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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy. | Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 3 | A bi-directional gap model for simulating the directional thermal radiance of row crops显示文摘Row crops are a kind of typical vegetation canopy between discrete canopy and continuous canopy. Kimes et al. studied the directional thermal radiation of row crops using the geometrical optical model, which simplified row structure as 'box' and neglected the gap among foliage and did not consider the emissivity effects. In this work we take account of the gaps along illumination and viewing directions and propose a bi-direction gap model on the basis of the idea of gap probability of discrete vegetation canopy introduced by 'Li-Strahler' and inter-correlation of continuous vegetation developed by Kuusk. It can be used to explain 'hot spot' effects in thermal infrared region. The gap model has been validated by field experiment on winter wheat planted in shape of rows and results show that the gap model is better than Kimes' model in describing the directionality of thermal infrared emission for row crops. | CHEN Liangfu (陈良富) LIU Qinhuo (柳钦火) FAN Wenjie (范闻捷) LI Xiaowen (李小文) XIAO Qing (肖青) YAN Guangjian (闫广建) TIAN Guoliang (田国良) | 2002 | Science China Earth Sciences2002，45，12： | 12 |
| 4 | Effect of gas emissions from Tianchi volcano (NE China) on environment and its potential volcanic hazards显示文摘The Tianchi volcano in the Changbai Mountains is located on the boundary between China and North Korea. There are many times of eruptions of the Tianchi volcano during the Holocene. One of its large eruptions occurred around 1000 years ago dated by 14C method and historical records. Composition of products of the largest Tianchi volcanic eruption studied is characterized by comendi- tic Plinian fallout and unwelded ignimbrite, which are mainly distributed in China and North Korea. Caldera is about 4.4 km long and 3.4 km wide, which had filled with water (e.g. Tianchi Lake). The Tianchi volcanic cone is about 2700 m high above sea level. The Tianchi Lake is located on the summit of the volcanic cone, that is also highest peak of the Changbai Mountains in northeastern China. This study analyzed Cl, F, S and H2O concentrations of melt inclusions in the phenocryst min- erals (anorthoclase and quartz) and co-existing matrix glasses using the electron microprobe and estimated environmental effect of Tianchi volcanic gases. The authors proposed a new method to evaluate future eruption of active volcano and estimate potential volcanic hazards based on contents of volatile emissions. Using this method, we made a perspective of future volcanic hazard in this re- gion. | GUO Zhengfu LIU Jiaqi HAN Jingtai HE Huaiyu DAI Guoliang YOU Haitao | 2006 | Science China Earth Sciences2006，49，3： | 9 |
| 5 | A review of flexible perovskite oxide ferroelectric films and their application显示文摘Many perovskite oxide ferroelectrics(e.g.PbZr_(1-x)Ti_(x)O_(3),BaTiO_(3),LiNbO_(3))are born with multitudinous robust performances and have been widely used in sensors,actuators,surface acoustic wave devices,and memories et al.However,their hardness,brittleness and harsh synthesis conditions(i.e.high temperature and oxygen ambience)restrain their application into flexible electronic devices which are significant components among the three pillars of modern society development,i.e.energy,information and materials.Here we review the preparation of flexible devices based on these oxide ferroelectrics,including transferring these freestanding films to flexible substrates after separating ferroelectric oxide films from the hard substrates,such as Si and SrTiO_(3) crystals,and also direct fabrication methods without transferring process.Subsequently,we summarize three kinds of representative flexible devices,i.e.flexible ferroelectric memories,sensors and generators.These inorganic electronics not only show excellent electric properties competitive with those corresponding electronics on hard substrates but also exhibit good flexibility similar to many organic flexible electronics. | Wenxiu Gao Yi Zhu Yaojin Wang Guoliang Yuan Jun-Ming Liu | 2020 | Journal of Materiomics2020，6，1： | 9 |
| 6 | Atomic structures of Zr-based metallic glasses显示文摘The atomic structures of Zr-Ni and Zr-Ti-Al-Cu-Ni metallic glasses were investigated by using classical molecular dynamic (MD),reverse Monte Carlo (RMC),ab initio MD (AIMD) simulations and high resolution transmission electron microscopy (HRTEM) techniques. We focused on the short-range order (SRO) and medium-range order (MRO) in the glassy structure. It is shown that there are icosahedral,FCC-and BCC-type SROs in the Zr-based metallic glasses. A structural model,characterized by imperfect ordered packing (IOP),was proposed based on the MD simulation and confirmed by the HRTEM observation. Furthermore,the evolution from IOP to nanocrystal during the crystallization of metallic glasses was also ex-plored. It is found that the growth from IOP to nanocrystal proceeds through three distinct stages: the formation of quasi-ordered structure with one-dimensional (1D) periodicity,then 2D periodicity,and finally the formation of 3D nanocrystals. It is also noted that these three growth steps are crosslinked. | HUI XiDong LIU XiongJun GAO Rui HOU HuaiYu FANG HuaZhi LIU ZiKui CHEN GuoLiang | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，4： | 8 |
| 7 | Dendrite-free all-solid-state lithium batteries with lithium phosphorous oxynitride-modified lithium metal anode and composite solid electrolytes显示文摘Dendrite formation on lithium (Li) metal anode is a key issue which hinders the development of rechargeable Li battery seriously. A novel method for suppress!ng Li dendrites via using Li phosphorous oxynitride (UPON) modified Li anode and Li1.5Al0.5Ge1.5(PO4)3-poly(ethylene oxide)(Li bistrifluoromethane-sulfonimide)(LAGP-PEO(LiTFSI)) composite solid electrolyte in all-solid-state Li battery is proposed, and the effect of the thickness of UPON on Li anode performarice is also studied. LiPON film with a thickness of 500 nm exhibits satisfactory interface property between Li metal anode and the LAGP-PEO(LiTFSI) solid electrolyte. The LiPON film provides a uniform Li^+ flux across the interface and effectively inhibits the formation of Li dendrites in all-solid-state Li batteries. The assembled all-solid-state Li cell Li(LiPON)/LAGP-PEO(LiTFSI)/LiFePO4 delivers an initial discharge capacity of 152.4 mAh·g^-1 and exhibits good cycling stability and rate performanee at 50 ℃. | Chunhua Wang Guoliang Bai Yifu Yang Xingjiang Liu Huixia Shao | 2019 | Nano Research2019，12，1： | 8 |
| 8 | Toward artificial intelligent self-cooling electronic skins:Large electrocaloric effect in all-inorganic flexible thin films at room temperature显示文摘Intelligent robots have assisted mankind in achieving and operating thousands of functions,especially with the arrival of the artificial intelligent.However,heat dissipation and thermal management in the intelligent robots remain big challenges,which limit their miniaturization and performance.Electrocaloric(EC)materials,which exhibit temperature change in response to the application or withdrawal of an electric field,open a new strategy for cooling technology and have gained a flurry of research interest in recent years.Toward artificial intelligent self-cooling electronic skins,large-scale flexible materials with high EC effect near room temperature are in demand.Here,we report a large room temperature EC effect in flexible Pb_(0.82)Ba_(0.08)La_(0.1)Zr0.9Ti_(0.1)O_(3)(PBLZT)inorganic thin films via a transfer-free cost-effective sol-gel process,assisted by unique two-dimensional mica substrates.The maximum adiabatic temperature change and isothermal entropy change of the flexible PBLZT thin films reach to 22.5 K and 25.9 J K^(-1) kg^(-1) at room temperature.In particular,the flexible PBLZT thin films exhibit a stable EC effect both under bending state and after bending for 20000 times.Our flexible EC materials offer an alternative strategy to the development of cooling technologies for both artificial intelligent robots and personal wearable cooling devices. | Ding Wang Xin Chen Guoliang Yuan Yanmin Jia Yiping Wang Arif Mumtaz Yaojin Wang Jun-Ming Liu | 2019 | Journal of Materiomics2019，5，1： | 7 |
| 9 | Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease: a randomized controlled clinical study显示文摘OBJECTIVE: To assess the efficacy and safety of Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease(HFMD). METHODS: A stratified-block randomized, double-blind, parallel-controlled, and multicenter clinical trial was conducted with 360 patients in five hospitals across China: Quanzhou Children's Hospital, Shijiazhuang No. 5 Hospital, Shanghai Public Health Centre, Hunan Provincial Children's Hospital, and Kaifeng Children's Hospital. Patients were randomized into three groups with 120 in each. Group A was treated with Western Medicine, group B with Reduning injection, a Chinese herbal medicine, and group C with both Reduning injection and Western Medicine. Results were compared for treatment efficacy and safety on HFMD. The clinical outcomes were observed as follows: fever and onset time of antifebrile effect(time to bring the body temperature down ≥0.5℃ after medication); cumulative time for fever recovery(body temperature recovering to normal and lasting more than 24 h without medication); cumulative time for rash disappearance(without new rashes or ulcers appearing and the original ones fading away); and cumulative time for mouth ulcer disappearance. RESULTS: For the onset time of the antifebrile effect, there was no statistical difference between groups A and B(P>0.05) and groups B and C(P> 0.05). However, there was a statistical difference between groups A and C(P<0.05), and the effect in group C was the best. For the cumulative time for rash disappearance, there was no statistical difference between groups A and B(P>0.05). There were statistical differences between groups A and C, and groups B and C(P<0.05), and the effect in group C was the best. For the cumulative time for mouth ulcers disappearance, there were no statistical differences among the three groups(P>0.05). CONCLUSION: Reduning injection with Western Medicine for symptomatic treatment is most effective for mild HFMD. No adverse reactions were observed. | Guoliang Zhang Jie Zhao Liyun He Shiyan Yan Ziqiang Zhuo Haojie Zheng Yongping Mu Shuangjie Li Xi Zhang Jihan Huang Xiuhui Li Jianping Liu Hehe Wan Chaoyu Wei Wei Xiao | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 7 |
| 10 | Study on variational aerosol fields over Beijing and its adjoining areas derived from Terra-MODIS and ground sunphotometer observation显示文摘This paper presents a comprehensive observa-tion technique on derived aerosols data from mobile sun-photometer graph and Terra-Moderate Resolution Imaging Spectroradiometer (MODIS) observation. Research results suggest that after being treated by the variational technique with respect to sunphotometer observations, the Terra- MODIS remote sensing aerosol data are remarkably im-proved, thus for the first time revealing features of the influ-ence of aerosols and pollution emissions of Beijing and its adjoining areas (Hebei, Shandong, etc. provinces). The re-gional impact features of aerosols are related with the pe-ripheral U-shape topography of Beijing. Analyses with Hy-brid Single Particle Lagrangian Integrated Trajectory model (HYSPLIT-4) and meteorological data in the case studied confirm the pollutants diffusion process along the trajectory from the sources in the south-west region, and the regional aerosol impact features. | XU Xiangde ZHOU Xiuji WENG Yonghui TIAN Guoliang LIU Yujie YAN Peng DING Guoan ZHANG Yuxiang MAO Jietai QIU Hong | 2003 | Chinese Science Bulletin2003，48，18： | 7 |
| 11 | Down-regulation of CEACAM1 in breast cancer显示文摘(CEACAM1 ) Carcinoembryonic 抗原相关的粘附分子 1 是一种类型属于 CEA 家庭的 1 transmembrane glycoprotein,它当在身体液体的也可溶的形式或房间上的膜界限形式出现,被发现了存在。异常 CEACAM1 表示与肿瘤前进被联系并且在许多人的恶意被发现了。增加的兴趣在乳癌被奉献给 CEACAM1 的表示,但是大多数这些调查结果是矛盾的。这研究的目的是详细地在乳癌调查 CEACAM1 表示。用染色的 immunohistochemical,我们发现那 CEACAM1 表情与 noncancerous 胸纸巾相比在乳癌纸巾被减少或输。另外,可溶的 CEACAM1 在乳癌房间线的文化媒介铺平是比在一个 nontumorigenic 乳房的那些显著地低的上皮的房间线。Immunofluorescence 分析一致地证明乳癌房间线有膜界限 CEACAM1 的相对低的表示。而且, CEACAM1 mRNA 和蛋白质表示层次在分别地用即时反向的 transcriptase 聚合酶链反应和西方的污点分析测量了的乳癌房间线是下面调整的。一起拿,我们的结果在乳癌表明 CEACAM1 的一条系统的下面规定并且建议恢复 CEACAM1 表示的策略可能对乳癌的治疗有用。 | Changcheng Yang Pingqing He Yiwen Liu Yiqing He Cuixia Yang Yan Du Muqing Zhou Wenjuan Wang Guoliang Zhang Man Wu Feng Gao | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 5 |
| 12 | Distributed Cooperative Control Algorithm for Multi-UAV Mission Rendezvous显示文摘Multiple unmanned aerial vehicles(UAVs)cooperative operation is the main form for UAVs fighting in battlefield,and multi-UAV mission rendezvous is the premise of cooperative reconnaissance and attack missions.We propose a rendezvous control strategy,which divides the rendezvous process into two parts:The loose formation rendezvous and the close formation rendezvous.In the first stage,UAVs are supposed to reach the specific target locations simultaneously and form a loose formation.A distributed control strategy based on first-order consensus algorithm is presented to achieve this goal.Then the second stage is designed based on the second-order consensus algorithm to complete the transition from the loose formation to the close formation.This process needs the speeds and heading angles of UAVs to reach an agreement.Besides,control algorithms with a virtual leader are proposed,by which the formation states can reach a specific value.Finally,simulation results show that the control algorithms are capable of realizing the mission rendezvous of multi-UAV and the consistence of UAVs′final states,which verify the effectiveness and feasibility of the designed control strategy. | Liu Guoliang Xing Dongjing Hou Jianyong Jin Guting Zhen Ziyang | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，6： | 5 |
| 13 | Metals in water and surface sediments from Henan reaches of the Yellow River,China显示文摘The concentrations of Cd,Cr,Cu,Ni,Pb and Zn were determined in the water and surface sediments from the Henan reaches of the Yellow River.Twenty-three sampling sites along the Yellow River and its tributaries were selected.Generally,metal concentrations were found to decrease in sequences of Zn>Cu>Pb>Cr>Ni>Cd in water and Zn>Cr>Pb>Ni>Cu>Cd in sediments.High levels of metal concentration were determined at a few stations of the river and its tributaries,such as Yiluo River,Si River and Qin River.The pollution of the Yellow River by Cd,Cr,Cu,Ni,Pb and Zn can be regarded as much higher compared to the background values,US EPA criteria(1999) and China water quality criteria(2002) .For sediments,metal lev-els except Pb did not significantly exceed the average shale levels and backgrounds in several countries including China.Data analysis manifests that positive correlations were found between Cu,Ni and Zn in water,and Pb,Ni,Zn and Cr in sediments. The Pearson correlation coefficient analysis and Cluster analysis were provided to assess the possible contamination sources. The results indicate a general appearance of serious pollution along the banks of the Yellow River.The wastewaters discharged by the mine plants,smelter plants,power plants,battery plants,tannery plants,etc.,and sewage inputs from the cities along the river banks may be the sources of metals. | Feng, JingLan Wang, GuoLiang Sun, JianHui Sun, ShengPeng Liu, XiangFu | 2010 | Science China Chemistry2010，53，5： | 5 |
| 14 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 15 | Experimental study of surface integrity and fatigue life in the face milling of Inconel 718显示文摘 | Xiangyu WANG Chuanzhen HUANG Bin ZOU Guoliang LIU Hongtao ZHU Jun WANG | 2018 | Frontiers of Mechanical Engineering2018，13，2： | 5 |
| 16 | Flexible memristors as electronic synapses for neuro- inspired computation based on scotch tape-exfoliated mica substrates显示文摘灵活 memristor 设备在便携计算机和集成电路由于他们的应用基于塑料底层吸引了可观的注意。然而,很塑料底层的 memristors 不能工作或在高温度的环境成年。在这研究, scotch-tape-exfoliated 云母被用作灵活 memristor 底层以便解决这些高温度的问题。我们的 TiN/ZHO/IGZO memristor,它被构造用一薄(10 m ) 云母底层,有优异灵活性和 thermostability。在把它弄弯 103 次以后,设备继续展出非凡的电的特征。它能也为在高、低的抵抗状态之间的转变被实现,甚至在多达 300 | Xiaobing Yan Zhenyu Zhou Jianhui Zhao Qi Liu Hong Wang Guoliang Yuan Jingsheng Chen | 2018 | Nano Research2018，11，3： | 5 |
| 17 | Targeting oncogenic Myc as a strategy for cancer treatment显示文摘The MYC family oncogene is deregulated in>50%of human cancers,and this deregulation is frequently associated with poor prognosis and unfavorable patient survival.Myc has a central role in almost every aspect of the oncogenic process,orchestrating proliferation,apoptosis,differentiation,and metabolism.Although Myc inhibition would be a powerful approach for the treatment of many types of cancers,direct targeting of Myc has been a challenge for decades owing to its“undruggable”protein structure.Hence,alternatives to Myc blockade have been widely explored to achieve desirable anti-tumor effects,including Myc/Max complex disruption,MYC transcription and/or translation inhibition,and Myc destabilization as well as the synthetic lethality associated with Myc overexpression.In this review,we summarize the latest advances in targeting oncogenic Myc,particularly for cancer therapeutic purposes. | Hui Chen Hudan Liu Guoliang Qing | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 5 |
| 18 | Adaptive Robust Motion Trajectory Tracking Control of Pneumatic Cylinders with LuGre Model-based Friction Compensation显示文摘Friction compensation is particularly important for motion trajectory tracking control of pneumatic cylinders at low speed movement. However, most of the existing model-based friction compensation schemes use simple classical models, which are not enough to address applications with high-accuracy position requirements. Furthermore, the friction force in the cylinder is time-varying, and there exist rather severe unmodelled dynamics and unknown disturbances in the pneumatic system. To deal with these problems effectively, an adaptive robust controller with LuGre model-based dynamic friction compensation is constructed. The proposed controller employs on-line recursive least squares estimation(RLSE) to reduce the extent of parametric uncertainties, and utilizes the sliding mode control method to attenuate the effects of parameter estimation errors, unmodelled dynamics and disturbances. In addition, in order to realize LuGre model-based friction compensation, the modified dual-observer structure for estimating immeasurable friction internal state is developed. Therefore, a prescribed motion tracking transient performance and final tracking accuracy can be guaranteed. Since the system model uncertainties are unmatched, the recursive backstepping design technology is applied. In order to solve the conflicts between the sliding mode control design and the adaptive control design, the projection mapping is used to condition the RLSE algorithm so that the parameter estimates are kept within a known bounded convex set. Finally, the proposed controller is tested for tracking sinusoidal trajectories and smooth square trajectory under different loads and sudden disturbance. The testing results demonstrate that the achievable performance of the proposed controller is excellent and is much better than most other studies in literature. Especially when a 0.5 Hz sinusoidal trajectory is tracked, the maximum tracking error is 0.96 mm and the average tracking error is 0.45 mm. This paper constructs an adaptive robust controller which can compensate the friction force in the cylinder. | MENG Deyuan TAO Guoliang LIU Hao ZHU Xiaocong | 2014 | Chinese Journal of Mechanical Engineering2014，27，4： | 5 |
| 19 | Development of an Intelligent Vehicle Experiment System显示文摘Existing vehicle experiment systems tend to focus on the research of vehicle dynamics by conducting performance tests on every system or some parts of the vehicle so as to improve the entire performance of the vehicle.Virtual technology is widely utilized in various vehicle test-beds.These test-beds are mainly used to simulate the driving training,conduct the research on drivers' behaviors,or give virtual demonstrations of the transportation environment.However,the study on the active safety of the running vehicle in the virtual environment is still insufficient.A virtual scene including roads and vehicles is developed by using the software Creator and Vega,and radars and cameras are also simulated in the scene.Based on dSPACE's rapid prototyping simulation and its single board DS1103,a simulation model including vehicle control signals is set up in MATLAB/Simulink,the model is then built into C code,and the system defined file(SDF) is downloaded to the DS1103 board through the experiment debug software ControlDesk and is kept running.Programming is made by mixing Visual C++ 6.0,MATLAB API and Vega API.Control signals are read out by invoking library function MLIB/MTRACE of dSPACE.All the input,output,and system state values are acquired by arithmetic and are dynamically associated with the running status of the virtual vehicle.An intelligent vehicle experiment system is thus developed by virtue of program and integration.The system has not only the demonstration function,such as general driving,cruise control,active avoiding collision,but also the function of virtual experiment.Parameters of the system can be set according to needs,and the virtual test results can be analyzed and studied and used for the comparison with the existing models.The system reflects the running of the intelligent vehicle in the virtual traffic environment,at the same time,the system is a new attempt performed on the intelligent vehicle travel research and provides also a new research method for the development of intelligent vehicles. | YANG Xinhong GAO Feng LIU Guoliang WANG Guofu XU Guoyan | 2010 | Chinese Journal of Mechanical Engineering2010，23，6： | 5 |
| 20 | Natural vegetation restoration of Liaodong oak(Quercus liaotungensis Koidz.) forests rapidly increased the content and ratio of inert carbon in soil macroaggregates显示文摘The lack of clarity of how natural vegetation restoration influences soil organic carbon(SOC) content and SOC components in soil aggregate fractions limits the understanding of SOC sequestration and turnover in forest ecosystems.The aim of this study was to explore how natural vegetation restoration affects the SOC content and ratio of SOC components in soil macroaggregates(>250 μm), microaggregates(53–250 μm), and silt and clay(<53 μm) fractions in 30-, 60-, 90-and 120-year-old Liaodong oak(Quercus liaotungensis Koidz.) forests, Shaanxi, China in 2015.And the associated effects of biomasses of leaf litter and different sizes of roots(0–0.5, 0.5–1.0, 1.0–2.0 and >2.0 mm diameter) on SOC components were studied too.Results showed that the contents of high activated carbon(HAC), activated carbon(AC) and inert carbon(IC) in the macroaggregates, microaggregates and silt and clay fractions increased with restoration ages.Moreover, IC content in the microaggregates in topsoil(0–20 cm) rapidly increased;peaking in the 90-year-old restored forest, and was 5.74 times higher than AC content.In deep soil(20–80 cm), IC content was 3.58 times that of AC content.Biomasses of 0.5–1.0 mm diameter roots and leaf litter affected the content of aggregate fractions in topsoil, while the biomass of >2.0 mm diameter roots affected the content of aggregate fractions in deep soil.Across the soil profiles, macroaggregates had the highest capacity for HAC sequestration.The effects of restoration ages on soil aggregate fractions and SOC content were less in deep soil than in topsoil.In conclusion, natural vegetation restoration of Liaodong oak forests improved the contents of SOC, especially IC within topsoil and deep soil.The influence of IC on aggregate stability was greater than the other SOC components, and the aggregate stability was significantly affected by the biomasses of litter, 0.5–1.0 mm diameter roots in topsoil and >2.0 mm diameter roots in deep soil.Natural vegetation restoration of Liaodong oak forests promoted SOC sequestration by soil macroaggregates. | SUN Lipeng HE Lirong WANG Guoliang JING Hang LIU Guobin | 2019 | Journal of Arid Land2019，11，6： | 5 |
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