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| 1 | Genome-wide SNP Genotyping Resolves Signatures of Selection and Tetrasomic Recombination in Peanut显示文摘花生(Arachis hypogaea;2n = 4x = 40 ) 是滋养的食物和维生素,矿物质,和健康脂肪的好来源。扩大基因并且为栽培花生的基因改进的 genomic 资源从栽培花生的双祖先的定序的染色体获得了动量。便于 Arachis 种类的高产量的 genotyping, 20 遗传型被重新定序,染色体宽的单个核苷酸多型性(SNP ) 被选择开发一个大规模 SNP genotyping 数组。为在 genotyping 应用程序的灵活性,在 tetraploid 和双种类之间多态的 SNP 为使用被包括在栽培并且种间的人口。一套 384 就职被用来测试导致生产了在双种类之间的高质量的多态的簇的 54 564 个标记的数组, 47 116 个多态的标记在之间栽培并且种间的混血儿,和在 A 以内的 15 897 个多态的标记。hypogaea germplasm。一另外 1193 个标记被识别那照亮的 genomic 区域展出 tetrasomic 再结合。而且,完成美国跑步者 germplasm 的家谱的一套精英栽培变种是 genotyped 并且过去常识别经历了积极选择的 genomic 区域。这些观察在栽培花生在新基因差异的包括上提供关键卓见并且将通知发展高分辨率的印射的人口。由于它的效率,范围,和灵活性,最新发达的 SNP 数组将为在 Arachis 的进一步基因、引起的应用程序是很有用的。 | Josh Clevenger Ye Chu Carolina Chavarro Gaurav Agarwal David J. Bertioli Soraya C.M. LeaI-Bertioli Manish K. Pandey Justin Vaughn Brian Abernathy Noelle A. Barkley Ran Hovav Mark Burow Spurthi N. Nayak Annapurna Chitikineni Thomas G. Isleib C. Corley Holbrook Scott A. Jackson Rajeev K. Varshney Peggy Ozias-Akins | 2017 | Molecular Plant2017，10，2： | 4 |
| 2 | Natural history of hepatitis b e antigen to antibody seroconversion in patients with normal serum aminotransferase levels显示文摘 | Chia-Ming Chu Shao-Jen Hung Justin Lin Dar-In Tai Yun-Fan Liaw | 2004 | The American Journal of Medicine2004，，12： | 2 |
| 3 | Replication of Alphaviruses: A Review on the Entry Process of Alphaviruses into Cells显示文摘 | Jason Yat-Sing Leung Mary Mah-Lee Ng Justin Jang Hann Chu Jay C. Brown | 2011 | Advances in Virology2011，，： | 1 |
| 4 | Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography显示文摘 | Delphine L. Chen Dong Zhou Wenhua Chu Phillip E. Herrbrich Lynne A. Jones Justin M. Rothfuss Jacquelyn T. Engle Marco Geraci Michael J. Welch Robert H. Mach | 2009 | Nuclear Medicine and Biology2009，，6： | 1 |
| 5 | Diagnostic performance of different specimens in detecting enterovirus A71 in children with hand,foot and mouth disease显示文摘Hand,foot and mouth disease(HFMD)is a major public health problem among children in the Asia-Pacific region.The optimal specimen for HFMD virological diagnosis remains unclear.Enterovirus A71(EV-A71)neutralizing antibody titres detected in paired sera were considered the reference standard for calculating the sensitivity,specificity,positive and negative predictive value of throat swabs,rectal swabs,stool,blood samples and cerebrospinal fluid(CSF)by RT-PCR or ELISA assay.In this study,clinical samples from 276 HFMD patients were collected for analysing the sensitivity of different kind of specimens.Our results showed that stool had the highest sensitivity(88%,95%CI:74%–96%)and agreement with the reference standard(91%).The order of diagnostic yield for EV-A71 infection was stool samplerectal swab>throat swab>blood sample>CSF sample,and using a combination of clinical samples improved sensitivity for enterovirus detection.The sensitivity of ELISA for IgM antibody detection in sterile-site specimens was significantly higher than that of RT-PCR(serum/plasma:62%vs.2%,CSF:47%vs.0%)(P<0.002).In conclusion,our results suggest that stool has the highest diagnostic yield for EV-A71-infected HFMD.If stool is unavailable,rectal swabs can be collected to achieve a similar diagnostic yield.Otherwise,throat swabs may be useful in detecting positive samples.Although IgM in blood or CSF is diagnostically accurate,it lacks sensitivity,missing 40%–50%of cases.The higher proportion of severe cases and shorter interval between onset and sampling contributed to the increase in congruency between clinical testing and the serological reference standard. | Yonghong Zhou Chongchen Zhou Kai Wang Qi Qiu Yibing Cheng Yu Li Peng Cui Lu Liang Peng Li Xiaowei Deng Lili Wang Wen Zheng Hui Gong Fang Wang Meng Xu Justin Jang Hann Chu Lance Turtle Hongjie Yu | 2023 | Virologica Sinica2023，38，2： | 1 |
| 6 | Effects of 12 weeks of probiotic supplementation on quality of life in colorectal cancer survivors: A double-blind, randomized, placebo-controlled trial显示文摘 | Jee-Yon Lee Sang-Hui Chu Justin Y. Jeon Mi-Kyung Lee Ji-Hye Park Duk-Chul Lee Ji-Won Lee Nam-Kyu Kim | 2014 | Digestive and Liver Disease2014，，： | 1 |
| 7 | Microbial resistance to nanotechnologies:An important but understudied consideration using antimicrobial nanotechnologies in orthopaedic implants显示文摘Microbial resistance to current antibiotics therapies is a major cause of implant failure and adverse clinical outcomes in orthopaedic surgery.Recent developments in advanced antimicrobial nanotechnologies provide numerous opportunities to effective remove resistant bacteria and prevent resistance from occurring through unique mechanisms.With tunable physicochemical properties,nanomaterials can be designed to be bactericidal,antifouling,immunomodulating,and capable of delivering antibacterial compounds to the infection region with spatiotemporal accuracy.Despite its substantial advancement,an important,but under-explored area,is potential microbial resistance to nanomaterials and how this can impact the clinical use of antimicrobial nanotechnologies.This review aims to provide a better understanding of nanomaterial-associated microbial resistance to accelerate bench-to-bedside translations of emerging nanotechnologies for effective control of implant associated infections. | Zhuoran Wu Brian Chan Jessalyn Low Justin Jang Hann Chu Hwee Weng Dennis Hey Andy Tay | 2022 | Bioactive Materials2022，7，10： | 1 |
| 8 | Developments towards antiviral therapies against enterovirus 71显示文摘 | Kan X. Wu Mary M.-L. Ng Justin J.H. Chu | 2010 | Drug Discovery Today2010，，23： | 1 |
| 9 | Chikungunya virus: an update on antiviral development and challenges显示文摘 | Parveen Kaur Justin Jang Hann Chu | 2013 | Drug Discovery Today2013，，： | 1 |
| 10 | Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography显示文摘 | Delphine L. Chen Dong Zhou Wenhua Chu Phillip E. Herrbrich Lynne A. Jones Justin M. Rothfuss Jacquelyn T. Engle Marco Geraci Michael J. Welch Robert H. Mach | 2009 | Nuclear Medicine and Biology2009，，6： | 1 |
| 11 | Synthesis, radiolabeling, and in vivo evaluation of an 18 F-labeled isatin analog for imaging caspase-3 activation in apoptosis显示文摘 | Dong Zhou Wenhua Chu Justin Rothfuss Chenbo Zeng Jinbin Xu Lynne Jones Michael J. Welch Robert H. Mach | 2006 | Bioorganic & Medicinal Chemistry Letters2006，，19： | 1 |
| 12 | Establish- ment of one - step SYBR green - based real time - PCR assay for rap- id detection and quantification of ehikungunya virus infection显示文摘 | Phui San Ho Mary Mab Lee Ng Justin Jang Hann Chu | 2010 | Vi- rology Journal2010，7，： | 1 |
| 13 | 早期流产的最佳处理方法是什么?显示文摘早期流产是指妊娠≤13周时发生的流产,是一种除了造成出血和疼痛等生理效应外,还可能对女性产生毁灭性心理影响的重大生活事件。在月经推迟、妊娠测试呈阳性的女性中,有四分之一最终会发生早期流产。在英国,每年约有12.5万例早期流产,其中有5万例需住院治疗。 | Justin Chu Adam J Devall Pollyanna Hardy Leanne Beeson Arri Coomarasamy 徐婷婷(译) 刘兴会(审校) | 2021 | 英国医学杂志中文版2021，24，7： | 0 |
| 14 | 专心工作 学习如何在家做“一生最好的工作”显示文摘在家办公?试试这些小提不身为作家和顾问,我有幸在过去五年来,大部分时间都在家工作。我之所以称之为“有幸”,是因为这样光是通勤费用就为我节省了数千美元,也节省了数千小时的宝贵时间。尽管在家工作有许多巨大的好处,却也带来一些独特的挑战。 | OLIVE CHU Justin Bariso John Boitnott 马励(译) | 2020 | 空中英语教室(高级版.彭蒙惠英语)2020，，9： | 0 |
| 15 | 中国-东盟传统药用植物抗呼吸道常见病毒研究进展显示文摘呼吸道病毒感染是全球范围内人类发病和死亡的主要原因之一,其致死率在所有传染病中居于首位。天然药用植物具有多成分、多靶点及多途径协同发挥抗病毒作用的特点,在抗呼吸道病毒新药开发方面具有极大的潜力。本文从《中国-东盟传统药物志》中350种药物进行筛选,对具有抗呼吸道病毒的药物以抗病毒种类数、化学成分、作用机制等进行分类统计,并对其抗呼吸道病毒感染的作用机制和物质基础进行阐述和分析,旨在从中国-东盟传统药用植物中筛选出抗呼吸道常见病毒的活性成分,以期为后续新药研发及临床治疗提供参考。 | 杜正彩 郝二伟 韦棪婷 陈晓璐 Jintanaporn Wattanathorn Tang Pei Ling Justin Jang Hann Chu 白钢 刘昌孝 侯小涛 邓家刚 | 2022 | 中成药2022，44，11： | 0 |
| 16 | Carry forward advantages of traditional medicines in prevention and control of outbreak of COVID-19 pandemic显示文摘Members of the China-ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research used the video conference platform to exchange and discuss the advantages of traditional medicine through the form of score exchange and report,and research and develop the amount and issues of the therapeutic COVID-19 products of concern.This paper mainly reviews the achievements of the implementation of the epidemic prevention and control plan,advances of scientific basic studies on SARS-CoV-2,analysis and screening of potential targets and pathways of antiviral compounds based on network pharmacology and development of antiviral food dual-use products.The authors believe that the declaration of the(10+3)special meeting of national leaders on epidemic prevention and control should raise the medical and pharmaceutical issues of common concern.It is the responsibility of our joint laboratory members to accelerate the development of traditional medicine research and industry.Also the authors believe that this exchange will certainly promote the development of the cause of cooperation. | Jia-gang Deng Xiao-tao Hou Tie-jun Zhang Gang Bai Er-wei Hao Justin Jang Hann Chu Jintanaporn Wattanathorn Panee Sirisa-ard Ch'ng Soo Ee John Low Chang-xiao Liu | 2020 | Chinese Herbal Medicines2020，12，3： | 0 |
| 17 | The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses显示文摘Positive-sense RNA viruses modify intracellular calcium stores,endoplasmic reticulum and Golgi apparatus(Golgi)to generate membranous replication organelles known as viral factories.Viral factories provide a conducive and substantial enclave for essential virus replication via concentrating necessary cellular factors and viral proteins in proximity.Here,we identified the vital role of a broadspectrum antiviral,peruvoside in limiting the formation of viral factories.Mechanistically,we revealed the pleiotropic cellular effect of Src and PLC kinase signaling via cyclin-dependent kinase 1 signaling leads to Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1(GBF1)phosphorylation and Golgi vesiculation by peruvoside treatment.The ramification of GBF1 phosphorylation fosters GBF1 deprivation consequentially activating downstream antiviral signaling by dampening viral factories formation.Further investigation showed signaling of ERK1/2 pathway via cyclin-dependent kinase 1 activation leading to GBF1 phosphorylation at Threonine 1337(T1337).We also showed 100%of protection in peruvoside-treated mouse model with a significant reduction in viral titre and without measurable cytotoxicity in serum.These findings highlight the importance of dissecting the broad-spectrum antiviral therapeutics mechanism and pave the way for consideration of peruvoside,host-directed antivirals for positive-sense RNA virus-mediated disease,in the interim where no vaccine is available. | Kan Xing Wu Thinesshwary Yogarajah Marcus Wing Choy Loe Parveen Kaur Regina Ching Hua Lee Chee Keng Mok Yi Hao Wong Patchara Phuektes Li Sze Yeo Vincent T.K.Chow Yong Wah Tan Justin Jang Hann Chu | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 0 |
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