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| 1 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 2 | Pre-oxidation of an extremely polluted industrial wastewater by the Fenton’s reagent显示文摘 | Nora San Sebastián Mart??nez Josep F??guls Fernández Xavier Font Segura Antoni Sánchez Ferrer | 2003 | Journal of Hazardous Materials2003，，3： | 2 |
| 3 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 4 | Chromatin structure of goat and sheep β21actoglobulin Gene differ 显示文摘 | Ramona N P Josep M F Armand S | 1998 | Biochem Biophys Res Com2mun1998，252，649： | 1 |
| 5 | A Multicenter, Randomized, Clinical Trial of Hormonal Therapy in the Prevention of Rebleeding From Gastrointestinal Angiodysplasia显示文摘 | Félix Junquera Faust Feu Michel Papo Sebastián Videla José Ramón Armengol Josep Mar??a Bordas Esteban Saperas Josep M. Piqué Juan-Ramón Malagelada | 2001 | Gastroenterology2001，，5： | 1 |
| 6 | Analyzing joint ventures with foreign partners 显示文摘 | JOSEP F BRODLEY | 1984 | Antitrust Law J1984，，1： | 1 |
| 7 | Sampling methods for ventilator-associated pneumonia: Validation using different histologic and microbiological references显示文摘 | Antoni Torres Neus Fàbregas Santiago Ewig Jorge Puig de la Bellacasa Torsten T. Bauer Josep Ramirez | 2000 | Critical Care Medicine2000，，8： | 1 |
| 8 | The Barcelona approach: Diagno sis, staging, and treatment of hepatocellular carcinoma显示文摘 | Josep M L Josep F Jordi B | 2004 | Liver Transpl2004，10，21： | 1 |
| 9 | Distributed control to ensure proportional load sharing and improve voltage regulation in low-voltage DC microgrids显示文摘 | SANDEEP A BAYLON G F JOSEP M G | 2013 | IEEE Transactions on Power Electronics2013，28，4： | 1 |
| 10 | Non- invasive brain-actuated control of a mobile robot by human EEG 显示文摘 | JOSEDEL R MILLAN F R JOSEP M | 2004 | Biomedical Engineering2004，51，6： | 1 |
| 11 | Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats 显示文摘 | Lloberas N Josep M C Marcalla F | 2006 | J Am Soc Nephrol2006，17，5： | 1 |
| 12 | Chromatin structure of goat and sheep β21actoglobnlin Gene differ 显示文摘 | Ramona N P Josep M F Armand S | 1998 | Biochem Biophys Res Commun1998，252，： | 1 |
| 13 | On the privacy offered by(k, d)-ano- nymity显示文摘 | Rolando T R Josep D F | 2013 | Information Systems2013，38，： | 1 |
| 14 | Noise-robust watermarking for numerical datasets显示文摘 | FRANCESC S JOSEP D F AGUSTI S | 2005 | Lecture Notes in Computer Science2005，3558，： | 1 |
| 15 | Sampling methods for ventilator-associated pneumonia: Validation using different histologic and microbiological references显示文摘 | Antoni Torres Neus Fàbregas Santiago Ewig Jorge Puig de la Bellacasa Torsten T. Bauer Josep Ramirez | 2000 | Critical Care Medicine2000，，： | 1 |
| 16 | Early Hormonal Markers of Pregnancy Outcome After In Vitro Fertilization and Embryo Transfer显示文摘 | Francisco Carmona Juan Balasch Montserrat Creus Francisco Fábregues Roser Casamitjana Salvadora Cívico Ester Vidal Josep M. Calafell Vicenta Moreno Juan A. Vanrell | 2003 | Journal of Assisted Reproduction and Genetics2003，，12： | 1 |
| 17 | Early Hormonal Markers of Pregnancy Outcome After In Vitro Fertilization and Embryo Transfer显示文摘 | Francisco Carmona Juan Balasch Montserrat Creus Francisco Fábregues Roser Casamitjana Salvadora Cívico Ester Vidal Josep M. Calafell Vicenta Moreno Juan A. Vanrell | 2003 | Journal of Assisted Reproduction and Genetics2003，，12： | 1 |
| 18 | Unmet needs and challenges in gastric cancer: The way forward显示文摘 | Florian Lordick William Allum Fátima Carneiro Emmanuel Mitry Josep Tabernero Patrick Tan Eric Van Cutsem Cornelis van de Velde Andrés Cervantes | 2014 | Cancer Treatment Reviews2014，，： | 1 |
| 19 | Pregnancy in systemic lupus erythematosus and antiphospholipid syn- drome 显示文摘 | Ricard C Josep F Francisco C | 2004 | National Arthritis Foundation (Singapore) 20th Anniversary Celebration Scientific Meeting2004，97，11： | 1 |
| 20 | A high sensitivity nitrate reductase assay and its application to vertically migrating Rhizasolenia mats显示文摘 | Josep L H Villareal T A Lipschultz F | 1997 | Aquatic Microbial Ecology1997，12，： | 1 |
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