|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system显示文摘MicroRNAs (miRNAs ) 是内长的 noncoding RNA (~ 22 nt ) 在细胞质在 post-transcriptional 水平调整目标基因表示。在房间原子核的要求功能的 argonaute 家庭蛋白质提示了我们假设那 miRNAs 的 miRNAs 和 miRNA 的存在的最近的发现可以也在房间原子核有规章的功能。在这研究,我们证明老鼠 miR-709 主要位于各种各样的房间类型的原子核并且它的原子本地化模式很快在 apoptotic 刺激之上变化。在房间原子核, miR-709 直接在 pri-miR-15a/16-1 上绑在一个 19-nt miR-709 识别元素并且阻止它处理成 pre-miR-15a/16-1,导致 miR-15a/16-1 成熟的抑制。而且,原子 miR-709 通过 miR-15a/16-1 小径参予房间 apoptosis 的规定。在摘要,现在的学习提供一 miRNA 能由直接在原子核指向他们的主要抄本控制另外的 miRNAs 的生物的续生说的第一条证据。 | Rui Tang Limin Li Dihan Zhu Dongxia Hou Ting Cao Hongwei Gu Jing Zhang Junyuan Chen Chen-Yu Zhang Ke Zen | 2012 | Cell Research2012，22，3： | 23 |
| 2 | Aberrant expression and function of TCF4 in the proliferation of hepatocellular carcinoma cell line BEL-7402显示文摘Wnt signaling pathway is essential for development and tumorigenesis,however,this signaling pathway in the progress of hepatocellular carcinoma (HCC) remains unclear. In this paper,we studied the function of human T-cell transcription factor-4 (TCF4),a key factor of Wnt signaling pathway,on the proliferation of HCC cell line. We showed that the expression of TCF4 mRNA in HCC cell line BEL-7402 was higher than that in immortalized normal liver cell line L02. Blockage of Wnt pathway by △NTCF4,a dominant negative TCF4,could suppress BEL-7402 cells growth and decrease the expression of cyclin D1 and c-myc,two of target genes of Wnt pathway. On the other hand,stimulating Wnt pathway by introducing a degradation-resistant β-catenin S37A could increase BEL-7402 cells proliferation. But all the treatments had no effect on L02 cells. Our data indicated that TCF4 might be another key factor in Wnt pathway involved in HCC cells proliferation and TCF4 could be an effective therapeutic target for suppressing the growth of hepatocellular cancers. | DongHongZHAO JianJunHONG ShiYingGUO RunLinYANG JunYUAN ChuanJunWEN KaiYaZHOU ChaoJunLI | 2004 | Cell Research2004，14，1： | 20 |
| 3 | Optimization of groove texture profile to improve hydrodynamic lubrication performance:Theory and experiments显示文摘It is well known that groove texture with a careful design can be used to enhance the load‐carrying capacity of oil film under the conditions of hydrodynamic lubrication.In this study,a general parametric model was developed,and agenetic algorithm‐sequential quadratic programming hybrid method was adopted to obtain the global‐optimum profile of the groove texture.The optimized profiles at different rotating speeds are all chevrons.The numerical analysis results verified the effect of the optimization.In addition to the numerical optimization,experiments were conducted to validate the superiority of the optimized results.The experimental results show that the optimized groove texture can efficiently reduce the coefficient of friction(COF)and the temperature rise of the specimen.In particular,the optimized groove textures can achieve stable ultra‐low COF values(COF<0.01)under certain conditions. | Wei WANG Yongyong HE Jun ZHAO Junyuan MAO Yutong HU Jianbin LUO | 2020 | Friction2020，8，1： | 13 |
| 4 | Distinct characteristics and new prognostic scoring system for Chinese patients with Waldenstr(o)m macroglobulinemia显示文摘 | Yi Shuhua Cui Rui Li Zengjun An Gang Qi Junyuan Zou Dehui Zhang Peihong Chen Huishu Wang Jianxiang Chang Hong Qiu Lugui | 2014 | Chinese Medical Journal2014，，12： | 12 |
| 5 | Thermodynamic conditions of framework grain dissolution of clastic rocks and its application in Kela 2 gas field显示文摘Feldspar and clastic debris are the most important constituent framework grains of sedimentary clastic rocks and their chemical dissolution plays an essential role in the formation and evolution of the secondary pore in the reservoir rocks. On the basis of thermodynamic phase equilibrium, this study investigates the chemical equilibrium relationships between fluid and various plagioclase and K-feldspar in diagenesis of the sediments, particularly, the impact of temperature and fluid compositions (pH, activity of K+, Na+, Ca2+ and so on) on precipitation and dissolution equilibria of feldspars. Feldspar is extremely easily dissolved in the acid pore water with a low salinity when temperature decreases. The dissolution of anorthite end-member of plagioclase is related to the Ca content of the mineral and the fluid, higher Ca either in the mineral or in the fluid, easier dissolution of the feldspar. Moreover, the dissolution of albite end-member of plagioclase is related to Na of both the mineral and fluid, lower Na out of both the mineral and fluid, easier dissolution of the mineral. Similarly, lower-K fluid is more powerful to dissolve K-feldspar than the higher. The anorthite component of plagioclase is most easily dissolved in ground water-rock system, the albite is the secondary, and K-feldspar is the most stable. Selective dissolution of plagioclase occurs in diagenesis because of the plagioclase solid solution that is mainly composed of albite and anorthite end-members, Ca-rich part of which is preferentially dissolved by the pore water, in contrast to the Na-rich parts. Based on investigation of reservoir quality, secondary pore, dissolution structures of feldspar, clay minerals and ground water chemistry of the Kela 2 gas field of Kuqa Depression in the Tarim basin of Western China, we discovered that the secondary pore is very well developed in the highest quality section of the reservoir, and the plagioclase of which was obviously selectively dissolved, in contrast to the overgrowth of K-feldspar. Chemistry of the ground water out of the highest quality section of the reservoir is consistent with the complete dissolution field of anorthite, partial dissolution field of albite component of plagioclase, and the precipitation of K-feldspar on the temperature-logK phase equilibrium diagram drawn from this study. The thermodynamic modeling calculation gave us an insight into formation of the secondary pore within the reservoir, and the dissolution of plagioclase an important cause of the secondary pore. It is assumed that the solvent to dissolve the plagioclase frame grains originated from the origin-enriched compacted fluid acids out of the mudstone buried beneath the top of geopressured zones in the Kuqa Depression. | LAI Xingyun, YU Bingsong, CHEN Junyuan, CHEN Xiaolin, LIU Jianqing, MEI Mingxiang, JING Weiguang & CHENG Suhua School of Earth Sciences and Mineral Resources, China University of Geosciences, Beijing 100083, China Key Laboratory of Lithospheric Tectonics, Deep-level Process and Exploration of Ministry of Education, Beijing 100083, China | 2005 | Science China Earth Sciences2005，48，1： | 9 |
| 6 | Design and application of a small electrode experimental installation for resistivity measurement of mineral and solid insulating material显示文摘There has not been an effective method to measure the resistivity of small-size sample of mineral and solid insulating material until now.According to the Chinese National Standard(GB/T1410-2006) and features of digital high resistance meter,a small electrode experimental installation was developed;it can work with current high resistance meter;the sample decreases to 18 mm from standard size 100 mm in diameter and reduces by 30.86 times in area.A three-electrode system is supported and precisely positioned by two insulating bases whose diameter is 60 mm and height is 20 mm,which ensures accuracy of device structure and reliability of measuring results.The key technological parameters are as follows:diameter of high voltage electrode is 18mm;diameter of measuring electrode is 14.6 mm;internal diameter and external diameter of guard electrode are 16 and 18 mm,respectively;the gap between guard electrode and measuring electrode is set at 0.6 mm.These parameters are adequate for the measurement of flat specimen of mineral and solid insulating material whose diameter is 18 mm.According to the confirmatory experiment on the volume resistivity and surface resistivity,the measuring results are almost the same,using a small electrode experimental installation and a standard electrode. | WANG Ling LUO Ke LI ZiQiang GUAN SongYun GE Wei ZHANG JunYuan | 2011 | Science China(Technological Sciences)2011，54，4： | 8 |
| 7 | Optimization of Vehicle Side Curtain Airbag Module Based on Computer Aided Engineering显示文摘Compared with other kinds of airbags,curtain airbag(CAB) has more complex structures and larger coverage area. The product development process depends on many module tests,sled tests and full size vehicle tests. Computer aided engineering(CAE) technology can replace tests to a great extent,also save test costs and product development time. This paper introduces the way of setting up simulation models and application of static deployment tests and free motion headform(FMH) tests to verify simulation models. In the CAB simulation,uniform pressure airbag models and computational fluid dynamics(CFD) models are all used. The uniform pressure airbag models are not able to simulate the pressure difference among different parts inside the cushion during inflating process. CFD-based CAB models are used to help the curtain airbag optimization design. Based on effective CAE simulation,the optimization analyses related to diffuser tube parameters,inflator mass flow rate and cushion folding patterns are discussed and performed in different cases. The optimization result shows that the proposed techniques are helpful to the parametric optimization design of side curtain airbag module in curtain airbag development process. | ZHANG Junyuan LI Dongjun BI Ying YANG Donglin QIU Feng | 2009 | Chinese Journal of Mechanical Engineering2009，22，4： | 6 |
| 8 | Precambrian phosphatized embryos and larvae from the Doushantuo Formation and their affinities, Guizhou (SW China)显示文摘Weng,an phosphates of the Precambrian Dou-shantuo Formation, Guizhou (southwestern China) preserve a large number of exquisite biological structures, which are mostly micro-spherical and represent seaweeds, acritarchs and developing eggs related to various groups of metazoans. Here is a report of a variety of developing eggs and larvae, which are most probably of Cnidarian affinity. The eggs ex-amined in the study are composed of early cleavage embryos and two-layered gastrulae. The early cleavage embryos are radial and total cleavage with equal-size blastomeres. The gastrulae mostly bear a large archenteron, which is filled with yolk-degrading organic matter. Ovoid to fusiform planula-like larvae identified in thin sections under light microscope are mostly mouthless and their gastrovascularcavity is filled with possible yolk-degrading organic matter. They are likely representatives of non-feeding larva. The uncommon planula-like structures are hollow, with each having a mouth-like structure on its narrow end. We inter-pret them as feeding larva. Study of these embryos with pos-sible Cnidarian affinities shed new insight on the origin ofmetazoans. | CHEN Junyuan CHI Huimei | 2005 | Chinese Science Bulletin2005，50，19： | 5 |
| 9 | Design and Optimization for the Occupant Restraint System of Vehicle Based on a Single Freedom Model显示文摘Throughout the vehicle crash event, the interactions between vehicle, occupant, restraint system (VOR) are complicated and highly non-linear. CAE and physical tests are the most widely used in vehicle passive safety development, but they can only be done with the detailed 3D model or physical samples. Often some design errors and imperfections are difficult to correct at that time, and a large amount of time will be needed. A restraint system concept design approach which based on single-degree-of-freedom occupant-vehicle model (SDOF) is proposed in this paper. The interactions between the restraint system parameters and the occupant responses in a crash are studied from the view of mechanics and energy. The discrete input and the iterative algorithm method are applied to the SDOF model to get the occupant responses quickly for arbitrary excitations (impact pulse) by MATLAB. By studying the relationships between the ridedown efficiency, the restraint stiffness, and the occupant response, the design principle of the restraint stiffness aiming to reduce occupant injury level during conceptual design is represented. Higher ridedown efficiency means more occupant energy absorbed by the vehicle, but the research result shows that higher ridedown efficiency does not mean lower occupant injury level. A proper restraint system design principle depends on two aspects. On one hand,the restraint system should lead to as high ridedown efficiency as possible, and at the same time, the restraint system should maximize use of the survival space to reduce the occupant deceleration level. As an example, an optimization of a passenger vehicle restraint system is designed by the concept design method above, and the final results are validated by MADYMO, which is the most widely used software in restraint system design, and the sled test. Consequently, a guideline and method for the occupant restraint system concept design is established in this paper. | ZHANG Junyuan MA Yue CHEN Chao ZHANG Yan | 2013 | Chinese Journal of Mechanical Engineering2013，26，3： | 5 |
| 10 | Investigation on Measurement of Size and Concentration of Solid Phase Particles in Gas-Solid Two Phase Flow显示文摘Gas-solid two phase flow measurements have a wide range of applications in industrial production and scientific research. Based on optical principle and image processing, a measurement method of solid phase particle size and concentration of gas-solid two phase flow was presented, and an experimental system was built. By theoretical analysis and image processing algorithms, solid phase particle sizes and concentrations in gas-solid two phase flow were achieved. | WANG Yueming LYU Xiaoqi LI Wentao YAO Guodong BAI Junyuan BAO An | 2018 | Chinese Journal of Electronics2018，27，2： | 4 |
| 11 | Extended tacrolimus release via the combination of lipid-based solid dispersion and HPMC hydrogel matrix tablets显示文摘The objective of this study is to evaluate the feasibility of obtaining extended release of tacrolimus by a novel combination of lipid-based solid dispersion and matrix-type extended release tablet techniques. Tacrolimus solid dispersion was prepared using glycerylbehenate(Compritol~?ATO888) and Pluronic F127 as the carrier materials with hot-melt method, which was then blended with hydrogel matrix materials, such as HPMC and lactose, the powders were directly compressed into tablets. In vitro drug release tests were carried out to evaluate the performance of the solid dispersions and the tablets. The dissolution rate of tacrolimus was significantly improved by the lipid-based solid dispersion, and the incorporation of HPC into the solid dispersion obviously improved its stability after storage. Extended release tablets loaded with tacrolimus solid dispersion showed prolonged drug release patterns over 24 h, the release patterns of the tablets can be tailored by the compositions of the matrix materials, including the types and content of HPMCs. A modified processing method that directly mixed the melted solid dispersion with HPMC powders improved the uniformity of the solid dispersion inside the tablet matrix and release profile. The release data of the extended release tablet fitted well to the Korsmeyer–Peppas model with n value of 0.85, which suggested diffusion-and erosion-controlled release mechanism. The combination of lipid-based solid dispersion and HPMC hydrogel matrix may find wide applications in the extended release dosage forms of high potent, water-insoluble drugs. | Hui Xu Li Liu Xuehui Li Junyuan Ma Rui Liu Shaoning Wang | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 3 |
| 12 | KEY TECHNIQUES OF MULTI-BODY MODELING OF OCCUPANT RESTRAINT SYSTEM OF VEHICLE SIDE IMPACT显示文摘基于多身体动力学,汽车方面结构和占有人的模拟模型“ s 动态回答被建立,用占有人损害模拟软件 MADYMO3D.These,模型包括汽车身体结构,影响障碍,位子和哑巴。multi-bodyand 关节的定义和基于 FE,联合建模的关节的动力学性质,模型,安装被介绍。MADYMO 的凯尔文元素被介绍也显示出在 non-adjoiningrigid 身体之间的力量行动。然后,提及的方法的所有例子被给。由模拟和真实测试的比较,在为主要结构和哑巴的生物学力学性质的模拟和真实测试之间的合同曲线被获得。结果显示出模型的精确性和有效性。 | ZHANG Junyuan ZHANG Min DING Rufang QIU Shaobo ZHANG Yu LI Hongjian | 2006 | Chinese Journal of Mechanical Engineering2006，19，3： | 3 |
| 13 | Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2显示文摘Dear Editor,Lassa virus(LASV)belongs to the Mammarenavirus genus,Arenaviridae family.Arenaviruses are classified into two main groups-Old World(OW)and New World(NW)-based on virus genetics,serology,antigenic properties and geographical relationships.The OW LASV and Lujo virus(LUJV),as well as NW Jurn'n virus(JUNV),Machupo virus(MACV),Guanarito virus(GTOV),Sabia virus(SABV)and Chapare virus(CHAPV),are known to cause severe hemorrhagic fever and are listed as biosafety level 4(BSL-4)agents.The arenavirus glycoprotein complex(GPC)contains three subunits-the retained stable-signal peptide(SSP),the receptor-binding subunit GP1,and the membrane fusion subunit GP2(Lenz et al.,2001).Notably,the proximate external membrane region and TM of GP2,together with the ectodomain loop and TMs of SSP,form an SSP-GP2 interface,playing essential roles in regulating membrane fusion,and providing targets for distinct fusion inhibitors(Larson et al.,2008;Lee et al.,2008;York et al.,2008;York and Nunberg,2009;Thomas et al.,2011;Burgeson et al.,2013a;Shankar et al.,2016;Wang et al.,2016;Wang et al.,2018).Among these inhibitors,ST-161 is LASV specific(Burgeson et al.,2013a).In this study,we conducted structure-activity relationship(SAR)optimization of ST-161.As a result,21 derivatives with IC50 values<1 pmol/L are presented in Table S1.Hit compounds 21,29 and 57 exhibiting robust inhibition of the LASV pseudotype virus(LASVpv,VSV backbone enveloped by LASV GPC with single cycle infection)entry with IC50 values lower than 0.2 nmol/L(Figs.1A and S1),as well as hit compound 72 with an ester bond instead of acylhydrazone,were further investigated.To test whether the four hit compounds inhibit LASV entry by blocking the GPC-mediated membrane fusion,the inhibition effects of these compounds against LASV GPC mediated fusion were quantitatively determined by dual-luciferase assay(Thomas et al.,2011;Wang et al.,2018). | Guangshun Zhang Junyuan Cao Yan Cai Yang Liu Yanli Li Peilin Wang Xiaoying Jia Mengmeng Zhang Gengfu Xiao Yu Guo Wei Wang | 2019 | Protein & Cell2019，10，2： | 3 |
| 14 | Global dynamics of a heroin epidemic model with age structure and nonlinear incidence显示文摘 | Junyuan Yang Xiaoxia Li Fengqin Zhang | 2016 | International Journal of Biomathematics2016，9，3： | 2 |
| 15 | Conformal and continuous deposition of bifunctional cobalt phosphide layers on p-silicon nanowire arrays for improved solar hydrogen evolution显示文摘垂直地排列的 p 硅 nanowire (SiNW ) 数组广泛地为太阳开车的氢进化作为有希望的光阴极在最近的年里被调查了。然而,有用一条简单、买得起的途径的两项高 photoelectrocatalytic 活动和长期的运作的稳定性的 SiNW 光阴极的制造是一项挑战性的任务。此处,我们报导 di 钴磷化物的保角、连续的免职(公司 2 P ) 经由一个划算的扔落下的方法的平版印刷术有图案的高度订的 SiNW 数组上的层由一个低温度的 phosphorization 处理列在后面。同样扔的公司 2 P 层由水晶的 nanoparticles 组成并且与 SiNWs 有亲密接触,形成明确的 SiNW@Co 2 P 核心 / 壳 nanostructure。保角、连续的公司 2 P 层作为能够实质地为氢进化反应改进 photoelectrocatalytic 活动的高度有效的催化剂工作(她的) 并且有效地使钝化保护他们免受相片氧化的伤害的 SiNWs,因此延长电极的一生。作为 aconsequence, SiNW@Co 2 有优化公司 2 P 层厚度展出一个高光电流密度 of-21.9 妈 ? 獡愠 ? 汥' 虪箳椰嬑郢 G? 祢愠猠牴楡桧晴牯慷摲洠汯整 ?慳瑬猠湹桴獥獩愠灰潲捡 | Sitaramanjaneva Mouli Thalluri Jerome Borme Kang Yu Junyuan Xu Isilda Amorim Joao Gaspar Liang Qiao Paulo Ferreira Pedro Alpuim Lifeng Liu | 2018 | Nano Research2018，11，9： | 2 |
| 16 | An investigation on the tribological behaviors of steel/copper and steel/steel friction pairs via lubrication with a graphene additive显示文摘In this study,the tribological behaviors of graphene as a lubricant additive for steel/copper and steel/steel friction pairs were compared.For the steel/copper friction pair,the graphene sheets remarkably decreased the coefficient of friction and wear scar depth under low loads,but these slightly increased under high loads.The steel/steel friction pair showed excellent tribological properties even under high loads.Severe plastic deformation on the copper surface reduced the stability of the graphene tribofilm because of a rough copper transfer film on the steel during the running-in period.The results provide a better understanding of the mechanism of graphene as a lubricant additive. | Junyuan MAO Guangyan CHEN Jun ZHAO Yongyong HE Jianbin LUO | 2021 | Friction2021，9，2： | 2 |
| 17 | Establishment and Validation for the Theoretical Model of the Vehicle Airbag显示文摘The current design and optimization of the occupant restraint system(ORS) are based on numerous actual tests and mathematic simulations. These two methods are overly time-consuming and complex for the concept design phase of the ORS, though they're quite effective and accurate. Therefore, a fast and directive method of the design and optimization is needed in the concept design phase of the ORS. Since the airbag system is a crucial part of the ORS, in this paper, a theoretical model for the vehicle airbag is established in order to clarify the interaction between occupants and airbags, and further a fast design and optimization method of airbags in the concept design phase is made based on the proposed theoretical model. First, the theoretical expression of the simplified mechanical relationship between the airbag's design parameters and the occupant response is developed based on classical mechanics, then the momentum theorem and the ideal gas state equation are adopted to illustrate the relationship between airbag's design parameters and occupant response. By using MATLAB software, the iterative algorithm method and discrete variables are applied to the solution of the proposed theoretical model with a random input in a certain scope. And validations by MADYMO software prove the validity and accuracy of this theoretical model in two principal design parameters, the inflated gas mass and vent diameter, within a regular range. This research contributes to a deeper comprehension of the relation between occupants and airbags, further a fast design and optimization method for airbags' principal parameters in the concept design phase, and provides the range of the airbag's initial design parameters for the subsequent CAE simulations and actual tests. | ZHANG Junyuan JIN Yang XIE Lizhe CHEN Chao | 2015 | Chinese Journal of Mechanical Engineering2015，28，3： | 2 |
| 18 | Corrigendum to“Delivery of coenzyme Q10 loaded micelle targets mitochondrial ROS and enhances efficiency of mesenchymal stem cell therapy in intervertebral disc degeneration”[Bioact.Mater.23(2023)247-260]显示文摘This corrects the article“Delivery of coenzyme Q10 loaded micelle targets mitochondrial ROS and enhances efficiency of mesenchymal stem cell therapy in intervertebral disc degeneration”in volume 23 on page 247.The authors regret that the printed version of the above article contains some errors which are not identified during the proofing stage. | Junyuan Sun Fei Yang Lianlei Wang Haichao Yu Zhijie Yang Jingjing Wei Krasimir Vasilev Xuesong Zhang Xinyu Liu Yunpeng Zhao | 2023 | Bioactive Materials2023，，6： | 2 |
| 19 | Discussion on the systematic position of the Early Cambrian priapulomorph worms显示文摘 | HUANG Diying CHEN Junyuan J. VANNIER | 2006 | Chinese Science Bulletin2006，51，2： | 2 |
| 20 | Self-adaptive phosphor coating technology for white LED packaging显示文摘变换黄磷的轻射出的二极管(pclead ) 它与黄黄磷采用蓝 LEDs 产生白色点亮照明,是点亮来源的广泛地使用的 solidstate。以便在带的薄片上与高质量进行黄磷层涂层,一种自我适应的涂层技术在这份报纸被介绍。与自我暴露方法相结合的一种泥浆涂层技术被使用并且发展了表明自我适应的涂层层的好处。为自我暴露,泥浆涂层暴露于除到以外的带的本身的蓝排放紫外(紫外) 做光致抗蚀剂 crosslinking 的轻外面。测量的结果显示有自我适应的涂层的白 LEDs 与常规涂层和另外的保角的涂层比那些显示出自我适应性到蓝轻、执行的更高空间的颜色一致性的紧张的尖分发。 | Haibo RAO Kun DING Jirong SONG Likun XIE Wei WANG Xianlong WAN Linsong ZHOU Junyuan LIAO | 2012 | Frontiers of Optoelectronics2012，5，2： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员