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| 1 | Cryptogenic multifocal ulcerous stenosing enteritis: Radiologic features and clinical behavior显示文摘AIM To investigate the characteristic radiologic findings of cryptogenic multifocal ulcerous stenosing enteritis(CMUSE) which can be differentiated from other similar bowel disease and to assess their clinical behavior.METHODS Twenty pathologically and clinically confirmed CMUSE patients(males:females = 8:12; mean age: 40.4 years) between March 2002 and August 2015 from seven academic centers in South Korea were retrospectively reviewed. We evaluated small bowel series(SBS; n = 25), computed tomography(CT) enterography(n = 21), magnetic resonance(MR) enterography(n = 2), and abdominopelvic CT(n = 18) images, focusing on enteric and perienteric manifestations. Any change in radiologic features during followup period was recorded. We evaluated clinical data including presenting symptoms, laboratory finding and presence of relapse from electronic medical records. Histopathologic findings were also evaluated. RESULTS The main symptoms were abdominal pain(n = 12) and anemia(n = 10). All patients showed small bowel strictures(n = 52, mean: 2.6 per patient) on initial CT/MR, located in the ileum(n = 47) or jejunum(n = 5). Strictures showed short-length(mean: 10.44 mm) and circumferential bowel wall thickening(mean: 5.56 mm) with layered enhancement(n = 48) that were also noted on initial SBS(n = 36) with shallow ulcers(n = 10). Some ulcerative lesions or wall thickening progressed into strictures on follow-up SBS/CT, and some strictures revealed recurrent ulceration on followup SBS. There were no penetrating disease features like fistula or abscess and no gastrointestinal tract involvement except the small bowel. Nine patients experienced disease recurrence(median relapse-free period: 32 mo) even post-operatively. Histopathologic features of surgically resected specimens were characterized as multiple superficial ulcerations confined to mucosa or submucosa and multiple strictures.CONCLUSION Under characteristic radiologic findings with multiple short-segmental strictures and/or shallow ulcers of the small intestine, CMUSE should be considered when assessing patients with recurrent abdominal pain and anemia. | Jiyoung Hwang Jin Sil Kim Ah Young Kim Joon Seok Lim Se Hyung Kim Min Ju Kim Mi Sung Kim Kyoung Doo Song Ji Young Woo | 2017 | World Journal of Gastroenterology2017，23，25： | 4 |
| 2 | Expert Opinions on the Concept of Blood Stasis in China: An Interview Study显示文摘Objective: To study various experts' opinions on the definition and diagnosis of blood stasis in China. Methods: We e-mailed the selected experts to explain the purpose of the study and to invite them to participate and asked them to name a time for the investigator to call them. Eight experts and five organizations were interviewed in the research community investigating blood stasis in China. Results: Six main categories emerged from the interviews:(1) blood stasis concepts;(2) blood stasis-related biomarkers;(3) methods of diagnosing blood stasis;(4) drugs for promoting blood circulation and dissipating stasis;(5) blood stasis-related diseases; and(6) blood stasis-related societies. The consensus among the interviewed experts was that the definition of blood stasis is rather complicated and that there is no gold standard marker for detecting blood stasis. Conclusion: This paper acquired experts' opinions on the definition and diagnosis of blood stasis in order to establish a modern concept of blood stasis. This paper also developed a diagnostic tool and diagnostic indices for blood stasis and identified biological indices and pathologic mechanisms related to blood stasis, which might be of great reference value in future blood stasis standardization research. | Tae-Young Choi Ji Hee Jun Ju Ah Lee Bongki Park Sooseong You Jeeyoun Jung Myeong Soo Lee | 2016 | Chinese Journal of Integrative Medicine2016，22，11： | 3 |
| 3 | Standardization and Future Directions in Pattern Identification Research: International Brainstorming Session显示文摘An international brainstorming session on standardizing pattern identification(PI) was held at the Korea Institute of Oriental Medicine on October 1, 2013 in Daejeon, South Korea. This brainstorming session was convened to gather insights from international traditional East Asian medicine specialists regarding PI standardization. With eight presentations and discussion sessions, the meeting allowed participants to discuss research methods and diagnostic systems used in traditional medicine for PI. One speaker presented a talk titled 'The diagnostic criteria for blood stasis syndrome: implications for standardization of PI'. Four speakers presented on future strategies and objective measurement tools that could be used in PI research. Later, participants shared information and methodology for accurate diagnosis and PI. They also discussed the necessity for standardizing PI and methods for international collaborations in pattern research. | Jeeyoun Jung Bongki Park Ju Ah Lee Sooseong You Terje Alraek 卞兆祥 Stephen Birch Tae-Hun Kim 徐浩 Chris Zaslawski Byoung-Kab Kang Myeong Soo Lee | 2016 | Chinese Journal of Integrative Medicine2016，22，9： | 3 |
| 4 | Diagnostic Indicators for Blood Stasis Syndrome Patients with Gynaecological Diseases显示文摘Objective: To investigate the important diagnostic indicators for blood stasis syndrome(BSS) in patients of childbearing age with gynaecological diseases. Methods: A partial least squared-discriminant analysis(PLS-DA) were applied to BSS symptoms data of patients with gynaecological diseases, and the diagnostic indicators used by doctors of Korean medicine(DKMs) among BSS patients with gynaecological diseases were also investigated. Results: A total of 103 patients of childbearing age with gynaecological diseases and 40 healthy controls were enrolled. Among the 103 patients, 63(61.7%) and 40(38.8%) were diagnosed with BSS and non-BSS, respectively, and BSS patients exhibited a more severe extent of disease. A score plot of PLS-DA showed clearly different patterns among the 3 groups. Based on the variable importance on projection of PLS-DA model, menstrual pains, dark lumps in the menstrual blood, ileocoecal tenderness and resistance, sharp pains, and sublingual varicosities were selected as the top five most important indicators. Moreover, more than 75% of DKMs chose dark lumps in menstrual blood, menstrual pain, and dark menstrual blood as the diagnostic indicators of BSS in patients with gynaecological diseases, and more than 49% of them also considered sharp pains, dark red tongue, sublingual varicosities, and tendency to bruise easily as diagnostic indicators of BSS. Conclusion: DKMs focused on menstrual symptoms and certain gynaecological symptoms to diagnose BSS patients of childbearing age with female diseases. | Jeeyoun Jung Mi Mi Ko Myeong Soo Lee So Min Lee Ju Ah Lee | 2018 | Chinese Journal of Integrative Medicine2018，24，10： | 3 |
| 5 | Extraction and identification of three major aldose reductase inhibitors from Artemisia montana显示文摘 | Hyun Ah Jung M.D. Nurul Islam Yong Soo Kwon Seong Eun Jin You Kyung Son Jin Ju Park Hee Sook Sohn Jae Sue Choi | 2010 | Food and Chemical Toxicology2010，，2： | 2 |
| 6 | A Functional Single Nucleotide Polymorphism in Mucin 1 , at Chromosome 1q22, Determines Susceptibility to Diffuse-Type Gastric Cancer显示文摘 | Norihisa Saeki Akira Saito Il Ju Choi Keitaro Matsuo Sumiko Ohnami Hirohiko Totsuka Suenori Chiku Aya Kuchiba Yeon–Su Lee Kyong–Ah Yoon Myeong–Cherl Kook Sook Ryun Park Young–Woo Kim Hideo Tanaka Kazuo Tajima Hiroshi Hirose Fumihiko Tanioka Yoshihiro Mats | 2011 | Gastroenterology2011，，3： | 1 |
| 7 | Treatment of Borrmann type IV gastric cancer with a neoadjuvant chemotherapy combination of docetaxel,cisplatin and 5-fluorouracil/leucovorin显示文摘 | Sun XC Lin J Ju AH | 2011 | J Int Med Res2011，39，6： | 1 |
| 8 | Electrical and Thermal Characterization of a Dielectrophoretic Chip with 3D Electrodes for Cells Manipulation显示文摘 | Francis Tay E H Liming Yu Ah Ju Pang Ciprian Iliescu | 2007 | Electrochimica Acta2007，52，： | 1 |
| 9 | Inhibition of advanced glycation endproducts formation by Korean thistle,Cirsium maackii显示文摘Objective:To evaluate inhibitoy potential of seven Korean thistles against the advanced glyeatinn endproducts(AGE) formation as well as to identify responsible compounds from the most active species.Methods:We used an in vitro AGE inhibition assay to evaluate the antidiabetic complication potential of the methanol extracts of the selected Korean thistles.Results:Among the seven Korean thistles,the leaves of Cirsium maackii(C.maackii) exhibited the most significant inhibitory activity against AGE formation.By means of bioassay-directed fractionation,a lignan.chlorogenic acid and 14 flavonoids were isolated from the active ethyl acetate soluble fraction of a methanol extract from C.maackii leaves.Luteolin and its 5-O-glueoside have been previously isolated:however,a lignan and 13 known compounds were isolated for the first lime from C maackii leaves in this study.Most of the isolated compounds exhibited inhibitory activities against potential AGE formation.Among them,cernuoside was shown to be the most potent AGE inhibitor with an IC_(50) value of 21.21 μ mol/L.Most importantly,two major flavonoids,luteolin and ils 5-O-glucoside,also significantly inhibited AGE formation,with IC_(50) values of36.33 and 37.47 μmol/L,respectively.Structure activity relationship revealed that the presence of free 3'and 4' dihydroxyl group in flavonoids skeleton played an important role in AGE inhibition.Conclusions:These results indicate that C.maackii and C maackii-derived flavonoids might be explored further to develop therapeutic agents for the prevention of diabetic eoniplicalions due to their significant inhibitory activity against AGE formation. | Hyun Ah Jung Jin Ju Park Byung Sun Min Hee Jin Jung Md.Nurul Islam Jae Sue Choi | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，1： | 1 |
| 10 | Biological Advantages of Porous Hydroxyapatite Scaffold Made by Solid Freeform Fabrication for Bone Tissue Regeneration显示文摘 | Byeong‐Ju Kwon Jungsung Kim Yong Hwa Kim Mi Hee Lee Hyun Sook Baek Dae Hyung Lee Hye‐Lee Kim Hyok Jin Seo Min Hyeon Lee Soon‐Young Kwon Min‐Ah Koo Jong‐Chul Park | 2013 | Artificial Organs2013，，7： | 1 |
| 11 | Adverse events associated withanterior cervical spine surgery显示文摘 | Daniels AH Riew KD Yoo JU | 2008 | J Am Acad Orthop Surg2008，12，： | 1 |
| 12 | Factor analytical study of the short version of the World Health Organization quality of life instrument显示文摘 | Ohaeri JU Olusina AK Al-Abassi AH | 2004 | Psychopathology2004，37，： | 1 |
| 13 | Adverse events associated with anterior cervical spine surgery 显示文摘 | Daniels AH Riew DK Yoo JU | 2008 | J Am Acad Orthop Surg2008，16，12： | 1 |
| 14 | Cervical length at 16-22 weeks' gestation and risk of preterm delivery 显示文摘 | Hibbard JU Tart M Moawad AH | 2000 | Obstet Gynecol2000，96，6： | 1 |
| 15 | In vitro mesengenic potential of human umbilical cord blood-derived mesenchymal stem cells显示文摘 | Eun Ji Gang Seung Hyun Hong Ju Ah Jeong Soo Han Hwang Seong Whan Kim II Ho Yang Chiyoung Ahn Hoon Han Hoeon Kim | 2004 | Biochemical and Biophysical Research Communications2004，，1： | 1 |
| 16 | Regular aspirin-use preceding the onset of primaryint racerebral hemorrhage is an independent predictor for death显示文摘 | Saloheimo P Ah OM Ju VS | 2006 | Stroke2006，37，1： | 1 |
| 17 | In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocyte-like cells显示文摘 | Seung H H Eun Ji Gang Ju Ah Jeong | 2005 | Biophysical Research Communications2005，330，2005： | 1 |
| 18 | Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina显示文摘 | Ju WK Neufeld AH | 2002 | J Comp Neurol2002，452，4： | 1 |
| 19 | Cervical length at 16 -22 weeks' gestation and risk of preterm delivery 显示文摘 | Hibbard JU Tart M Moawad AH | 2000 | Obstet Gynecol2000，96，6： | 1 |
| 20 | Drug-In- duced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multifl orum Thunb显示文摘 | Kyoung Ah Jung Hyun Ju Min Seung Suk Yoo | 2011 | Gut Liver2011，5，4： | 1 |
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