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| 1 | Data-Driven Approaches for Spatio-Temporal Analysis:A Survey of the State-of-the-Arts显示文摘With the advancement of telecommunications,sensor networks,crowd sourcing,and remote sensing technology in present days,there has been a tremendous growth in the volume of data having both spatial and temporal references.This huge volume of available spatio-temporal(ST)data along with the recent development of machine learning and computational intelligence techniques has incited the current research concerns in developing various data-driven models for extracting useful and interesting patterns,relationships,and knowledge embedded in such large ST datasets.In this survey,we provide a structured and systematic overview of the research on data-driven approaches for spatio-temporal data analysis.The focus is on outlining various state-of-the-art spatio-temporal data mining techniques,and their applications in various domains.We start with a brief overview of spatio-temporal data and various challenges in analyzing such data,and conclude by listing the current trends and future scopes of research in this multi-disciplinary area.Compared with other relevant surveys,this paper provides a comprehensive coverage of the techniques from both computational/methodological and application perspectives.We anticipate that the present survey will help in better understanding various directions in which research has been conducted to explore data-driven modeling for analyzing spatio-temporal data. | Monidipa Das Soumya K.Ghosh | 2020 | Journal of Computer Science & Technology2020，35，3： | 2 |
| 2 | Facies analysis and paleoenvironmental interpretation of Piacenzian carbonate deposits from the Guitar Formation of Car Nicobar Island,India显示文摘Facies characterization of Piacenzian(late Pliocene) carbonate sediments of the Guitar Formation in Car Nicobar Island, India and the subsequent integration of paleoecological data have been applied to interpret the paleoenvironment of the coralline algal-reef deposits. Thin-section analysis reveals that Amphiroa, Corallina and Jania are the dominant geniculate corallines, while Lithothamnion, Mesophyllum, Phymatolithon, Lithophyllum, Spongites and Lithoporella are the major non-geniculate corallines contributing to the sedimentary facies. Numerous small and larger benthic foraminifera also dominate the biogenic assemblages. Corals, barnacle shells, echinoid spines, fragments of bryozoans, mollusks and ostracodes are the subordinate constituents. Grainstones dominate the studied facies while packstones and boundstones(with wackestone elements) are the sub-lithofacies showing a fair representation. Six carbonate facies presenting a complete reef complex have been distinguished that were deposited in shallow intertidal, back-reef shelf/lagoon, reef and deeper fore-reef shelf settings. Evidences of coralline algal and benthic foraminiferal assemblages, taphonomic signatures of abrasion and fragmentation, grain size, angularity and encrustation indicate a shallow to relatively deeper bathymetric horizon of approximately 10-60 m that corresponds to a regime of high to moderate hydrodynamic conditions. | Amit K.Ghosh Suman Sarkar | 2013 | Geoscience Frontiers2013，4，6： | 2 |
| 3 | Oesophageal peristaltic transition zone defects: real but few and far between显示文摘 | S. K.Ghosh J. E.Pandolfino M. A.Kwiatek P. J.Kahrilas | 2008 | Neurogastroenterology & Motility2008，，12： | 1 |
| 4 | Active power measurement in nonsinusoidal environments显示文摘 | Larry G.Durante Prasanta K.Ghosh | | 0，，03： | 1 |
| 5 | Modification of LLDPE using esterified styrene maleic anhydride copolymer: Study of its properties and environmental degradability显示文摘 | JaykisorPal HarpalSingh Anup. K.Ghosh | 2004 | J Appl Polym Sci2004，，1： | 1 |
| 6 | Coherent-interface-induced strain in large lattice-mismatched materials:A new approach for modeling Raman shift显示文摘Strain engineering as one of the most powerful techniques for tuning optical and electronic properties of III-nitrides requires reliable methods for strain investigation.In this work,we reveal,that the linear model based on the experimental data limited to within a small range of biaxial strains(<0.2%),which is widely used for the non-destructive Raman study of strain with nanometer-scale spatial resolution is not valid for the binary wurtzite-structure group-III nitrides GaN and AlN.Importantly,we found that the discrepancy between the experimental values of strain and those calculated via Raman spectroscopy increases as the strain in both GaN and AlN increases.Herein,a new model has been developed to describe the strain-induced Raman frequency shift in GaN and AlN for a wide range of biaxial strains(up to 2.5%).Finally,we proposed a new approach to correlate the Raman frequency shift and strain,which is based on the lattice coherency in the epitaxial layers of superlattice structures and can be used for a wide range of materials. | Andrian V.Kuchuk Fernando Mde Oliveira Pijush K.Ghosh Yuriy I.Mazur Hryhorii V.Stanchu Marcio D.Teodoro Morgan E.Ware Gregory J.Salamo | 2022 | Nano Research2022，15，3： | 1 |
| 7 | Hydrometallurgical application for treating a Nigerian chalcopyrite ore in chloride medium:Part I.Dissolution kinetics assessment显示文摘The dissolution kinetics of a Nigerian chalcopyrite ore in hydrochloric acid was studied in this article.Acid concentration,reaction temperature,and ore particle size were chosen as experimental parameters.The chemical and morphological studies of the ore before and after leaching at optimal conditions were carried out by X-ray difraction(XRD)and scanning electron microscopy(SEM).It is revealed that increasing the acid concentration and system temperature and decreasing the ore particle size greatly enhances the dissolution rate.The dissolution kinetics was found to follow the shrinking core model for the difusion control mechanism where the activation energy(Ea)of 32.92 kJ·mol 1was obtained for the process and supported by morphological changes at a higher dissolution of 91.33%. | Alafara A.Baba Kuranga I.Ayinla Folahan A.Adekola Rafiu B.Bale Malay K.Ghosh Abdul G.F.Alabi Abdul R.Sheik Ismael O.Folorunso | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，11： | 1 |
| 8 | Targeting PD-1/PD-L1 in cancer immunotherapy:An effective strategy for treatment of triple-negative breast cancer(TNBC)patients显示文摘Maintaining the balance between eliciting immune responses against foreign pro-teins and tolerating self-proteins is crucial for maintenance of homeostasis.The functions of programmed death protein 1(PD-1)and its ligand programmed death ligand 1(PD-L1)are to inhibit immune responses so that over-reacting immune cells does not cause any damage to its own body cells.However,cancer cells hijack this mechanism to attenuate immune cells functions and create an immunosuppressive environment that fuel their continuous growth and proliferation.Over the past few years’rapid development in cancer immunotherapy has opened a new avenue in cancer treatment.Blockade of PD-1 and PD-L1 has become a potential strategy that rescue the functions of immune cells to fight against cancer with high efficacy.Initially,immune checkpoint monotherapies were not very successful,making breast cancer less immunogenic.Although,recent reports support the presence of tumor infiltrating lympho-cytes(TILs)in breast cancer that make it favorable for PD-1/PD-L1 mediated immunotherapy,which is effective in PD-L1 positive patients.Recently,anti-PD-1(pembrolizumab)and anti-PD-L1(atezolizumab)gets FDA approval for breast cancer treatment and make PD-1/PD-L1 immunotherapy is meaningful for further research.Likewise,this article gathered understand-ing of PD-1 and PD-L1 in recent years,their signaling networks,interaction with other mole-cules,regulations of their expressions and functions in both normal and tumor tissue microenvironments are crucial to find and design therapeutic agents that block this pathway and improve the treatment efficacy.Additionally,authors collected and highlighted most of the important clinical trial reports on monotherapy and combination therapy. | Sunny Kumar Mouli Chatterjee Pratyasha Ghosh Kirat K.Ganguly Malini Basu Mrinal K.Ghosh | 2023 | Genes & Diseases2023，10，4： | 1 |
| 9 | Comparative efficacy of a phytogenic feed additive and an antibiotic growth promoter on production performance, caecal microbial population and humoral immune response of broiler chickens inoculated with enteric pathogens显示文摘The aim of this work was to compare the efficacy of a commercially available phytogenic feed additive(PFA) and an antibiotic growth promoter, which was bacitracin methylene disalicylate(BMD), on performance, nutrient retention, caecal colonization of bacteria and humoral immune responses against Newcastle disease in broiler chickens challenged orally with Salmonella enteritidis and Escherichia coli.One-day-old male Cobb 400 broiler chicks(n = 120) were fed with 1) a negative control(NC) diet, which is the basal diet without any added growth promoter, 2) a positive control(PC) diet, the basal diet supplemented with BMD, 500 mg/kg and 3) a diet supplemented with PFA(150 mg/kg) for 39 days and the birds were inoculated with S. enteritidis and E. coli on d 28. Supplementation of PFA improved body weight, feed conversion ratio, retention of N and crude fiber, increased fecal moisture content and decreased digesta transit time as compared with the NC and PC groups(P <0.01). Both the PC and the PFA was found to be equally effective in controlling the surge in numbers of Salmonella and E. coli following oral inoculation of these bacteria as compared with the NC group(P <0.05) at 24 h past inoculation. Caecal content analysis on d 39 indicated lower numbers of Salmonella, E. coli and Clostridium in the PC and PFA groups as compared with the NC group(P <0.05). The number of Lactobacillus in the PFA group was higher than those in the NC and PC groups(P <0.05). Humoral immune response,measured as hemagglutination inhibition titer against Newcastle disease, was better in the PC and PFA groups compared with the NC group(P <0.05) at d 21 but the difference did not last till d 39. The heterophil to lymphocyte ratio was narrower(P <0.001) and alkaline phosphatase activity was higher(P <0.01) in the PFA group as compared with the NC and PC groups on d 39. It was concluded that the PFA, which is animal, environment and consumer friendly, may be used as an effective replacement for common in-feed antibiotics like BMD to enhance broiler performance especially when the birds are exposed to heavy infections on fields. | Toshi Wati Tapan K.Ghosh Basharat Syed Sudipto Haldar | 2015 | Animal Nutrition2015，，3： | 1 |
| 10 | DEAD-box RNA helicases with special reference to p68:Unwinding their biology,versatility,and therapeutic opportunity in cancer显示文摘In the era of advancement,the entire world continues to remain baffled by the increased rate of progression of cancer.There has been an unending search for novel thera-peutic targets and prognostic markers to curb the oncogenic scenario.The DEAD-box RNA he-licases are a large family of proteins characterized by their evolutionary conserved D-E-A-D(Asp-Glu-Ala-Asp)domain and merit consideration in the oncogenic platform.They perform multidimensional functions in RNA metabolism and also in the pathology of cancers.Their bio-logical role ranges from ribosome biogenesis,RNA unwinding,splicing,modification of second-ary and tertiary RNA structures to acting as transcriptional coactivators/repressors of various important oncogenic genes.They also play a crucial role in accelerating oncogenesis by pro-moting cell proliferation and metastasis.DDX5(p68)is one of the archetypal members of this family of proteins and has gained a lot of attention due to its oncogenic attribute.It is found to be overexpressed in major cancer types such as colon,brain,breast,and prostate cancer.It exhibits its multifaceted nature by not only coactivating genes implicated in cancers but also mediating crosstalk across major signaling pathways in cancer.Therefore,in this review,we aim to illustrate a comprehensive overview of DEAD-box RNA helicases especially p68 by focusing on their multifaceted roles in different cancers and the various signaling pathways affected by them.Further,we have also briefly discoursed the therapeutic interventional approaches with the DEAD-box RNA helicases as the pharmacological targets for designing in-hibitors to pave way for cancer therapy. | Shaheda Tabassum Mrinal K.Ghosh | 2023 | Genes & Diseases2023，10，4： | 0 |
| 11 | COVID-19 therapeutics:Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery显示文摘Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes the compli-cated disease COVID-19.Clinicians are continuously facing huge problems in the treatment of patients,as COVID-19-specific drugs are not available,hence the principle of drug repurpos-ing serves as a one-and-only hope.Globally,the repurposing of many drugs is underway;few of them are already approved by the regulatory bodies for their clinical use and most of them are in different phases of clinical trials.Here in this review,our main aim is to discuss in detail the up-to-date information on the target-based pharmacological classification of repurposed drugs,the potential mechanism of actions,and the current clinical trial status of various drugs which are under repurposing since early 2020.At last,we briefly proposed the probable phar-macological and therapeutic drug targets that may be preferred as a futuristic drug discovery approach in the development of effective medicines. | Sunny Kumar Malini Basu Pratyasha Ghosh Uttam Pal Mrinal K.Ghosh | 2023 | Genes & Diseases2023，10，4： | 0 |
| 12 | Distributed multi-agent temporal-difference learning with full neighbor information显示文摘This paper presents a novel distributed multi-agent temporal-difference learning framework for value function approximation,which alows agents using all the neighbor information instead of the information from only one neighbor.With full neighbor information,the proposed framework(1)has a faster convergence rate,and(2)is more robust compared to the state of-the art approaches.Then we propose a distributed multi-agent discounted temporal dfferene algorithm and a distributed muli-agent average cost temporal diference leaming algorithm based on th framework.Moreover,the two proposed algorthms'theoretical convergence proofs are provided.Numerical simulation resuts show that our proposed algorihms are superior to the gossip-based algorithm in convergence speed,robustness to noise and time-varying network topology. | Zhinan Peng Jiangping Hu Rui Luo Bijoy K.Ghosh | 2020 | Control Theory and Technology2020，18，4： | 0 |
| 13 | Minimum energy optimal external torque control of human binocular vision显示文摘In this paper,we consider eyes from the human binocular system,that simultaneously gaze on stationary point targets in space,while optimalal skipping from one target to the next,by rotaing their individual gaze drecton.The head is assume fixed on the torso and the rotaing gaze direction of the two eyes are assumed restricted to pass through a point in the visual space.It is further assumed that,individullly the rotations of the two eyes satisfy the well known Listing's law.We formulate and study acombined optimal gaze rotation for the two eyes,by constructing a single Riemanmian metric,on the asociaced parameter space.The goal is to optimally rotate so that the convergent gaze changes between two pre-specified target points in a finite time interval[0,1].The cost function we choose is the total energy,measured by the L2?norm,of the six extenal torques on the binocular system.The torque functions are synthesized by solving an associated*two-point boundary value problem.The paper demonstrates,via simulation,the shape of the optimal gaze trajectory of the focused point of the bin-ocular system.The Euclidean distance between the initial and the final point is compared to the arc:length of the optimal trajectory.The consumed energy.is computed for diferent eye movement chores and discussed in the paper.Via simulation we observe that certain eye movement maneuvers are energy fficicnt and demonstrate that the optimal external torque is a linear function in time.We also explore and conclude that spitting an arbitry opimal eye movement into optimal vergence and version components is not energy fficient although this is how the human oculomotor control seems to operate.Opimal gaze tajectories and opimal extermal torque functions reported in this paper is new. | Bijoy K.Ghosh Bhagya Athukorallage | 2020 | Control Theory and Technology2020，18，4： | 0 |
| 14 | Non-Gaussian normal diffusion in low dimensional systems显示文摘Brownian particles suspended in disordered crowded environments often exhibit non-Gaussian normal diffusion(NGND),whereby their displacements grow with mean square proportional to the observation time and non-Gaussian statistics.Their distributions appear to decay almost exponentially according to“universal”laws largely insensitive to the observation time.This effect is generically attributed to slow environmental fluctuations,which perturb the local configuration of the suspension medium.To investigate the microscopic mechanisms responsible for the NGND phenomenon,we study Brownian diffusion in low dimensional systems,like the free diffusion of ellipsoidal and active particles,the diffusion of colloidal particles in fluctuating corrugated channels and Brownian motion in arrays of planar convective rolls.NGND appears to be a transient effect related to the time modulation of the instantaneous particle’s diffusivity,which can occur even under equilibrium conditions.Consequently,we propose to generalize the definition of NGND to include transient displacement distributions which vary continuously with the observation time.To this purpose,we provide a heuristic one-parameter function,which fits all time-dependent transient displacement distributions corresponding to the same diffusion constant.Moreover,we reveal the existence of low dimensional systems where the NGND distributions are not leptokurtic(fat exponential tails),as often reported in the literature,but platykurtic(thin sub-Gaussian tails),i.e.,with negative excess kurtosis.The actual nature of the NGND transients is related to the specific microscopic dynamics of the diffusing particle. | Qingqing Yin Yunyun Li Fabio Marchesoni Subhadip Nayak Pulak K.Ghosh | 2021 | Frontiers of physics2021，16，3： | 0 |
| 15 | Chaperone-assisted E3 ligase CHIP:A double agent in cancer显示文摘The carboxy-terminus of Hsp70-interacting protein(CHIP)is a ubiquitin ligase and co-chaperone belonging to Ubox family that plays a crucial role in the maintenance of cellular homeostasis by switching the equilibrium of the folding-refolding mechanism towards the proteasomal or lysosomal degradation pathway.It links molecular chaperones viz.HSC70,HSP70 and HSP90 with ubiquitin proteasome system(UPS),acting as a quality control system.CHIP contains charged domain in between N-terminal tetratricopeptide repeat(TPR)and C-terminal Ubox domain.TPR domain interacts with the aberrant client proteins via chaperones while Ubox domain facilitates the ubiquitin transfer to the client proteins for ubiquitination.Thus,CHIP is a classic molecule that executes ubiquitination for degradation of client proteins.Further,CHIP has been found to be indulged in cellular differentiation,proliferation,metastasis and tumorigenesis.Additionally,CHIP can play its dual role as a tumor suppressor as well as an oncogene in numerous malignancies,thus acting as a double agent.Here,in this review,we have reported almost all substrates of CHIP established till date and classified them according to the hallmarks of cancer.In addition,we discussed about its architectural alignment,tissue specific expression,sub-cellular localization,folding-refolding mechanisms of client proteins,E4 ligase activity,normal physiological roles,as well as involvement in various diseases and tumor biology.Further,we aim to discuss its importance in HSP90 inhibitors mediated cancer therapy.Thus,this report concludes that CHIP may be a promising and worthy drug target towards pharmaceutical industry for drug development. | Sunny Kumar Malini Basu Mrinal K.Ghosh | 2022 | Genes & Diseases2022，9，6： | 0 |
| 16 | The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports显示文摘Glioma and cerebral ischemic stroke are two major events that lead to patient death worldwide.Although these conditions have different physiological incidences,~10%of ischemic stroke patients develop cerebral cancer,especially glioma,in the postischemic stages.Additionally,the high proliferation,venous thrombosis and hypercoagulability of the glioma mass increase the significant risk of thromboembolism,including ischemic stroke.Surprisingly,these events share several common pathways,viz.hypoxia,cerebral inflammation,angiogenesis,etc.,but the proper mechanism behind this co-occurrence has yet to be discovered.The hypercoagulability and presence of the D-dimer level in stroke are different in cancer patients than in the noncancerous population.Other factors such as atherosclerosis and coagulopathy involved in the pathogenesis of stroke are partially responsible for cancer,and the reverse is also partially true.Based on clinical and neurosurgical experience,the neuronal structures and functions in the brain and spine are observed to change after a progressive attack of ischemia that leads to hypoxia and atrophy.The major population of cancer cells cannot survive in an adverse ischemic environment that excludes cancer stem cells(CSCs).Cancer cells in stroke patients have already metastasized,but early-stage cancer patients also suffer stroke for multiple reasons.Therefore,stroke is an early manifestation of cancer.Stroke and cancer share many factors that result in an increased risk of stroke in cancer patients,and vice-versa.The intricate mechanisms for stroke with and without cancer are different.This review summarizes the current clinical reports,pathophysiology,probable causes of co-occurrence,prognoses,and treatment possibilities. | Mrinal K.Ghosh Dipankar Chakraborty Sibani Sarkar Arijit Bhowmik Malini Basu | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 0 |
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