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| 1 | Dilemma of first line regimens in metastatic pancreatic adenocarcinoma显示文摘Pancreatic cancer is one of the deadliest cancers,ranking fourth among cancer-related deaths. Despite all the major molecular advances and treatment breakthroughs, mainly targeted therapies, the cornerstone treatment of metastatic pancreatic cancer(m PC) remains cytotoxic chemotherapy. In 2016, more than 40 years after the introduction of gemcitabine in the management of m PC, the best choice for first-line treatment has not yet been fully elucidated. Two main strategies have been adopted to enhance treatment efficacy. The first strategy is based on combining non-cross resistant drugs, while the second option includes the development of newer generations of chemotherapy. More recently, two new regimens, FOLFIRINOX and gemcitabine/nab-paclitaxel(GNP), have both been shown to improve overall survival in comparison with gemcitabine alone, at the cost of increased toxicity. Therefore, the best choice for first line therapy is a matter of debate. For some authors, FOLFIRINOX should be the first choice in patients with an Eastern Cooperative Oncology Group score(0-1) given its lower hazard ratio. However, others do not share this opinion. In this paper, we review the main comparison points between FOLFIRINOX and GNP. We analyze the two pivotal trials to determine the similarities and differences in study design. In addition, we compare the toxicity profile of the two regimens as well as the impact on quality of life. Finally, we present studies revealing real life experiences and review the advantages and disadvantages of possible second-line therapies including their cost effectiveness. | Marwan Ghosn Tony Ibrahim Tarek Assi Elie El Rassy Hampig Raphael Kourie Joseph Kattan | 2016 | World Journal of Gastroenterology2016，22，46： | 2 |
| 2 | Is routine second-look endoscopy effective after endoscopic hemostasis in acute peptic ulcer bleeding? A meta-analysis显示文摘 | Sara El Ouali Alan N. Barkun Jonathan Wyse Joseph Romagnuolo Joseph J.Y. Sung Ian M. Gralnek Marc Bardou Myriam Martel | 2012 | Gastrointestinal Endoscopy2012，，2： | 2 |
| 3 | A Functional Polymorphism of Toll-Like Receptor 4 Gene Increases Risk of Gastric Carcinoma and Its Precursors显示文摘 | Georgina L. Hold Charles S. Rabkin Wong–Ho Chow Malcolm G. Smith Marilie D. Gammon Harvey A. Risch Thomas L. Vaughan Kenneth E.L. McColl Jolanta Lissowska Witold Zatonski Janet B. Schoenberg William J. Blot N. Ashley G. Mowat Joseph F. Fraumeni Emad M. El | 2007 | Gastroenterology2007，，3： | 2 |
| 4 | Diagnostic utility of B-typena- triuretic peptide in critically illpatientswith pulmonary edema: aprospective cohort study显示文摘 | Joseph EL AjeetV Brian KG | 2008 | Crit Care2008，12，1： | 1 |
| 5 | Birth weight and asth- ma incidence by asthma phenotype pattern in a racially diverse co- hort followed through adolescence 显示文摘 | Johnson CC Peterson EL Joseph CL | 2015 | J Asthma2015，16，： | 1 |
| 6 | Modeling radiation pneumonitis risk with clinical, dosimetric, and spatial parameters显示文摘 | Andrew J. Hope Patricia E. Lindsay Issam El Naqa James R. Alaly Milos Vicic Jeffrey D. Bradley Joseph O. Deasy | 2006 | International Journal of Radiation Oncology Biology Physics2006，，1： | 1 |
| 7 | Adjunctive throcectomy for acute myoc:ardial infarction: a Bayesian Metu-analysis 显示文摘 | Mongeon FP Belisle P Joseph L el al | 2010 | Cirt: Cardiovasc Inlet''2010，3，： | 1 |
| 8 | Use of transthoracic echocar- diography combined with venous uhrasonography in palients with pulmonary embolism显示文摘 | Mansencal N Redheuil A Joseph T eL al | 2004 | Intern J Cardio12004，96，： | 1 |
| 9 | Does core needle breast biopsy accurately reflect breast pathology 显示文摘 | Joseph P Crowe J Rebecca J el al | 2003 | Surgery2003，134，4： | 1 |
| 10 | Computed tomography of the normal temporomandibular joint显示文摘 | Christiansen EL Terence T Joseph R | 1987 | Scand J Dent Res1987，95，49： | 1 |
| 11 | Modeling radiation pneumonitis risk with clinical, dosimetric, and spatial parameters显示文摘 | Andrew J. Hope Patricia E. Lindsay Issam El Naqa James R. Alaly Milos Vicic Jeffrey D. Bradley Joseph O. Deasy | 2006 | International Journal of Radiation Oncology Biology Physics2006，，1： | 1 |
| 12 | Recent findings from phase V of the United States -Japan cooperative earthquake research program 显示文摘 | El -Tawil Sherif Bracci Joseph | 2004 | Journal of Structural Engineering2004，130，2： | 1 |
| 13 | Enolase Activity and isoenzyme distribution in human brain regions and tumors 显示文摘 | Joseph J Felix F Cruz Sanehez el al | 1996 | J Neurochem1996，66，6： | 1 |
| 14 | Abrogation of the Rb/p16 tumor suppressive pathway in virtually all pancreatic carcinomas 显示文摘 | Mieke S Ralph H Joseph G et el | 1997 | Cancer Res1997，57，8： | 1 |
| 15 | Behcet's Disease 显示文摘 | Paul A Yates Joseph B el al | 2006 | Int Ophth almol Clin2006，46，2： | 1 |
| 16 | Prediction of anchorage failure for reinforced concrete beams strengthened with fiber reinforced polymer plates显示文摘 | Mahmand T El Mihimy Joseph W Tedesco | 2001 | ACI Structural Journal2001，98，3： | 1 |
| 17 | Ventilator - associatedpneu monia:A review显示文摘 | Joseph NM Sistla S Dutta TK el al | 2010 | Eur J Intern Med2010，21，： | 1 |
| 18 | The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis显示文摘 | Mottillo S Filion KB Genest J Joseph L Pilote L Poirier P Rinfret S Schiffrin EL Eisenberg MJ | | 0，，14： | 1 |
| 19 | Biochemical and Cytochemical Aspects of the Interactions of Chitosan and Botrytis Cinerea in Bell Pepper Fruit CPostharvest 显示文摘 | Ahmed El Ghaouth Joseph Arul Charles Wilson | 1997 | Biology and Technology1997，12，2： | 1 |
| 20 | A Bayesian network approach for modeling local failure in lung cancer显示文摘 | Jung Hun Oh Jeffrey Craft Rawan Al Lozi Manushka Vaidya Yifan Meng Joseph O Deasy Jeffrey D Bradley Issam El Naqa | 2011 | Physics in Medicine and Biology2011，，6： | 1 |
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