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| 1 | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. | Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun | 2015 | World Journal of Gastroenterology2015，21，45： | 9 |
| 2 | Efficacy and cost analysis of transrectal ultrasound-guided prostate biopsy under monitored anesthesia显示文摘镇静可以在指导的 transrectal 超声(TRUS ) 期间疼痛地导致减小前列腺活体检视。我们试图在在护理费用的指导 TRUS 的前列腺活体检视和相关增加期间评估 propofol 和 remifentanil 注入的联合的功效和安全。从 1 月到 2010 年 9 月,经历 transrectal 前列腺活体检视的 100 个人被使随机化进二个组。在组 1, 50 个病人收到了 propofol 和 remifentanil 的联合注入;在组 2, 50 个病人收到了 lidocaine 果冻。在指导 TRUS 的活体检视被执行以后,疼痛和耐心的满足被一个 10 点评估视觉模拟规模(管) ,和一张费用相关的耐心的满足问询表被所有病人完成。病人们也被问他们是否将愿意由一样的方法经历重复活体检视。在 1 看了显著地更低的管的组的病人在组 2 比那些得分(吝啬的管分数:0.9 ± 1.1 对 6.3 ± 2.5;P< 0.001 ) 。另外,耐心的满足规模在组 1 是显著地更高的(P=0.002 ) 。尽管全面费用在组 1 是显著地更高的(P=0.006 ) ,就费用而言的耐心的满足规模在这个组(P=0.009 ) 也是更高的。propofol 和 remifentanil 的联合在指导 TRUS 的前列腺活体检视期间是到减少病人疼痛和增加病人满足的一条安全、有效的路。尽管费用在收到了镇静,期望的组是更高的,病人展出了提高的满足和心甘情愿由一样的方法重复活体检视。 | Sung Gu Kang Bum Sik Tae Sam Hong Min Young Hwii Ko Seok Ho Kang Jeong Gu Lee Je Jong Kim Jun Cheon | 2011 | Asian Journal of Andrology2011，13，5： | 5 |
| 3 | The biochemical efficacy of primary cryoablation combined with prolonged total androgen suppression compared with radiotherapy on high-risk prostate cancer: a 3-year pilot study显示文摘为了在高风险的前列腺癌症,联合本地治疗的一条综合途径和雄激素剥夺治疗(ADT ) 的管理获得有益的效果,被使用。我们比较了在与与 ADT 相结合的延长 ADT 和放射相结合的前列腺(CSAP ) 的主要 cryosurgical 脱离之间的生物化学的回答,它是在高风险的疾病的确定的形式。收到的 CSAP 在治疗以后与 ADT 相结合 3 个月在前并且直到 24 个月的 33 个高风险的病人的一个总数。这个耐心的组与另外一个被匹配为 ADT 与一样的协议经历了三维的保角的放射治疗(3D-CRT ) 的 33 个病人。生物化学的复发(BCR ) 被美国社会为治疗学的放射肿瘤学(ASTRO ) 估计 0.5 ng mL 的定义,菲尼克斯定义和前列腺特定的抗原(PSA ) 截止 ? 1。中部的后续是为 CSAP + ADT 的 11.9 个月组织的 61.0 卤和为 3D-CRT + ADT 的 15.8 个月组织的 86.0 卤。在 CSAP 组,包括 rectourethral 管和不能自制的主要复杂并发症没被注意。在 CSAP + ADT 组, 57.0% 用 ASTRO 定义有 BCR, 21.2% 使用菲尼克斯定义并且 54.5% 使用 0.5 ng mL 的 PSA 截止 ? 1。在 3D-CRT + ADT 组, 54.5% , 21.2% 和 54.5% 分别地用 ASTRO,菲尼克斯和 PSA 定义有 BCR。在 CSAP + ADT 组, BCR 免费的幸存(BRFS ) 是 54 卤用 ASTRO 定义的 10 个月, 65 卤用菲尼克斯定义的 5 个月和 51 卤用 0.5 ng mL 的 PSA 截止的 4 个月 ? 1。在 3D-CRT + ADT 组, BRFS 是 68 卤 12, 93 卤 19 和 70 卤分别地使用 ASTRO,菲尼克斯和 PSA 定义的 18 个月。由木头等级测试,为每个组的 BRFS 价值不是统计上不同的。这中间术语的结果显示与延长 ADT 相结合的主要 CSAP 在高风险的前列腺癌症与放射疗法相比提供平行生物化学的回答。 | Young Hwii Ko Seok Ho Kang Young Je Park Hong Seok Park Du Geon Moon Jeong Gu Lee Duck Ki Yoon Je Jong Kim Jun Cheon | 2010 | Asian Journal of Andrology2010，12，6： | 3 |
| 4 | Liquid-liquid phase separation in polysulfone/Solvent/ Water Systems显示文摘 | Je Young Kim Hwan Kwang Lee Ki Jun Baik Sung Chul Kim | 1997 | Journal of applied polymer science1997，65，： | 1 |
| 5 | Stable fixation of distal clavicle fracture with comminuted superior cortex using oblique T-plate and cerclage wiring显示文摘 | Je Hyun Yoo Jun Dong Chang Yong Jin Seo et M | 2009 | Injury2009，40，4： | 1 |
| 6 | Changing pattern of antibiotic resistance of H elicobacter pylori in children during 20 years in J inju, S outh K orea显示文摘 | Ji‐Hyun Seo Jin‐Su Jun Jung Sook Yeom Ji Sook Park Hee‐Shang Youn Gyung‐Hyuck Ko Seung‐Chul Baik Woo‐Kon Lee Myung‐Je Cho Kwang‐Ho Rhee | 2013 | Pediatr Int2013，，3： | 1 |
| 7 | Scaffolding of antigen receptors for immuno-genic versus tolerogenic signaling显示文摘 | Jun JE Goodnow CC | 2003 | Nat Immunol2003，4，： | 1 |
| 8 | Association between periodonti- tis and preeclampsia in never-smokers: a prospective study 显示文摘 | Ha JE Jun JK Ko H J | 2014 | J Clin Periodontol2014，41，9： | 1 |
| 9 | Stable fwation of distal clavicle fracture with comminuted superior cortex using oblique T-plate and cerclage wlrlng显示文摘 | Je Hyun Yoo Jun Dong Chang Young Jin Seo et a/ | 2009 | Injury2009，40，： | 1 |
| 10 | Association between periodontitis and preeclampsia in never-smokers: a prospective study显示文摘 | Ha JE Jun JK Ko HJ | 2014 | J Clin Periodontol2014，41，9： | 1 |
| 11 | Functional characterization of naturally occurring melittin peptide isoforms in two honey bee species, Apis mellifera and Apis cerana显示文摘 | Doori Park Je Won Jung Mi Ok Lee Si Young Lee Boyun Kim Hye Jun Jin Jiyoung Kim Young-Joon Ahn Ki Won Lee Yong Sang Song Seunghun Hong James E. Womack Hyung Wook Kwon | 2014 | Peptides2014，，： | 1 |
| 12 | Three-dimensional reconstruction based on images from spiral high-resolution computed tomography of the temporal bone: Anatomy and clinical application显示文摘 | Jun BC Song SW Cho JE | 2005 | J Laryngol Otol2005，119，9： | 1 |
| 13 | Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea 显示文摘 | Rueh RJ Cheng Shu jun Klaunig JE | 1989 | Careinogenesis1989，10，6： | 1 |
| 14 | Three-dimensional reconstructure based on images from spirsl high-res- olution computed tomography the temporal bone: anatomy and clinical application 显示文摘 | Jun Be Song SW Cho JE | 2005 | J Laryngol2005，119，7： | 1 |
| 15 | Three dimensional reconstruc- tion based on images from spiral high-resolution computed tomo- graphy of the temporal bone: anatomy and clinical application 显示文摘 | Jun BC Song SW Cho JE | 2005 | J Laryngol Otol2005，119，9： | 1 |
| 16 | Three-dimensional recon-struction based on images from spiral high-resolution computed tomography of the temporal hone: anatomy and clinical application显示文摘 | Jun BC Song SW Cho JE | 2005 | J Laryngol Otol2005，119，： | 1 |
| 17 | Changing pattern of antibiotic resistance of H elicobacter pylori in children during 20 years in J inju, S outh K orea显示文摘 | Ji‐Hyun Seo Jin‐Su Jun Jung Sook Yeom Ji Sook Park Hee‐Shang Youn Gyung‐Hyuck Ko Seung‐Chul Baik Woo‐Kon Lee Myung‐Je Cho Kwang‐Ho Rhee | 2013 | Pediatr Int2013，，3： | 1 |
| 18 | High-dose dietary zinc promotes prostate intraepithelial neoplasia in a murine tumor induction mode显示文摘 | Young Hwii Ko Yu Jeong Woo Jin Wook Kim Hoon Choi Seok Ho Kang Jeong Gu Lee Je Jong Kim Hong Seok Park Jun Cheon | 2010 | Asian Journal of Andrology2010，12，2： | 1 |
| 19 | Anti-tumor activity of Acinetobacter baumannii outer membrane protein A on dendritic cell-based immunotherapy against murine melanoma显示文摘 | Jun Sik Lee Jung Wook Kim Chul Hee Choi Won Kee Lee Hae Young Chung Je Chul Lee | 2008 | The Journal of Microbiology2008，，： | 1 |
| 20 | STAT3 is apotential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells显示文摘 | Jun JE Lee HG Cho IH | 2005 | FASEBJ2005，19，10： | 1 |
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