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| 1 | Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer显示文摘Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity.Dendritic cell(DCs)vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality.Lung cancer is a lethal disease with the highest morbidity and mortality rate in the world.Despite the rapid development of targeted therapy and immune checkpoint inhibitors for lung cancer in recent years,their efficacy is still unsatisfactory overall.Therefore,there is an urgent unmet clinical need for lung cancer treatment.Here,we attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous DC vaccine and conducted a single-arm,2 medical centers,pilot study initiated by the investigator(ChiCTR-ONC 16009100,NCT02956551).The patients enrolled were patients with heavily treated metastatic lung cancer.Candidate neoantigens were derived from whole-exome sequencing and RNA sequencing of fresh biopsy tissues as well as bioinformatics analysis.A total of 12 patients were enrolled in this study.A total of 85 vaccine treatments were administered with a median value of 5 doses/person(range:3-14 doses/person).In total,12-30 peptide-based neoantigens were selected for each patient.AIl treatment-related adverse events were grade 1-2 and there were no delays in dosing due to toxic effects.The objective effectiveness rate was 25%;the disease control rate was 75%;the median progression-free survival was 5.5 months and the median overall survival was 7.9 months.This study provides new evidence for neoantigen vaccine therapy and new therapeutic opportunities for lung cancer treatment. | Zhenyu Ding Qing Li Rui Zhang Li Xie Yang shu Song Gao Peipei Wang Xiaoqing Su Yun Qin Yuelan Wang Juemin Fang Zhongzheng Zhu Xuyang Xia Guochao Wei Hui Wang Hong Qian Xianling Guo Zhibo Gao Yu Wang Yuquan Wei Qing Xu Heng Xu Li Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
| 2 | Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer显示文摘Given that only a subset of patients with colorectal cancer(CRC)benefit from immune checkpoint therapy,efforts are ongoing to identify markers that predict immunotherapeutic response.Increasing evidence suggests that microbes influence the efficacy of cancer therapies.Fusobacterium nucleatum induces different immune responses in CRC with different microsatellite-instability(MSI)statuses.Here,we investigated the effect of F.nucleatum on anti-PD-L1 therapy in CRC.We found that high F.nucleatum levels correlate with improved therapeutic responses to PD-1 blockade in patients with CRC.Additionally,F.nucleatum enhanced the antitumor effects of PD-L1 blockade on CRC in mice and prolonged survival.Combining F.nucleatum supplementation with immunotherapy rescued the therapeutic effects of PD-L1 blockade.Furthermore,F.nucleatum induced PD-L1 expression by activating STING signaling and increased the accumulation of interferon-gamma(IFN-γ)^(+)CD8^(+)tumor-infiltrating lymphocytes(TILs)during treatment with PD-L1 blockade,thereby augmenting tumor sensitivity to PD-L1 blockade.Finally,patient-derived organoid models demonstrated that increased F.nucleatum levels correlated with an improved therapeutic response to PD-L1 blockade.These findings suggest that F.nucleatum may modulate immune checkpoint therapy for CRC. | Yaohui Gao Dexi Bi Ruting Xie Man Li Jing Guo Hu Liu Xianling Guo Juemin Fang Tingting Ding Huiyuan Zhu Yuan Cao Meichun Xing Jiayi Zheng Qing Xu Qian Xu Qing Wei Huanlong Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 3 |
| 3 | Study on instantaneous detection of harmonics and reactive currents in single phase active power filter显示文摘 | FU Zhenyu LIU Juemin ZHANG Yanlin | 2006 | Electric Drive2006，36，3： | 1 |
| 4 | A Comparison Between the Distinct Element Method and the Finite Element Method for Analysis of the Stability of an Excavation in Jointed Rock显示文摘 | CHARLES FAIRHURS JUEMIN PEI | | 0，，01： | 1 |
| 5 | Expression of toll-like receptor 4 is down-regulated during progression of cervical neoplasia显示文摘 | Li Yu Liantang Wang Mengzhen Li Juemin Zhong Zhuo Wang Shangwu Chen | 2010 | Cancer Immunology Immunotherapy2010，，7： | 1 |
| 6 | Expression of toll-like receptor 4 is down-regulated during progression of cervical neoplasia显示文摘 | Li Yu Liantang Wang Mengzhen Li Juemin Zhong Zhuo Wang Shangwu Chen | 2010 | Cancer Immunology Immunotherapy2010，，7： | 1 |
| 7 | Researches on medium-- and short-term earthquake prediction by crustal deformation measurement显示文摘 | Wanju Bo Juemin Xie Yang Bingshun | 1997 | Journal of Earthquake Prediction Research1997，6，4： | 1 |
| 8 | Unstable fault deformation and information synthesis显示文摘 | Wanju Bo Juemin Xie Lou Guanshou | 1997 | Acta Seismologica Sinica1997，10，2： | 1 |
| 9 | A Comparison Between the Distinct Element Method and the Finite Element Method for Analysis of the Stability of an Excavation in Jointed Rock显示文摘 | Charles Fairhurst Juemin Pei | 1990 | Tunnelling and Underground Space Technology1990，5，1： | 1 |
| 10 | Polypyrimidine Tract-Binding Protein Regulates Enterovirus 71 Translation Through Interaction with the Internal Ribosomal Entry Site显示文摘Enterovirus 71(EV71), a major causative agent of hand, foot, and mouth disease, has caused periodic infection outbreaks in children in the Asia–Pacific region. In order to describe the largely unknown life cycle of EV71, the molecular basis of its virus-host interactions must first be determined. The 50 untranslated region of EV71 contains a cloverleaf-like structure and internal ribosomal entry site(IRES), which play an important role in transcription and translation of viral protein. We found that polypyrimidine tract-binding protein 1(PTB) bound to the IRES of EV71. RNA recognition motifs 1 and 2 of PTB were responsible for its binding to the EV71 IRES. Moreover, PTB protein was shuttled from nucleus to cytoplasm after EV71 infection. Additionally, IRES activity and viral protein production were inhibited by PTB knockdown. These results suggest that PTB interacts with the EV71 IRES, and positively regulates viral protein translation. | Juemin Xi Fei Ye Guanzhou Wang Wei Han Zhizhong Wei Bin Yin Jiangang Yuan Boqin Qiang Xiaozhong Peng | 2019 | Virologica Sinica2019，34，1： | 1 |
| 11 | A Comparison Between the Distinct Element Method and the Finite Element Method for Analysis of the Stability of an Excavation in Jointed Rock显示文摘 | Charles Fairhurst Juemin Pei | 1990 | Tunneling and Underground Space Technology1990，5，1： | 1 |
| 12 | Splicing factor SF3B3,a NS5-binding protein,restricts ZIKV infection by targeting GCH1显示文摘Zika virus(ZIKV),a positive-sense single-stranded RNA virus,causes congenital ZIKV syndrome in children and Guillain-Barre Syndrome(GBS)in adults.ZIKV expresses nonstructural protein 5(NS5),a large protein that is essential for viral replication.ZIKV NS5 confers the ability to evade interferon(IFN)signalling;however,the exact mechanism remains unclear.In this study,we employed affinity pull-down and liquid chromatography-tandem mass spectrometry(LC-MS/MS)analyses and found that splicing factor 3b subunit 3(SF3B3)is associated with the NS5-Flag pull-down complex through interaction with NS5.Functional assays showed that SF3B3 overexpression inhibited ZIKV replication by promoting IFN-stimulated gene(ISG)expression whereas silencing of SF3B3 inhibited expression of ISGs to promote ZIKV replication.GTP cyclohydrolase I(GCH1)is the first and ratelimiting enzyme in tetrahydrobiopterin(BH4)biosynthesis.NS5 upregulates the expression of GCH1 during ZIKV infection.And GCH1 marginally promoted ZIKV replication via the IFN pathway.Additionally,GCH1 expression is related to the regulation of SF3B3.Overexpression of the SF3B3 protein effectively reduced GCH1 protein levels,whereas SF3B3 knockdown increased its levels.These findings indicated that ZIKV NS5 binding protein SF3B3 contributed to the host immune response against ZIKV replication by modulating the expression of GCH1. | Tanxiu Chen Hao Yang Penghui Liu Moliduer Hamiti Xintian Zhang Yi Xu Wenqi Quan Yong Zhang Wenhai Yu Li Jiao Tingfu Du Juemin Xi Bin Yin Wei Zhou Shuaiyao Lu Xiaozhong Peng | 2023 | Virologica Sinica2023，38，2： | 0 |
| 13 | Reminiscences of Kochen Chu, My Teacher显示文摘Two accomplished educators stood out inthe history of China during 20th century.Oneis Mr.Cai Yuanpei and the other is Mr.Kochen Chu.During World War Two,Zhejiang Universitymoved four times due to the attack ofJapanese agressors.Led by Chu,president ofZhejiang University,we students trekkedacross mountains and rivers.I saw how | Xie Juemin Guo Chengang | 1997 | 文化交流1997，，1： | 0 |
| 14 | Environment Elements and Polution Factors Systemativally Identifying and Bolting in Environment Impact Assessment | SHI Xiaofeng YANG Guodong Xue Juemin Department of Environmental Science,Shanxi University 030006 | 1998 | Systems Science and Systems Engineering1998，8，3： | 0 |
| 15 | From the Folk Stage to the World Arena Farmer Painting Activity in Yaozhuang Town显示文摘On August,24,2013,a group of farmers from Yaozhuang,a town in Zhejiang Province,came to Changning Art Museum of Shanghai with their 70 paintings.These paintings showed the working and living of local farmers in a vivid fashion and brought fresh and simple atmosphere to Shanghai people.As a town both ancient and modern in Zhejiang Province,it is home to a va riety of traditional arts originated from Jiangnan(regions south of the Yangtze River)folk culture.The hardworking farmers are depicting their happiness with their own hands. | Zhang Juemin Su Lijun | 2013 | China & The World Cultural Exchange2013，79，12： | 0 |
| 16 | EFFECTS OF AN INDWELLING HOLLOW FIBER OXYGENATOR ON BLOOD FLOW IN THE VENA CAVA: THEORETIC,MATHEMATICAL,AND EXPERIMENTAL CONSIDERATIONS显示文摘Modeling for evaluation of effects of an indwelling hollow fiber oxygenator on the blood flow in human vena cava was carried out with involving an additional resistance term and variable vessel radius in the blood flow equation.The test of the stress-strain relationshiP of Pig′s vena cava was performed usingthe precise stress-strain instrument in our laboratory. The relationship between thecircumferential strain and stress of difrerent sections were introduced in determining the aditional resistance to the blood flow. An explicit difference method and iteration method were used to determine the additional pressure drop. The calculatedresults quantitatively reveal that the effect of the indwelling oxygenator on theblood flow is dependent upon the configuration of the oxygenator,the size of the vena cava vessel and its elasticity,and the blood flow,etc.. The low elastic modulus ofthe vena cava decreases the additional pressure drop significantly. | Xiaoping Tan Juemin Pei Junkai Chen Mongshi Chen Yong Huang(Department of Engineering MechanicsSichuan Union University. Chengdu 610065,China) | 1998 | Chinese Journal of Biomedical Engineering(English Edition)1998，7，2： | 0 |
| 17 | Correction To: Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer显示文摘Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/S41392-021-00795-x,published online 19 November 2021 In this article^(1) Qing Wei should have been denoted as a corresponding author along with Huanlong Qin,but was inadvertently removed during the production process.The original article has been corrected. | Yaohui Gao Dexi Bi Ruting Xie Man Li Jing Guo Hu Liu Xianling Guo Juemin Fang Tingting Ding Huiyuan Zhu Yuan Cao Meichun Xing Jiayi Zheng Qing Xu Qian Xu Qing Wei Huanlong Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 18 | Field-level characterization of strrong coupling between excitons and surface plasmon polaritons in J-aggregate/metal hybrid nanostructures显示文摘 | Wei Wang Ephraim Sommer Antonietta De Sio Parin ch Vasa Juemin Yi Hong Zhang | 2017 | 光电工程2017，44，2： | 0 |
| 19 | Defect evolution in GaN thin film heterogeneously integrated with CMOS-compatible Si(100)substrate by ion-cutting technology显示文摘Ion-cutting technology is an ingenious solution to the highquality heterogeneous integration of Ga N thin films with CMOS-compatible Si(100)substrate,which provides a platform to combine Ga N-based optoelectronics,high-frequency and high-power electronics with digital signal processing,logic computation,and control of Si(100)CMOS[1]. | Hangning SHI Ailun YI Jiaxin DING Xudong LIU Qingcheng QIN Juemin YI Junjie HU Miao WANG Demin CAI Jianfeng WANG Ke XU Fengwen MU Tadatomo SUGA RenéHELLER Mao WANG Shengqiang ZHOU Wenhui XU Kai HUANG Tiangui YOU Xin OU | 2023 | Science China(Information Sciences)2023，66，11： | 0 |
| 20 | A Model of Vary in Distance Leslie Matrix of the Giant Panda's Population at Wu-YiPeng,Wolong | XUE Juemin HAN Chunlian Shanxi University, 030006 Shanxi, Agriculture Science Academy, 030031 ZHANG Hemin Wolong Natural Reserve Management Office, 623006 | 1997 | Systems Science and Systems Engineering1997，7，1： | 0 |
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