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| 1 | Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: A feasibility study显示文摘AIM: To develop novel biomarkers of rectal radiotherapy, we measured gene expression profiles on biopsies taken before and during preoperative radiotherapy. METHODS: Six patients presenting with a locally advanced rectal cancer (T>T2, N0/Nx, M0) eligible for preoperative radiotherapy (45 Gy in 25 fractions) were selected in a pilot study. Six tumor and 3 normal tissues biopsies were taken before and during radiotherapy,after a dose of 7.2 Gy at a median time of 1 h following irradiation (0:27-2:12). Tumor or normal tissue purity was assessed by a pathologist prior to RNA extraction. Mean RNA content was 23 μg/biopsy (14-37) before radiotherapy and 22.7 μg/biopsy (12-35) during radiotherapy. After RNA amplification, biopsies were analysed with 54K HG-U133A Plus 2.0 Affymetrix expression micro-arrays. Data were normalized according to MAS5 algorithm. A gene expression ratio was calculated as: (gene expression during radiotherapy-gene expression before radiotherapy)/gene expression before radiotherapy. Were selected genes that showed a ratio higher than ± 0.5 in all 6 patients. RESULTS: Microarray analysis showed that preoperative radiotherapy significantly up-regulated 31 genes and down-regulated 6 genes. According to the Gene Ontology project classification, these genes are involved in protein metabolism (ADAMDEC1 ; AKAP7 ; CAPN5 ; CLIC5 ; CPE ; CREB3L1 ; NEDD4L ; RAB27A), ion transport (AKAP7 ; ATP2A3 ; CCL28 ; CLIC5 ; F2RL2 ; NEDD4L ; SLC6A8), transcription (AKAP7 ; CREB3L1 ; ISX ; PAB-PC1L ; TXNIP), signal transduction (CAPN5 ; F2RL2 ; RA- B27A ; TNFRSF11A), cell adhesion (ADAMDEC1 ; PXDN ; SPON1 ; S100A2), immune response (CCL28 ; PXDN ; TNFRSF11A) and apoptosis (ITM2C ; PDCD4 ; PVT1). Up-regulation of 3 genes (CCL28 ; CLIC5 ; PDCD4) was detected by 2 different probes and up-regulation of 2 genes (RAB27A ; TXNIP) by 3 probes. CONCLUSION: Micro-arrays can efficiently assess early transcriptomic changes during preoperative radiotherapy for rectal cancer, and may help better understand tumor radioresistance. | Stephane Supiot Wilfried Gouraud Loc Campion Pascal Jezéquel Bruno Buecher Josiane Charrier Marie-Francoise Heymann Marc-Andre Mahé Emmanuel Rio Michel Chérel | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | Production of nitric oxide (NO) in human hydatidosis: Relationship between nitrite production and interferon-γ levels显示文摘 | Chafia Touil-Boukoffa Brigitte Bauvois Josiane Sancéau Boussad Hamrioui Juana Wietzerbin | 1998 | Biochimie1998，，： | 2 |
| 3 | Cryopreservation of human germinal vesicle stage and in vitro matured M II oocytes: influence of cryopreservation media on the survival, fertilization, and early cleavage divisions显示文摘 | Anuradha Goud Pravin Goud Chen Qian Josiane Van der Elst Georges Van Maele Marc Dhont | 2000 | Fertility and Sterility2000，，3： | 1 |
| 4 | Peroxisome proliferator-activated receptor mediates the adaptive response to fasting显示文摘 | Sander Kersten Josiane Seydoux Jeffrey M | 1999 | J Clin Invest1999，103，： | 1 |
| 5 | Association between maternal blood cadmium during pregnancy and birth weight and the risk of fetal growth restriction: The EDEN mother–child cohort study显示文摘 | Mehdi Menai Barbara Heude Remy Slama Anne Forhan Josiane Sahuquillo Marie-Aline Charles Chadi Yazbeck | 2012 | Reproductive Toxicology2012，，4： | 1 |
| 6 | P2PDating:Real life inspired semantic overlay networks for web search 显示文摘 | JOSIANE XAVIER PARREIRA SEBASTIAN MICHEL | 2007 | Information Processing and Management2007，，43： | 1 |
| 7 | Building development monitoring in multitemporal remotely sensed image pairs with stochastic birth-death dynamics显示文摘 | Csaba B Xavier D Josiane Z | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，1： | 1 |
| 8 | Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression显示文摘 | Olivier Boss Sonia Samec Ariane Paoloni-Giacobino Colette Rossier Abdul Dulloo Josiane Seydoux Patrick Muzzin Jean-Paul Giacobino | 1997 | FEBS Letters1997，，1： | 1 |
| 9 | Anti-inflammatory ,antinociceptive and cytotoxic effects of the methanolextract of Cecropia Pachystachya Trecul 显示文摘 | DANIELLE M O A 1SADEL V A L JOSIANE M S | 2013 | PhytotherapyResearch2013，27，6： | 1 |
| 10 | The Resin from Protium heptaphyllum Prevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms显示文摘 | Karine Maria Martins Bezerra Carvalho José Delano Barreto Marinho Filho Tiago Sousa de Melo Ana Jérsia Araújo Josiane da Silva Quetz Maria do Perpétuo Socorro Saldanha da Cunha Karina Moura de Melo Armenio Andre de Carvalho Almeida da Silva Adriana Rocha | 2015 | Evidence-Based Complementary and Alternative Medicine2015，，： | 1 |
| 11 | The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation显示文摘 | Giovanni Solinas Serge Summermatter Davide Mainieri Marcel Gubler Luciano Pirola Matthias P. Wymann Sandro Rusconi Jean-Pierre Montani Josiane Seydoux Abdul G. Dulloo | 2004 | FEBS Letters2004，，3： | 1 |
| 12 | 查看详情显示文摘 | Koray Kayabol Josiane Zerubia | | 0，，2： | 1 |
| 13 | Obese adolescents who gained/maintained or lost weight had similar body composition and cardiometabolic risk factors following a multidisciplinary intervention显示文摘 | JOSIANE A DANILO F LUZIA J H | 2014 | J Exerc Sci Fitness2014，12，1： | 1 |
| 14 | Quality of life among elderly people receiving home care services 显示文摘 | Josiane de Jesus Martins | 2009 | Acta Paul Enferm2009，22，3： | 1 |
| 15 | Extension of phase correlation to subpixel registration显示文摘 | Hassan Foroosh Josiane B Zerubia Marc Berthod | 2002 | IEEE Transactions on Image Processing2002，11，3： | 1 |
| 16 | VANET Routing on City Roads Using Real- Time Vehicular Traffic Information 显示文摘 | Josiane Nzouonta Neeraj Rajgure Guiling (Grace) Wang | 2009 | IEEE Transactions on Vehicular Technology2009，9，7： | 1 |
| 17 | Polycyclic aromatic hydrocarbons in atmospheric particles in the metropolitan area of Porto Alegre,Brazil显示文摘 | JULIANA B D JOSIANE G M ELBA C T JOSEMAR L S | 2005 | Atmospheric Environment2005，39，9： | 1 |
| 18 | Le Livre à l'Export et la Francophonie 2012显示文摘 | Josiane Castelbou | | 0，，： | 1 |
| 19 | EXPORTATIONS VERS LES PAYS FRANCOPHONES显示文摘 | Josiane Castelbou | | 0，，： | 1 |
| 20 | Effects of compression stockings during exercise and recovery on blood lactate kinetics显示文摘 | Diana Rimaud Laurent Messonnier Josiane Castells Xavier Devillard Paul Calmels | 2010 | European Journal of Applied Physiology2010，，2： | 1 |
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