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| 1 | Downstaging and resection of hepatocellular carcinoma in patients with extrahepatic metastases after stereotactic therapy显示文摘Background:A combination of tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies with local regional therapy has elicited yield substantial clinical benefits in patients who have hepatocellular carcinoma(HCC)with extrahepatic metastases.Using this treatment strategy to convert HCC patients with extrahepatic metastases from unresectable to resectable has not yet been reported.Methods:Consecutive hepatocellular carcinoma patients with extrahepatic metastases who received first-line therapy with a combination of TKIs and anti-PD-1 antibodies and at least one local regional therapy were analysed.Results:Nine patients with localized disease who received first-line systemic therapy were enrolled.At baseline,all of them had oligometastatic disease,namely,Barcelona Clinic Liver Cancer stage C(or Chinese Liver Cancer stage IIIB).The most common treatment administered was lenvatinib plus anti-PD-1 antibody and transarterial chemoembolization,and the median time span from systemic therapy to surgery was 3.2(IQR,2.8-6.2)months.Three patients achieved a pathological complete response.Six patients underwent laparoscopic surgery,and the other 3 patients underwent open surgery.After a median follow-up of 10.2(IQR,8.6-20.0)months,7 patients survived without disease recurrence,and 2 experienced tumour recurrence.All patients had any-grade AEs,and 55.6%of the patients experienced grade 3 AEs.Fatigue was the most common AE,followed by elevated aminotransferase levels and hypertension.Conclusions:Stereotactic therapy is a feasible conversion therapy for HCC patients with extrahepatic metastases to become resectable.This is the first study to analyse therapeutic outcomes of patients receiving these therapies for HCC with extrahepatic metastases. | Xiaobo Yang Haifeng Xu Bangyou Zuo Xu Yang Jin Bian Junyu Long Dongxu Wang Junwei Zhang Cong Ning Yanyu Wang Ziyu Xun Yunchao Wang Xin Lu Yilei Mao Xinting Sang Haitao Zhao | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 17 |
| 2 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 3 | Fermented mixed feed alters growth performance,carcass traits,meat quality and muscle fatty acid and amino acid profiles in finishing pigs显示文摘This study was conducted to investigate the effects of fermented mixed feed(FMF)on growth performance,carcass traits,meat quality,muscle amino acid and fatty acid composition and mRNA expression levels of genes related to lipid metabolism in finishing pigs.In the present study,144 finishing pigs(Duroc×Berkshire×Jiaxing Black)were randomly allocated to 3 dietary treatments with 4 replicate pens per group and 12 pigs per pen.The dietary treatments included a basal diet(CON),a basal diet+5%FMF and a basal diet+10%FMF.The experiment lasted 38 d after 4 d of acclimation.The results showed that 5%and 10%FMF significantly increased the average daily gain(ADG)of the females but not the males(P<0.05),but FMF supplementation showed no impact on carcass traits.Moreover,10%FMF supplementation increased the meat color45 min and meat color24 h values,while it decreased the shear force relative to CON(P<0.05).In addition,10%FMF significantly increased the contents of flavor amino acids(FAA),total essential AA(EAA),total non-EAA(NEAA)and total AA relative to CON(P<0.05).Furthermore,the diet supplemented with 10%FMF significantly increased the concentration of n-3 polyunsaturated fatty acids(PUFA),n-6 PUFA and total PUFA,and the PUFA to saturated fatty acids ratio(P<0.05),suggesting that FMF supplementation increased meat quality.Moreover,compared with the CON,10%FMF supplementation increased the mRNA expression of lipogenic genes,including CEBPα,PPARγ,SREBP1 and FABP4,and upregulated the expression of unsaturated fatty acid synthesis(ACAA1 and FADS2).Together,our results suggest that 10%FMF dietary supplementation improved the female pigs’growth performance,improved the meat quality and altered the profiles of muscle fatty acids and amino acids in finishing pigs.This study provides a reference for the production of high-quality pork. | Shiqi Liu Man Du Yuang Tu Wenjing You Wentao Chen Guoliang Liu Junyue Li Yizhen Wang Zeqing Lu Tenghao Wang Tizhong Shan | 2023 | Animal Nutrition2023，，1： | 4 |
| 4 | Artificial Structural Colors and Applications显示文摘Structural colors are colors generated by the interaction between incident light and nanostructures.Structural colors have been studied for decades due to their promising advantages of long-term stability and environmentally friendly properties compared with conventional pigments and dyes.Previous studies have demonstrated many artificial structural colors inspired by naturally generated colors from plants and animals.Moreover,many strategies consisting of different principles have been reported to achieve dynamically tunable structural colors.Furthermore,the artificial structural colors can have multiple functions besides decoration,such as absorbing solar energy,anti-counterfeiting,and information encryption.In the present work,we reviewed the typical artificial structural colors generated by multilayer films,photonic crystals,and metasurfaces according to the type of structures,and discussed the approaches to achieve dynamically tunable structural colors. | Zhiyi Xuan Junyu Li Qingquan Liu Fei Yi Shaowei Wang Wei Lu | 2021 | The Innovation2021，2，1： | 3 |
| 5 | Numerical Simulation of Water and Sand Blowouts When Penetrating Through Shallow Water Flow Formations in Deep Water Drilling显示文摘In this study, we applied a two-phase flow model to simulate water and sand blowout processes when penetrating shallow water flow(SWF) formations during deepwater drilling. We define ‘sand' as a pseudo-component with high density and viscosity, which can begin to flow with water when a critical pressure difference is attained. We calculated the water and sand blowout rates and analyzed the influencing factors from them, including overpressure of the SWF formation, as well as its zone size, porosity and permeability, and drilling speed(penetration rate). The obtained data can be used for the quantitative assessment of the potential severity of SWF hazards. The results indicate that overpressure of the SWF formation and its zone size have significant effects on SWF blowout. A 10% increase in the SWF formation overpressure can result in a more than 90% increase in the cumulative water blowout and a 150% increase in the sand blowout when a typical SWF sediment is drilled. Along with the conventional methods of well flow and pressure control, chemical plugging, and the application of multi-layer casing, water and sand blowouts can be effectively reduced by increasing the penetration rate. As such, increasing the penetration rate can be a useful measure for controlling SWF hazards during deepwater drilling. | REN Shaoran LIU Yanmin GONG Zhiwu YUAN Yujie YU Lu WANG Yanyong XU Yan DENG Junyu | 2018 | Journal of Ocean University of China2018，17，1： | 2 |
| 6 | Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis显示文摘Tumor microenvironment contributes to poor prognosis of pancreatic adenocarcinoma(PAAD)patients.Proper regulation could improve survival.Melatonin is an endogenous hormone that delivers multiple bioactivities.Here we showed that pancreatic melatonin level is associated with patients'survival.In PAAD mice models,melatonin supplementation suppressed tumor growth,while blockade of melatonin pathway exacerbated tumor progression.This anti-tumor effect was independent of cytotoxicity but associated with tumor-associated neutrophils(TANs),and TANs depletion reversed effects of melatonin.Melatonin induced TANs infiltration and activation,therefore induced cell apoptosis of PAAD cells.Cytokine arrays revealed that melatonin had minimal impact on neutrophils but induced secretion of Cxcl2 from tumor cells.Knockdown of Cxcl2 in tumor cells abolished neutrophil migration and activation.Melatonin-induced neutrophils presented an N1-like anti-tumor phenotype,with increased neutrophil extracellular traps(NETs)causing tumor cell apoptosis through cell-to-cell contact.Proteomics analysis revealed that this reactive oxygen species(ROS)-mediated inhibition was fueled by fatty acid oxidation(FAO)in neutrophils,while FAO inhibitor abolished the anti-tumor effect.Analysis of PAAD patient specimens revealed that CXCL2 expression was associated with neutrophil infiltration.CXCL2,or TANs,combined with NET marker,can better predict patients'prognosis.Collectively,we discovered an anti-tumor mechanism of melatonin through recruiting N1-neutrophils and beneficial NET formation. | Yau-tuen Chan Hor-yue Tan Yuanjun Lu Cheng Zhang Chien-shan Cheng Junyu Wu Ning Wang Yibin Feng | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 7 | Emission trends and source characteristics of SO2, NOx, PM10 and VOCs in the Pearl River Delta region from 2000 to 2009 显示文摘 | Lu Qing Zheng Junyu Ye Siqi | 2013 | Atmospheric Environment2013，76，： | 1 |
| 8 | Dating for Jifanggou metamorphic complex in central Jilin and its tectonic implications显示文摘Based on the results of four regional geological surveys of 1: 50000 including Shulan County map in Jilin,taking Shulan area as the study area,the authors re-delineated the rock type assemblages,e.g. metamorphic rhyolite,metamorphic tuffaceous breccia lava,sericite-quartz schist and tremolite altered rock,etc.,and the structural contacts between them. With the help of in-situ LA-ICP-MS U-Pb dating for zircons,it is concluded that the zircon crystallization ages of the metamorphic rhyolite,the metamorphic andesitic tuff breccia lava and the tremolite altered rock are 339. 1 ± 1. 3 Ma( n = 27,MSWD = 0. 78),351. 8 ± 1. 7 Ma( n = 21,MSWD = 0.82),and 362.0±1.8 Ma( n = 43,MSWD = 2.2) respectively. The metamorphic complex is actually a set of tectonic melange which comprises the rocks in different types,sources,times,or tectonic settings,and was formed by tectonism. | WANG Zhongcheng LU Xiaoping ZHAO Juan TAO Junyu CHEN Mingjian | 2017 | Global Geology2017，20，4： | 1 |
| 9 | Engineering organoid microfluidic system for biomedical and health engineering:A review显示文摘In recent years,organoid technology,i.e.,in vitro three-dimensional(3D)tissue culture,has attracted increasing attention in biomedical engineering.Organoids are cell complexes induced by differentiation of stem cells or organ-progenitor cells in vitro using 3D culture technology.They can replicate the key structural and functional characteristics of the target organs in vivo.With the opening up of this new field of health engineering,there is a need for engineering-system approaches to the production,control,and quantitative analysis of organoids and their microenvironment.Traditional organoid technology has limitations,including lack of physical and chemical microenvironment control,high heterogeneity,complex manual operation,imperfect nutritional supply system,and lack of feasible online analytical technology for the organoids.The introduction of microfluidic chip technology into organoids has overcome many of these limitations and greatly expanded the scope of applications.Engineering organoid microfluidic system has become an interdisciplinary field in biomedical and health engineering.In this review,we summarize the development and culture system of organoids,discuss how microfluidic technology has been used to solve the main technical challenges in organoid research and development,and point out new opportunities and prospects for applications of organoid microfluidic system in drug development and screening,food safety,precision medicine,and other biomedical and health engineering fields. | Yifan Xing Junyu Liu Xiaojie Guo Haipeng Liu Wen Zeng Yi Wang Chong Zhang Yuan Lu Dong He Shaohua Ma Yonghong He Xin-Hui Xing | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 1 |
| 10 | Emission trends and source characteristics of SO 2 , NO x , PM 10 and VOCs in the Pearl River Delta region from 2000 to 2009显示文摘 | Qing Lu Junyu Zheng Siqi Ye Xingling Shen Zibing Yuan Shasha Yin | 2013 | Atmospheric Environment2013，，： | 1 |
| 11 | Development of stem cell-based therapy for Parkinson’s disease显示文摘Parkinson’s disease(PD)is one of the most common neurodegenerative disorders of aging,characterized by the degeneration of dopamine neurons(DA neurons)in the substantial nigra,leading to the advent of both motor symptoms and non-motor symptoms.Current treatments include electrical stimulation of the affected brain areas and dopamine replacement therapy.Even though both categories are effective in treating PD patients,the disease progression cannot be stopped.The research advance into cell therapies provides exciting potential for the treatment of PD.Current cell sources include neural stem cells(NSCs)from fetal brain tissues,human embryonic stem cells(hESCs),induced pluripotent stem cells(iPSCs)and directly induced dopamine neurons(iDA neurons).Here,we evaluate the research progress in different cell sources with a focus on using iPSCs as a valuable source and propose key challenges for developing cells suitable for large-scale clinical applications in the treatment of PD. | Fabin Han Deborah Baremberg Junyu Gao Jing Duan Xianjie Lu Nan Zhang Qingfa Chen | 2015 | Translational Neurodegeneration2015，4，1： | 1 |
| 12 | Emission trends and source characteristics of SO 2 , NO x , PM 10 and VOCs in the Pearl River Delta region from 2000 to 2009显示文摘 | Qing Lu Junyu Zheng Siqi Ye Xingling Shen Zibing Yuan Shasha Yin | 2013 | Atmospheric Environment2013，，： | 1 |
| 13 | Emission trends and source characteristics of SO2 , NO~, PM10 and VOCs in the Pearl River Delta region from 2000 to 2009 显示文摘 | LU Qing ZHENG Junyu YE Siqi | 2013 | Atmospheric Environment2013，76，： | 1 |
| 14 | A refined 2010-based VOC emission inventory and its improvement on modeling regional ozone in the Pearl River Delta Region, China 显示文摘 | YIN Shasha ZHENG Junyu LU Qing | 2015 | Science of the Total Environment2015，514，： | 1 |
| 15 | Preparation of bamboo-like PPy nanotubes and their application for removal of Cr(VI) ions in aqueous solution显示文摘 | Shangkun Li Xiaofeng Lu Xiang Li Yanpeng Xue Chengcheng Zhang Junyu Lei Ce Wang | 2012 | Journal of Colloid And Interface Science2012，，1： | 1 |
| 16 | New Discovery of the Devonian Orthoclase Granite of Nenjiang–Heihe Structural belt, China and its Zircon U-Pb Data显示文摘Objective The Nenjiang–Heihe structural belt is located in the eastern Xing’anling Mongolian Orogenic Belt between the Songnen block and Xiang’an block.This structural belt has long been the focus of geological scholars(Miao Laicheng et al.,2003;Liang Chenyue et al.,2011;Li Chao et al.,2017),which has complex geological condition, | YANG Fan NA Fuchao ZHANG Guangyu WANG Yan FU Junyu SUN Wei CHEN Jingsheng LI Bin LIU Miao PANG Xuejiao SHI Yi SHI Lu | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 0 |
| 17 | Modulating the tumor microenvironment via oncolytic virus and PI3K inhibition synergistically restores immune checkpoint therapy response in PTEN-deficient glioblastoma显示文摘Dear Editor,Glioblastoma(GBM)is a lethal primary brain cancer,with a median survival of less than 2 years.1 Immune checkpoint blockades(ICBs)have revolutionized cancer therapy in the last decade,but they have little clinical benefit in GBM.1 Genomic and transcriptomic analysis revealed a significant enrichment of PTEN mutations in GBM patients resistant to ICBs.2 PTEN deficiency activates the phosphatidylinositol 3-kinase(PI3K)-AKT pathway to shape an immunosuppressive microenvironment. | Fan Xing Jingshu Xiao Junyu Wu Jiaming Liang Xiaoyu Lu Liping Guo Ping Li Panpan Hou Chunmei Li Deyin Guo | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 18 | Multiple-Channel Weight-Based CNN Fault Diagnosis Method显示文摘It is difficult to comprehensively extract device status information for CNNs under a single source high-frequency timing signal,and CNNs cannot effec-tively achieve precise identification and classification based on the importance of multichannel features.This article proposes a CNN fault diagnosis method based on multi-channel weight adaptation.This methodfirst normalizes different data sources as input as different channels of CNN,and uses the characteristics of convolutional networks to achieve the characteristics of different data sources.Fusion and extraction.Then,the SNET module is embedded into the CNN net-work,adapted to the weight of each channel,and the accuracy of classification is improved.Finally,through comparative experiments,this method can further improve the accuracy of fault recognition. | Peng Xu Xinyu Liu Junyu Lin Zhongyu Lu Fengming Li Husheng Gou | 2023 | 国际计算机前沿大会会议论文集2023，，1： | 0 |
| 19 | Atomic mechanisms of hexagonal close-packed Ni nanocrystallization revealed by in situ liquid cell transmission electron microscopy显示文摘The fundamental understanding of the mechanism underlying the early stages of crystallization of hexagonal-close-packed(hcp)nanocrystals is crucial for their synthesis with desired properties,but it remains a significant challenge.Here,we report using in situ liquid cell transmission electron microscopy(TEM)to directly capture the dynamic nucleation process and track the real-time growth pathway of hcp Ni nanocrystals at the atomic scale.It is demonstrated that the growth of amorphous-phase-mediated hcp Ni nanocrystals is from the metal-rich liquid phases.In addition,the reshaped preatomic facet development of a single nanocrystal is also imaged.Theoretical calculations further identify the non-classical features of hcp Ni crystallization.These discoveries could enrich the nucleation and growth model theory and provide useful information for the rational design of synthesis pathways of hcp nanocrystals. | Junyu Zhang Miao Li Zewen Kang Bensheng Xiao Haichen Lin Jingyu Lu Haodong Liu Xue Zhang Dong-Liang Peng Qiaobao Zhang | 2022 | Nano Research2022，15，7： | 0 |
| 20 | Dynamic phasor-based hybrid simulation for multi-inverter grid-connected system显示文摘To realize the efficient transient simulation of a grid-connected power generation system based on multiple inverters, this paper proposes a hybrid simulation method integrating the models of electromagnetic transient and dynamic phasors. Based on a demonstration of the concepts and properties of dynamic phasors, the models of single-phase and three-phase inverters described by dynamic phasors are established first. Considering the numerical compatibility problem between dynamic phasors and instantaneous values, an interface scheme between dynamic phasors and instantaneous values is designed, and the efficiency and precision differences of various transformation methods are compared in detail.Finally, by utilizing MATLAB/Simulink, a hybrid simulation platform of a multi-inverter grid-connected system is built, and the efficiency and accuracy of the hybrid simulation are validated via comparison with the full electromagnetic transient simulation. | Peng Yang Qian Li Junyu Zhao Juanjuan Lu Yunfei Xu | 2023 | Global Energy Interconnection2023，6，2： | 0 |
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