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| 1 | Prognostic factors and time-related changes influence results of colorectal liver metastases surgical treatment:A single-center analysis显示文摘AIM:To analyze the prognostic factors involved in survival and cancer recurrence in patients undergoing surgical treatment for colorectal liver metastases(CLM) and to describe the effects of time-related changes on survival and recurrence in these patients.METHODS:From January 1994 to January 2006,236 patients with CLM underwent surgery with the aim of performing curative resection of neoplastic disease at our institution and 189(80%) of these patients underwent resection of CLM with curative intention.Preoperative,intraoperative and postoperative data,including primary tumor and CLM pathology results,were retrospectively reviewed.Patients were divided into two time periods:a first period from January 1994 to January 2000(n = 93),and a second period from February 2000 to January 2006(n = 143).RESULTS:Global survival at 1,3 and 5 years in patients undergoing hepatic resection was 91%,54% and 47%,respectively.Patients with preoperative extrahepatic disease,carcinoembryonic antigen(CEA) levels over 20 ng/dL,more than four nodules or extrahepatic invasion at pathological analysis had worse survival.Tumor recurrence rate at 1 year was 48.3%,being more frequent in patients with preoperative and pathological extrahepatic disease and CEA levels over 20 ng/dL.Although patients in the second time period had more adverse prognostic factors,no differences in overall survival and recurrence were observed between the two periods.CONCLUSION:Despite advances in surgical technique and better adjuvant treatments and preoperative imaging,careful patient staging and selection is crucial to continue offering a chance of cure to patients with CLM. | Josep Martí María Marta Modolo Josep Fuster Jaume Comas Rebeca Cosa Joana Ferrer Victor Molina Juan Romero Constantino Fondevila Ramón Charco Juan Carlos García-Valdecasas | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 2 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 3 | Effect of femtosecond laser-assisted lens surgery on the optic nerve head and the macula显示文摘AIM: To evaluate the effect of femtosecond laser-assisted lens surgery(FLALS;cataract surgery or refractive lens exchange) on the structure of the optic nerve head and the macula.METHODS: This prospective longitudinal study included healthy eyes undergoing FLALS. Eyes with glaucoma or any other ocular disease that could alter optical coherence tomography results were excluded. Retinal nerve fiber layer(RNFL), Bruch’s membrane opening-minimum rim width(BMO-MRW) and macular thickness(MT) were measured preoperatively, 1 and 6 mo after surgery using spectral-domain optical coherence tomography(SD-OCT). Changes between preoperative and postoperative values were evaluated.RESULTS: A total of 87 eyes of 46 patients were included in this study. Preoperative RNFL, BMO-MRW and MT in microns(μm) were 100.77±10.39, 330.31±49.99 and 276.30±33.39, respectively. Postoperative RNFL, BMO-MRW and MT were 104.74±11.55, 348.32±54.05 and 279.83±22.65 1 mo after surgery and 102.93±11.17, 343.11±53.4 and 278.90±22.19 6 mo after surgery, respectively;which equals an increase of 3.93%, 5.45% and 1.27%,respectively, 1 mo after surgery, and 2.14%, 3.87% and 0.94% 6 mo after surgery. The differences between the preoperative and the postoperative RNFL and BMO-MRW values were statistically significant(P<0.001). Regarding MT values, there were not statistically significant differences(P=0.26).CONCLUSION: Our study suggests that FLALS does not have a negative impact on the structural status of the optic nerve head in healthy eyes, assessed by SD-OCT. There is a slight increase in the values of RNFL, BMO-MRW and MT 1 mo and 6 mo after surgery. | Josefina Renones de Abajo Beatriz Estévez Jorge Jesús María González Martín Humberto Carreras Díaz Juan Francisco Loro Ferrer Alfonso Antón López | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 2 |
| 4 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 5 | Synthesis of sugar esters in solvent mictures by lipases from Thermomyces lanuginosus and Candida antarctica B, and their antimicrobial properties显示文摘 | Manuel Ferrer Juan Soliveri | 2005 | EnzymeMicrobTechnol2005，36，： | 1 |
| 6 | Analyses of genetic diversity in Cuban rice varieties using isozyme, RAPD and AFLP markers显示文摘 | Jorge Luis Fuentes Fabio Escobar Alba Alvarez Geraldo Gallego Miriam Cristina Duque Mirle Ferrer Juan Enrrique Deus Joe M. Tohme | 1999 | Euphytica1999，，2： | 1 |
| 7 | Graft and viral outcomes in retransplantation for hepatitis C virus recurrence and HCV primary liver transplantation: a case–control study显示文摘 | Josep Martí Sofia De la Serna Gonzalo Crespo Xavier Forns Joana Ferrer Constantino Fondevila Miquel Navasa Josep Fuster Juan Carlos García‐Valdecasas | 2014 | Clin Transplant2014，，7： | 1 |
| 8 | Effects of intravenous albumin in patients with cirrhosis and episodic hepatic encephalopathy: A randomized double-blind study显示文摘 | Macarena Simón-Talero Rita García-Martínez Maria Torrens Salvador Augustin Susana Gómez Gustavo Pereira Mónica Guevara Pere Ginés Germán Soriano Eva Román Jordi Sánchez-Delgado Roser Ferrer Juan C. Nieto Pilar Sunyé Inma Fuentes Rafael Esteban Juan Córdob | 2013 | Journal of Hepatology2013，，6： | 1 |
| 9 | Neurologic Outcome of Posttraumatic Refractory Intracranial Hypertension Treated With External Lumbar Drainage显示文摘 | Josep M. Abadal-Centellas Juan A. Llompart-Pou Javier Homar-Ramírez Jon Pérez-Bárcena Ainhoa Rosselló-Ferrer Jordi Ibá?ez-Juvé | 2007 | The Journal of Trauma: Injury Infection and Critical Care2007，，2： | 1 |
| 10 | Forecasting traffic accidents using disaggregated data显示文摘 | Garca Ferrer A A de Juan Poncela P | 2006 | International Journal of Forecasting2006，，22： | 1 |
| 11 | Results of laparoscopic radiofrequency ablation for HCC . Could the location of the tumour influence a complete response to treatment? A single European centre experience显示文摘 | Sofía Serna Ramón Vilana Santiago Sánchez‐Cabús David Calatayud Joana Ferrer Victor Molina Constantino Fondevila Jordi Bruix Josep Fuster Juan‐Carlos García‐Valdecasas | 2015 | HPB2015，，5： | 1 |
| 12 | Integrative Molecular Analysis of Intrahepatic Cholangiocarcinoma Reveals 2 Classes That Have Different Outcomes显示文摘 | Daniela Sia Yujin Hoshida Augusto Villanueva Sasan Roayaie Joana Ferrer Barbara Tabak Judit Peix Manel Sole Victoria Tovar Clara Alsinet Helena Cornella Brandy Klotzle Jian–Bing Fan Christian Cotsoglou Swan N. Thung Josep Fuster Samuel Waxman Juan Carlos | 2013 | Gastroenterology2013，，4： | 1 |
| 13 | Ae2 a,b -Deficient Mice Develop Antimitochondrial Antibodies and Other Features Resembling Primary Biliary Cirrhosis显示文摘 | January T. Salas Jesús M. Banales Sarai Sarvide Sergio Recalde Alex Ferrer Iker Uriarte Ronald P.J. Oude Elferink Jesús Prieto Juan F. Medina | 2008 | Gastroenterology2008，，5： | 1 |
| 14 | Synthesis of sugar esters in solvent mictures by lipases from thermomyces lanuginosus and candida antarctica B,and their antimicrobial properties显示文摘 | Manuel Ferrer Juan Soliveri | 2005 | Enzyme and Microblal Technology2005，36，： | 1 |
| 15 | NAD- specific, glutamate dehydrogenase from Thermus thermophilus HB8: Purification and enzymatic properties显示文摘 | Jose Luis Ruiz Juan Ferrer Monica Camacho | 1998 | FEMS Microbiology letters1998，159，： | 1 |
| 16 | Synthesis of sugar esters in solvent mixtures by lipases from Thermomyces lanuginosus and Candida antarctica B,and their antimicrobial properties显示文摘 | FERRER M JUAN S PLOU F J P | 2005 | Enzyme and Microbial Technology2005，36，4： | 1 |
| 17 | Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice显示文摘 | Agustín Rodríguez Esther Pérez-Gracia Juan Carlos Espinosa Martí Pumarola Juan María Torres Isidro Ferrer | 2006 | Acta Neuropathologica2006，，5： | 1 |
| 18 | Synthesis of sugar esters in solvent mixtures by lipases from Thermomyces lanuginosus and Candida antarctica B, and their antimicrobial properties 显示文摘 | Manuel Ferrer Juan Soliveri Francisco J Plou | 2005 | Enzyme and Microbial Technology2005，，36： | 1 |
| 19 | Multivari- ate image analysis: a review with applieations显示文摘 | PARTS-MONTALBAN J M DE JUAN A FERRER A | 2011 | Chemometrics and Intelligent Laboratory Systems2011，107，1： | 1 |
| 20 | Synthesis of sugar esters in solvent mixtures by lipases from Thermomyces lanuginosus and Candida antarctica B,and their antimicrobial properties显示文摘 | Manuel Ferrer Juan Soliveri Francisco J Plou | 2005 | Enzyme and Microbial Technology2005，36，42： | 1 |
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