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| 1 | Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin显示文摘瞄准:Microcirculatory 机能障碍和免费的氧激进分子是在严重尖锐胰腺炎的致病的重要因素。另外的氧交货可能每氧化提高类脂化合物,但是可以也改进胰腺的微循环。这研究在严重尖锐胰腺炎的一个啮齿类动物模型在氧激进分子和微循环的形成上估计免费细胞的牛的血红素的效果。方法:在尖锐胰腺炎 Wistar 老鼠的正式就职以后的十五分钟收到了任何一个 0.8 mL 牛的血红素(HBOC-200 ) , hydroxyethyl 淀粉(HES ) 或保证血量正常替换的生理盐水的 2.4 mL。在检查的 6 h 以后,胰每氧化产品 malondialdehyde (MDA ) 为类脂化合物的间接测量被切除并且很快处理了并且在胰腺的织物减少了谷胱甘肽(GSH ) 。结果:HBOC-200 的单个申请改进了胰腺的微循环并且显著地减少了组织病理学说的织物损坏。MDA 的织物集中没在这些组之间不同。另外,在 GSH 层次的差别都没被检测。结论:不过 HBOC-200 和 HES 的单个申请改进胰腺的微循环,在类脂化合物的没有差别每氧化,产品被检测。另外的氧供应(HBOC-200 ) 的有益的效果不每氧化导致提高的类脂化合物。 | Helge Kleinhans Oliver Mann Paulus G Schurr Jussuf T Kaifi Bente Hansen Jakob R Izbicki Tim Strate | 2006 | World Journal of Gastroenterology2006，12，18： | 6 |
| 2 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 3 | HER-2 amplification is highly homogenous in gastric cancer显示文摘 | Andreas H. Marx Lars Tharun Johanna Muth Ana-Maria Dancau Ronald Simon Emre Yekebas Jussuf T. Kaifi Martina Mirlacher Tim H. Brümmendorf Carsten Bokemeyer Jakob R. Izbicki Guido Sauter | 2009 | Human Pathology2009，，6： | 3 |
| 4 | Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer显示文摘 | Jussuf T Kaifi Emre F | 2005 | J Nail Cancer Inst2005，97，24： | 1 |
| 5 | Postpancreatectomy Hemorrhage: Diagnosis and Treatment: An Analysis in 1669 Consecutive Pancreatic Resections显示文摘 | Emre F. Yekebas Lars Wolfram Guellue Cataldegirmen Christian R. Habermann Dean Bogoevski Alexandra M. Koenig Jussuf Kaifi Paulus G. Schurr Michael Bubenheim Claus Nolte-Ernsting Gerhard Adam Jakob R. Izbicki | 2007 | Annals of Surgery2007，，2： | 1 |
| 6 | Aggressive Surgery Improves Long-term Survival in Neuroendocrine Pancreatic Tumors: An Institutional Experience显示文摘 | Paulus G. Schurr Tim Strate Kim Rese Jussuf T. Kaifi Uta Reichelt Susanne Petri Helge Kleinhans Emre F. Yekebas Jakob R. Izbicki | 2007 | Annals of Surgery2007，，2： | 1 |
| 7 | Activated leukocyte cell adhesion molecule (CD166)—Its prognostic power for colorectal cancer patients显示文摘 | Michael Tachezy Hilke Zander Florian Gebauer Andreas Marx Jussuf T. Kaifi Jakob R. Izbicki Maximilian Bockhorn | 2012 | Journal of Surgical Research2012，，1： | 1 |
| 8 | Postpancreatectomy Hemorrhage: Diagnosis and Treatment: An Analysis in 1669 Consecutive Pancreatic Resections显示文摘 | Emre F. Yekebas Lars Wolfram Guellue Cataldegirmen Christian R. Habermann Dean Bogoevski Alexandra M. Koenig Jussuf Kaifi Paulus G. Schurr Michael Bubenheim Claus Nolte-Ernsting Gerhard Adam Jakob R. Izbicki | 2007 | Annals of Surgery2007，，2： | 1 |
| 9 | Postpancreatectomy Hemorrhage: Diagnosis and Treatment: An Analysis in 1669 Consecutive Pancreatic Resections显示文摘 | Emre F. Yekebas Lars Wolfram Guellue Cataldegirmen Christian R. Habermann Dean Bogoevski Alexandra M. Koenig Jussuf Kaifi Paulus G. Schurr Michael Bubenheim Claus Nolte-Ernsting Gerhard Adam Jakob R. Izbicki | 2007 | Annals of Surgery2007，，2： | 1 |
| 10 | Monitoring of Loss of Heterozygosity in Serum Microsatellite DNA Among Patients with Gastrointestinal Stromal Tumors Indicates Tumor Recurrence显示文摘 | Tamina Rawnaq Heidi Schwarzenbach Paulus G. Schurr Kathrin Freise Stephan Brandl Jakob R. Izbicki Jussuf T. Kaifi | 2011 | Journal of Surgical Research2011，，1： | 1 |
| 11 | L1 is a potential marker for poorly-differentiated pancreatic neuroendocrine carcinoma显示文摘瞄准:在胰腺的神经内分泌肿瘤决定 L1 的表示并且相关它与这个肿瘤的分类。方法:我们回顾地在原发性瘤或转移的石蜡节上由免疫组织化学在胰腺的神经内分泌肿瘤的 63 种情况中分析了 L1 表示。染色被过氧化物酶技术对人的 L1 与单音的同种细胞的抗体 UJ127.11 执行。所有肿瘤被分类根据分类同样区分得好的神经内分泌肿瘤和癌或糟糕区分的神经内分泌癌。结果:L1 在 5 被检测(7.9%) 63 个胰腺的神经内分泌肿瘤。(44.4%) 四 9 糟糕区分的癌表示了 L1。相反,仅仅(1.9%) 1 为 L1 54 个区分得好的肿瘤或癌是积极的。没有表示在正常胰腺的织物的 Langerhans 小岛房间被发现。生气桌子分析显示出在 L1 表示和胰(P<0.01 ) 的神经内分泌肿瘤的分类之间的一个重要协会。结论:L1 明确地在被知道有最糟的预后的糟糕区分的胰腺的神经内分泌癌被表示。L1 可能是为与胰腺的神经内分泌癌诊断的病人的风险预言的一个标记。 | Jussuf T Kaifi Ulrich Zinnkann Emre F Yekebas Paulus G Schurr Uta Reichelt Robin Wachowiak Henning C Fiegel Susann Petri Melitta Schachner Jakob RIzbicki | 2006 | World Journal of Gastroenterology2006，12，1： | 1 |
| 12 | L1 is associated with micrometastatic spread and poor outcome in colorectal cancer 显示文摘 | Jussuf TK Uta R Alexander Q | 2007 | Mod Pathol2007，20，： | 1 |
| 13 | Gastrointestinal stromal tumor (GIST) recurrence following surgery: review of the clinical utility of imatinib treatment显示文摘 | Kevin Staveley-O’Carroll Harold A. Harvey Y Jiang Niraj J Gusani Jovenel Cherenfant Isabelle Deshaies Kevin F Staveley-O’Carroll Jussuf Kaifi Eric T. Kimchi | 2010 | 2010 (defa)2010，，： | 1 |
| 14 | Extended central pancreatic resection as an alternative for extended left or extended right resection for appropriate pancreatic neoplasms显示文摘 | Guellue Cataldegirmen Claus G. Schneider Dean Bogoevski Alexandra Koenig Jussuf T. Kaifi Maximilian Bockhorn Lena S. Deutsch Yogesh Vashist Jakob R. Izbicki Emre F. Yekebas | 2010 | Surgery2010，，3： | 1 |
| 15 | Is It Time for a New TNM Classification in Esophageal Carcinoma?显示文摘 | Dean Bogoevski Florian Onken Alexandra Koenig Jussuf T. Kaifi Paulus Schurr Guido Sauter Jakob R. Izbicki Emre F. Yekebas | 2008 | Annals of Surgery2008，，4： | 1 |
| 16 | Postpancreatectomy Hemorrhage: Diagnosis and Treatment: An Analysis in 1669 Consecutive Pancreatic Resections显示文摘 | Emre F. Yekebas Lars Wolfram Guellue Cataldegirmen Christian R. Habermann Dean Bogoevski Alexandra M. Koenig Jussuf Kaifi Paulus G. Schurr Michael Bubenheim Claus Nolte-Ernsting Gerhard Adam Jakob R. Izbicki | 2007 | Annals of Surgery2007，，2： | 1 |
| 17 | Identifying patient-specific flow of signal transduction perturbed by multiple single-nucleotide alterations显示文摘Background:Identifying patient-specific flow of signal transduction perturbed by multiple single-nucleotide alterations is critical for improving patient outcomes in cancer cases.However,accurate estimation of mutational effects at the pathway level for such patients remains an open problem.While probabilistic pathway topology methods are gaining interest among the scientific community,the overwhelming majority do not account for network perturbation effects from multiple single-nucleotide alterations.Methods:Here we present an improvement of the mutational forks formalism to infer the patient-specific flow of signal transduction based on multiple single-nucleotide alterations,including non-synonymous and synonymous mutations.The lung adenocarcinoma and skin cutaneous melanoma datasets from TCGA Pan-Cancer Atlas have been employed to show the utility of the proposed method.Results:We have comprehensively characterized six mutational forks.The number of mutated nodes ranged from one to four depending on the topological characteristics of a fork.Transitional confidences(TCs)have been computed for every possible combination of single-nucleotide alterations in the fork.The performed analysis demonstrated the capacity of the mutational forks formalism to follow a biologically explainable logic in the identification of high-likelihood signaling routes in lung adenocarcinoma and skin cutaneous melanoma patients.The findings have been largely supported by the evidence from the biomedical literature.Conclusion:We conclude that the formalism has a great chance to enable an assessment of patient-specific flow by leveraging information from multiple single-nucleotide alterations to adjust the transitional likelihoods that are solely based on the canonical view of a disease. | Olha Kholod Chi-Ren Shyu Jonathan Mitchem Jussuf Kaifi Dmitriy Shin | 2020 | Quantitative Biology2020，8，4： | 0 |
| 18 | Association of rare SPINK1 gene mutation with another base substitution in chronic pancreatitis patients显示文摘AIM: To verify and expand the known spectrum of serine protease inhibitor Kazal type 1 (SPINK1) gene mutations in chronic pancreatitis. METHODS: DNA extracted from 172 chronic pancreatitis patients was assayed for SPINK1 gene mutations by PCR and DNA sequencing. A control cohort of 90 unrelated healthy individuals was analysed by the same methods for presence of common populational polymorphisms, and frequency of five-loci haplotypes was calculated. Linkages of gene aberrations in single SPINK1 gene copies were analysed by long-distance PCR followed by allele-specifi c PCR and DNA sequencing. RESULTS: The most frequent SPINK1 gene mutation N34S was found at a frequency of 6%. Furthermore, we detected the heterozygous intervening sequence (IVS) 3 + 2 T > C mutated gene in 2 German patients and 1 Macedonian chronic pancreatitis patient. In all three SPINK1 gene copies an additional rare base substitution was found: 5’untranslated region (UTR)-215 G > A. Poly-morphism analysis revealed that all three affected genes carried the same fi ve-loci haplotype. DNA sequencing of another chronic pancreatitis-related gene PRSS1 (cationic trypsinogen) did not reveal any mutations in these 3 pa-tients.CONCLUSION: We found in 3 (2%) of 172 chronic pancreatitis patients an IVS3 + 2 T > C SPINK1 gene mutation and a base substitution 5’UTR-215 G > A inthe same gene copy. Most probably the 5’UTR-215 G >A represents a rare polymorphism and not a mutationas previously concluded. Haplotype analysis suggests acommon origin of the IVS3 + 2 T > C mutation in thesepatients. | Viacheslav N Kalinin Jussuf T Kaifi Heidi Schwarzenbach Anatoly S Sergeyev Bjoern C Link Dean Bogoevski Yogesh Vashist Jakob R Izbicki Emre F Yekebas | 2006 | World Journal of Gastroenterology2006，12，33： | 0 |
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