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| 1 | Suppository naproxen reduces incidence and severity of post-endoscopic retrograde cholangiopancreatography pancreatitis: Randomized controlled trial显示文摘AIM: To determine the efficacy of rectally administered naproxen for the prevention of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP).METHODS: This double-blind randomized control trial conducted from January 2013 to April 2014 at the Gastrointestinal and Liver Diseases Research Center in Rasht, Iran. A total of 324 patients were selected from candidates for diagnostic or therapeutic ERCP by using the simple sampling method. Patients received a single dose of Naproxen(500 mg; n = 162) or a placebo(n = 162) per rectum immediately before ERCP. The overall incidence of PEP, incidence of mild to severe PEP, serum amylase levels and adverse effects were measured. The primary outcome measure was the development of pancreatitis onset of pain in the upper abdomen and elevation of the serum amylase level to > 3 × the upper normal limit(60-100 IU/L) within 24 h after ERCP. The severity of PEP was classified according to the duration of therapeutic intervention for PEP: mild, 2-3 d; moderate 4-10 d; and severe, > 10 d and/or necessitated surgical or intensive treatment, or contributed to death.RESULTS:PEP occurred in 12 %(40/324) o f participants, and was significantly more frequent in the placebo group compared to the naproxen group(P < 0.01). Of the participants, 25.9%(84/324) developed hyperamylasemia within 2 h of procedure completion, among whom only 35 cases belonged to the naproxen group(P < 0.01). The incidence of PEP was significantly higher in female sex, in patients receiving pancreatic duct injection, more than 3 times pancreatic duct cannulations, and ERCP duration more than 40 min(P s < 0.01). There were no statistically significant differences between the groups regarding the procedures or factors that might increase the risk of PEP, sphincterotomy, precut requirement, biliary duct injection and number of pancreatic duct cannulations. In the subgroup of patients with pancreatic duct injection, the rate of pancreatitis in the naproxen group was significantly lower than that in the placebo(6 patients vs 23 patients, P < 0.01, RRR = 12%, AR = 0.3, 95%CI: 0.2-0.6). Naproxen reduced the PEP in patients with ≥ 3 pancreatic cannulations(P < 0.01, RRR = 25%, AR = 0.1, 95%CI: 0.1-0.4) and an ERCP duration > 40 min(P < 0.01, RRR = 20%, AR = 0.9, 95%CI: 0.4-1.2).CONCLUSION: Single dose of suppository naproxen administered immediately before ERCP reduces the incidence of PEP. | Fariborz Mansour-Ghanaei Farahnaz Joukar Zahra Taherzadeh Homayoon Sokhanvar Tolou Hasandokht | 2016 | World Journal of Gastroenterology2016，22，21： | 4 |
| 2 | Seven-day quintuple regimen as a rescue therapy for Helicobacter pylori eradication显示文摘AIM: To determine the efficacy of two quintupleregimens for eradication of Helicobacter pylori(H. pylori) in patients who failed previous therapies.METHODS: This prospective, open-label, randomized controlled trial was a phase Ⅱ study conducted from April 2011 to March 2012 at the Gastrointestinal and Liver Diseases Research Center in Rasht, Iran. A total of 208 patients with dyspepsia who failed previous H. pylori eradication with a ten-day quadruple therapy were enrolled. A random block method was used to assign patients to one of two treatment groups. Patients in the first group were treated with 240 mg bismuth subcitrate, 20 mg omeprazole, 1000 mg amoxicillin, 500 mg clarithromycin and 500 mg tinidazole(BOACT group). Patients in the second group received a regimen containing 240 mg bismuth subcitrate, 20 mg omeprazole, 500 mg tetracycline, 500 mg metronidazole and 200 mg ofloxacin(BOTMO group). Both regimens were given twice daily for a duration of seven days. The eradication was confirmed by a 14 C urea breath test 12 wk after completion of therapy. Patient compliance and drug side effects were evaluated at the end of the treatment period. The success rates were calculated by intention-to-treat and per-protocol analyses.RESULTS: A total of 205 patients completed the course of treatment, with three patients excluded due to drug intolerance. The mean age of patients did not differ between the BOACT and BOTMO groups(41.6 ± 12.2 years vs 39.6 ± 11.8 years), and no significant differences were found between the two groups in terms of age, sex, smoking habits or the initial eradication regimen. The intention-to-treat and perprotocol eradication rates were significantly higher in the BOTMO group(86.5%, 95%CI: 0.85-0.87 and 86.7%, 95%CI: 0.80-0.89, respectively) compared with the BOACT group(75.5%, 95%CI: 0.73-0.76 and 76%, 95%CI: 0.69-0.80, respectively)(P < 0.05). Univariate analyses for both groups did not show any association of sex, smoking and initial therapeutic regimen witheradiation rate(P > 0.05 for all). Significantly more patients experienced side effects in the BOACT group compared to the BOTMO group(77.4% vs 36.6%, P < 0.01). This difference was exemplified by increases in headache and taste disturbance(P < 0.05).CONCLUSION: Quintuple therapy with a BOTMO regimen is an alternative second-line rescue therapy for Iranian patients with failed first-line eradication treatment of H. pylori. | Fariborz Mansour-Ghanaei Farahnaz Joukar Mohammad Reza Naghipour Atena Forouhari Seyed Mohammad Seyed Saadat | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 3 | Knowledge about Gastric Carcinoma in North of Iran, A High Prevalent Region for Gastric Carcinoma: A Population - Based Telephone Survey 显示文摘 | Fariborz Mansour - Ghanaei Farahnaz Joukar Fatemeh Soati | 2012 | Asian Pac J Cancer Prev2012，13，7： | 1 |
| 4 | Suscepti- bility to life-threatening ventricular arrhythmias in an animal model of paradoxical sleep deprivation 显示文摘 | Joukar S Ghorbani-Shahrbabaki S Hajali V | 2013 | Sleep Med2013，14，12： | 1 |
| 5 | Serum gastrin and the pepsinogen I/II ratio as markers for diag- nosis of permalignant gastric lesions 显示文摘 | Shafaghi A Mansour Ghanaei F Joukar F et ol | 2013 | Asian Pac J Cancer Prev2013，14，6： | 1 |
| 6 | Serum :astrin and the pepsinogen I / 1I ratio as markers for diagnosisof premalignant gastric lesions显示文摘 | shafaghi A Mansour Ghanaei F Joukar F | 2013 | Asian Pac J Cancer Prev2013，14，39： | 1 |
| 7 | Protective effects of saffron ( Crocus sativus ) against lethal ventricular ar- rhythmias induced by heart reperfusion in rat: a potential anti-ar- rhythmic agent 显示文摘 | Joukar S Ghasemipour-Afshar E Sheibani M | 2013 | Pharm Biol2013，51，7： | 1 |
| 8 | Neuroprotective an- tioxidant effect of sex steroid hormones in traumatic brain injury 显示文摘 | Shahrokhi N Haddad MK Joukar S | 2012 | Pak J Pharm Sci2012，25，1： | 1 |
| 9 | The effect of saffron consumption on biochemical and histopathological heart Indices of rats with myocardial infarction 显示文摘 | Joukar S Najafipour H Khaksari M | 2010 | Cardiov Toxicol2010，10，1： | 1 |
| 10 | Clinical Validation of an Office-Based 14C-UBT (Heliprobe) for H. pylori Diagnosis in Iranian Dyspeptic Patients显示文摘 | Fariborz Mansour-Ghanaei Omid Sanaei Farahnaz Joukar Y. Yamaoka | 2011 | Gastroenterology Research and Practice2011，，： | 1 |
| 11 | Screening of precancerous gastric lesions by serum pepsinogen,gastrin-17,anti-helicobacter pylori and anti-CagA antibodies in dyspeptic patients over 50 years old in Guilan Province,north of Iran显示文摘 | Mansour-Ghanaei F Joukar F Rajpout Y | 2014 | Asian Pac J Cancer Prev2014，15，18： | 1 |
| 12 | Protective effects of saffron (Crocus sativus) against lethal ventricular arrhythmias induced by heart reperfusion in rat: a potential anti-arrhythmic agent显示文摘 | Joukar S Ghasemipour-Afshar E Sheibani M | 2013 | Pharm Biol2013，51，7： | 1 |
| 13 | Serum gastrin and the pepsinogenⅠ/Ⅱratio as markers for diagnosis of premalignant gastric lesions显示文摘 | Shafaghi A Mansour-Ghanaei F Joukar F | 2014 | Asian Pacific J Cancer Prev2014，14，6： | 1 |
| 14 | Association between knowledge,locus of control and health belief with selfmanagement,Hb A1c level and number of attendances in type 1diabetes mellitus patients显示文摘 | Mansour-Ghanaei R Joukar F Soati F | 2013 | Int J Clin Exp Med2013，6，6： | 1 |
| 15 | Screening of precancerous gastric lesions by serum pepsinogen, gastrin-17, anti-helicobacter pylori and anti-CagA antibodies in dyspeptic patients over 50 years old in Guilan Province, north of Iran显示文摘 | MANSOUR-GHANAEI F JOUKAR F RAJPOUT Y | 2014 | Asian Pac J Cancer Prey2014，15，18： | 1 |
| 16 | Neuroprotective antioxidant effect of sex steroid hormones in traumatic brain injury显示文摘 | Nader Shahrokhi Mohammad K Haddad Siavash Joukar | 2012 | Pak J Pharm Sci2012，25，1： | 1 |
| 17 | Knowledge and attitude of medical science students toward Hepatitis B and C Infections 显示文摘 | Roya Mansour-Ghanaei Farahnaz Joukar Fatemeh Souti | 2013 | Int J Clin Exp Med2013，，3： | 1 |
| 18 | Protective effects of saffron( Crocus sativus)against lethal ventricular arrhyhmias induced by heart reperfusion in rat:A potential anti-arrhythmic agent 显示文摘 | JOUKAR S GHASEMIPOUR-AFSHAR E SHEIBANI M | 2013 | Pharm Biol2013，51，7： | 1 |
| 19 | Efficacy of Melissa officinalis in sup- pressing ventricular arrhythmias following ischemia-reperfusion of the heart :a comparison with amiodarone显示文摘 | Joukar S Zarisfi Z Sepehri G | 2014 | Med Princ Pract2014，23，4： | 1 |
| 20 | Efficacy of Melissa officinalis in suppressing ventricular arrhythmias following ischemia-reperfusion of the heart:a comparison with amiodarone显示文摘 | Joukar S Zarisfi Z Sepehri G | 2014 | Med Princ Pract2014，23，4： | 1 |
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