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| 1 | Neoadjuvant radiotherapy for rectal cancer management显示文摘Thirty per cent of all colorectal tumours develop in the rectum.The location of the rectum within the bony pelvis and its proximity to vital structures presents significant therapeutic challenges when considering neoadjuvant options and surgical interventions.Most patients with early rectal cancer can be adequately managed by surgery alone.However,a significant proportion of patients with rectal cancer present with locally advanced disease and will potentially benefit from down staging prior to surgery.Neoadjuvant therapy involves a variety of options including radiotherapy,chemotherapy used alone or in combination.Neoadjuvant radiotherapy in rectal cancer has been shown to be effective in reducing tumour burden in advance of curative surgery.The gold standard surgical rectal cancer management aims to achieve surgical removal of the tumour and all draining lymph nodes,within an intact mesorectal package,in order to minimise local recurrence.It is critically important that all rectal cancer cases are discussed at a multidisciplinary meeting represented by all relevant specialties.Pre-operative staging including CT thorax,abdomen,pelvis to assess for distal disease and magnetic resonance imaging to assess local involvement is essential.Staging radiology and MDT discussion are integral in identifying patients who require neoadjuvant radiotherapy.While Neoadjuvant radiotherapy is potentially beneficial it may also result in morbidity and thus should be reserved for those patients who are at a high risk of local failure,which includes patients with nodal involvement,extramural venous invasion and threatened circumferential margin.The aim of this review is to discuss the role of neoadjuvant radiotherapy in the management of rectal cancer. | Gerard Feeney Rishabh Sehgal Margaret Sheehan Aisling Hogan Mark Regan Myles Joyce Michael Kerin | 2019 | World Journal of Gastroenterology2019，25，33： | 28 |
| 2 | Current concepts in total femoral replacement显示文摘Total femoral replacement(TFR) is a salvage arthroplasty procedure used as an alternative to lower limb amputation. Since its initial description in the mid-20^(th) century, this procedure has been used in a variety of oncologic and non-oncologic indications. The most compelling advantage of TFR is the achievement of immediate fixation which permits early mobilization. It is anticipated that TFR will be increasingly performed as the rate of revision arthroplasty rises worldwide. The existing literature is mainly composed of a rather heterogeneous mix of retrospective case series and a wide assortment of case reports. Numerous TFR prostheses are currently available and the surgeon must understand the unique implications of each implant design. Long-term functional outcomes are dependent on adherence to proper technique and an appropriate physical therapy program for postoperative rehabilitation. Revision TFR is mainly performed for periprosthetic infection and the severe femoral bone loss associated with aseptic revisions. Depending on the likelihood of attaining infection clearance, it may sometimes be advisable to proceed directly to hip disarticulation without attempting salvage of the TFR. Other reported complications of TFR include hip joint instability, limb length discrepancy, device failure, component loosening, patellar maltracking and delayed wound healing. Further research is needed to better characterize the long-term functional outcomes and complications associated with this complex procedure. | Deepak Ramanathan Marcelo BP Siqueira Alison K Klika Carlos A Higuera Wael K Barsoum Michael J Joyce | 2015 | World Journal of Orthopedics2015，6，11： | 6 |
| 3 | A search engine for 3D models显示文摘 | Thomas Funkhouser Patrick Min Michael Kazhdan Joyce Chen Alex Halderman David Dobkin David Jacobs | 2003 | ACM Transactions on Graphics (TOG)2003，，1： | 3 |
| 4 | Quantitative Eas- ing And Unconventionalmonetary Policy - An Introduction显示文摘 | Michael Joyce David Miles Andrew Scott and Dimitri Vayanos | 2012 | The Economic Journal2012，，122： | 1 |
| 5 | Quantitative Easing and Unconventional Monetary Policy-an Introduction显示文摘 | Michael Joyce David Miles Andrew Scott and Dimitri Vayanos | 2012 | The Economic Journal2012，122，564： | 1 |
| 6 | Derivation of pluripotent stem cells from cultured human primordial germ cells 显示文摘 | Shamblott A Michael J Joyce A | 1998 | Dev Biol1998，95，13： | 1 |
| 7 | Quantitative easing and unconventional monetary policy-an introduction显示文摘 | Michael Joyce David Miles | 2012 | The Economic Journal2012，，11： | 1 |
| 8 | Trusted System Concepts显示文摘 | Marshall D Abrams Ph D Michael V Joyce | 1995 | Computers & Security1995，14，1： | 1 |
| 9 | Trusted Computing Update显示文摘 | Marshall D Abrams Ph D Michael V Joyce | 1995 | Computers & Security1995，14，1： | 1 |
| 10 | Extracting inflation expectations and inflation risk premia from the term structure: A joint model of the UK nominal and real yield curves显示文摘 | Michael A.S. Joyce Peter Lildholdt Steffen Sorensen | 2009 | Journal of Banking and Finance2009，，2： | 1 |
| 11 | Clinical outcomes of the Realize Adjustable Gastric Band-C at 2 years in a United States population显示文摘 | Scott A. Cunneen Collin E.M. Brathwaite Christopher Joyce Keith Gersin Keith Kim Jon L. Schram Erik B. Wilson Michael Schwiers Mario Gutierrez | 2013 | Surgery for Obesity and Related Diseases2013，，： | 1 |
| 12 | MicroRNA expression in colorectal cancer显示文摘 | Pier Jr Morin Niamh M. Hogan Myles R. Joyce Michael J. Kerin | 2012 | Cancer Biomarkers2012，，： | 1 |
| 13 | Differential proteoglycan and hyaluronan distribution in calcified aortic valves显示文摘 | Elizabeth H. Stephens Jerome G. Saltarrelli L. Scott Baggett Indrajit Nandi Joyce J. Kuo Alan R. Davis Elizabeth A. Olmsted-Davis Michael J. Reardon Joel D. Morrisett Kathryn Jane Grande-Allen | 2011 | Cardiovascular Pathology2011，，6： | 1 |
| 14 | Trusted computing update显示文摘 | Marshall D Abrams Michael V Joyce | 1995 | Computers & Security1995，14，1： | 1 |
| 15 | A Taxing Problem:The Complementary Use of Hard and Soft OR in the Public Sector显示文摘 | Joyce Brown Ceri Cooper Michael Pidd | 2006 | European Journal of Operational Research2006，，172： | 1 |
| 16 | Trusted system concepts显示文摘 | Marshall D Abrams Michael V Joyce | 1995 | Computers and Security1995，14，1： | 1 |
| 17 | Clustering categorical data sets using tabu search techniques 显示文摘 | MICHAEL K N JOYCE C W | 2002 | Pattern Recognition2002，35，： | 1 |
| 18 | Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial显示文摘 | David Neal Franz Elena Belousova Steven Sparagana E Martina Bebin Michael Frost Rachel Kuperman Olaf Witt Michael H Kohrman J Robert Flamini Joyce Y Wu Paolo Curatolo Petrus J de Vries Vicky H Whittemore Elizabeth A Thiele James P Ford Gaurav Shah Helene | 2012 | The Lancet2012，，： | 1 |
| 19 | Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway显示文摘 | Vesselina G. Cooke Valerie S. LeBleu Doruk Keskin Zainab Khan Joyce T. O’Connell Yingqi Teng Michael B. Duncan Liang Xie Genta Maeda Sylvia Vong Hikaru Sugimoto Rafael M. Rocha Aline Damascena Ricardo R. Brentani Raghu Kalluri | 2012 | Cancer Cell2012，，： | 1 |
| 20 | Intensity modulated radiotherapy in nasopharyngeal carcinoma: dosimetric advantage over conventional plans and feasibility of dose escalation显示文摘 | Michael KMK Ricky MCC Joyce S | 2003 | Int J Radiat Oncol Biol Phys2003，56，： | 1 |
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