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| 1 | Cenozoic magmatic activity and oblique uplifting of the Ailao Mountain: Evidence from a short-period dense seismic array显示文摘Geological studies show that the southern part of Ailaoshan-Red River shear zone(ALSRRSZ)has experienced complex metallogenic processes and multi-stage non-uniform uplifting,called oblique uplifting since the Cenozoic.To detect the deep structure and geodynamic background beneath Daping,Chang’an and other gold and polymetallic deposits in this area,we carried out a high-density short-period seismic array survey in southern Yunnan province.The array used is approximately240 km long with an interval of 500 m between two adjacent stations.Based on the data collected by the array,we used H-κstacking and common conversion point(CCP)methods of receiver functions to reveal the fine crustal structure beneath this array,which was located from Lvchun(western end)to the east and ended in Maguan.The three main conclusions are as follows.(1)The average crustal thickness is approximately 37 km and the Vp/Vsratio is 1.75.However,the thickness and Vp/Vsratio of the Ailao Mountain are rather greater or higher than those of the western Lanping-Simao Basin and eastern South-China block.These results may indicate that the crust is rich in ferromagnesian minerals or has a thermal fluid anomaly after orogenic movement.(2)There are two obvious inclined interfaces beneath the Ailao Mountain in the mid-upper crust,which suggests that strong deformation occurred there during the orogenic period.Some evidences,such as the weak converted-wave Pms phase from the Moho,low P-wave velocities of the upper mantle,high surface heat flow values,and generally developed hot springs,indicate that a strong crust-mantle interaction exists in the southern segments of the Ailaoshan-Red River shear zone.These interactions include a diapir of mantle-sourced magma(stronger in the east than that in the west),lateral collision from the Indian Plate,and the differential uplift caused by the strike-slip movement of the Red River Fault.All of above deep processes led to the Cenozoic oblique uplifting of Ailao Mountain.(3)By combining the location of the deposits on the surface,characteristics of the average crustal Vp/Vsratio,hypocenters of the small earthquakes along the research profile,Moho shape,and horizontal variations of the Pms phase amplitudes,we speculate that the Ailaoshan Fault was the upgoing conduit for metallogenic magma and played a significant role in the Cenozoic development of the multiform metal deposits around the Ailao Mountain area. | Lu ZHANG Zhiming BAI Tao XU Zhenbo WU Minfu HUANG Guiping YU Junlei CHEN Mengjie ZHENG | 2020 | Science China Earth Sciences2020，63，9： | 1 |
| 2 | YAP mediates the positive regulation of hnRNPK on the lung adenocarcinoma H1299 cell growth显示文摘Lung cancer is the leading cause of cancer death worldwide, and non-small cell lung cancer (NSCLC) accounts for 80%–85% of diagnostic cases. The molecular mechanisms of NSCLC pathogenesis are not well understood. Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is a multifunctional protein that regulates gene expression and signal transduction and closely associated with tumorigenesis, but its mechanism of action in the pathogenesis of NSCLC is unclear. In this study, we observed that the expression pattern of hnRNPK in H1299 lung adenocarcinoma cells varied depending on the cell density in culture. Moreover, hnRNPK stimulated the ability of proliferation and colony formation of H1299 cells, which is important for the multilayered cell growth in culture. We further investigated whether there is an association between hnRNPK and the elements involved in the cell contact inhibition pathway. By using quantitative reverse transcriptase-polymerase chain reaction assay and a YAP activity reporter system, we found that hnRNPK upregulated the mRNA and protein levels and transcriptional activity of Yes-associated protein 1 (YAP), a master negative regulator of Hippo contact inhibition pathway. Furthermore, YAP knockdown with siRNA abolished the stimulatory effect of hnRNPK on H1299 cell proliferation. These results suggested that YAP could be one of the effectors of hnRNPK. Our data may provide new clues for further understanding the biological functions of hnRNPK, particularly in the context of lung adenocarcinoma oncogenesis. | Lipei Xu Tingting Zhang Wensi Huang Xiaohui Liu Junlei Lu Xuejuan Gao Yun-Fang Zhang Langxia Liu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，7： | 1 |
| 3 | Experimental study of a 3D printed permanent implantable porous Ta-coated bone plate for fracture fixation显示文摘Metal plates have always been the gold standard in the clinic for internal fracture fixation due to their high strength advantages.However,high elastic modulus can cause stress shielding and lead to bone embrittlement.This study used an electron beam melting method to prepare personalized porous Ti6Al4V(pTi)bone plates.Then,chemical vapor deposition(CVD)technology coats tantalum(Ta)metal on the pTi bone plates.The prepared porous Ta-coated bone plate has an elastic modulus similar to cortical bone,and no stress shielding occurred.In vitro experiments showed that compared with pTi plates,Ta coating significantly enhances the attachment and proliferation of cells on the surface of the scaffold.To better evaluate the function of the Ta-coated bone plate,animal experiments were conducted using a coat tibia fracture model.Our results showed that the Ta-coated bone plate could effectively fix the fracture.Both imaging and histological analysis showed that the Ta-coated bone plate had prominent indirect binding of callus formation.Histological results showed that new bone grew at the interface and formed good osseointegration with the host bone.Therefore,this study provides an alternative to bio-functional Ta-coated bone plates with improved osseointegration and osteogenic functions for orthopaedic applications. | Baoyi Liu Zhijie Ma Junlei Li Hui Xie Xiaowei Wei Benjie Wang Simiao Tian Jiahui Yang Lei Yang Liangliang Cheng Lu Li Dewei Zhao | 2022 | Bioactive Materials2022，7，4： | 0 |
| 4 | Adiabaticity in state preparation for spin squeezing of large atom ensembles显示文摘Spin-squeezed state is a many-body entangled state of great interest for precision measurements.Although the absolute sensitivity at the standard quantum limit is better for a larger atom number,the greater dominance of classical noises over atom projection noise makes it harder to achieve spin squeezing.Here,we show both theoretically and experimentally that adiabatic pulse control of the pump field in state preparation is indispensable to sufficient noise suppression,which is the prerequisite for spin squeezing.This technique is generally applicable to spin-squeezing experiments involving a large ensemble and is thus of significance for quantum metrolog yapplications. | SHENCHAO JIN HAN BAO JUNLEI DUAN XINGDA LU MINGFENG WANG KAI-FENG ZHAO HENG SHEN YANHONG XIAO | 2021 | Photonics Research2021，9，11： | 0 |
| 5 | Reductive lipid nanoparticles loaded with vinorelbine inhibit chemotherapy-induced invasion of cancer cells by modulating ENPP2显示文摘Cancer is a predominant culprit behind worldwide death and accounts for up to 10 million deaths every year.Chemotherapy is the primary therapeutic method employed for cancer in clinical settings and is essential in controlling tumor progression.Despite the advances in this field,tumor invasion and metastasis during treatment remain a significant cause of treatment failure.Nevertheless,the underlying mechanisms involving such a disappointing phenomenon are still not fully elucidated.Vinorelbine(VNB)extends the lifespan of many cancer patients in the clinic as an emerging chemotherapy drug approved by Food and Drug Administration(FDA).However,VNB-induced tumor metastasis is still an intractable problem,which may be closely related to the abnormal oxidative stress generated during VNB-mediated treatment.Hence,the study aims to construct a reductive nanosystem loaded with VNB,called VNB-VNP,to improve cancer cure rates and reduce tumor metastasis.With the reductive component vitamin E,VNB-VNP can effectively reduce oxidative stress and significantly outperform free VNB in preventing tumor progression.The transcriptome analysis shows that VNB-VNP can alleviate the over-expression of ectonucleotide pyrophosphatase/phosphodiesterase 2(ENPP2),which may be the main reason why VNB-VNP can inhibit tumor invasion and metastasis.Overall,the research designs a new platform for VNB treatment,which demonstrates promising efficacy in inhibiting neoplastic progression and identifies a new mechanism associated with VNB-induced tumor metastasis,which may offer several valuable references for enhancing chemotherapy efficacy in clinical anti-tumor therapy. | Xiaoqi Zhao Xuemeng Guo Mei Pang Weigen Qiu Zhenyu Luo Qing Lin Yichao Lu Hang Yin Sijie Wang Huihui Liu Junlei Zhang Lihua Luo Jian You | 2024 | Nano Research2024，17，4： | 0 |
| 6 | Improving iconic memory through contrast detection training with HOA-corrected vision显示文摘Iconic memory and short-term memory are not only crucial for perception and cognition,but also of great importance to mental health.Here,we first showed that both types of memory could be improved by improving limiting processes in visual processing through perceptual learning.Normal adults were trained in a contrast detection task for ten days,with their higher-order aberrations(HOA)corrected in real-time.We found that the training improved not only their contrast sensitivity function(CSF),but also their iconic memory and baseline information maintenance for short-term memory,and the relationship between memory and CSF improvements could be well-predicted by an observer model.These results suggest that training the limiting component of a cognitive task with visual perceptual learning could improve visual cognition.They may also provide an empirical foundation for new therapies to treat people with poor sensory memory. | Ling Gong Junlei Zhao Yun Dai Zili Wang Fang Hou Yudong Zhang Zhong-Lin Lu Jiawei Zhou | 2024 | Fundamental Research2024，4，1： | 0 |
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