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| 1 | Climate change regionalization in China(1961–2010)显示文摘Since climatic condition is the important foundation for human subsistence and development and the key factor in sustainable development of economy and society, climate change has been a global issue attracting great attentions of politicians, scientists, governments, and the public alike throughout the world. Existing climate regionalization in China aims to characterize the regional differences in climate based on years of the mean value of different climate indexes. However, with the accelerating climate change nowadays, existing climate regionalization cannot represent the regional difference of climate change, nor can it reflect the disasters and environmental risks incurred from climate changes. This paper utilizes the tendency value and fluctuation value of temperature and precipitation from 1961 to 2010 to identify the climate change quantitatively, and completes the climate change regionalization in China(1961–2010) with county administrative regionalization as the unit in combination with China's terrain feature. Level-I regionalization divides China's climate change(1961–2010) into five tendency zones based on the tendency of temperature and precipitation, which are respectively Northeast China-North China warm-dry trend zone, East China-Central China wet-warm trend zone, Southwest China-South China dry-warm trend zone, Southeast Tibet-Southwest China wet-warm trend zone, and Northwest China-Qinghai-Tibet Plateau warm-wet trend zone; level-II regionalization refers to fourteen fluctuation regions based on level-I regionalization according to the fluctuation of temperature and precipitation. | SHI PeiJun SUN Shao WANG Ming LI Ning WANG JingAi JIN YunYun GU XiaoTian YIN WeiXia | 2014 | Science China Earth Sciences2014，57，11： | 22 |
| 2 | The Clinical Outcomes of Three Surgical Managements on Primary Angle-closure Glaucoma显示文摘Purpose: To investigate the efficacy of trabeculectomy, phacotrabeculectomy and phaco-emulsification in the management of primary angle closure glaucoma (PACG). Methods: A prospective observational study was performed in 88 chronic PACG patients (97 eyes) who were divided into three groups following defined indications to receive different surgical interventions. The indications and clinical outcomes were evaluated. The mean follow-up was (17.7±4.9) months. Results: Success rate in trabeculectomy, phacotrabeculectomy and phacoemulsification group was 81.08%, 78.57‰ and 81.25‰, respectively. The anterior chamber depth was deeper and the angle was wider postoperatively vs. preoperatively both in phaco-trabeculectomy and phacoemulsification group. No obvious changes were seen in trabeculectomy group. The coefficient of outflow facility of aqueous humor (C values) significantly increased in three groups postoperatively (P < 0.01). No severe intra-operative complications were found and the incidence of postoperative complications was low. Five eyes sustained hypotony 3±1.87 months in trabeculectomy group and 1 eye happened malignant glaucoma in phacotrabeculectomy group. The visual acuity in patients with phacotrabeculectomy plus intraocular lens implantation and those only with phacoemulsification plus intraocular lens implantation were improved 78.57% and 93.74%, respectively. No significant improvement was found in trabeculectomy group (χ2 = 47.10, P < 0.001). Conclusion: Three surgical interventions were beneficial to manage PACG and with co-existing cataract. The indication choosing was suggested according to visual acuity, angle closure circumference, cataract, medication requirements and optic nerve damage. Phacotrabeculectomy was recommended for angle closed ≥180° circumference while phacoemulsification for angle closed < 180°. | Xiulan Zhang Leilei Teng Ang Li Shaolin Du Yunyun Zhu Jian Ge | 2007 | 眼科学报2007，23，2： | 16 |
| 3 | Ice radar investigation at Dome A, East Antarctica:Ice thickness and subglacial topography显示文摘Dome A, located in the central East Antarctic ice sheet (EAIS), is the highest summit of the Antarctic ice sheet. From ice-sheet evolution modeling results, Dome A is likely to preserve over one million years of the Earth's paleo-climatic and -environmental records, and considered an ideal deep ice core drilling site. Ice thickness and subglacial topography are critical factors for ice-sheet models to determine the timescale and location of a deep ice core. During the 21st and 24th Chinese National Antarctic Research Expedition (CHINARE 21, 2004/05; CHINARE 24, 2007/08), ground-based ice radar systems were used to a three-dimensional investigation in the central 30 km×30 km region at Dome A. The successfully obtained high resolution and accuracy data of ice thickness and subglacial topography were then interpolated into the ice thickness distribution and subglacial topography digital elevation model (DEM) with a regular grid resolution of 140.5 m×140.5 m. The results of the ice radar investigation indicate that the average ice thickness in the Dome A central 30 km×30 km region is 2233 m, with a minimal ice thickness of 1618 m and a maximal ice thickness of 3139 m at Kunlun Station. The subglacial topography is relatively sharp, with an elevation range of 949-2445 m. The typical, clear mountain glaciation morphology is likely to reflect the early evolution of the Antarctic ice sheet. Based on the ice thickness distribution and subglacial topography characteristics, the location of Kunlun Station was suggested to carry out the first high-resolution, long time-scale deep ice core drilling. However, the internal structure and basal environments at Kunlun Station still need further research to determine. | CUI XiangBin SUN Bo TIAN Gang TANG XueYuan ZHANG XiangPei JIANG YunYun GUO JingXue LI Xin | 2010 | Chinese Science Bulletin2010，55，4： | 11 |
| 4 | SCM-198 protects endometrial stromal cells from oxidative damage through Bax/Bcl-2 and ERK signaling pathways显示文摘In creasi ng amounts of evidence dem on strated that accumulative reactive oxyge n species (ROS) and apoptosis of human endometrial stromal cells (ESCs) are closely associated with endometrial dysfunction induced by oxidative stress, which plays an important role in the pathological process of multiple gyn ecological and reproduction-related diseases. SCM-198, an alkaloid active component of Leonurus japonicas Houtt, has been reported to have anti-oxidative activity. However, the specific mechanisms of SCM-198 in the prevention of endometrial damage remain unknown. In the present study, we assessed the effect of SCM-198 on hydrogen peroxide (H2O2Hnduced oxidative injury in ESCs. ESCs were pretreated with SCM-198 for 4 h and then challenged with H2O2.Morphology ch a nges, apoptosis rate, and intracellular ROS producti on were measured to assess the level of oxidative injury. Flow cytometry and western blot analysis were performed to detect the expression levels of Bax, Bcl-2, active-caspase-3, and mitogen-activated protein kinases pathways. Classic inflammation cytokines were measured by real-time polymerase chain reactions. Our results showed that SCM-198 attenuated apoptosis and ROS generation of ESCs induced by H2O2. H2O2 induced the apparent apoptotic characteristics, including fragmentation of DNA, upregulation of Bax/Bcl2, activation of caspase-3, and secretion of inflammation cytokines, which were all ameliorated by SCM-198. Furthermore, H2O2-induced apoptosis-related ERK1/2 pathway activation was restrained by SCM-198 pretreatme nt. These fin dings suggested that SCM-198 could protect ESCs from oxidative injury, mainly by inhibiting oxidative stress and reducing apoptosis. | Yunyun Li Yikong Lin Xixi Huang Chunfang Xu Xinhua Liu Li Wang Min Yu Dajin Li Yizhun Zhu Meirong Du | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 10 |
| 5 | Preliminary results of ice radar investigation along the traverse between Zhongshan and Dome A in East Antarctic ice sheet:Ice thickness and subglacial topography显示文摘During the 24th Chinese National Antarctic Research Expedition(CHINARE 24,2007/08),a ground-based ice radar was used to survey ice thickness and subglacial topography along the 1170 km traverse between Zhongshan and Dome A in East Antarctic ice sheet(EAIS).Ice-bedrock interface was detected along 82%of the traverse and data was collected at a horizontal resolution of <5.6 m.The data was processed to produce curves of ice thickness distribution and subglacial topography along the traverse.The results indicate that,along the traverse,the average ice thickness is 2037 m,smaller than the average ice thickness in EAIS;the thickest ice is at 730 km,and the thinnest ice(891 m)is at the edge of the ice sheet,but the slightly larger ice thickness(1078 m) in inland appears at 1020 km;the average subglacial topography elevation is 728 m,greatly larger than the average value in EAIS, and the largest elevation reaches up to 2650 m at 1034 km.The lowest terrain is located at 765 km.In further inland of 900?1170 km,the subglacial topography is relatively high due to the existence of the Gamburtsev Subglacial Mountains in the region.Generally,the influence of subglacial topography on ice surface is not significant,except at 900 km where great rise of subglacial topography causes evident uplift of ice surface.Where ice-bedrock interface was detected,the frequent and strong change of ice thickness and subglacial topography in small-scale means large bedrock roughness along the traverse,and is considered as the result of the integrated influence of ice flow,basal environments and geology.The segment where bedrock was not detected has very large ice thickness.The strong ice flow there also makes internal structure more complicated and induces serious attenuation of radar signals. | CUI XiangBin SUN Bo TIAN Gang TANG XueYuan ZHANG XiangPei JIANG YunYun GUO JingXue LI Xin | 2010 | Chinese Science Bulletin2010，55，24： | 8 |
| 6 | Tropospheric biennial oscillation of the western Pacific subtropical high and its relationships with the tropical SST and atmospheric circulation anomalies显示文摘There is the significant period of tropospheric biennial Oscillation(TBO)over East Asian monsoon region at the interannual timescales,which has the important influences on East China climate.Based on a set of reconstructed indices which describes the western Pacific subtropical high(WPSH)objectively,this paper focuses on the TBO component of WPSH,one of the key members of the East Asian Monsoon system,and its relationships with the tropical SST and atmospheric circulation anomalies.It is found that(1)As an important interannual component of WPSH,the time series of TBO has the obvious transition in the late1970s,and the variability of the WPSH’s TBO component is more significant after the late 1970s.(2)The time-lag correlations between the WPSH’s TBO and the tropical sea surface temperature(SST)anomalies in several key ocean regions are more significant and have longer correlation duration than the raw data.The response of the western boundary index to ENSO is earlier than the intensity index,and the time-lag correlations of them are up to maximum when lagging ENSO by 3–5 months and 5–6months,respectively.(3)In the course of the WPSH’s TBO cycle,the occurrence of the El Ni o-like anomaly in the tropical central-eastern Pacific in winter is always coupled with the weak East Asian winter monsoon,with the most significant enhancing phase of the WPSH’TBO.In contrast,the La Ni a-like anomaly in the central-eastern Pacific in winter is coupled with the strong East Asian winter monsoon,with the most weakening phase of the WPSH’s TBO.(4)The distribution of the tropical SST and atmospheric circulations anomalies are asymmetric in the TBO cycle.The WPSH’s TBO is more significant in the period of the developing El Ni o-like anomaly in central-eastern Pacific than in the period of the developing La Ni a-like anomaly.Therefore,during the period of developing El Ni o-like anomaly,more attention should be paid to the interannual component of TBO signal in the short-term climate prediction. | LIU YunYun DING YiHui GAO Hui LI WeiJing | 2013 | Chinese Science Bulletin2013，58，30： | 8 |
| 7 | Inorganic arsenic contamination of rice from Chinese major rice-producing areas and exposure assessment in Chinese population显示文摘This study examined the total arsenic(Ast) and inorganic arsenic(Asi) content in the main rice growing area of China. The results were compared with other countries and then used for dietary exposure assessment. A total of 446 rice samples from 15 main rice-growing provinces and autonomous regions of China were collected and then divided into unpolished and polished rice. Total arsenic and arsenic species were analyzed in a total of 892 subsamples using inductively coupled plasma-mass spectrometry(ICP-MS) and high performance liquid chromatography(HPLC) coupled ICP-MS, respectively. National Ast means were 255 μg/kg of unpolished rice and 143 μg/kg of polished rice. Asi was found to be the predominant species and mean levels were 209 μg/kg of unpolished rice and 108 μg/kg of polished rice, respectively. Exposure assessment to Asi in polished rice has been calculated for the margin of exposure(MOE), which highlights the fact that Asi levels in the Chinese rice should arouse public health concern. | Xiaowei Li Ke Xie Bing Yue Yunyun Gong Yi Shao Xiaohong Shang Yongning Wu | 2015 | Science China(Information Sciences)2015，58，12： | 7 |
| 8 | Effects of elevated CO_2 on the nutrient compositions and enzymes activities of Nilaparvata lugens nymphs fed on rice plants显示文摘Elevated CO 2 may reduce the tolerance of Nilaparvata lugen (N. lugens) to adverse environmental factors through the biological and physiological degeneration of N. lugens. In an artificial climate box, under 375 and 750 μL L 1 CO 2 levels, the rice stems nutrient content, the nutrient content and enzyme activities of N. lugens nymph fed on rice seedlings exposed to ambient and elevated CO 2 were studied. The results showed that rice stems had significantly higher protein and total amino acid levels under ambient than elevated CO 2 levels. Nymphs had significantly higher protein levels in the ambient CO 2 treatment, while their glucose levels were significantly lower under ambient CO 2 conditions. Significantly higher trypsin activity was observed in nymphs grown in elevated CO 2 . Significantly lower activities of the protective enzymes total superoxide dismutase and catalase were observed in the nymphs under ambient CO 2 . Meanwhile, the activity of the detoxification enzyme glutathione S-transferase was significantly higher in the ambient CO 2 treatment. Measuring how energy and resources were allocated to enzymes in N. lugens nymphs under elevated CO 2 conditions can provide a more meaningful evaluation of their metabolic tolerances to adverse climatic conditions. | ZENG YunYun HUANG WenKun SU Li WU Gang ZHUANG Jing ZHAO WanYun HUA HongXia LI JunSheng XIAO NengWen XIONG-YanFei | 2012 | Science China(Life Sciences)2012，55，10： | 7 |
| 9 | Single event upset sensitivity of 45 nm FDSOI and SOI FinFET SRAM显示文摘In this work single event upset(SEU) sensitivity of 45 nm fully depleted silicon-on-insulator(FDSOI) static random access memory(SRAM) cell and that of SOI fin-shaped field-effect-transistor(FinFET) SRAM cell have been investigated by 3D TCAD simulations.The critical charges and SEU threshold linear energy transfer(LET) value of the two SRAM cells are consistent due to similar gate capacitance.The low electrical field and the high recombination rate account for the non-sensitivity to SEU in heavily doped drain region.Compared with FDSOI SRAM,SOI FinFET SRAM cell exhibits lower SEU sensitivity at the center of the gate.The smaller sensitive area in SOI FinFET SRAM cell may result in a smaller SEU saturation cross section than that of SOI FinFET SRAM. | TANG Du LI YongHong ZHANG GuoHe HE ChaoHui FAN YunYun | 2013 | Chinese Science Bulletin2013，58，7： | 6 |
| 10 | SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is the ongoing global pandemic that poses substantial challenges to public health worldwide.A subset of COVID-19 patients experience systemic inflammatory response,known as cytokine storm,which may lead to death.Receptor-interacting serine/threonine-protein kinase 1(RIPK1)is an important mediator of inflammation and cell death.Here,we examined the interaction of RIPK1-mediated innate immunity with SARS-CoV-2 infection.We found evidence of RIPK1 activation in human COVID-19 lung pathological samples,and cultured human lung organoids and ACE2 transgenic mice infected by SARS-CoV-2.Inhibition of RIPK1 using multiple smallmolecule inhibitors reduced the viral load of SARS-CoV-2 in human lung organoids.Furthermore,therapeutic dosing of the RIPK1 inhibitor Nec-1s reduced mortality and lung viral load,and blocked the CNS manifestation of SARS-CoV-2 in ACE2 transgenic mice.Mechanistically,we found that the RNA-dependent RNA polymerase of SARS-CoV-2,NSP12,a highly conserved central component of coronaviral replication and transcription machinery,promoted the activation of RIPK1.Furthermore,NSP12323L variant,encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy,Italy,that carries a Pro323Leu amino acid substitution in NSP12,showed increased ability to activate RIPK1.Inhibition of RIPK1 downregulated the transcriptional induction of proinflammatory cytokines and host factors including ACE2 and EGFR that promote viral entry into cells.Our results suggest that SARS-CoV-2 may have an unexpected and unusual ability to hijack the RIPK1-mediated host defense response to promote its own propagation and that inhibition of RIPK1 may provide a therapeutic option for the treatment of COVID-19. | Gang Xu Ying Li Shengyuan Zhang Haoran Peng Yunyun Wang Dekang Li Taijie Jin Zhuohao He Yilun Tong Chunting Qi Guowei Wu Kangyun Dong Jizhou Gou Yang Liu Tongyang Xiao Jing Qu Liang Li Liang Liu Ping Zhao Zheng Zhang Junying Yuan | 2021 | Cell Research2021，31，12： | 6 |
| 11 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 12 | Predictors of dysphagia screening and pneumonia among patients with acute ischaemic stroke in China:findings from the Chinese Stroke Center Alliance(CSCA)显示文摘Background and purpose Guidelines recommend dysphagia screening to identify those at high risk of pneumonia.However,little is known about the prevalence and predictors of dysphagia screening and pneumonia among patients with acute ischaemic stroke in China.Methods Using data from the Chinese Stroke Center Alliance,which is a multicentre,prospective,consecutive patient enrolment programme,univariate and multivariate analyses were conducted to identify patient and hospital characteristics associated with dysphagia screening and pneumonia during acute hospitalisation.Results Of 790811 patients admitted to 1476 hospitals,622718(78.7%)underwent dysphagia screening,and 64398(8.1%)developed pneumonia.Patients in stroke units were more likely to be screened for dysphagia than those not in stroke units(OR 1.50;95%CI 1.48 to 1.52),while patients with a past history of stroke were less likely to be screened(OR 0.87;95%CI 0.86 to 0.88).Dysphagia screening(OR 1.46;95%CI 1.30 to 1.65),dysphagia(OR 7.31;95%CI 7.15 to 7.46),and admission to stroke units(OR 1.17;95%CI 1.14 to 1.19)were significantly associated with a greater risk of pneumonia.Conclusions Dysphagia was a critical factor in the development of pneumonia.Nearly one in five patients with acute ischaemic stroke in the Chinese Stroke Center Alliance were not screened for dysphagia.Pneumonia prevention during acute hospitalisation is dependent not only on dysphagia screening but also on the effectiveness of subsequent dysphagia management interventions.Further studies are needed to elucidate the relationship between dysphagia screening,stroke unit care and pneumonia in patients with acute ischaemic stroke. | Jianshu Liang Zhike Yin Zixiao Li Hongqiu Gu Kaixuan Yang Yunyun Xiong Yongjun Wang Chunjuan Wang | 2022 | Stroke & Vascular Neurology2022，7，4： | 5 |
| 13 | The five major autoimmune diseases increase the risk of cancer:epidemiological data froma large-scale cohort study in China显示文摘Background:Cancer incidence and mortality have received critical attention during the long-term management of morbidities in patients with autoimmune diseases(AIDs).This study aimed to investigate and compare the risk of cancer associated with five major AIDs in a large-scale Chinese cohort.Methods:A total of 8,120 AID patients consecutively admitted to a national tertiary referral center in China were included and followed-up for 38,726.55 patient-years,including those with systemic lupus erythematosus(SLE),rheumatoid arthritis(RA),Sjoren’s syndrome(SS),systemic scleroderma(SSc),and idiopathic inflammatory myositis(IIM).Demographic data,cancer incidence,predilecting sites and cancer onset time were recorded and compared among the five AIDs.Results:Four hundred and thirty(5.3%)patients developed cancer.Their median agewas 57.5 years and AID durationwas 79.8 months.The estimated total standardized incidence ratio(SIR)of cancer in AIDs patients was 3.37,with the highest SIR observed in IIM(4.31),followed by RA(3.99),SSc(3.77),SS(2.88)and SLE(2.58).The increased SIR of cancers in AID patients showed a female predominance(female vs.male:3.59 vs.2.77)and younger patient involvement(age<50 vs.≥50 years:4.88 vs.3.04).Patientswith SLE had increased SIRs for developing hematologic malignancies and solid tumors located in the urinary bladder,corpus uteri and cervix uteri.Patients with SS had a significantly high SIR for developing non-Hodgkin’s lymphoma.Within 3 years of IIM diagnosis,74.6%of the patients developed cancer and they had a high risk of ovarian cancer.RA was associated with a wide distribution of scancers,including non-Hodgkin’s lymphoma,gynecologic,urinary tract,thyroid gland and lung cancers.SSc patients had increased SIRs for developing cervical uterine,lung,and breast cancers.Conclusion:Patients with five major AIDs in China had an increased risk of developing cancer,with a predominance in women and younger patients,although cancer incidence,predilection sites and cancer onset time may vary greatly in each AID entity. | Ziyue Zhou Huazhen Liu Yiying Yang Jingya Zhou Lidan Zhao Hua Chen Yunyun Fei Wen Zhang Mengtao Li Yan Zhao Xiaofeng Zeng Fengchun Zhang Huaxia Yang Xuan Zhang | 2022 | Cancer Communications2022，42，5： | 4 |
| 14 | Design, Synthesis and Insecticidal Activity of Novel Anthranilic Diamides Containing Oxime Ester and Diacylhydrazine Moieties显示文摘 | LIU Chen ZHANG Jifeng ZHOU Yunyun WANG Baolei XIONG Lixia LI Zhengming | 2014 | Chemical Research in Chinese Universities2014，30，2： | 4 |
| 15 | Identification of long noncoding RNAs involved in resistance to downy mildew in Chinese cabbage显示文摘Brassica downy mildew,a severe disease caused by Hyaloperonospora brassicae,can cause enormous economic losses in Chinese cabbage(Brassica rapa L.ssp.pekinensis)production.Although some research has been reported recently concerning the underlying resistance to this disease,no studies have identified or characterized long noncoding RNAs involved in this defense response.In this study,using high-throughput RNA sequencing,we analyzed the disease-responding mRNAs and long noncoding RNAs in two resistant lines(T12–19 and 12–85)and one susceptible line(91–112).Clustering and Gene Ontology analysis of differentially expressed genes(DEGs)showed that more DEGs were involved in the defense response in the two resistant lines than in the susceptible line.Different expression patterns and proposed functions of differentially expressed long noncoding RNAs among T12–19,12–85,and 91–112 indicated that each has a distinct disease response mechanism.There were significantly more cis-and trans-functional long noncoding RNAs in the resistant lines than in the susceptible line,and the genes regulated by these RNAs mostly participated in the disease defense response.Furthermore,we identified a candidate resistance-related long noncoding RNA,MSTRG.19915,which is a long noncoding natural antisense transcript of a MAPK gene,BrMAPK15.Via an agroinfiltration-mediated transient overexpression system and virus-induced gene silencing technology,BrMAPK15 was indicated to have a greater ability to defend against pathogens.MSTRG.19915-silenced seedlings showed enhanced resistance to downy mildew,probably because of the upregulated expression of BrMAPK15.This research identified and characterized long noncoding RNAs involved in resistance to downy mildew,laying a foundation for future in-depth studies of disease resistance mechanisms in Chinese cabbage. | Bin Zhang Tongbing Su Peirong Li Xiaoyun Xin Yunyun Cao Weihong Wang Xiuyun Zhao Deshuang Zhang Yangjun Yu Dayong Li Shuancang Yu Fenglan Zhang | 2021 | Horticulture Research2021，8，1： | 3 |
| 16 | OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING显示文摘Stimulator of interferon genes(STING)is an adaptor protein that is critical for effective innate antiviral and antitumor immunity.The activity of STING is heavily regulated by protein ubiquitination,which is fine-tuned by both E3 ubiquitin ligases and deubiquitinases.Here,we report that the deubiquitinase OTUD5 interacts with STING,cleaves its K48-linked polyubiquitin chains,and promotes its stability.Consistently,knockout of OTUD5 resulted in faster turnover of STING and subsequently impaired type I IFN signaling following cytosolic DNA stimulation.More importantly,Lyz2-Cre Otud5^(fl/Y) mice and CD11-Cre Otud5^(fl/Y) mice showed more susceptibility to herpes simplex virus type 1(HSV-1)infection and faster development of melanomas than their corresponding control littermates,indicating that OTUD5 is indispensable for STING-mediated antiviral and antitumor immunity.Our data suggest that OTUD5 is a novel checkpoint in the cGAS-STING cytosolic DNA sensing pathway. | Yunyun Guo Fei Jiang Lingli Kong Haifeng Wu Honghai Zhang Xiaorong Chen Jian Zhao Baoshan Cai Yanqi Li Chunhong Ma Fan Yi Lei Zhang Bingyu Liu Yi Zheng Lingqiang Zhang Chengjiang Gao | 2021 | Cellular & Molecular Immunology2021，18，8： | 2 |
| 17 | Excellent Terahertz shielding performance of ultrathin flexible Cu/graphene nanolayered composites with high stability显示文摘Electromagnetic interference(EMI)shielding at Terahertz(THz)frequency range attracts increasing attention due to the rapid development of THz science and technologies.EMI shielding materials with small thickness,high shielding effectiveness(SE),good flexibility and stability are highly desirable.Herein,an ultrathin flexible copper/graphene(Cu/Gr)nanolayered composite are prepared,which can reach the average EMI SE of 60.95 dB at 0.1–1.0 THz with a thickness of only 160 nm,indicating that more than 99.9999%of the THz wave power can be shielded.Furthermore,the Cu/Gr nanolayered composite also exhibits excellent oxidation resistance,with a 93.09%maintenance rate for EMI SE value after heating at 120℃for 3 h in air,far higher than that of the bare Cu film(62.15%).Besides,the Cu/Gr nanolayered composite exhibits good mechanical flexibility and flexural fatigue resistance.The EMI SE value of the Cu/Gr nanolayered composite shows a maintenance rate of 98.87%even after 1500 times bending cycles,obviously higher than that of multilayer Cu film(93.07%).These results demonstrate that the ultrathin flexible Cu/Gr nanolayered composites with excellent shielding performance and good stability have a broad application prospect in THz shielding for wearable devices and next generation mobile communication equipment. | Shengyue Hou Wenle Ma Guanghao Li Yi Zhang Yunyun Ji Fei Fan Yi Huang | 2020 | Journal of Materials Science & Technology2020，52，17： | 2 |
| 18 | Methylenetrahydrofolate Reductase Gene C677T Polymorphism and Diabetic Retinopathy: a Meta-Analysis显示文摘Objective To investigate the association between the methylenetetrahydrofolate reductase gene C677T(MTHFR C677T)polymorphism and diabetic retinopathy(DR).Methods A total of 6971 subjects including 2707 DR patients and 4264 controls from 23 studies were enrolled in the study.A random-effects model was applied to estimate the overall effects and the stratified effects of the MTHFR C677T polymorphism on the risk of DR,and study quality was also assessed.Results Strong associations were observed between the MTHFR C677T polymorphism and DR.The carries of MTHFR C677T were more likely to be found in the DR group in relative to the healthy control group with odds ratio 1.6&2.55,and 2.31 respectively in allele contrast model(T vs.C,95%CZ:1.29-2.18,P<0.001,f=7&4%),homozygous model(TT vs.CC,95%CZ:1.70-3.83,P=0.008,72=54.4%)and dominant model(TT+CT vs.CC,95%CZ:1.62-3.29,P<0.001,12=74.7%).This association can also be found in contrast to the Ned(non-complicated diabetic mellitus)group(allele contrast,OR—1.50,95%Ch 1.07-2.11,P=0.032,I2=62.1%;homozygous,OR—2.39,9S%CZ:1.06-5.38,P=0.017,Z2=66.7%;dominant,OR=1.59,95%CZ:0.97-2.62,P=0.056,I2=56.5%).For the heterozygous model(CT vs.CC),the association was significant in contrast to the healthy control group(OR=1.46,95%CZ:1.64-3.69,P=0,P=77.3%),while in contrast to the Ned control group the association was not statistically meaningful(OR=1.38,95%CZ:0.87-2.18,P=0.131,Z2=43.7%).For the recessive model,1.92-fold increased risk was found only in contrast to the Ned control group(95%C1:1.07-3.43,P=0.064,P=55.0%).There was no significant association found in the models in contrast to the DM control group.Conclusion In this meta-analysis,we found an association between the MTHFR C677T polymorphism and DR,especially in contrast to the Ned control group.Further studies are required to establish more definite relationship. | Chang Shen Meng Zhao Yunyun Li Ningpu Liu | 2020 | Chinese Medical Sciences Journal2020，35，1： | 2 |
| 19 | Precursory influence of the Antarctic Oscillation on the onset of Asian summer monsoon显示文摘The Asian summer monsoon(ASM) begins firstly over the Indo-China Peninsula in early May and over the South China Sea(SCS) in mid-May.The different monsoon onset dates can exert distinct effects on the summer rainfall in Asia.Statistical results indicate that the Antarctic Oscillation(AAO) in the boreal winter has a significant precursory influence on the ASM onset dates.In stronger AAO years,both the Mascarene high and the Australia high in March are stronger owing to the 'see-saw' structure of atmospheric circulation over the subtropics and higher latitudes in the Southern Hemisphere,and the tropical intertropical convergence zone(ITCZ) is deeper.Thus,the pressure gradient between the subtropical and tropical regions increases in spring.As a result,the Somalia cross-equatorial flow(SCEF) occurs earlier,strengthens,and enhances the westerlies over the tropical Indian Ocean.The enhanced westerlies impel an eastward withdrawal of the western Pacific subtropical high and intensify the convergence and rising motion at the lower troposphere,accelerating the burst of ASM.Differently,weaker AAO weakens the pressure gradient between the tropical and subtropical regions and delays the establishment of SCEF,resulting in a delayed onset of ASM.This study extends the leading time of seasonal forecast of ASM onset from the previous spring to winter and provides useful information about precursory signals in climate prediction operation. | GAO Hui LIU YunYun WANG YongGuang LI WeiJing | 2013 | Chinese Science Bulletin2013，58，6： | 2 |
| 20 | Review on Effects of Sunlight on the Internal Quality of Peach Fruit显示文摘On the basis of referring plenty of literatures, we summed up the research advance in effects of sun light on the internal quality of peach fruit. This paper discussed the effect of light on the internal quality of peach fruit under the conditions of open cultivation, protected cultivation, bagging and surface covering with reflective film, the mechanism of occurrence and the technical measures to improve the utilization rate of light and light energy, and prospected the future research work. | Zhisheng MA Yuehui WANG Ruixia BAI Jianming LI Yunyun JIA | 2021 | Agricultural Biotechnology2021，10，1： | 2 |
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