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| 1 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 2 | Zircon SHRIMP U-Pb dating of granites from Dulan and the chronological framework of the North Qaidam UHP belt, NW China显示文摘Zircon SHRIMP dating of granites from Dulan,east segment of North Qaidam UHP belt shows that they are 406.6±3.5 Ma for Yematan-E,407.3±4.3 and 397±6 Ma for Balijiehatan-W,404.5±4.0 and 397.0±3.7 Ma for Shuiwenzhan-N,380.5±5.0 Ma for Shuiwenzhan-S,382.5±3.6 and 372.5±2.8 Ma for Chachagongma.These granites from Dulan represent the products of the third and fourth periods of Paleozoic magmatism in North Qaidam.Geochemically,the granitoids with metalumious to weak peratuminous are quartz diorite,granodiorite,and granite in composition and mainly belong to calc-alkaline series,a few samples to calc or alkali-calc series.The third period of granites is a rock association of granodiorite+granite,with initial 87Sr/86Sr ratios from 0.7082 to 0.7110 and T2DM model ages from 1.41–1.90 Ga;and the fourth period of granites is a rock association of quartz diorite+granodiorite+granite,with initial 87Sr/86Sr ratios from 0.7072 to 0.7091 and T2DM model ages from 1.07–1.38 Ga.Therefore,the third period of granites has higher initial 87Sr/86Sr ratios and T2DM model ages.On the contrary,the fourth period of granites has Nd(t)values from 0.6 to-3.0,higher than that of the third granite with Nd(t)values-3.2 to-9.3.Thus,the data comparison indicates that the third granites may derive from Paleo-proterzoic continental crust with mantle material whereas the fourth granites may derive from the Meso-proterzoic basalt crust with continental material.Combined with regional geology,we thought that the third granites were formed relative to plate exhumation and the fourth granites to delamination of the lithospheric mantle. | WU CaiLai GAO YuanHong LI ZhaoLi LEI Min QIN HaiPeng LI MinZe LIU ChunHua Ronald B FROST Paul T ROBINSON Joseph L WOODEN | 2014 | Science China Earth Sciences2014，57，12： | 21 |
| 3 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 4 | Key factors in developing the trinitrobenzene sulfonic acid-induced post-inflammatory irritable bowel syndrome model in rats显示文摘AIM:To investigate the key factors in developing the trinitrobenzene sulfonic acid(TNBS)-induced postinflammatory irritable bowel syndrome(PI-IBS)model in rats. METHODS:TNBS was administered to rats at the following conditions:(1)with different doses(20,10,5 mg/0.8 mL per rat);(2)with same dose in different concentrations(20 mg/rat,25,50 mg/mL);(3)in different ethanol percentage(25%,50%);and(4)at depth either 4 cm or 8 cm from anus.At 5 d and 4 wk after TNBS administration,inflammation severity and inflammation resolution were evaluated.At 4 and 8 wk after TNBS application,visceral hyperalgesia and enterochromaffin(EC)cell hyperplasia were assayed by abdominal withdrawal reflex test,silver staining and capillary electrophoresis. RESULTS:Our results showed that:(1)TNBS induced dose-dependent acute inflammation and inflammation resolution.At 5 d post TNBS,the pathological score and myeloperoxidase(MPO)activity in all TNBS treated rats were significantly elevated compared to that of the control(9.48±1.86,8.18±0.67,5.78± 0.77 vs 0,and 3.55±1.11,1.80±0.82,0.97±0.08 unit/mg vs 0.14±0.01 unit/mg,P<0.05).At 4 wk post TNBS,the pathological score in high and median dose TNBS-treated rats were still significantly higher than that of the control(1.52±0.38 and 0.80±0.35 vs 0,P<0.05);(2)Intracolonic TNBS administration position affected the persistence of visceral hyperalgesia.At 4 wk post TNBS,abdominal withdrawal reflex (AWR)threshold pressure in all TNBS-treated groups were decreased compared to that of the control(21.52 ±1.73 and 27.10±1.94 mmHg vs 34.44±1.89 mmHg,P<0.05).At 8 wk post TNBS,AWR threshold pressure in 8 cm administration group was still significantly decreased(23.33±1.33 mmHg vs 36.79±2.29 mmHg,P<0.05);(3)Ethanol percentage affected the TNBS-induced inflammation severity and visceral hyperalgesia.In TNBS-25%ethanol-treated group,the pathological score and MPO activity were significantly lowered compared to that of the TNBS-50%ethanoltreated group,while AWR threshold pressure were significantly elevated(36.33±0.61 mmHg vs 23.33±1.33 mmHg,P<0.05);and(4)TNBS(5 mg/0.8 mL per rat, in 50%ethanol,8 cm from anus)-treated rats recovered completely from the inflammation with acquired visceral hyperalgesia and EC cell hyperplasia at 4 wk after TNBS administration.CONCLUSION:TNBS dosage,concentration,intraco-lonic administration position,and ethanol percentage play important roles in developing visceral hyperalgesia and EC cell hyperplasia of TNBS-induced PI-IBS rats. | Hong-Yan Qin Hai-Tao Xiao Justin CY Wu Brian M Berman Joseph JY Sung Zhao-Xiang Bian | 2012 | World Journal of Gastroenterology2012，18，20： | 10 |
| 5 | Biomass Carbon Storage and Its Sequestration Potential of Afforestation under Natural Forest Protection Program in China显示文摘Based on the data from China′s Seventh Forest Inventory for the period of 2004–2008, area and stand volume of different types and age-classes of plantation were used to establish the relationship between biomass density and age of planted forests in different regions of the country. Combined with the plantation area in the first-stage of the Natural Forest Protection(NFP) program(1998–2010), this study calculated the biomass carbon storage of the afforestation in the first-stage of the program. On this basis, the carbon sequestration potential of these forests was estimated for the second stage of the program(2011–2020). Biomass carbon storage of plantation established in the first stage of the program was 33.67 Tg C, which was majority accounted by protection forests(30.26 Tg C). There was a significant difference among carbon storage in different regions, which depended on the relationship of biomass carbon density, forest age and plantation area. Under the natural growth, the carbon storage was forecasted to increase annually from 2011 to 2020, reaching 96.03 Tg C at the end of the second-stage of the program in 2020. The annual growth of the carbon storage was forecasted to be 6.24 Tg C/yr, which suggested that NFP program has a significant potential for enhancing carbon sequestration in plantation forests under its domain. | ZHOU Wangming Bernard Joseph LEWIS WU Shengnan YU Dapao ZHOU Li WEI Yawei DAI Limin | 2014 | Chinese Geographical Science2014，24，4： | 10 |
| 6 | Forest Carbon Storage and Tree Carbon Pool Dynamics under Natural Forest Protection Program in Northeastern China显示文摘The Natural Forest Protection(NFP) program is one of the Six Key Forestry Projects which were adopted by the Chinese Government since the 1980s to address important natural issues in China. It advanced to protecting and restoring the structures and functions of the natural forests through sustainable forest management. However, the role of forest carbon storage and tree carbon pool dynamics since the adoption of the NFP remains unknown. To address this knowledge gap, this study calculated forest carbon storage(tree, understory, forest floor and soil) in the forest region of northeastern(NE) China based on National Forest Inventory databases and field investigated databases. For tree biomass, this study utilized an improved method for biomass estimation that converts timber volume to total forest biomass; while for understory, forest floor and soil carbon storage, this study utilized forest type-specific mean carbon densities multiplied by their areas in the region. Results showed that the tree carbon pool under the NFP in NE China functioned as a carbon sink from 1998 to 2008, with an increase of 6.3 Tg C/yr, which was mainly sequestrated by natural forests(5.1 Tg C/yr). At the same time, plantations also acted as a carbon sink, reflecting an increase of 1.2 Tg C/yr. In 2008, total carbon storage in forests covered by the NFP in NE China was 4603.8 Tg C, of which 4393.3 Tg C was stored in natural forests and 210.5 Tg C in planted forests. Soil was the largest carbon storage component, contributing 69.5%–77.8% of total carbon storage; followed by tree and forest floor, accounting for 16.3%–23.0% and 5.0%–6.5% of total carbon storage, respectively. Understory carbon pool ranged from 1.9 to 42.7 Tg C, accounting for only 0.9% of total carbon storage. | WEI Yawei YU Dapao Bernard Joseph LEWIS ZHOU Li ZHOU Wangming FANG Xiangmin ZHAO Wei WU Shengnan DAI Limin | 2014 | Chinese Geographical Science2014，24，4： | 9 |
| 7 | Subtyping Animal Influenza Virus with General Multiplex RT-PCR and Liquichip High Throughput (GMPLex)显示文摘This study developed a multiplex RT-PCR integrated with luminex technology to rapidly subtype simultaneously multiple influenza viruses. Primers and probes were designed to amplify NS and M genes of influenza A viruses HA gene of H1, H3, H5, H7, H9 subtypes, and NA gene of the N1 and N2 subtypes. Universal super primers were introduced to establish a multiplex RT-PCR (GM RT-PCR). It included three stages of RT-PCR amplification, and then the RT-PCR products were further tested by LiquiChip probe, combined to give an influenza virus (IV) rapid high throughput subtyping test, designated as GMPLex. The IV GMPLex rapid high throughput subtyping test presents the following features: high throughput, able to determine the subtypes of 9 target genes in H1, H3, H5, H7, H9, N1, and N2 subtypes of the influenza A virus at one time; rapid, completing the influenza subtyping within 6 hours; high specificity, ensured the specificity of the different subtypes by using two nested degenerate primers and one probe, no cross reaction occurring between the subtypes, no non-specific reactions with other pathogens and high sensitivity. When used separately to detect the product of single GM RT-PCR for single H5 or N1 gene, the GMPLex test showed a sensitivity of 10-5(= 280ELD50) forboth tests and the Luminex qualitative ratio results were 3.08 and 3.12, respectively. When used to detect the product of GM RT-PCR for H5N1 strain at the same time, both showed a sensitivity of 10-4(=2800 ELD50). The GMPLex rapid high throughput subtyping test can satisfy the needs of influenza rapid testing. | Zhi-feng Qin Jie Sun Ti-kang Lu Shao-ling Zeng Qun-yi Hua Qing-yan Ling Shu-kun Chen Jian-qiang Lv Cai-hong Zhang Bing Cheng Zhou-xi Ruan Ying-zuo Bi Joseph J Giambrone Hong-zhuan Wu | 2012 | Virologica Sinica2012，27，2： | 8 |
| 8 | A statistical analysis of spatiotemporal variations and determinant factors of forest carbon storage under China's Natural Forest Protection Program显示文摘The Natural Forest Protection Program(NFPP)is one of the key ecological forestry programs in China.It not only facilitates the improvement of forest ecological quality in NFPP areas,but also plays a significant role in increasing the carbon storage of forest ecosystems.The program covers 17 provinces,autonomous regions,and municipalities with correspondingly diverse forest resources and environments,ecological features,engineering measures and forest management regimes,all of which affect regional carbon storage.In this study,volume of timber harvest,tending area,pest-infested forest,firedamaged forest,reforestation,and average annual precipitation,and temperature were evaluated as factors that influence carbon storage.We developed a vector autoregression model for these seven indicators and we studied the dominant factors of carbon storage in the areas covered by NFPP.Timber harvest was the dominant factorinfluencing carbon storage in the Yellow and Yangtze River basins.Reforestation contributed most to carbon storage in the state-owned forest region in Xinjiang.In state-owned forest regions of Heilongjiang and Jilin Provinces,the dominant factors were forest fires and forest cultivation,respectively.For the enhancement of carbon sequestration capacity,a longer rotation period and a smaller timber harvest are recommended for the Yellow and Yangtze River basins.Trees should be planted in stateowned forests in Xinjiang.Forest fires should be prevented in state-owned forests in Heilongjiang,and greater forest tending efforts should be made in the state-owned forests in Jilin. | Shengnan Wu Jiaqi Li Wangming Zhou Bernard Joseph Lewis Dapao Yu Li Zhou Linhai Jiang Limin Dai | 2018 | Journal of Forestry Research2018，29，2： | 7 |
| 9 | Crescentic dune migration and stabilization: Implications for interpreting paleo-dune deposits as paleoenvironmental records显示文摘Paleo-dune deposits have been widely used as a proxy indicator of past dune activity, which is further used to reconstruct paleoclimates. However, recent studies have critically examined the reproducibility of dune chronologies and the complexity of paleo-dune deposits as paleoenvironmental records. This paper addresses questions on the paleoenvironmental implications of dune chronostratigraphies that have been raised by those reviews, in the specific case of crescentic dunes, using a case study from the Mu Us dune field, north-central China. The processes of turn-over and stabilization of relatively small crescentic dunes are first investigated by observational evidence. In combination with the analysis of a simplified sand preservation model and stratigraphic records, the effect of dune morphodynamics on sand preservation is demonstrated. It is especially evident that thick, nearly instantaneously deposited sand units record dune stabilization near the very end of a dune activity episode, while thin sand units may signal the preservation of sand deposited earlier in episodes of activity. Interpreting the distribution of luminescence ages that indicate sand deposition over time is not as simple as assumed in some previous work. Low frequency of sand ages could indicate an interval of either dune field stabilization or extensive dune activity but poor sand preservation. A peak of sand age frequency likely represents a shift in dune field activity towards stabilization, not a peak of active dune extent, especially if it partially overlaps with an independently identified interval of stabilization(e.g. one recorded by paleosols). The nature and magnitude of these biases in the distribution of sand ages over time are strongly affected by the magnitude of net sand accumulation, which is in turn related to sand supply, transport capacity and sand availability, and ultimately climate change. Relatively short dune stabilization and turn-over time(10~1 to 10~2 yrs) indicate that dune geomorphic processes can quickly respond to short-term disturbance, but the chronology of that response must be interpreted in light of how those processes influence age distributions. | XU Zhiwei Joseph A. MASON LU Huayu YI Shuangwen ZHOU Yali WU Jiang HAN Zhiyong | 2017 | Journal of Geographical Sciences2017，27，11： | 7 |
| 10 | Screening for gastric cancer in Asia: current evidence and practice显示文摘 | Wai K Leung Ming-shiang Wu Yasuo Kakugawa Jae J Kim Khay-guan Yeoh Khean Lee Goh Kai-chun Wu Deng-chyang Wu Jose Sollano Udom Kachintorn Takuji Gotoda Jaw-town Lin Wei-cheng You Enders KW Ng Joseph JY Sung | 2008 | Lancet Oncology2008，，3： | 7 |
| 11 | Hematological disorders and pulmonary hypertension显示文摘Pulmonary hypertension(PH),a serious disorder with a high morbidity and mortality rate,is known to occur in a number of unrelated systemic diseases.Several hematological disorders such as sickle cell disease,thalassemia and myeloproliferative diseases develop PH which worsens the prognosis.Associated oxidant injury and vascular inflammation cause endothelial damage and dysfunction.Pulmonary vascular endothelial damage/dysfunction is an early event in PH resulting in the loss of vascular reactivity,activation of proliferative and antiapoptotic pathways leading to vascular remodeling,elevated pulmonary artery pressure,right ventricular hypertrophy and premature death.Hemolysis observed in hematological disorders leads to free hemoglobin which rapidly scavenges nitric oxide(NO),limiting its bioavailability,and leading to endothelial dysfunction.In addition,hemolysis releases arginase into the circulation which converts L-arginine to ornithine,thus bypassing NO production.Furthermore,treatments for hematological disorders such as immunosuppressive therapy,splenectomy,bone marrow transplantation,and radiation have been shown to contribute to the development of PH.Recent studies have shown deregulated iron homeostasis in patients with cardiopulmonary diseases including pulmonary arterial hypertension(PAH).Several studies have reported low iron levels in patients with idiopathic PAH,and iron deficiency is an important risk factor.This article reviews PH associated with hematological disorders and its mechanism:and iron homeostasis and its relevance to PH. | Rajamma Mathew Jing Huang Joseph M Wu John T Fallon Michael H Gewitz | 2016 | World Journal of Cardiology2016，8，12： | 6 |
| 12 | Effect of Tangnaikang on TGF-β_1-induced transdifferentiation of human renal tubular epithelial HK-2 cells显示文摘OBJECTIVE: To explore the function of Tangnaikang (TNK) in the prevention and treatment of renal interstitial fibrosis through transdifferentiation of the human renal tubular epithelial cell line HK-2 induced by transforming growth factor-β1(TGF-β1).METHODS: HK-2 cells cultured in dulbecco's modified eagle medium/F12 (1∶1) with 10% fetal calf serum were divided into six groups: blank control group, TGF-β1 group (TGF-β1 10 ng/mL), serum control group (TGF-β1 10 ng/mL+10% serum), treatment group 1 (TGF-β1 10 ng/mL+ 5% TNK serum),treatment group 2 (TGF-β1 10 ng/mL+10% TNK serum), and treatment group 3 (TGF-β1 10 ng/mL+20% TNK serum). Cell proliferation was detected by 4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Expression of α-smooth muscle actin (α-SMA) and E-cadherin were observed by immunohistochemical assay. The contents of collagen Ⅰ (Col Ⅰ), collagen Ⅲ (Col Ⅲ), and fibronectin (FN) in the culture medium supernatant were detected by ELISA.RESULTS: E-cadherin was expressed and α-SMA was not expressed in normal HK-2 cells. In HK-2 cells cultured with TGF-β1,α-SMA expression significantly increased, HK-2 cells significantly proliferated, and secretion of Col Ⅰ, Col Ⅲ, and FN significantly increased compared with the blank control group (all P<0.05). In the HK-2 cells cultured with TGF-β1 and TNK serum, the expression of α-SMA significantly decreased, the expression of E-cadherin significantly increased, and the cell proliferation and the secretion of Col Ⅰ, Col Ⅲ and FN were significantly inhibited compared with the TGF-β1 group (all P<0.05).CONCLUSION: TNK can inhibit cell proliferation and reduce secretion of Col Ⅰ, Col Ⅲ, and FN.This indicates that TNK can inhibit transdifferentiation of human renal tubular epithelial cells induced by TGF-β1, with the effect of preventing and treating renal interstitial fibrosis. | Lixia Yang Xinhuan Ma Tao Cheng Tonghua Liu Lili Wu Wen Sun Margetts Peter Joseph | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 5 |
| 13 | Effect of glycine addition on the in-vitro corrosion behavior of AZ31 magnesium alloy in Hank’s solution显示文摘This study reports on the effect of the addition of Glycine to Hank’s solution on the in-vitro corrosion behavior of AZ31 magnesium(Mg)alloy at 37℃and a pH of 7.4 studied by using potentiodynamic polarization(PDP),hydrogen collecting techniques and electrochemical impedance spectroscopy(EIS)in combination with surface characterization techniques such as optical microscopy(OM),scanning electron microscopy(SEM),energy dispersive spectroscopy(EDS),X-ray diffraction(XRD)and X-ray photoelectron spectroscopy analysis(XPS).The results reveal that adsorption of glycine initially subdues the dissolution of AZ31 Mg alloy while in long run it enhances the dissolution of the alloy due to the commencement of the chelation effect of glycine with Ca^(2+) released from hydroxyapatite.The chelation of glycine with Ca^(2+) induces the formation of cracks in the surface film which further promotes the dissolution of AZ31 Mg alloy thereby forming a porous corrosion products layer on the surface of the alloy.As a result,both the continuous dissolution of AZ31 magnesium alloy and the hydrogen evolution rate(HER)are enhanced with increasing the immersion time in Hank’s solution. | Durga Bhakta Pokharel Liping Wu Junhua Dong Amar Prasad Yadav Dhruba Babu Subedi Madhusudan Dhakal Lin Zha Xin Mu Aniefiok Joseph Umoh Wei Ke | 2021 | Journal of Materials Science & Technology2021，，22： | 4 |
| 14 | Carbamylated erythropoietin regulates immune responses and promotes long-term kidney allograft survival through activation of PI3K/AKT signaling显示文摘Modulation of alloimmune responses is critical to improving transplant outcome and promoting long-term graft survival.To determine mechanisms by which a nonhematopoietic erythropoietin(EPO)derivative,carbamylated EPO(CEPO),regulates innate and adaptive immune cells and affects renal allograft survival,we utilized a rat model of fully MHC-mismatched kidney transplantation.CEPO administration markedly extended the survival time of kidney allografts compared with the transplant alone control group.This therapeutic effect was inhibited when the recipients were given LY294002,a selective inhibitor of the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway or anti-EPO receptor(EPOR)antibody,in addition to CEPO.In vitro,CEPO inhibited the differentiation and function of dendritic cells and modulated their production of proinflammatory and anti-inflammatory cytokines,along with activating the PI3K/AKT signaling pathway and increasing EPOR mRNA and protein expression by these innate immune cells.Moreover,after CD4^(+)T cells were exposed to CEPO the Th1/Th2 ratio decreased and the regulatory T cell(Treg)/Th17 ratio increased.These effects were abolished by LY294002 or anti-EPOR antibody,suggesting that CEPO regulates immune responses and promotes kidney allograft survival by activating the PI3K/AKT signaling pathway in an EPOR-dependent manner.The immunomodulatory and specific signaling pathway effects of CEPO identified in this study suggest a potential therapeutic approach to promoting kidney transplant survival. | Ning Na Daqiang Zhao Jinhua Zhang Jiaqing Wu Bin Miao Heng Li Yingxun Luo Zuofu Tang Wensheng Zhang Joseph A.Bellanti Song Guo Zheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 15 | Clinical significance of hepatic derangement in severe acute respiratory syndrome显示文摘AIM: Elevation of alanine aminotransferase (ALT) level is commonly seen among patients suffering from severe acute respiratory syndrome (SARS). We report the progression and clinical significance of liver derangement in a large cohort of SARS patient.METHODS: Serial assay of serum ALT was followed in patients who fulfilled the WHO criteria of SARS. Those with elevated ALT were compared with those with normal liver functions for clinical outcome. Serology for hepatitis B virus (HBV) infection was checked. Adverse outcomes were defined as oxygen desaturation, need of intensive care unit (ICU) and mechanical ventilation and death.RESULTS: Two hundred and ninety-four patients were included in this study. Seventy (24%) patients had elevated serum ALT on admission and 204 (69%) patients had elevated ALT during the subsequent course of illness. Using peak ALT >5×ULN as a cut-off and after adjusting for potential confounding factors, the odds ratio of peak ALT>5x ULN for oxygen desaturation was 3.24 (95%CI 1.23-8.59, P = 0.018), ICU care was 3.70 (95% CI 1.38-9.89, P = 0.009), mechanical ventilation was 6.64 (95%CI 2.22-19.81, P = 0.001) and death was 7.34(95%CI 2.28-24.89, P = 0.001). Ninety-three percent of the survived patients had ALT levels normalized or were on the improving trend during follow-up. Chronic hepatitis B was not associated with worse clinical outcomes.CONCLUSION: Reactive hepatitis is a common complication of SARS-coronavirus infection. Those patients with severe hepatitis had worse clinical outcome. | Henry Lik-Yuen Chan Ambrose Chi-Pong Kwan Ka-Fai To Sik-To Lai Paul Kay-Sheung Chan Wai-Keung Leung Nelson Lee Alan Wu Joseph Jao-Yiu Sung | 2005 | World Journal of Gastroenterology2005，11，14： | 4 |
| 16 | Printable Aligned Single-Walled Carbon Nanotube Film with Outstanding Thermal Conductivity and Electromagnetic Interference Shielding Performance显示文摘Ultrathin,lightweight,and flexible aligned single-walled carbon nanotube(SWCNT)films are fabricated by a facile,environmentally friendly,and scalable printing methodology.The aligned pattern and outstanding intrinsic properties render“metal-like”thermal conductivity of the SWCNT films,as well as excellent mechanical strength,flexibility,and hydrophobicity.Further,the aligned cellular microstructure promotes the electromagnetic interference(EMI)shielding ability of the SWCNTs,leading to excellent shielding effectiveness(SE)of~39 to 90 dB despite a density of only~0.6 g cm^(−3) at thicknesses of merely 1.5-24μm,respectively.An ultrahigh thickness-specific SE of 25693 dB mm^(−1) and an unprecedented normalized specific SE of 428222 dB cm^(2)g^(−1) are accomplished by the freestanding SWCNT films,significantly surpassing previously reported shielding materials.In addition to an EMI SE greater than 54 dB in an ultra-broadband frequency range of around 400 GHz,the films demonstrate excellent EMI shielding stability and reliability when subjected to mechanical deformation,chemical(acid/alkali/organic solvent)corrosion,and high-/low-temperature environments.The novel printed SWCNT films offer significant potential for practical applications in the aerospace,defense,precision components,and smart wearable electronics industries. | Zhihui Zeng Gang Wang Brendan F.Wolan Na Wu Changxian Wang Shanyu Zhao Shengying Yue Bin Li Weidong He Jiurong Liu Joseph W.Lyding | 2022 | Nano-Micro Letters2022，14，11： | 4 |
| 17 | Cell Stem Cell:利用干细胞制造出的心肌细胞有助精准心血管医疗取得进展显示文摘在一项新的研究中。来自美国斯坦福大学医学院的研究人员发现利用人诱导性多能干细胞(iPS细胞)制造的心肌细胞忠实地反映供者天然的心脏组织中关键基因的表达模式。因此,这些细胞能够被用来预测病人是否可能经历药物相关的心脏损伤。相关研究结果在线发表在Cell Stem Cell期刊上。论文标题为"Transcriptome Profiling of Patient -Specific Human iPSC - ardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro". | Elena Matsa Paul W. Burridge Kun-Hsing Yu John H. Ahrens Vittavat Termglinchan Haodi Wu Chun Liu Praveen Shukla Nazish Sayed Jared M. Churko Ningyi Shao Nicole A. Woo Alexander S. Chao Joseph D. Gold Ioannis Karakikes Michael P. Snyder Joseph C. Wu | 2016 | 现代生物医学进展2016，0，32： | 4 |
| 18 | Mitotic phosphorylation of PRC1 at Thr470 is required for PRC1 oligomerization and proper central spindle organization显示文摘在细胞分裂期间,染色体分离被和着丝点的锭子微导管的相互作用安排。进在分开的染色单体之间的一支组织中央锭子的 interpolarmicrotubules 的戏剧的改变为胞质分裂的开始和实行被要求。中央锭子组织要求有丝分裂的 kinesins, chromosomal 旅客蛋白质建筑群,和微导管捆绑蛋白质 PRC1。由在 Thr470 和 Thr481 的 Cdc2 的 PRC1 isphosphorylated 在有丝分裂期间。然而,在 Thr470 的功能的关联 ofPRC1 磷酸化留下了逃犯。这里,我们证明 thenon-phosphorylatable 异种 PRC1 (T470A ) 然而并非 phospho-mimicking 异种 PRC1 (T470E ) 的那表情引起中央锭子的异常组织。Immunoprecipitation 实验与野类型的 PRC1 显示那 bothPRC1 (T470A ) 和 PRC1 (T470E ) 突变蛋白质伙伴,建议 Thr470 的 thatphosphorylation 不改变 PRC1 自我协会。另外,在 vitroco 沉积,实验证明 PRC1 绑在独立于 Thr470 的 phosphorylationstate 的微导管。胶化过滤实验建议了 PRC1 的 Thr470 promotesoligomerization 的那磷酸化。给 Thr470 磷酸化的那预防禁止 PRC1oligomerization 试管内并且引起中央锭子体内的一个异常组织的事实,我们建议这 phosphorylation 依赖的 PRC1 oligomerization 保证中央锭子汇编在房间周期发生在适当时间。 | Chuanhai Fu Feng Yan Fang Wu Quan Wu Joseph Whittaker Haiying Hu Renming Hu Xuebiao Yao | 2007 | Cell Research2007，17，5： | 3 |
| 19 | Robust Optimization of the Output Voltage of Nanogenerators by Statistical Design of Experiments显示文摘Nanogenerators were first demonstrated by deflecting aligned ZnO nanowires using a conductive atomic force microscopy(AFM)tip.The output of a nanogenerator is affected by three parameters:tip normal force,tip scanning speed,and tip abrasion.In this work,systematic experimental studies have been carried out to examine the combined effects of these three parameters on the output,using statistical design of experiments.A statistical model has been built to analyze the data and predict the optimal parameter settings.For an AFM tip of cone angle 70°coated with Pt,and ZnO nanowires with a diameter of 50 nm and lengths of 600 nm to 1μm,the optimized parameters for the nanogenerator were found to be a normal force of 137 nN and scanning speed of 40μm/s,rather than the conventional settings of 120 nN for the normal force and 30μm/s for the scanning speed.A nanogenerator with the optimized settings has three times the average output voltage of one with the conventional settings. | Jinhui Song Huizhi Xie Wenzhuo Wu V.Roshan Joseph C.F.Jeff Wu Zhong Lin Wang | 2010 | Nano Research2010，3，9： | 3 |
| 20 | Screening for gastric cancer in Asia: current evidence and practice显示文摘 | Wai K Leung Ming-shiang Wu Yasuo Kakugawa Jae J Kim Khay-guan Yeoh Khean Lee Goh Kai-chun Wu Deng-chyang Wu Jose Sollano Udom Kachintorn Takuji Gotoda Jaw-town Lin Wei-cheng You Enders KW Ng Joseph JY Sung | 2008 | Lancet Oncology2008，，3： | 3 |
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