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| 1 | Calcium signaling and T-type calcium channels in cancer cell cycling显示文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers. | James T Taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka Ming Li | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 2 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 3 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 4 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 5 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 6 | Product platform design: method and application显示文摘 | SIMPSON T W JONATHAN R A M MISTREE F | 2001 | Research in Engineering Design2001，13，1： | 1 |
| 7 | Costefficient methods for marine pollution monitoring at Casey Station, East Antarctica:The choice of sieve meshsize and taxonom ic resolu- tion 显示文摘 | BELINDA W T MARTIN J R JONATHAN S S | 2003 | Marine Pollution Bulletin2003，46，： | 1 |
| 8 | Use of the Delphi method I resolring complex water resources issues显示文摘 | Jonathan G T Stephen D R | 2003 | Journal of the American Water Resources Association2003，39，1： | 1 |
| 9 | Follicle stimula ting hormone (FSH) actives the P mitogen activated protein ki- nase pathway, inducing small heat shock protein phosphorylation and cell rounding in immature rat ovarian granulosa cells显示文摘 | Evelyn T M Joshu A C Jonathan C R J | 1998 | En docrinology1998，139，7： | 1 |
| 10 | Product platform design: method and application 显示文摘 | SIMPSON T W JONATHAN R A M MISTREEF | 2001 | Research in Engineering Design2001，13，1： | 1 |
| 11 | BMP-7 and proximal tubule epithelial cells:activation of multiple signaling pathways reveals a novel anti-fibrotic mechanism显示文摘 | Motazed R Colville-Nash P Jonathan T | 2008 | Pharm Res2008，25，10： | 1 |
| 12 | Product platform design: Method and application 显示文摘 | Simpson T W Jonathan R M Mistree F | 2001 | Research in Engineering Design2001，13，1： | 1 |
| 13 | Consensus-degen- erate hybrid oligonucleotide primers (CODEHOPs)for the detec- tion of novel viruses in non-human primates显示文摘 | Jeannette P S Jonathan T R Gregory B | 2009 | Methods2009，49，1： | 1 |
| 14 | Treatment of post - stroke depression withAntidepressants 显示文摘 | JONATHAN R T DAVIDSON M D ZHANG W | 2008 | The Journal of Alter and Complementary Medicine2008，14，7： | 1 |
| 15 | Neonatal infratentorial subdural hematoma contributing to obstructive hydrocephalus in the setting of therapeutic cooling: A case report显示文摘BACKGROUND Symptomatic neonatal subdural hematomas usually result from head trauma incurred during vaginal delivery,most commonly during instrument assistance.Symptomatic subdural hematomas are rare in C-section deliveries that were not preceded by assisted delivery techniques.Although the literature is inconclusive,another possible cause of subdural hematomas is therapeutic hypothermia.CASE SUMMARY We present a case of a term neonate who underwent therapeutic whole-body cooling for hypoxic ischemic encephalopathy following an emergent C-section delivery for prolonged decelerations.Head ultrasound on day of life 3 demonstrated a rounded mass in the posterior fossa.A follow-up brain magnetic resonance imaging confirmed hypoxic ischemic encephalopathy and clarified the subdural hematomas in the posterior fossa causing mass effect and obstructive hydrocephalus.CONCLUSION The aim of this report is to highlight the rarity and importance of mass-like subdural hematomas causing obstructive hydrocephalus,particularly in the setting of hypoxic ischemic encephalopathy and therapeutic whole-body cooling. | Lee K Rousslang Elizabeth A Rooks Jaren T Meldrum Kristopher G Hooten Jonathan R Wood | 2021 | World Journal of Radiology2021，13，9： | 1 |
| 16 | Meta-Analysis of Calcium Supplementation for the Prevention of Postmenopausal Osteoporosis显示文摘 | Beverley S George W Ann C Nicole Z Vivian R Lauren G Zulma O Joan P Jonathan A Peter T Gordon G | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 17 | Cost-efficient methods for marine pollution monitoring at Casey Station, East Antarctica: the choice of sieve meshsize and taxonomic resolution 显示文摘 | Belinda W T Martin J R Jonathan S S | 2003 | Marine Pollution Bulletin2003，46，： | 1 |
| 18 | Phosphorylation of phosp- hazenes and its effects on thermal properties and rire re- tardant behavior显示文摘 | Allcock H R Jonathan P T | 2007 | Polymer Engine ering and Science2007，40，： | 1 |
| 19 | Feature-subspace aggregating: Ensembles for stable and unstable learners 显示文摘 | KAI M T JONATHAN R W SWEE C T | 2011 | Machine Learning2011，82，3： | 1 |
| 20 | Cost-efficient methods for marine pollution monitoring at Casey Station, East Antarctica: the choice of sieve mesh-size and taxonomic resolution显示文摘 | Belinda W T Martin J R Jonathan S S | 2003 | Marine Pollution Bulletin2003，46，： | 1 |
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