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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Evaluation of three-dimensional biofilms on antibacterial bonding agents containing novel quaternary ammonium methacrylates显示文摘Antibacterial adhesives are promising to inhibit biofilms and secondary caries.The objectives of this study were to synthesize and incorporate quaternary ammonium methacrylates into adhesives,and investigate the alkyl chain length effects on three-dimensional biofilms adherent on adhesives for the first time.Six quaternary ammonium methacrylates with chain lengths of 3,6,9,12,16 and 18were synthesized and incorporated into Scotchbond Multi-Purpose.Streptococcus mutans bacteria were cultured on resin to form biofilms.Confocal laser scanning microscopy was used to measure biofilm thickness,live/dead volumes and live-bacteria percentage vs.distance from resin surface.Biofilm thickness was the greatest for Scotchbond control;it decreased with increasing chain length,reaching a minimum at chain length 16.Live-biofilm volume had a similar trend.Dead-biofilm volume increased with increasing chain length.The adhesive with chain length 9 had 37%live bacteria near resin surface,but close to 100%live bacteria in the biofilm top section.For chain length 16,there were nearly 0%live bacteria throughout the three-dimensional biofilm.In conclusion,strong antibacterial activity was achieved by adding quaternary ammonium into adhesive,with biofilm thickness and live-biofilm volume decreasing as chain length was increased from 3 to 16.Antibacterial adhesives typically only inhibited bacteria close to its surface;however,adhesive with chain length 16 had mostly dead bacteria in the entire three-dimensional biofilm.Antibacterial adhesive with chain length 16 is promising to inhibit biofilms at the margins and combat secondary caries. | Han Zhou Michael D Weir Joseph M Antonucci Gary E Schumacher Xue-Dong Zhou Hockin H K Xu | 2014 | International Journal of Oral Science2014，6，2： | 5 |
| 3 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 4 | Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study显示文摘 | JT Moller P Cluitmans LS Rasmussen P Houx H Rasmussen J Canet P Rabbitt J Jolles K Larsen CD Hanning O Langeron T Johnson PM Lauven PA Kristensen A Biedler H van Beem O Fraidakis JH Silverstein JEW Beneken JS Gravenstein | 1998 | The Lancet . 1998 (9106)1998，，9106： | 2 |
| 5 | Paternal smoking, genetic polyrnorphisms in CYP1A1 and childhood leukemia risk 显示文摘 | Lee K M Ward M H Han S | 2009 | Leukemia Res2009，33，2： | 1 |
| 6 | Quantum-inspired Evolutionary Algorithm for a Class of Combinatorial Optimization 显示文摘 | Han K H Kim J H | 2002 | IEEE Transactions on Evolutionary Computation (S 1089-778X)2002，6，6： | 1 |
| 7 | Solubility of stearic acid in supercritical CO2 with cosolvents显示文摘 | ZHONG M H HAN B X YAN H K | 1997 | J Supercrit Fluid1997，10，： | 1 |
| 8 | Fabrication of Aluminum/Copper Clad Composite Using Hot Hydrostatic Extrusion Process and Its Material Characteristics显示文摘 | Rhee K Y Han W Y Park H J | 2004 | Materials Science and Engineering2004，384，12： | 1 |
| 9 | Effects of dietary buffering characteristic and protected or unprotected acids on piglet growth, digestibility and characteristics of gut content显示文摘 | BOSI P JUNG H J HAN I K | 1999 | Asian Aust J Anim Sci1999，12，7： | 1 |
| 10 | Microstruetural characterization of Al2O3-Ni composites prepared by electroless deposition 显示文摘 | OH I H LEE J Y HAN J K | 2005 | Surf Coat Technol2005，192，： | 1 |
| 11 | Improved enzymatic hydrolysis yield of rice straw using electron beam irradiation pretreatment显示文摘 | Bak J S Ko J K Han Y H | 2009 | Bioresource Technology2009，100，： | 1 |
| 12 | Effect of supplemental synthetic anaino acids to the low diels on the perfnrmanee of growing pigs显示文摘 | Jin C F Kim I H Han I K | 1998 | Asian Australas J Anita Sci1998，11，1： | 1 |
| 13 | Abstracting Access Patterns of Dynamic Memory Using Regular Expressions 显示文摘 | Jeon J Shin K Han H | 2008 | ACM Transactions on Architecture and Code Optimization2008，5，4： | 1 |
| 14 | Medullary thyroid carcinoma: comparison with papillary thyroid carcinoma and application of current sonographic cdteria显示文摘 | Lee S Shin J H Han B K | 2010 | AJR Am J Roentgenol2010，194，4： | 1 |
| 15 | Surface graft copolymerization induced adhesion of polyaniline film to poly(trafluoroethylene) film and copper foil显示文摘 | Ma Z H Han H S Tan K L | 1999 | Eur Polym J1999，35，： | 1 |
| 16 | Effect of ethanol extracted propolis on fatoxidation of meatproducts显示文摘 | Han SK Park H K | 1996 | Korean Journal of Ani-mal Science (Korea Republic)1996，38，1： | 1 |
| 17 | Association between hepatitis B virus infection and HLA-DR type in Korea显示文摘 | Ahn S H Han K H Park J Y | 2000 | J Hepat2000，31，6： | 1 |
| 18 | Effects of supplemental synthetic amino acids to the low diets on the performance of growing pigs显示文摘 | JIN C F KIM I H HAN K | 1999 | Asian-Aus J Anim Sci1999，11，： | 1 |
| 19 | Effect of nonradiative recombination on light emitting properties of two-dimensional photonic crystal slab structures 显示文摘 | Han-Youl Ryu Dae-Sung Song J K H Ⅱ -Yong Han | 2001 | Applied Physics Letters2001，78，9： | 1 |
| 20 | MR-387 A and B, new aminopeptidase N inhibitors, produced by Streptomyces neyagawaensis SL-387显示文摘 | Chung M C Chun H K Han K H | 1996 | J Antibiot (Tokyo)1996，49，1： | 1 |
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