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| 1 | Genome-wide Expansion and Expression Divergence of the Basic Leucine Zipper Transcription Factors in Higher Plants with an Emphasis on Sorghum显示文摘Plant bZIP transcription factors play crucial roles in multiple biological processes.However,little is known about the sorghum bZIP gene family although the sorghum genome has been completely sequenced.In this study,we have carried out a genome-wide identification and characterization of this gene family in sorghum.Our data show that the genome encodes at least 92 bZIP transcription factors.These bZIP genes have been expanded mainly by segmental duplication.Such an expansion mechanism has also been observed in rice,arabidopsis and many other plant organisms,suggesting a common expansion mode of this gene family in plants.Further investigation shows that most of the bZIP members have been present in the most recent common ancestor of sorghum and rice and the major expansion would occur before the sorghum-rice split era.Although these bZIP genes have been duplicated with a long history,they exhibited limited functional divergence as shown by nonsynonymous substitutions (Ka)/synonymous substitutions (Ks) analyses.Their retention was mainly due to the high percentages of expression divergence.Our data also showed that this gene family might play a role in multiple developmental stages and tissues and might be regarded as important regulators of various abiotic stresses and sugar signaling. | Jizhou Wang Junxia Zhou Baolan Zhang Jeevanandam Vanitha Srinivasan Ramachandran Shu-Ye Jiang | 2011 | Journal of Integrative Plant Biology2011，53，3： | 41 |
| 2 | Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent显示文摘铁在 Parkinson 的疾病(PD ) 起一个关键作用。substantia nigra (SN ) 的增加的铁内容在 PD 病人,和二价的金属 transporter 被发现了(DMT1 ) 1 被显示了在两个导致 MPTP 的 PD 模型和 PD 病人的 SN 起来调整。然而,位于 DMT1 起来规定下面的机制大部分是未知的。在现在的学习,我们观察到那在 6-hydroxydopamine ( 6-OHDA )的 SN 导致了 PD 老鼠,有铁的 DMT1 应答的元素(怒火, DMT1+IRE ),然而并非没有怒火( DMT1?IRE )的 DMT1 ,是起来调整的,建议那增加的 DMT1+IRE 表情可能在 PD 老鼠说明 nigral 铁累积。这可能性进一步被估计在一在里面 vitro 学习使用 6-OHDA-treated 和 DMT1+IRE-over-expressing MES23.5 房间。在 6-OHDA-treated MES23.5 房间,增加了铁规章的蛋白质(IRP ) 1 并且 IRP2 表示被观察,当 IRP 的 silencing 戏剧性地减少了时 6-OHDA-induced DMT1+IRE 起来规定。有 N-acetyl-L-cysteine 的预告的处理充分由 6-OHDA-induced 的抑制压制了 IRP 起来规定氧化应力。增加的 DMT1+IRE 表示由 MES23.5 房间导致了增加的铁流入。我们的数据提供 DMT1+IRE 起来规定能说明细胞内部的氧化应力和那增加了的 6-OHDA-induced 开始的 IRE/IRP-dependent 6-OHDA-induced 铁累积的直接证据细胞内部的铁的层次导致加重的氧化应力。这研究的结果提供在 PD 的处理支持抗氧化剂的使用的新奇证据,旨在禁止由 DMT1 表示的规定的铁累积。 | Hong Jiang Ning Song Huamin Xu Shuzhen Zhang Jun Wang Junxia Xie | 2010 | Cell Research2010，20，3： | 25 |
| 3 | Characteristics and dynamics analysis of Populus euphratica populations in the middle reaches of Tarim River显示文摘Populus euphratica Oliv. is widely distributed along the Tarim River. Maintaining stability of P. euphratica population is important to local development. This study explored the static life table, survivorship curves and four function curves (survival rate, cumulative mortality rate, mortality density, and hazard rate), and development index of P. euphratica population in the middle reaches of Tarim River. The results indicated that the age structure of P. euphratica population belonged to positive pyramidal type, which meant young age-class individuals occupied most populations. The number ofⅠ-Ⅱage classes accounted for 66.2% of whole population, and this indicated that there were abundant subsequent seedlings resources to support the growth of P. euphratica population in the middle reaches of Tarim River. The survivorship curve of P. euphratica belonged to the Deevey Ⅲ (concave-type) and the development index was 47.72%. Four function curves revealed that the individuals of P. euphratica sharply decreased at the initial stage and then leveled off at the late stage of survival curve. Time sequence prediction models predicted that the number of midlife individuals would increase in future 10, 20, 30 years, and P. euphratica population grew steadily as a result of rich saplings. | Wu, JunXia Zhang, XiMing Deng, ChaoZhou Liu, GuoJun Li, Hong | 2010 | Journal of Arid Land2010，2，4： | 9 |
| 4 | Anti-inflammatory and Immunomodulatory Effects of Marine n-3 Polyunsaturated Fatty Acids on Human Health and Diseases显示文摘The pharmaceutical effects of n-3 polyunsaturated fatty acids(n-3 PUFAs) as dietary nutrients on human health and diseases have gained much attention and are investigated for decades. Docosahexaenoic acid(DHA), eicosapentaenoic acid(EPA) and docosapentaenoic acid(DPA) are the three major n-3 PUFAs enriched in marine organisms, such as fish, shrimp, algae, and so on. It has been well known that n-3 PUFAs, especially DHA and EPA, are beneficial in reducing the risk of cardiovascular and cerebrovascular diseases. Accumulating evidence suggests that n-3 PUFAs might cure inflammatory diseases through several mechanisms, such as plasma membrane remodeling of lymphocytes, down-regulating pro-inflammatory cytokines, and alternating adhesion molecule expressions. Several molecular targets of n-3 PUFAs on immune-regulation have also been identified, such as GPR120(FFA4), protein kinase C(PKC), and PPAR-γ. However, it remains inconclusive if dietary n-3 PUFAs function the same both in vitro and in vivo based on cohort studies. This review will focus on the molecular targets and mechanisms of anti-inflammatory and immunomodulatory effects of n-3 PUFAs on human health and diseases, such as obesity, tumor, diabetes, and autoimmune diseases. | ZHANG Yiran MIN Junxia ZHANG Lijuan | 2019 | Journal of Ocean University of China2019，18，2： | 5 |
| 5 | Estimating life-cycle energy payback ratio of overhead transmission line toward low carbon development显示文摘The energy conservation plays an important role for low carbon development.In order to evaluate the energy conservation in the full life-cycle,a scheme to estimate the energy consumption,or alternatively the energy pay,in constructing an overhead transmission line is proposed in this paper.The analysis of a typical projection is given for demonstration.With new additional overhead transmission lines,the energy consumption,known as the power loss in power network,is expected to be decline,which is defined in this paper as the energy payback.In order to estimate this kind of contribution,the scheme that consisted of load forecast,production simulation for generating systems,load flow simulation and power loss calculation has been proposed.Case studies,based on the IEEE 24-bus test system,are given to demonstrate the efficacy of the schemes.Moreover,several presumptive scenarios are deployed and analysed with the presented schemes for comparison. | Xiaoming DONG Chongqing KANG Ning ZHANG Huaguang YAN Junxia MENG Xinsheng NIU Xin TIAN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，1： | 5 |
| 6 | The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis显示文摘Dear Editor,Ferroptosis is an iron-dependent,non-apoptotic form of regulated cell death characterized by an accumulation of lipid.derived reactive oxygen species(ROS).The small-molecule compo und erastin in duces ferroptosis via in hibiti ng the cystineglutamate antiporter system x_(c).which consists of two subunits,namely the light chain xCT and the heavy chain 4F2hc(encoded by the SLC7A11 and SLC3A2 genes,respectively).^(1-4) | Renhong Yan Enjun Xie Yaning Li Jin Li Yuanyuan Zhang Ximin Chi Xueping Hu Lei xu Tingjun Hou Brent R.Stockwell Junxia Min Qiang Zhou Fudi Wang | 2022 | Cell Research2022，32，7： | 4 |
| 7 | The terrestrial locomotion of a mole cricket with foreleg amputation显示文摘Mole cricket is a unique insect, it not only can dig and excavate under ground with its specialized forelimb, but also can achieve terrestrial locomotion. This study focused on the difference of kinematics between mole crickets and normal insects in terrestrial walking. In order to study the function of the specialized foreleg, the adjustments made to the foreleg amputation were discussed by analyzing the motion ability, gait, and body posture of the mole cricket with and without forelegs. The results show that mole crickets walk in terrestrial locomotion by using a special tripod gait, with the clumsy foreleg not as functional as normal hexapods. Mole cricket can make corresponding adjustments for the situation of missing forelegs, and achieve required motion stability with remained four legs. | ZHANG Yan ZHANG JunXia REN LuQuan | 2015 | Science China(Technological Sciences)2015，58，6： | 3 |
| 8 | Kinematics Analysis and Optimization of the Fast Shearing-extrusion Joining Mechanism for Solid-state Metal显示文摘Dynamical Joining of the solid-state metal is the key technology to realize endless hot rolling. The heating and laser welding method both require long joining time. Based on super deformation method, a 7-bar and 2-slider mechanism was developed in Japan, and the joining time is less than 0.5 s, however the length of each bar are not reported and this mechanism is complex. A relatively simple 6-bar and 1-slider mechanism is put forward, which can realize the shearing and extrusion motion of the top and bottom blades with a speed approximately equal to the speed of the metal plates. In order to study the kinematics property of the double blades, based on complex vector method, the multi-rigid-body model is built, and the displacement and speed functions of the double blades, the joining time and joining thickness are deduced, the kinematics analysis shows that the initial parameters can't satisfy the joining process. Hence, optimization of this mechanism is employed using genetic algorithm(GA) and the optimization parameters of this mechanism are obtained, the kinematics analysis show that the joining time is less than 0.1 s, the joining thickness is more than 80% of the thickness of the solid-state metal, and the horizontal speeds of the blades are improved. A new mechanism is provided for the joining of the solid-state metal and a foundation is laid for the design of the device. | ZHANG Shuangjie YAO Yunfeng LI Lingchong WANG Lijuan LI Junxia LI Qiang | 2015 | Chinese Journal of Mechanical Engineering2015，28，6： | 3 |
| 9 | Microstructure Evolution and Mechanical Behavior of Laser Melting Deposited TA15 Alloy at 500℃ under In-Situ Tension in SEM显示文摘TA15 alloy fabricated by laser melting deposition was investigated at 500℃ under tensile deformation. The damage behavior of microstructure was analyzed by the real time observation of the microstructure evolution, microcracks initiation and propagation using in-situ tensile equipment fitted in the SEM chamber. Finally, the mechanism of fracture was discussed. The result showed anisotropic mechanical properties in X-and Z-direction. The existence of columnar β grains and its orientation to the tensile direction were the major factors inducing the anisotropic mechanical properties. As compared to Z-direction specimen, high tensile strength was observed in X-direction specimen due to the resistance in slips propagation provided by the prior-β grain boundaries( β GBs). Accumulation of the cracks at prior β GB caused the shear fracture. In case of Z-direction specimen, parallel orientation of prior β GB and GB α with the tensile direction resulted in a homogeneous deformation. The high reduction of cross section showed the enhanced ductile characteristics at high temperature. | Muhammad Rizwan Junxia Lu Fei Chen Ruxia Chai Rafi Ullah Yuefei Zhang Ze Zhang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，9： | 2 |
| 10 | The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells显示文摘Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate. | Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 11 | Temporal and spatial changes in Bt toxin expression in Bt-transgenic poplar and insect resistance in field tests显示文摘Extensive planting of Bacillus thuringiensis(Bt)-transgenic plants economically benefits society; however, the potential risk they pose is receiving increasing attention. This study used enzyme-linked immunosorbent assay and fluorescence quantitative PCR(RT-PCR) to monitor the temporal and spatial dynamics of the expression of Bt toxic protein in a forest of 6- to 8-year-old trees of transgenic insect-resistant poplar 741 for three consecutive years. The enrichment, distribution, and degradation of Bt toxic protein and the influence of transgenic poplars on the targeted insect population, Hyphantria cunea, were investigated. The content of Cry1Ac toxic protein dynamically changed in transgenic poplar. During the annual growth cycle, the content initially increased, then decreased in the long and the short branches of the crown and in the root system, peaking in August. During the study, the protein did not accumulate overtime. The m RNA transcription of gene Cry1Ac was almost consistent with the level of the protein, but transcription peaked in July. In the transgenic and control forestland, microscale levels of the Cry1Ac toxic protein were detected from the soil, but increased accumulation was not observed with the planting year of transgenic poplar. Meanwhile, Bt was isolated and detected molecularly from the soil in the experimental forestland. A systematic investigation of the density of H.cunea in the experimental transgenic poplar forest indicated that transgenic Pb29 poplar could resist insects to a certain degree. At peak occurrence of the targeted insects,the density of H. cunea in the experimental forest was significantly lower than in the nontransgenic poplar forest. | Yiwen Zhang Jun Zhang Jinping Lan Jinmao wang Junxia Liu Minsheng Yang | 2016 | Journal of Forestry Research2016，27，6： | 2 |
| 12 | Quantitative Analysis of Faults in Huizhou Sub-basin, Pearl River Mouth Basin显示文摘This study used 2 D seismic profiles to investigate the Cenozoic evolution of faults in the Huizhou Sub-basin. It aims to define the basin structure style through describing the geometric features of the faults and quantitatively analyzing their activities. The results indicate that the boundary faults in the Huizhou Sub-basin display en echelon arrangement in plan view, which indicates that, it was caused by a kind of oblique extension. Calculating the fault slips shows long-term activities of faults occurred in the basin, and some boundary faults kept active after 5.5 Ma. The evolution history of the fault system is reconstructed. Initially, during the Eocene–Early Oligocene, mainly NNE-NE and NW trending faults and NE striking grabens and half-grabens formed in the basin and a series of faults system controlled the deposition. During the Late Oligocene–Early Miocene, the structural activities were relatively weak, the fault activity and the fault growth rate decreased sharply. Finally, in the late stage from Late Miocene to the present, the structure movement was re-activated, and some faults were also reactivated. Our study will help better understand the structural features and evolution of the petroleum-bearing basins in the northern margin of the South China Sea. | Boubacar Hamidou Leyla Junxia Zhang Linlong Yang | 2018 | Journal of Earth Science2018，29，1： | 2 |
| 13 | Overexpression of astrocyte-elevated gene-1 is associated with cervicalcarcinoma progression and angiogenesis显示文摘 | Min Long Ke Dong Ping Gao Xi Wang Li Liu Shuhui Yang Fang Lin Junxia Wei Huizhong Zhang | 2013 | Oncology Reports2013，，3： | 2 |
| 14 | Susceptibility of patients with chronic obstructive pulmonary disease to heart rate difference associated with the short-term exposure to metals in ambient fine particles:A panel study in Beijing,China显示文摘Susceptibility of patients with chronic obstructive pulmonary disease(COPD)to cardiovascular autonomic dysfunction asso-ciated with exposure to metals in ambient fine particles(PM2.5,particulate matter with aerodynamic diameter≤2.5µm)remains poorly evidenced.Based on the COPDB(COPD in Beijing)panel study,we aimed to compare the associations of heart rate(HR,an indicator of cardiovascular autonomic function)and exposure to metals in PM2.5 between 53 patients with COPD and 82 healthy controls by using linear mixed-effects models.In all participants,the HR levels were significantly associated with interquartile range increases in the average concentrations of Cr,Zn,and Pb,but the strength of the associations differed by exposure time(from 1.4%for an average 9 days(d)Cr exposure to 3.5%for an average 9 d Zn exposure).HR was positively associated with the average concentrations of PM2.5 and certain metals only in patients with COPD.Associations between HR and exposure to PM2.5,K,Cr,Mn,Ni,Cu,Zn,As,and Se in patients with COPD significantly differed from those in health controls.Furthermore,association between HR and Cr exposure was robust in COPD patients.In conclusion,our findings indicate that COPD could exacerbate difference in HR following exposure to metals in PM2.5. | Ke Gao Xi Chen Xiaoying Li Hanxiyue Zhang Mengxiao Luan Yuan Yao Yifan Xu Teng Wang Yiqun Han Tao Xue Junxia Wang Mei Zheng Xinghua Qiu Tong Zhu | 2022 | Science China(Life Sciences)2022，65，2： | 2 |
| 15 | Improved EEMD-based standardization method for developing long tree-ring chronologies显示文摘Long tree-ring chronologies can be developed by overlapping data from living trees with data from fossil trees through cross-dating.However,low-frequency climate signals are lost when standardizing tree-ring series due to the'segment length curse'.To alleviate the segment length curse and thus improve the standardization method for developing long tree-ring chronologies,here we first calculated a mean value for all the tree ring series by overlapping all of the tree ring series.The growth trend of the mean tree ring width(i.e.,cumulated average growth trend of all the series)was determined using ensemble empirical mode decomposition.Then the chronology was developed by dividing the mean value by the growth trend of the mean value.Our improved method alleviated the problem of trend distortion.Long-term signals were better preserved using the improved method than in previous detrending methods.The chronologies developed using the improved method were better correlated with climate than those developed using conservative methods.The improved standardization method alleviates trend distortion and retains more of the low-frequency climate signals. | Xianliang Zhang Junxia Li Xiaobo Liu Zhenju Chen | 2020 | Journal of Forestry Research2020，31，6： | 2 |
| 16 | Transfer function based equivalent modeling method for wind farm显示文摘To effectively study the dynamics of power systems with large-scale wind farms(WFs), an equivalent model needs to be developed. It is well known that back-toback converters and their controllers are important for the dynamic responses of the wind turbine(WT) under disturbances. However, the detailed structure and parameters of the back-to-back converters and their controllers are usually unknown to power grid operators. Hence, it is difficult to build an accurate equivalent model for the WF using the component model-based equivalent modeling method. In this paper, a transfer function based equivalent modeling method for the WF is proposed. During modeling, the detailed structure and parameters of the WF are not required. The objective of the method is reproducing the output dynamics of the WF under the variation of the wind speed and power grid faults. A decoupled parameter-estimation strategy is also developed to estimate the parameters of the equivalent model. A WF that consists of 16 WTs is used to test the proposed equivalent model. Additionally,the proposed equivalent modeling method is applied to build the equivalent model for a real WF in Northwest China. The effectiveness of the proposed method is validated by the real measurement data. | Feng WU Junxia QIAN Ping JU Xiaoping ZHANG Yuqing JIN Dan XU Michael STERLING | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，3： | 2 |
| 17 | Sensitive and Selective Fluorescent and Colorimetric Sensor for Ag^+ Based on the Supramolecular Self-Assembly in Semi-Water显示文摘在用超级快方法的半水的离子的 ultratrace 层次的特定的识别仍然是为环境监视的挑战。此处,我们报导一荧光灯并且 colormetric 传感器(ZH ) 基于超分子自己组装,其结构被银离子的 ultratrace 的增加破坏。这个过程支持了可见颜色改变的肉眼或与一个宽 pH 范围一起熄灭的荧光紧张。系统的研究揭示了很高的选择(0. | Taibao Wei Haili Zhang Wenting Li Wenjuan Qu Junxia Su Qi Lin Youming Zhang Hong Yao | 2017 | Chinese Journal of Chemistry2017，35，8： | 1 |
| 18 | Motion Characteristics of the Appendages of Mole Crickets during Burrowing显示文摘Mole crickets,Gryllotalpa orientalis,have a pair of fully specialized forelegs for burrowing and employ an efficient underground excavating pattern,which provides excellent biological example for design of bionic underground excavation equipment.In this study,the excavating pattern and kinematic features of mole crickets were obtained by using high-speed motion capture system and employing a transparent hydrogel as the analogue for soil.The two-dimensional motion characteristics of the forelegs of mole crickets during burrowing were captured and analyzed.The results show that the forelegs of the mole cricket employ a unique excavating pattern,which consists of foreword digging and horizontal expansion.We label this pattern a digging-expanding mode.An excavating cycle includes the digging and expanding motion of the forelegs,rotation caused by the midlegs and hindlegs,and forward thrust by the hindlegs.The excavating motion of the left and right forelegs is alternately carried out.This study can inspire the design of bionic tunnelling mechanisms and underground excavation equipment. | Yan Zhang Jiafeng Cao Qi Wang Pengfei Wang Yueying Zhu Junxia Zhang | 2019 | Journal of Bionic Engineering2019，16，2： | 1 |
| 19 | Dynamic Microwave-Assisted Extraction of Total Ginsenosides from Ginseng Fibrous Roots显示文摘A dynamic microwave-assisted extraction(DMAE) method is established for the extraction of total ginsenosides from ginseng fibrous roots. The extraction process has been simulated and its main affection factors(liquid/solid ratio K of solvent to ginseng powders(V/m), irradiation time, irradiation temperature, extracting solution concentration, flow rate of solvent and microwave power) have been optimized by response surface methodology(RSM). The optimum conditions of extraction are the liquid/solid ratio of 270 m L/g, the extraction temperature of 75 ℃, the extraction time of 35 min, ethanol concentration of 70%(V/V), the solvent flow rate of 1.3 m L/min, and the microwave power of 500 W. The yield of ginsenosides obtained by the proposed DAME method is(15.0±0.7) %, which is well agreement with the yield predicted by the model. Compared with static microwave-assisted extraction, DMAE has a higher extraction yield and can avoid the degradation of ginsenoside. | ZHANG Yuefei LI Yali LIU Zhe ZHONG Ling CHI Ruan YU Junxia | 2015 | Wuhan University Journal of Natural Sciences2015，20，3： | 1 |
| 20 | ACIMMYR2, an Inhib- itor of Dicer-Mediated Biogenesis of Oncomir miR-21, Reverses Epithelial- Mesenchymal Transition and Suppresses Tumor Growth and Progression显示文摘 | Zhendong Shi Junxia Zhang Xiaomin Qian | 2013 | Cancer Res2013，73，17： | 1 |
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