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| 1 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 2 | Dieulafoy's lesion:A case series study显示文摘AIM: Dieulafoy's lesion (DL) accounts for 1-5.8% of cases of acute upper gastrointestinal bleeding (GIB). Its mortality is high, approaching 20%, despite recent advances in endoscopic therapy. We aimed to report our experience in the treatment of DL.METHODS: A retrospective case study of all patients with DL between January 1993 and January 2003 was done. Characteristics, treatment methods, success rates and 30-d mortality of the patients were analyzed. RESULTS: Thirty-six patients were noted to have DL in the study period. Thirty-three records were available for assessment in which 35 DL were identified. The median age of the patients was 67 years with male to female ratio of 5.6:1. Significant comorbidities existed in 69% of the patients. Eighty-nine percent of the DL was found at first endoscopy, three DL at laparotomy. Significant coexistent endoscopic findings existed in 23%. Hemostasis was achieved in 88% by using adrenaline injection, or in combination with heater probe application at first endoscopy. Four cases had re-bleeding, all were successfully treated endoscopically. The 30-d mortality rate was 23%.CONCLUSION: Successful endoscopic hemostasis could be achieved in 100% of cases of DL. The overall mortality may still remain high, mainly due to the comorbidities and age of these patients. | RS Walmsley Yuk-Tong Lee Joseph JY Sung | 2005 | World Journal of Gastroenterology2005，11，23： | 4 |
| 3 | Linear accelerator-based stereotaxic radiosurgery for brain metastases: the influence of number of lesions on survival 显示文摘 | Adler JR Cox RS | 1996 | J Clin Oncol1996，14，4： | 1 |
| 4 | The SERS activi- ty of asupported Ag nanocube strongly depends on its orien- tation relative tolaser polarization显示文摘 | Joseph MM Zhiyuan L Andrew RS | 2007 | Nano Letters2007，7，4： | 1 |
| 5 | Factor Ⅸ complex for the correction of traumatic coagulopathy 显示文摘 | Joseph B Amini A Friese RS | 2012 | J Trauma Acute Care Surg2012，72，4： | 1 |
| 6 | Virally induced changes in cellular microRNAs maintain latency of human cytomegalovirus in CD34(+)progenitors显示文摘 | Poole E McGregor Dallas SR Colston J Joseph RS Sinclair J | 2011 | JOURNAL OF GENERAL VIROLOGY2011，92，7： | 1 |
| 7 | Prevalence of malnutrition in general medical patients显示文摘 | Bruce RS Blackburn GI Joseph Vitale | 1976 | JAMA1976，235，4： | 1 |
| 8 | Glutathione peroxidase condon 198 polymorphism variant increase lung cancer risk 显示文摘 | Joseph A Mark R | 2003 | Cancer Res2003，63，： | 1 |
| 9 | F, mctional anatomy of a common semantic system for words and pictures显示文摘 | VANDENBERGHE R PRICE C Wise R Josephs O Frackowiak RS | 1996 | Nature1996，383，： | 1 |
| 10 | Apparent lability of neural tube closure in laboratory animals and humans显示文摘 | John MD Anthony RS Joseph FH | 1999 | Am J Med Genet1999，87，2： | 1 |
| 11 | Orthopedic aspects of the Marfan phenotype显示文摘 | Joseph KN Kane HA Milner RS | 1992 | Clin Orthop1992，277，： | 1 |
| 12 | 5-aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis and proctitis显示文摘 | Lloyd RS Francois M Scott G Malcolm R Norton G Fred S Thomas M Joseph S Ed Prokipchuk Lowell B | 1987 | Gastroenterology1987，92，35： | 1 |
| 13 | Renal angiomyolipoma associated with lymph node involvement and renal cell carcinoma in patients with tuberous sclerosis显示文摘 | Taylor RS Joseph DB Kohaut EC | 1989 | J Uro11989，141，4： | 1 |
| 14 | Structural Snapshots of Human HDAC8 ProvideInsights into the Class I His- tone Deacetylases显示文摘 | John RS Robert JS Bradley AK Clifford M Joseph DH Andy JJ Christine L Andrew A Joseph JB Ellen C Jie T Bi CS Erik V Robert W Ellen ML Douglas RD Gyorgy S Marc N Mark WK Ronald VS Duncan EM and Leslie WT | 2004 | Structure2004，12，： | 1 |
| 15 | Factor IX complex for the correction of traumatic coagulopathy显示文摘 | Joseph B Amini A Friese RS | 2012 | J Trauma A-cute Care Surg2012，72，4： | 1 |
| 16 | Orthopedic aspects of the Marfan phenotype显示文摘 | Joseph KN Kane HA Milner RS | 1992 | Clin Orthop1992，277，： | 1 |
| 17 | Cortical and subcortical control of tongue movement in humans: a functional neuroimaging study using Fmri显示文摘 | Corfield DR Murphy K Josephs O Fink GR Frackowiak RS Guz A | 1999 | J Physiol1999，86，： | 1 |
| 18 | Five-year course and outcome of dysthymic disorder:a prospective,naturalistic followup study显示文摘 | Danael NK Joseph ES Suzanne RS | 2000 | Ameracan J Psychiatry2000，157，： | 1 |
| 19 | Prevalence of malnutrition in general medical patients显示文摘 | Bruce RS Blackburn GL Joseph Vitale | 1976 | JAMA1976，235，4： | 1 |
| 20 | CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells显示文摘 | Volker H Joseph RS Michael G | 1998 | Nature1998，391，： | 1 |
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