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| 1 | Epithelial-mesenchymal transition and cancermetastasis显示文摘上皮间充质的转变(EMT ) 开始在哺乳动物,以及维持重要身体的稳定性的一个基本生物事件的 embryogenesis 期间被看作生理的现象。最近的研究显示 EMT 在各种各样的肿瘤前进,上皮的癌症通过入侵并且转移起一个关键作用。房间特征在 EMT,房间在失去房间房间和房间矩阵相互作用和顶端的极性期间被改变,重新组织他们的细胞骨架,并且变得孤立,对 anoikis 能动,以及抵抗,然后成为塑造锭子的间充质的房间。这评论在关于 EMT 学习房间形态发生,制造者和分子的机制规定上放强调,讨论在 EMT 和癌症发展和转移之间的关系。 | Junjian Deng Ximing Xu | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，3： | 7 |
| 2 | Assessing site-safeguard effectiveness and habitat preferences of Bar-headed Geese (Anser indicus) at their stopover sites within the Qinghai-Tibet Plateau using GPS/ GSM telemetry显示文摘Background:The Bar-headed Goose(Anser indicus)breeds across the high plains and plateau of Central Asia and winters in the Qinghai-Tibet Plateau(QTP),the Yunnan-Guizhou Plateau and the Indian sub-continent.Of the two recognized discrete flyways of the Bar-headed Goose,the Eastern Tibetan Flyway(ETF)is the larger,comprising at least six migration routes.However,we remain ignorant about their migratory connectivity,habitat use and effectiveness of site-safeguard mechanisms set in place for the species.Methods:We tracked 30 ETF Bar-headed Geese from Chinese and Mongolian breeding areas to their wintering grounds using GPS/GSM transmitters,to determine their migration routes and stopover staging patterns within the QTP,overlaying these upon GIS layers of protected area status and habitat type,to model their habitat selection.Results:In total,14 tagged Bar-headed Geese provided information on their entire autumn migration and 4 geese on their entire spring migration.Qinghai Lake marked birds overwintered in the QTP(n=2),geese tagged in Mongolia wintered either in the QTP(n=3)or in India/Bangladesh(n=9),representing three of the migration routes within the ETF.In total,tagged birds staged at 79 different stopover sites within QTP in autumn and 23 in spring,of which 65%(autumn)and 59%(spring)of all fixes fell within the boundaries of either National Nature Reserves(NNRs)or Important Birds Areas(IBAs)in the QTP.Bar-headed Geese predominantly occurred on four land-cover types:grassland(mostly by day),water bodies(at night),wetlands and bare substrates(salt flats,dry lake/river substrates and plough)with little change in proportion.Generalized linear mixed models comparing presence with pseudo-absence data suggested geese strongly selected for wetlands as staging habitat,avoiding bare substrates in spring.Conclusions:Based on our limited observations of these tagged geese,this study is the first to show that the current designated National Nature Reserves in place in the staging areas within the QTP appear adequate to protect this increasing population.In addition,Hala Lake in Qinghai Province and adjacent areas used as initial QTP staging during autumn migration(currently outside of designated as NNRs/IBAs)are recommended for protection,based on their use by tagged birds from this study.Habitat modelling confirmed the importance of natural wetlands as feeding areas and safe areas of open water as roosting places. | Junjian Zhang Yanbo Xie Laixing Li Nyambayar Batbayar Xueqin Deng Iderbat Damba Fanjuan Meng Lei Cao Anthony David Fox | 2020 | Avian Research2020，11，4： | 5 |
| 3 | 长链非编码RNA在肿瘤中的研究(英文)显示文摘Long non-coding RNAs(lncRNAs), gradually being paid attention to, have been found playing a critical role in regulation of cellular processes such as cell growth and apoptosis, what is more, accumulating evidence indicates that lncRNAs also play a critical role in regulation of carcinogenesis and cancer progression. Here, we will summarize the recent researches about some lncRNAs in the development of cancers, hoping to give a new view about the study in the mechanisms involved in carcinogenesis and tumor progression. | Tingting Yu Ximing Xu Yi Hu Junjian Deng Biao Chen Nana Han Meixia Zhang | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，1： | 1 |
| 4 | Contrasting habitat use and conservation status of Chinese-wintering and other Eurasian Greater White-fronted Goose(Anser albifrons)populations显示文摘Background:GPS/GSM tracking data were used to contrast use of(i)habitats and(ii)protected areas between three Arctic-nesting Greater White-fronted Geese(Anser albifrons,GWFG)populations throughout the annual cycle.We wished to demonstrate that the East Asian Continental Population(which winters on natural wetlands in the Chinese Yangtze River floodplain and is currently declining)avoids using farmland at multiple wintering sites.We also gath-ered tracking evidence to support general observations from two increasing population of GWFG,the North Sea-Baltic(which winters in Europe)and the West Pacific(which winter in Korea and Japan)winter mostly within farmland landscapes,using wetlands only for safe night roosts.Methods:We tracked 156 GWFG throughout their annual cycle using GPS/GSM transmitters from these three popu-lations to determine migration routes and stopover staging patterns.We used Brownian Bridge Movement Models to generate summer,winter and migration stopover home ranges which we then overlaid in GIS with land cover and protected area boundary at national level to determine habitat use and degree of protection from nature conserva-tion designated areas.Results:Data confirmed that 73%of European wintering GWFG homes ranges were from within farmland,com-pared to 59%in Japan and Korea,but just 5%in China,confirming the heavy winter use of agricultural landscapes by GWFG away from China,and avoidance of farmland at multiple sites within the Yangtze River floodplain.The same GWFG used farmland in northeast China in spring and autumn,confirming their experience of exploiting such habi-tats at other stages of their annual cycle.Chinese wintering birds showed the greatest overlap with protected areas of all three populations,showing current levels of site safeguard are failing to protect this population.Conclusions:Results confirm the need for strategic planning to protect the East Asian Continental GWFG popu-lation.While the site protection network in place to protect the species seems adequate,it has failed to stop the declines.Buffalo grazing could serve as one simple strategy to improve the condition of feeding habitats at Dongting Lake and Poyang Lake in the Yangtze,where vast Carex meadows exist.In addition,while we warn against pushing GWFG to winter farmland feeding in China because of the long-term potential to conflict with agricultural interests,we recommend experimental sacrificial,disturbance-free farmland within designated refuge areas adjacent to the Yangtze River floodplain wetland reserves as a manipulative experiment to improve the conservation status of this population in years when natural food sources are limited. | Xueqin Deng Qingshan Zhao Junjian Zhang Andrea Kölzsch Diana Solovyeva Inga Bysykatova-Harmey Zhenggang Xu Helmut Kruckenberg Lei Cao Anthony David Fox | 2021 | Avian Research2021，12，4： | 1 |
| 5 | Parallel computing of multi-contingency optimal power flow with transient stability constraints显示文摘To deal with the high dimensionality and computational density of the Optimal Power Flow model with Transient Stability Constraints(OTS),a credible criterion to determine transient stability is proposed based on swing curves of generator rotor and the characteristics of transient stability.With this method,the swing curves of all generator rotors will be independent one another.Therefore,when a parallel computing approach based on the MATLAB parallel toolbox is used to handle multi-contingency cases,the calculation speed is improved significantly.Finally,numerical simulations on three test systems including the NE-39 system,the IEEE 300-bus system,and 703-bus systems,show the effectiveness of the proposed method in reducing the computing time of OTS calculation. | Yude Yang Anjun Song Hui Liu Zhijun Qin Jun Deng Junjian Qi | 2018 | Protection and Control of Modern Power Systems2018，3，1： | 0 |
| 6 | A matrix-perturbation-theory-based optimal strategy for small-signal stability analysis of large-scale power grid显示文摘In this paper,a sensitivity matrix based approach is proposed to improve the minimum damping ratio.The proposed method also avoids burdensome deviation calculations of damping ratio of large-scale power grids when compared to the Small-Signal-Stability Constrained Optimal Power Flow(SSSC-OPF)approach.This is achieved using the Matrix Perturbation Theory(MPT)to deal with the 2nd order sensitivity matrices,and the establishment of an optimal corrective control model to regulate the output power of generating units to improve the minimum damping ratio of power grids.Finally,simulation results on the IEEE 9-bus,IEEE 39-bus and a China 634-bus systems show that the proposed approach can significantly reduce the burden of deviation calculation,while enhancing power system stability and ensuring calculation accuracy. | Yude Yang Jixing Zhao Hui Liu Zhijun Qin Jun Deng Junjian Qi | 2018 | Protection and Control of Modern Power Systems2018，3，1： | 0 |
| 7 | Dosimetric consequences of tumor volume changes after kilovoltage cone-beam computed tomography for non-operative lung cancer during adaptive intensity-modulated radiotherapy or fractionated stereotactic radiotherapy显示文摘Objective The aim of this study was to investigate tumor volume changes with kilovoltage cone-beam computed tomography(k V-CBCT) and their dosimetric consequences for non-operative lung cancer during intensity-modulated radiotherapy(IMRT) or fractionated stereotactic radiotherapy.Methods Eighteen patients with non-operative lung cancer who received IMRT consisting of 1.8–2.2 Gy/fraction and five fractions per week or stereotactic radiotherapy with 5–8 Gy/fraction and three fractions a week were studied. k V-CBCT was performed once per week during IMRT and at every fraction during stereotactic radiotherapy. The gross tumor volume(GTV) was contoured on the k V-CBCT images,and adaptive treatment plans were created using merged k V-CBCT and primary planning computed tomography image sets. Tumor volume changes and dosimetric parameters,including the minimum dose to 95%(D95) or 1%(D1) of the planning target volume(PTV),mean lung dose(MLD),and volume of lung tissue that received more than 5(V5),10(V10),20(V20),and 30(V30) Gy were retrospectively analyzed.Results The average maximum change in GTV observed during IMRT or fractionated stereotactic radiotherapy was –25.85%(range,–13.09% ––56.76%). The D95 and D1 of PTV for the adaptive treatment plans in all patients were not significantly different from those for the initial or former adaptive treatment plans. In patients with tumor volume changes of >20% in the third or fourth week of treatment during IMRT,adaptive treatment plans offered clinically meaningful decreases in MLD and V5,V10,V20,and V30; however,in patients with tumor volume changes of < 20% in the third or fourth week of treatment as well as in patients with stereotactic radiotherapy,there were no significant or clinically meaningful decreases in the dosimetric parameters.Conclusion Adaptive treatment planning for decreasing tumor volume during IMRT may be beneficial for patients who experience tumor volume changes of >20% in the third or fourth week of treatment. | Jian Hu Ximing Xu Guangjin Yuan Wei Ge Liming Xu Aihua Zhang Junjian Deng | 2015 | Oncology and Translational Medicine2015，1，5： | 0 |
| 8 | 放疗诱导人肝细胞癌上皮-间质转化(英文)显示文摘Objective: Epithelial-mesenchymal transition (EMT) is a critical early event for the invasion and metastasis of many carcinomas. In the present study, we examined EMT markers in the residual cancer cells of hepatocellular carcinoma (HCC) after radiotherapy. Methods: Eight patients with large HCC who underwent hepatectomy with preoperative radiothera- py were studied. The expressions of E-cadherin and vimentin were determined immunohistochemically in the residual cancer cells of HCC following radiotherapy, and also in the pre-radiotherapy biopsy cancer cells. Results: Histological analysis showed that some residual cancer cells of HCC displayed an elongated spindle or fibroblast-like shape. The expression of E- cadherin was markedly reduced or negative in the spindle residual cancer cells, but the expression of vimentin significantly in- duced. However, the above changes were not found in the pre-radiotherapy biopsy cancer cells. Conclusion: EMT is induced in the residual cancer cells of HCC following radiotherapy, which may facilitate the systemic dissemination of cancer cells. | Ximing Xu Junjian Deng Guangjin Yuan Miao Xiang Biao Chen Jiao Yang Yiqiao Zhang Lei Shi Zuguo Li | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，9： | 0 |
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