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| 1 | Evaluation of the Tropical Variability from the Beijing Climate Center's Real-Time Operational Global Ocean Data Assimilation System显示文摘The second-generation Global Ocean Data Assimilation System of the Beijing Climate Center(BCC_GODAS2.0) has been run daily in a pre-operational mode.It spans the period 1990 to the present day.The goal of this paper is to introduce the main components and to evaluate BCC_GODAS2.0 for the user community.BCC_GODAS2.0 consists of an observational data preprocess,ocean data quality control system,a three-dimensional variational(3DVAR) data assimilation,and global ocean circulation model[Modular Ocean Model 4(MOM4)].MOM4 is driven by six-hourly fluxes from the National Centers for Environmental Prediction.Satellite altimetry data,SST,and in-situ temperature and salinity data are assimilated in real time.The monthly results from the BCC_GODAS2.0 reanalysis are compared and assessed with observations for 1990-2011.The climatology of the mixed layer depth of BCC-GODAS2.0 is generally in agreement with that of World Ocean Atlas 2001.The modeled sea level variations in the tropical Pacific are consistent with observations from satellite altimetry on interannual to decadal time scales.Performances in predicting variations in the SST using BCC_GODAS2.0 are evaluated.The standard deviation of the SST in BCC-GODAS2.0 agrees well with observations in the tropical Pacific.BCC-GODAS2.0 is able to capture the main features of E1 Nino Modoki I and Modoki Ⅱ,which have different impacts on rainfall in southern China.In addition,the relationships between the Indian Ocean and the two types of E1 Nino Modoki are also reproduced. | Wei ZHOU Mengyan CHEN Wei ZHUANG Fanghua XU Fei ZHENG Tongwen WU Xin WANG | 2016 | Advances in Atmospheric Sciences2016，33，2： | 5 |
| 2 | Interconnected sandwich structure carbon/Si-SiO_2/carbon nanospheres composite as high performance anode material for lithium-ion batteries显示文摘In the present work,an interconnected sandwich carbon/Si-SiO_2/carbon nanospheres composite was prepared by template method and carbon thermal vapor deposition(TVD).The carbon conductive layer can not only efficiently improve the electronic conductivity of Si-based anode,but also play a key role in alleviating the negative effect from huge volume expansion over discharge/charge of Si-based anode.The resulting material delivered a reversible capacity of 1094 mAh/g,and exhibited excellent cycling stability.It kept a reversible capacity of 1050 mAh/g over 200 cycles with a capacity retention of 96%. | Yuanjin Du Mengyan Hou Dan Zhou Yonggang Wang Congxiao Wang Yongyao Xia | 2014 | Journal of Energy Chemistry2014，23，3： | 3 |
| 3 | The Combined Effect of Plastic Particles Size and Concentration on Rotifers’ (Brachionus plicatilis) Performance显示文摘The presence of microplastics in aquatic ecosystems is of increasing global concern.Nano-sized plastics,in particular,can penetrate the cell membrane and cause biological death.Our study evaluated the combined impacts of several polystyrene mi-crospheres’sizes and nominal concentrations on the overall performance changes of Brachionus plicatilis.Experimental animals were exposed to three microplastic sizes(0.08,0.5 and 6μm)and five nominal concentrations(0,0.5,2,8,32μg mL−1)for 20 d.Our results showed that the toxicological effect of particle size on rotifers did not significantly depend on the nominal concentration.The interaction between the nominal concentration and size occurred only for body length and lorica width.Specifically,high nominal concentrations of microplastics that were close to nanometer size significantly impaired the overall vitality of rotifers,embodied in shortage of body type,delay in the arrival of maturity,reduction in the cumulative number of neonates,and the advance of the death process.In comparison,fair-sized size(0.5 and 6μm)displayed non-significant damage except for individual groups.Most notably,the net reproductive yield was only a third of what it was in the original environment,implying that there was not much fertility left.Besides,with the development of rotifers,the adverse effects of polystyrene microsphere drive had become more and more serious. | SUI Yanming WANG Senyang MOHSEN Mohamed ZHANG Longsheng SHEN Mengyan LIU Zhiquan NGUYEN Haidang ZHANG Shengmao LI Kaixing LV Linlan DONG Xuexing | 2022 | Journal of Ocean University of China2022，21，2： | 3 |
| 4 | The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells显示文摘Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate. | Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 5 | Self-Actuated, Thermo-Responsive Hydrogel Valves for Lab on a Chip显示文摘 | Jing Wang Zongyuan Chen Michael Mauk Kuang-Sheng Hong Mengyan Li Shu Yang Haim H. Bau | 2005 | Biomedical Microdevices2005，，4： | 1 |
| 6 | EIF4E over-expresses and enhances cell proliferation and cell cycle progression in nasopharyngeal carcinoma显示文摘 | Mengyan Wu Yingxia Liu Xiaoqing Di Haixian Kang Hua Zeng Yi Zhao Kangrong Cai Tianyun Pang Sen Wang Yunhong Yao Xinrong Hu | 2013 | Medical Oncology2013，，1： | 1 |
| 7 | Gas chromatographic enantiomer separation on single and mixed cyclodextrin derivative chiral stationary phases 显示文摘 | NIE Mengyan ZHOU Liangmo WANG Qinghai | 2000 | Chromatographia2000，51，1112： | 1 |
| 8 | Kinetic Limits of Graphite Anode for Fast‑Charging Lithium‑Ion Batteries显示文摘Fast-charging lithium-ion batteries are highly required,especially in reducing the mileage anxiety of the widespread electric vehicles.One of the biggest bottlenecks lies in the sluggish kinetics of the Li^(+)intercalation into the graphite anode;slow intercalation will lead to lithium metal plating,severe side reactions,and safety concerns.The premise to solve these problems is to fully understand the reaction pathways and rate-determining steps of graphite during fast Li^(+)intercalation.Herein,we compare the Li^(+)diffusion through the graphite particle,interface,and electrode,uncover the structure of the lithiated graphite at high current densities,and correlate them with the reaction kinetics and electrochemical performances.It is found that the rate-determining steps are highly dependent on the particle size,interphase property,and electrode configuration.Insufficient Li^(+)diffusion leads to high polarization,incomplete intercalation,and the coexistence of several staging structures.Interfacial Li^(+)diffusion and electrode transportation are the main rate-determining steps if the particle size is less than 10μm.The former is highly dependent on the electrolyte chemistry and can be enhanced by constructing a fluorinated interphase.Our findings enrich the understanding of the graphite structural evolution during rapid Li^(+)intercalation,decipher the bottleneck for the sluggish reaction kinetics,and provide strategic guidelines to boost the fast-charging performance of graphite anode. | Suting Weng Gaojing Yang Simeng Zhang Xiaozhi Liu Xiao Zhang Zepeng Liu Mengyan Cao Mehmet Nurullah Ateş Yejing Li Liquan Chen Zhaoxiang Wang Xuefeng Wang | 2023 | Nano-Micro Letters2023，15，11： | 1 |
| 9 | EIF4E over-expresses and enchances cell proliferation and cell cycle progression in nasopharyngeal carci- noma 显示文摘 | Mengyan Wu Yingxia Liu Xiaoqing Di Haixian Kang Hua Z Yi Zhao Kangyong Cai Tianyun Pang Sen Wang Yun- hong Yao Xinrong Hu | 2013 | Med Oncol2013，30，1： | 1 |
| 10 | Investigation of impact fracture behavior of automobile laminated glass by 3D discrete element method显示文摘 | ZANG Mengyan LEI Zhou WANG Shuangfeng | 2007 | Computational Mechanics2007，41，： | 1 |
| 11 | Influence of the Gaussian colored noise and electromagnetic radiation on the propagation of subthreshold signals in feedforward neural networks显示文摘Iterative methods are used to simulate the in vitro feedforward neural networks in physiological experiments.Emissivity can be propagated to a minimum of ten groups.However,the discharge activity of each group will be more synchronized.The feedforward neural networks have a wide range of applications in machine learning,and the weight of synapses considerably influences the propagation of weak signals.Herein,we investigated the effect of Gaussian colored noise and electromagnetic radiation on the propagation of the subthreshold excitatory postsynaptic current signals in the input layer of the multilayer Izhikevich neural feedforward networks.In the absence of electromagnetic radiation,the excitatory postsynaptic current signal is stably propagated and amplified in multilayer feedforward neural networks under the optimal Gaussian colored noise strength or correlation time in the output layer of the network.Compared with the case in which there is no electromagnetic radiation,the presence of electromagnetic radiation slightly reduces the propagation of weak signals.Further,the time required to propagate the excitatory postsynaptic current signal to the output layer increases with the increasing feedback gain.The feedforward neural network considered in this study is a considerably simple model.More complex structures,such as backward connection and delayed feedback,can be observed in real biological systems.Hence,the next step will be to study more complex neural models with neuron models based on the physiological experimental data and compare them with real biological systems.Furthermore,the study of neural networks can be combined with an experimental study about the auditory nervous system of bats to understand the biological mechanism associated with the auditory system function of bats from two perspectives. | GE MengYan WANG GuoWei JIA Ya | 2021 | Science China(Technological Sciences)2021，64，4： | 1 |
| 12 | Fine-tuning brassinosteroid biosynthesis via 3′UTR-dependent decay of CPD mRNA modulates wood formation in Populus显示文摘Brassinosteroids(BRs)are plant hormones that regulate wood formation in trees.Currently,little is known about the post-transcriptional regulation of BR synthesis.Here,we show that during wood formation,fine-tuning BR synthesis requires 3′UTR-dependent decay of Populus CONSTITUTIVE PHOTOMORPHOGENIC DWARF 1(PdCPD1).Overexpression of PdCPD1 or its 3′UTR fragment resulted in a significant increase of BR levels and inhibited secondary growth.In contrast,transgenic poplars repressing PdCPD13′UTR expression displayed moderate levels of BR and promoted wood formation.We show that the Populus GLYCINE-RICH RNA-BINDING PROTEIN1(PdGRP1)directly binds to a GU-rich element in 3′UTR of Pd CPD1,leading to its mRNA decay.We thus provide a post-transcriptional mechanism underlying BRs synthesis during wood formation,which may be useful for genetic manipulation of wood biomass in trees. | Dian Wang Xiaoning Hao Li Xu Mengyan Zhao Congpeng Wang Xihao Yu Yingzhen Kong Mengzhu Lu Gongke Zhou Guohua Chai Xianfeng Tang | 2023 | Journal of Integrative Plant Biology2023，65，8： | 0 |
| 13 | Miriplatin-loaded liposome,as a novel mitophagy inducer,suppresses pancreatic cancer proliferation through blocking POLG and TFAM-mediated mtDNA replication显示文摘Pancreatic cancer is a more aggressive and refractory malignancy.Resistance and toxicity limit drug efficacy.Herein,we report a lower toxic and higher effective miriplatin(MPt)-loaded liposome,LMPt,exhibiting totally different anti-cancer mechanism from previously reported platinum agents.Both in gemcitabine(GEM)-resistant/sensitive(GEM-R/S)pancreatic cancer cells,LMPt exhibits prominent anti-cancer activity,led by faster cellular entry-induced larger accumulation of MPt.The level of caveolin-1(Cav-1)determines entry rate and switch of entry pathways of LMPt,indicating a novel role of Cav-1 in nanoparticle entry.After endosome-lysosome processing,in unchanged metabolite,MPt is released and targets mitochondria to enhance binding of mitochondria protease LONP1 with POLG and TFAM,to degrade POLG and TFAM.Then,via PINK1-Parkin axis,mitophagy is induced by POLG and TFAM degradation-initiated mitochondrial DNA(mtDNA)replication blocking.Additionally,POLG and TFAM are identified as novel prognostic markers of pancreatic cancer,and mtDNA replication-induced mitophagy blocking mediates their pro-cancer activity.Our findings reveal that the target of this liposomal platinum agent is mitochondria but not DNA(target of most platinum agents),and totally distinct mechanism of MPt and other formulations of MPt.Self-assembly offers LMPt special efficacy and mechanisms.Prominent action and characteristic mechanism make LMPt a promising cancer candidate. | Xiaowei Wang Mengyan Wang Meilian Cai Rongguang Shao Guimin Xia Wuli Zhao | 2023 | Acta Pharmaceutica Sinica B2023，13，11： | 0 |
| 14 | Rectifying the Neoproterozoic Stratigraphic Framework of Eastern Jiangnan Orogen, Southeast China显示文摘Studies on the metamorphic and related magmatic rocks within the Jiangnan Orogen,southern China,are important to understand the formation and evolution of this Neoproterozoic orogen because they can provide evidence for revealing the tectonic evolution of the South China Block.Following on from earlier attempts at stratigraphic correlation and creating a framework for the low-grade metamorphosed basement,new first-hand information on the composition and deformation of the East Jiangnan Orogen basement indicates that the sedimentary rocks in the north are composed of the sequential Shangxi Group(Gp)and the overlying Likou Gp,with a clear regional unconformity in between.The Likou Gp includes the Zhentou Formation(Fm.)and the Dengjia Fm.,with the previously named Puling Fm.only basalt interbeds within the Dengjia Fm.The Xucun granodiorite pluton of^830 Ma intrudes the Shangxi Gp,thereby resulting in a 100 mwide hornfels zone within the wall rocks,indicating that the formation of the group occurred earlier than that of the pluton.By contrast,the southern metamorphic rocks of the Xikou Gp and the overlying Jingtan Fm.are flaky,disordered,and strongly deformed.The Jingtan Fm.is roughly equivalent to the Heshangzhen Gp and includes the Zhoujiacun conglomerates in the lower part and a rhyolite in the upper part with interbedded basalt.This assessment of Neoproterozoic stratigraphic sequences and magmatic rocks in the east of the Jiangnan Orogen differs from and rectifies previous studies,emphasizing that explanation of analytical results,particularly geochronology,should be consistent with facts gathered in the field. | YU Xinqi LIU Junlai CHEN Ziwei HU Jun ZENG Yan LIU Xiu LIU Mengyan HE Yu MENG Linghui WANG Zishen | 2020 | Acta Geologica Sinica(English Edition)2020，94，6： | 0 |
| 15 | In situ reduction strategy towards high conductivity,anti-freezing and super-stretchable rGO based hydrogel for diverse flexible electronics显示文摘Hydrogels electrolytes with flexibility and high conductivity have been widely used in kinds of flexible electronics.However,hydrogels always suffer from the inevitable freezing of water at subzero temperatures,which results in the sacrificing of their electrical properties.Herein,an anti-freezing,flexible hydrogel based on in situ reduction of graphene oxide(GO)and laponite has been developed as electrolyte for high performance supercapacitor and sensitive sensors.The crosslinked GO and laponite in polyacrylamide(PAM)resulted in an enhanced mechanical property,while the in-situ reduction of GO in the hydrogel enhanced the conductivity and diminishes the aggregated of GO.These features guarantee a reliable electro signal as sensor and a high performance of the supercapacitor.Besides,in the process of preparation of reduced graphene oxide(rGO)hydrogel,the addition of ethylene glycol(EG)and KOH,endows the hydrogel antifreeze properties.This anti-freezing electrolyte can be stretched to a strain of 1600%and maintained a specific capacitance of 37.38 F·g^(-1) at-20℃.In addition,the photothermal conversion character of rGO in the hydrogel,endows it’s the potential application in wound healing.The overall merits of the hydrogel will open up a new avenue for sensitive sensor and energy storage device in practical applications. | Xin Zhang Junhao Wang Mengyan Wang Dongxu Liu Zhuo Wang | 2024 | Nano Research2024，17，5： | 0 |
| 16 | The electric field effect on the sensitivity of tin oxide gas sensors on nanostructured substrates at low temperature显示文摘A novel low-temperature SnO_(2) gas sensor was prepared and studied on silicon nanostructures formed by femtosecond laser irradiation.By applying a bias voltage on the silicon substrate to alter the charge distribution on the surface of the SnO_(2),carbon monoxide(CO),and ammonia(NH_(3))gas can be distinguished by the same sensor at room temperature.The experimental results are explained with a mechanism that the sensor works at low temperature because of adsorption of gas molecules that trap electrons to the surface of the SnO_(2). | Haizhou Ren Haibin Huo Pengtao Wang Cong Wang Sai Liu Mengyan Shen Hongwei Sun Marina Ruths | 2014 | International Journal of Smart and Nano Materials2014，5，4： | 0 |
| 17 | Elimination of an unfavorable allele conferring pod shattering in an elite soybean cultivar by CRISPR/Cas9显示文摘Pod shattering can lead to devastating yield loss of soybean and has been a negatively selected trait in soybean domestication and breeding.Nevertheless,a significant portion of soybean cultivars are still pod shattering-susceptible,limiting their regional and climatic adaptabilities.Here we performed genetic diagnosis on the shattering-susceptible trait of a national registered cultivar,Huachun6(HC6),and found that HC6 carries the susceptible genotype of a candidate Pod dehiscence 1(PDH1)gene,which exists in a significant portion of soybean cultivars.We next performed genome editing on PDH1 gene by clustered regularly interspaced short palindromic repeats(CRISPR)-CRISPR-associated protein 9(Cas9).In T2 progenies,several transgene-free lines with pdh1 mutations were characterized without affecting major agronomic traits.The pdh1 mutation significantly improved the pod shattering resistance which is associated with aberrant lignin distribution in inner sclerenchyma.Our work demonstrated that precision breeding by genome editing on PDH1 holds great potential for precisely improving pod shattering resistance and adaptability of soybean cultivars. | Zhihui Zhang Jie Wang Huaqin Kuang Zhihong Hou Pingping Gong Mengyan Bai Shaodong Zhou Xiaolei Yao Shikui Song Long Yan Yuefeng Guan | 2022 | aBIOTECH2022，3，2： | 0 |
| 18 | Edge engineering in chemically active two-dimensional materials显示文摘When 'cut off' continuous and uniform basal plane of two-dimensional(2D)materials,edges appear at cross-sections.Such edges with unique one-dimensional(1D)structures and bound-states significantly alter materials’local chemical activities and have been extensively investigated as model platforms for investigating structure–property–performance relationships for chemistry.Many interesting phenomena have been discovered in the past decades,highlighting the importance of interactions between active species and edge atoms at the atomic level and making 1D edges as emerging catalysts with high efficiency,promising candidates for battery and electrochemical contacts.Here,this review focuses on the recent progress of edge synthesis and structural engineering methods,understanding of edge structure–activity mechanisms,and potential applications using edge sites.Challenges and prospects are also envisioned. | Lijun Zhou Mengyan Li Wei Wang Cong Wang Huiping Yang Yang Cao | 2022 | Nano Research2022，15，11： | 0 |
| 19 | Highly sensitive gas sensors on low-cost nanostructured polymer substrates显示文摘SnO_(2)thin-film gas sensors have been successfully fabricated on nanospiked polyurethane polymer surfaces,which are replicated by a low-cost soft nanolithography method from silicon nanospike structures formed with femtosecond laser irradiations.Measurements revealed significant response to carbon monoxide(CO)gas at room temperature,which is considerably different from the sensors of SnO_(2)thin films coated on smooth surfaces that show no response to CO gas at room temperature.The high area/volume ratio and sharp structures of the nanospikes enhance the sensitivity of SnO_(2)at room temperature.This will greatly decrease the electrical power consumption of the gas sensor and the cost for calibrations,and has great potential for application in other sensing systems. | Haibin Huo Haizhou Ren Cong Wang Mengyan Shen | 2011 | International Journal of Smart and Nano Materials2011，2，1： | 0 |
| 20 | Characteristic analysis of layered PMSEs measured with different elevation angles at VHF based on an experimental case显示文摘Polar Mesosphere Summer Echoes(PMSEs)are very strong radar echoes observed at altitudes near the polar summer mesopause.One of the essential properties of these radar echoes is that they can give useful diagnostic information about the physics of the scattering process.In this paper,the related characteristics of PMSEs measured with the European Incoherent SCATter Very High Frequency(EISCAT VHF)224 MHz radar on 13–15 July 2010 are studied at different elevation angles from 78°to 90°.It is found that the PMSEs peak power and strongest PMSEs average power occur at the same elevation angles.Also interesting is that the strongest PMSEs occur at off-vertical angles when a PMSEs has a layered(multilayer)structure.And reflection may have more significant effects on PMSEs when there are double or multilayer PMSEs.Possible explanations regarding these observations are discussed. | ShuCan Ge HaiLong Li Bin Xu Tong Xu Lin Meng MaoYan Wang Abdel Hannachi MengYan Zhu Lina Broman Safi Ullah Abdur Rauf | 2021 | Earth and Planetary Physics2021，5，1： | 0 |
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