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12篇 您的检索式:作者名="Jung GL"
    题名 作者 年代 出处 被引量
1Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression,which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells显示文摘Fukuda R Hirota K Fan F Jung YD Ellis LM Semenza GL 0,,41:1
2Late-course accelerated ra-diotherapy for localized esophageal carcinoma显示文摘Zhao KL Shi XH Jung GL 2004Int J Radial On-col Biol Phys2004,60,:1
3Relationship between body and brain temperature in traurnatically brain-injurecl显示文摘Jung JY Lyeth Clifton Gl 1991J Nenrosurg1991,74,:1
4Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression,which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells显示文摘Fukuda R Hirota K Fan F Jung YD Ellis LM Semenza GL 0,,41:1
5Real-time-Elastografie von Leberl?sionen bei Thermotherapie in vitro: Korrelation zur Histopathologie显示文摘P. Wiggermann E.-M. Jung S. Gl?ckner P. Hoffstetter W. Uller A. Vasilj A. Schreyer C. Stroszczynski 2012Ultraschall in Med2012,,02:1
6Late - course acceleratedhyper- fractionatedradiotherapy for localized esophageal carcinoma 显示文摘Zhao KL Shi XH Jung GL 2004Int J Radial Oncol Biol Phys2004,60,1:1
7Decreased serum brain-derived neurotrophic factor levels in elderly korean with dementia显示文摘Jung GL Bae SS Young SY 2009Psychiatry Invest2009,6,5:1
8Relationship between depressive symptoms and long-term mortality in patients with heart failure 显示文摘Jung W Kuchibhatla M Clary GL 2007Am Heart2007,154,1:1
9Bilateral sudden deafness as a prodrome of anterior inferior eerebellar artery infarction显示文摘Hyung L Gregory TW Jung GL 2001Arch Neurol2001,58,:1
10The usefulness of albumin-adjusted ischemia-modi ed albumin index as early detecting marker for ischemic stroke显示文摘Jung HA Sang CC Wee GL 2011Neuml Sci2011,32,:1
11Relationship between body and brain temperature in traurnatieally brain- injurecl显示文摘Jung JY Lyeth BG Clifton GL 1991J Nenrosurg1991,74,:1
12A variant in IL6ST with a selective IL-11 signaling defect in human and mouse显示文摘The GP130 cytokine receptor subunit encoded by IL6ST is the shared receptor for ten cytokines of the IL-6 family. We describe a homozygous non-synonymous variant in IL6 ST(p.R281 Q) in a patient with craniosynostosis and retained deciduous teeth. We characterize the impact of the variant on cytokine signaling in vitro using transfected cell lines as well as primary patient-derived cells and support these findings using a mouse model with the corresponding genome-edited variant Il6 st p.R279 Q. We show that human GP130 p.R281 Q is associated with selective loss of IL-11 signaling without affecting IL-6, IL-27, OSM, LIF, CT1, CLC, and CNTF signaling. In mice Il6 st p.R279 Q lowers litter size and causes facial synostosis and teeth abnormalities. The effect on IL-11 signaling caused by the GP130 variant shows incomplete penetrance but phenocopies aspects of IL11 RA deficiency in humans and mice. Our data show that a genetic variant in a pleiotropic cytokine receptor can have remarkably selective defects.Tobias Schwerd Freia Krause Stephen R.F.Twigg Dominik Aschenbrenner Yin-Huai Chen Uwe Borgmeyer Miryam Müller Santiago Manrique Neele Schumacher Steven A.Wall Jonathan Jung Timo Damm Claus-Christian Glüer Jürgen Scheller Stefan Rose-John E.Yvonne Jones Arian Laurence Andrew O.M.Wilkie Dirk Schmidt-Arras Holm H.Uhlig 2020Bone Research2020,8,2:0
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