|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Hepatocellular carcinoma locoregional therapies:Outcomes and future horizons显示文摘Hepatocellular carcinoma(HCC)is the most common primary cancer of the liver and has an overall five-year survival rate of less than twenty percent.For patients with unresectable disease,evolving liver-directed locoregional therapies provide efficacious treatment across the spectrum of disease stages and via a variety of catheter-directed and percutaneous techniques.Goals of locoregional therapies in HCC may include curative intent in early-stage disease,bridging or downstaging to surgical resection or transplantation for early or intermediate-stage disease,and local disease control and palliation in advanced-stage disease.This review explores the outcomes of chemoembolization,bland embolization,radioembolization,and percutaneous ablative therapies.Attention is also given to prognostic factors related to each of the respective techniques,as well as future directions of locoregional therapies for HCC. | Mina S Makary Stuart Ramsell Eric Miller Eliza W Beal Joshua D Dowell | 2021 | World Journal of Gastroenterology2021，27，43： | 2 |
| 4 | Breast and lung metastasis from pancreatic neuroendocrine carcinoma显示文摘Pancreatic neuroendocrine tumors(PNETs) are an uncommon malignancy,accounting for a small percentage of all pancreatic malignancies.Due to their insidious course,most PNETs present with metastatic disease.Although reports in the literature describe PNET metastasis to the liver,lung and brain,to date there are no reports of stage Ⅳ disease involving the breast.Moreover,the lack of consensus regarding classification and treatment of this entity leaves practitioners without standards of practice or a firm base from which to formulate prognosis.In this report,the case of a previously healthy 51-year-old woman with stage Ⅳ PNET is examined.After combined neoadjuvant therapy with 5-fluorouracil,carboplatin,etoposide and radiation,surgical resection revealed metastatic PNET to the breast and lung,with no microscopic evidence of residual disease within the pancreas.An extensive analysis of the presentation,diagnosis,imaging modalities,treatment options,and prognosis is included in the discussion.As demonstrated by our review,there is a need for further studies to delineate inconclusive evidence with respect to subtype classification,treatment and prognosis of PNETs. | Shevonne Satahoo-Dawes Joshua Palmer Eddie W Manning Ⅲ Joe Levi | 2011 | World Journal of Radiology2011，3，1： | 2 |
| 5 | Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study显示文摘BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney failure.Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is paramount.AIM To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 patients.The primary outcome was the occurrence of DGF.RESULTS The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressure<110 mmHg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/min.CONCLUSION We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine. | Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu | 2021 | World Journal of Transplantation2021，11，4： | 2 |
| 6 | Evaluation and treatment of internal impingement of the shoulder in overhead athletes显示文摘One of the most common pathologic processes seen in overhead throwing athletes is posterior shoulderpain resulting from internal impingement. 'Internal impingement' is a term used to describe a constellation of symptoms which result from the greater tuberosity of the humerus and the articular surface of the rotator cuff abutting the posterosuperior glenoid when the shoulder is in an abducted and externally rotated position. The pathophysiology in symptomatic internal impingement is multifactorial,involving physiologic shoulder remodeling,posterior capsular contracture,and scapular dyskinesis. Throwers with internal impingement may complain of shoulder stiffness or the need for a prolonged warm-up,decline in performance,or posterior shoulder pain. On physical examination,patients will demonstrate limited internal rotation and posterior shoulder pain with a posterior impingement test. Common imaging findings include the classic 'Bennett lesion' on radiographs,as well as articular-sided partial rotator cuff tears and concomitant SLAP lesions. Mainstays of treatment include intense non-operative management focusing on rest and stretching protocols focusing on the posterior capsule. Operative management is variable depending on the exact pathology,but largely consists of rotator cuff debridement. Outcomes of operative treatment have been mixed,therefore intense non-operative treatment should remain the focus of treatment. | Keith T Corpus Christopher L Camp David M Dines David W Altchek Joshua S Dines | 2016 | World Journal of Orthopedics2016，7，12： | 2 |
| 7 | Miniature reeonfigurable three-dimensional fractal tree antennas 显示文摘 | Joshua S P Douglas H W | 2004 | IEEE Trans on Antennas Propagat2004，52，8： | 1 |
| 8 | Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome 显示文摘 | YOSHIMOTO M JOSHUA A M CUNHA I W | 2008 | Mod Pathol2008，21，12： | 1 |
| 9 | Note, China' s Latest 'Threat' to the United States: The Failed CNOOC - UNO- CAL Merger and Its Implications for Exon - Florio and CFIUS 显示文摘 | See Casselman Joshua W | 2007 | Indiana International & Comparative Law Review2007，17，： | 1 |
| 10 | The potential for contamination of soil and surface waters from sewage sludge (hiosolids) in a sheep grazing study, Australia 显示文摘 | Joshua W D Michalk D L Curtis I H | 1998 | Geoderma1998，84，： | 1 |
| 11 | Visibility of wavelet quantization noise 显示文摘 | ANDREW B W GLORIA Y Y JOSHUA AS | 1997 | IEEETransactions on Image Processing1997，6，8： | 1 |
| 12 | Rationale for the use of optical mice chips for economic and accurate vehicle tracking 显示文摘 | JOSHUA D J DALE W C JON M A | 2007 | Automation Science Engineering2007，，9： | 1 |
| 13 | Approximating the nondominated front using the Pareto archived evolution strategy显示文摘 | Joshua D K David W C | 2000 | Evolutionary Computation2000，8，2： | 1 |
| 14 | Tube and shell side coupled thermal analysis of an HTGR helical tube once through steam generator using porous media method显示文摘 | Joshua Tanner Olson Li X W Wu X X | 2014 | Annals of Nuclear Energy2014，64，2： | 1 |
| 15 | Approximating the non-dominated front using the pareto archived evolution strategy显示文摘 | DAVID W C | 2000 | Evolutionary Computation2000，8，2： | 1 |
| 16 | Phycobilisome diffusion is required for light-state transitions in cyanobacteria显示文摘 | Joshua S Mullineaux C W | 2004 | Plant Physiology2004，135，： | 1 |
| 17 | Enhanced atherosclerosis and kidney dysfunction in eNOS-/-Apoe-/-mice are ameliorated by enalapril treatment显示文摘 | Joshua W Knowles Robert L | | 0，，04： | 1 |
| 18 | The vascu-lar system as a target of metal toxicity显示文摘 | Walter C P Joshua R E Daniel W N | 2008 | ToxicolSci2008，102，： | 1 |
| 19 | Urban Productivity and Factor Growth in the Late 19th Century显示文摘 | Bostic Raphael W Joshua S Gans Scott Sterm | 1997 | Journal of Urban Economics1997，，41： | 1 |
| 20 | Price discovery and causality in the australian share price index futures market显示文摘 | DAVID W | 1999 | Aus tralian Journal of Management1999，，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员