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| 1 | Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies显示文摘膝关节骨性关节炎(OA)是世界上最常见的关节炎,其发病率逐年上升。不断上涨的治疗费用给患者带来了经济负担。膝关节OA治疗的两个早期干预目标是减轻膝关节的疼痛和关节软骨的损害。目前用于治疗膝关节OA的方法虽取得了一定疗效,但仍没有一种方法可达到全膝关节置换术(TKA)的治疗效果。TKA主要应用于治疗末期膝关节OA,其缺点是有手术侵入性和手术费用昂贵。因而,应该重视创新性的再生技术,以推迟甚至消除患者对TKA的需求。一些基于生物材料和细胞的疗法目前正处于发展阶段,并已在临床前和临床研究方面取得了初步进展。单独或联合应用先进的生物材料和干细胞治疗膝关节OA可减轻疼痛,使损害的关节软骨再生。在此综述中,我们讨论了膝关节OA疼痛和软骨损害的发病机制,并探讨了该病的最新治疗策略及其局限性。 | Jorge L. Escobar Ivirico Maumita Bhattacharjee Emmanuel Kuyinu Lakshmi S. Nair Cato T. Laurencin | 2017 | Engineering2017，3，1： | 3 |
| 2 | Non-incineration medical waste treatment technologies显示文摘 | Jorge Emmanuel phD CHMM PE | 2001 | Health Care Without Harm2001，45，12： | 1 |
| 3 | Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: Impact on vaccine design for placental malaria显示文摘 | Bita Bordbar Nicaise Tuikue Ndam Emmanuelle Renard Sayeh Jafari-Guemouri Livingstone Tavul Charlie Jennison Sédami Gnidehou Rachida Tahar Dionicia Gamboa Jorge Bendezu Didier Menard Alyssa E. Barry Philippe Deloron Audrey Sabbagh | 2014 | Infection Genetics and Evolution2014，，： | 1 |
| 4 | Vasorelaxant activity of extracts obtained from Apium graveolens:Possible source for vasorelaxant molecules isolation with potential antihypertensive effect显示文摘Objective:To investigate the vasorelaxant effect of organic extracts from Apium graveolens(A.graveolens)which is a part of a group of plants subjected to pharmacological and phytochemical study with the purpose of offering it as an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects.Methods:An ex vivo method was employed to assess the vasorelaxant activity.This consisted of using rat aortic rings with and without endothelium precontracted with norepinephrine.Results:All extracts caused concentration-dependent relaxation in precontracted aortic rings with and without endothelium;the most active extracts were Dichloromethane and Ethyl Acetate extracts from A.graveolens.These results suggested that secondary metabolites responsible for the vasorelaxant activity belong to a group of compounds of medium polarity.Also,our evidence showed that effect induced by dichloromethane and ethyl acetate extracts from A.graveolens is mediated probably by calcium antagonism.Conclusions:A.graveolens represents an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects. | Vergara-Galicia Jorge Jimenez-Ramirez Luis Angel Tun-Suarez Adrian Aguirre-Crespo Francisco Salazar-Gomez Anuar Estrada-Soto Samuel Sierra-Ovando Angel Hernandez-Nunez Emmanuel | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，10： | 1 |
| 5 | Innovative Education and Training in high power laser plasmas(PowerLaPs) for plasma physics, high power laser-matter interactions and high energy density physics-theory and experiments显示文摘The Erasmus Plus programme’Innovative Education and Training in high power laser plasmas’,otherwise known as PowerLaPs,is described.The PowerLaPs programme employs an innovative paradigm in that it is a multi-centre programme where teaching takes place in five separate institutes with a range of different aims and styles of delivery.The ’in class’ time is limited to four weeks a year,and the programme spans two years.PowerLaPs aims to train students from across Europe in theoretical,applied and laboratory skills relevant to the pursuit of research in laserplasma interaction physics and inertial confinement fusion(ICF).Lectures are intermingled with laboratory sessions and continuous assessment activities.The programme,which is led by workers from the Technological Educational Institute(TEI)of Crete,and supported by co-workers from the Queen’s University Belfast,the University of Bordeaux,the Czech Technical-University in Prague,Ecole Polytechnique,the University of Ioannina,the University of Salamanca and the University of York,has just completed its first year.Thus far three Learning Teaching Training(LTT)activities have been held,at the Queen’s University Belfast,the University of Bordeaux and the Centre for Plasma Physics and Lasers(CPPL)of TEI Crete.The last of these was a two-week long Intensive Programme(IP),while the activities at the other two universities were each five days in length.Thus far work has concentrated upon training in both theoretical and experimental work in plasma physics,high power laser-matter interactions and high energy density physics.The nature of the programme will be described in detail and some metrics relating to the activities carried out to date will be presented. | John Pasley Georgia Andrianaki Andreas Baroutsos Dimitri Batani Emmanouil P.Benis Marco Borghesi Eugene Clark Donna Cook Emmanuel D'Humieres Vasilios Dimitriou Brendan Dromey Michael Ehret Ioannis Fitilis Anastasios Grigoriadis Satya Kar Evaggelos Kaselouris Ondrej Klimo Michel Koenig Kyriaki Kosma George Koundourakis Milan Kucharik Aveen Lavery Jiri Limpouch Yannis Orphanos Nektarios A.Papadogiannis Stelios Petrakis Dave Riley Maria Serena Rivetta Laura Tejada Pascual Joao Jorge Santos Alexandros Skoulakis Ioannis Tazes Vladimir Tikhonchuk Jocelain Trela Calliope Tsitou Luca Volpe Steven White Mark Yeung Michael Tatarakis | 2019 | High Power Laser Science and Engineering2019，7，2： | 0 |
| 6 | Why is malaria associated with poverty? Findings from a cohort study in rural Uganda显示文摘Background:Malaria control and sustainable development are linked,but implementation of‘multisectoral’intervention is restricted by a limited understanding of the causal pathways between poverty and malaria.We investigated the relationships between socioeconomic position(SEP),potential determinants of SEP,and malaria in Nagongera,rural Uganda.Methods:Socioeconomic information was collected for 318 children aged six months to 10 years living in 100 households,who were followed for up to 36 months.Mosquito density was recorded using monthly light trap collections.Parasite prevalence was measured routinely every three months and malaria incidence determined by passive case detection.First,we evaluated the association between success in smallholder agriculture(the primary livelihood source)and SEP.Second,we explored socioeconomic risk factors for human biting rate(HBR),parasite prevalence and incidence of clinical malaria,and spatial clustering of socioeconomic variables.Third,we investigated the role of selected factors in mediating the association between SEP and malaria.Results:Relative agricultural success was associated with higher SEP.In turn,high SEP was associated with lower HBR(highest versus lowest wealth index tertile:Incidence Rate Ratio 0.71,95%confidence intervals(CI)0.54–0.93,P=0.01)and lower odds of malaria infection in children(highest versus lowest wealth index tertile:adjusted Odds Ratio 0.52,95%CI 0.35–0.78,P=0.001),but SEP was not associated with clinical malaria incidence.Mediation analysis suggested that part of the total effect of SEP on malaria infection risk was explained by house type(24.9%,95%CI 15.8–58.6%)and food security(18.6%,95%CI 11.6–48.3%);however,the assumptions of the mediation analysis may not have been fully met.Conclusion:Housing improvements and agricultural development interventions to reduce poverty merit further investigation as multisectoral interventions against malaria.Further interdisplinary research is needed to understand fully the complex pathways between poverty and malaria and to develop strategies for sustainable malaria control. | Lucy S.Tusting John Rek Emmanuel Arinaitwe Sarah G.Staedke Moses R.Kamya Jorge Cano Christian Bottomley Deborah Johnston Grant Dorsey Steve W.Lindsay Jo Lines | 2016 | Infectious Diseases of Poverty2016，5，1： | 0 |
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