示文摘体细胞重编程的各种机理已经有很多的报道,但是线粒体信号的不同信号和功能还不清楚。 | Zhongfu Ying Keshi Chen Lingjun Zheng Yi Wu Linpeng Li Rui Wang Qi Long Liang Yang Jingyi Guo Deyang Yao Yong Li Feixiang Bao Ge Xiang Jinglei Liu Qiaoying Huang Zhiming Wu Andrew Paul Hutchins Duanqing Pei 刘兴国 | 2017 | 科学新闻2017，19，4： | 0 |
| 16 | Metal-organic frameworks and their composites for advanced lithium-ion batteries:Synthesis,progress and prospects显示文摘Metal-organic frameworks(MOFs)are among the most promising materials for lithium-ion batteries(LIBs)owing to their high surface area,periodic porosity,adjustable pore size,and controllable chemical composition.For instance,their unique porous structures promote electrolyte penetration,ions transport,and make them ideal for battery separators.Regulating the chemical composition of MOF can introduce more active sites for electrochemical reactions.Therefore,MOFs and their related composites have been extensively and thoroughly explored for LIBs.However,the reported reviews solely include the applications of MOFs in the electrode materials of LIBs and rarely involve other aspects.A systematic review of the application of MOFs in LIBs is essential for understanding the mechanism of MOFs and better designing related MOFs battery materials.This review systematically evaluates the latest developments in pristine MOFs and MOF composites for LIB applications,including MOFs as the main materials(anode,cathode,separators,and electrolytes)to auxiliary materials(coating layers and additives for electrodes).Furthermore,the synthesis,modification methods,challenges,and prospects for the application of MOFs in LIBs are discussed. | Chengcai Liu Borong Wu Tao Liu Yuanxing Zhang Jingwen Cui Lingjun Huang Guoqiang Tan Ling Zhang Yuefeng Su Feng Wu | 2024 | Journal of Energy Chemistry2024，89，2： | 0 |
| 17 | 评估帕博利珠单抗在中国晚期黑色素瘤患者中的应用:基于KEYNOTE-151研究的3年随访数据显示文摘中国肢端和黏膜黑色素瘤的发病率较高,但治疗选择有限,晚期黑色素瘤患者的生存率普遍较低。对Ib期KEYNOTE-151研究的初步分析显示,帕博利珠单抗在作为二线药物治疗中国晚期黑色素瘤患者中,表现出了良好的耐受性和优异的临床抗肿瘤活性。本研究分析了3年随访的研究数据,纳入一线治疗后进展的不可切除的III/IV期中国黑色素瘤患者,给予帕博利珠单抗2 mg/kg治疗,每3周1次,最长使用35剂。主要终点为安全性和客观缓解率(objective response rate,ORR);次要终点包括疗效维持时间(duration of response,DOR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。根据RECIST v1.1标准,采用独立中心盲法评估患者疗效。此外,根据黑色素瘤亚型,以及BRAF突变状态和PD-L1表达状态(仅肢端黑色素瘤)进行亚组分析。本研究共纳入103例患者,中位随访时间[从首次用药到数据截止时间(2020年7月13日)]为44.6个月[四分位距(interquartile range,IQR):39.1–46.2]。85.4%的患者发生了任一级别的治疗相关不良事件(treatment-related adverse events,TRAEs),12.6%的患者发生了3/4级的TRAEs,无5级TRAE发生。3例患者因TRAEs(免疫相关肝炎、肺炎和关节炎)停药。免疫相关AEs和输液反应发生比例为34.0%(3/4级,2.9%)。ORR为17.6%(95%CI:10.8–26.4;1例完全缓解/17例部分缓解),中位DOR为13.8个月(范围:2.7–37.4+)。中位PFS为2.8个月(95%CI:2.7–3.5),36个月的PFS率为5.0%。中位OS为13.2个月(95%CI:10.4–16.5),36个月的OS率为22.3%。肢端黑色素瘤中位OS为14.8个月,非肢端皮肤黑色素瘤为13.5个月,黏膜黑色素瘤为7.4个月。在肢端黑色素瘤亚组中,程序性死亡配体-1(programmed death ligand-1,PD-L1)阳性的中位OS为22.8个月,PD-L1阴性的中位OS为8.4个月,BRAF野生型的中位OS为18.5个月,BRAF突变型的中位OS为5.8个月。综上,本研究对3年随访数据分析结果表明,帕博利珠单抗作为二线治疗在中国晚期黑色素瘤患者中的安全性可控,且达到了具有临床意义的抗肿瘤活性,使部分患者获得持久缓解。亚组分析表明PD-L1阳性和BRAF野生型的肢端黑色素瘤患者从该治疗中获益较大,但由于亚组样本量较小,该研究结论仍需进一步验证。 | Lu Si Xiaoshi Zhang Yongqian Shu Hongming Pan Di Wu Jiwei Liu Lili Mao Xuan Wang Xizhi Wen Yanhong Gu Lingjun Zhu Shijie Lan Xin Cai Scott J.Diede Haiyan Dai Cuizhen Niu Jianfeng Li Jun Guo 李雯钰(翻译校对) 斯璐(点评) | 2023 | 癌症2023，42，8： | 0 |
| 18 | Difluorocarbene-derived rapid late-stage trifluoromethylation of 5-iodotriazoles for the synthesis of^(18)F-labeled radiotracers显示文摘Difluorocarbene has emerged as a valuable intermediate to synthesize fluorides.However,difluorocarbene-derived synthesis of^(19)F/^(18)F-trifluoromethyl triazoles has not been explored.Herein,we reported the Cu(I)-promoted difluorocarbene-derived^(19)F/^(18)F-trifluoromethylation of iodotriazoles using KF/K^(18)F as the fluorine source.This approach rapidly generated a wide range of 5-trifluoromethyl-1,2,3-triazoles in good yields showing high functional group compatibility.The reaction was effective for late-stage functionalization of bioactive molecules and^(18)F-trifluoromethylation of iodotriazoles.This work provides a practical synthetic methodology for the development of triazole drugs and^(18)F-radiotracers for positron emission tomography. | Fang Yuan Hongbao Sun Cheng Yang Haojie Yang Lili Pan Xiaoyang Zhang Rong Tian Lingjun Li Wei Chen Xiaoai Wu Haoxing Wu | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 19 | Establishment and Evaluation of a Prediction Model of BLR for Severity in Coronavirus Disease 2019显示文摘Background:Coronavirus disease 2019(COVID-19)is an emerging infectious disease and has spread worldwide.Clinical risk factors associated with the severity in COVID-19 patients have not yet been well delineated.The aim of this study was to explore the risk factors related with the progression of severe COVID-19 and establish a prediction model for severity in COVID-19 patients.Methods:We retrospectively recruited patients with confirmed COVID-19 admitted in Enze Hospital,Taizhou Enze Medical Center(Group)and Nanjing Drum Tower Hospital between January 24 and March 12,2020.Take the Taizhou cohort as the training set and the Nanjing cohort as the validation set.Severe case was defined based on the World Health Organization Interim Guidance Report criteria for severe pneumonia.The patients were divided into severe and non-severe groups.Epidemiological,laboratory,clinical,and imaging data were recorded with data collection forms from the electronic medical record.The predictive model of severe COVID-19 was constructed,and the efficacy of the predictive model in predicting the risk of severe COVID-19 was analyzed by the receiver operating characteristic curve(ROC).Results:A total of 402 COVID-19 patients were included in the study,including 98 patients in the training set(Nanjing cohort)and 304 patients in the validation set(Nanjing cohort).There were 54 cases(13.43%)in severe group and 348 cases(86.57%)in nonsevere group.Logistic regression analysis showed that bodymassindex(BMI)and lymphocyte count wereindependent risk factors for severe COVID-19(all P<0.05).Logistic regression equation based on risk factors was established as follows:Logit(BL)=–5.552–5.473L+0.418BMI.The area under the ROC curve(AUC)of the training set and the validation set were 0.928 and 0.848,respectively(allP<0.001).The model was simplified to get a new model(BMI and lymphocyte count ratio,BLR)for predicting severe COVID-19 patients,and the AUC in the training set and validation set were 0.926 and 0.828,respectively(all P<0.001).Conclusions:Higher BMI and lower lymphocyte count are critical factors associated with severity of COVID-19 patients.The simplified BLR model has a good predictive value for the severe COVID-19 patients.Metabolic factors involved in the development of COVID-19 need to be further investigated. | Zebao He Fajuan Rui Hongli Yang Zhengming Ge Rui Huang Lingjun Ying Haihong Zhao Chao Wu Jie Li | 2022 | Infectious Diseases & Immunity2022，2，2： | 0 |
| 20 | Machine learning accelerated carbon neutrality research using big data-from predictive models to interatomic potentials显示文摘Carbon neutrality has been proposed as a solution for the current severe energy and climate crisis caused by the overuse of fossil fuels, and machine learning(ML) has exhibited excellent performance in accelerating related research owing to its powerful capacity for big data processing. This review presents a detailed overview of ML accelerated carbon neutrality research with a focus on energy management, screening of novel energy materials, and ML interatomic potentials(MLIPs), with illustrations of two selected MLIP algorithms: moment tensor potential(MTP) and neural equivariant interatomic potential(NequIP). We conclude by outlining the important role of ML in accelerating the achievement of carbon neutrality from global-scale energy management, unprecedented screening of advanced energy materials in massive chemical space, to the revolution of atomicscale simulations of MLIPs, which has the bright prospect of applications. | WU LingJun XU ZhenMing WANG ZiXuan CHEN ZiJian HUANG ZhiChao PENG Chao PEI XiangDong LI XiangGuo MAILOA Jonathan P HSIEH Chang-Yu WU Tao YU Xue-Feng ZHAO HaiTao | 2022 | Science China(Technological Sciences)2022，65，10： | 0 |
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