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| 1 | LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition显示文摘Despite the structural conservation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity.Here,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.Mechanistically,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding RNA,GAEA(Glucose Aroused for EMT Activation),which associates with an RNA-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of PTEN.The MEX3C-catalyzed PTEN^K27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase activity.With this altered enzymatic activity,PTEN^K27-polyUb dephosphorylates the phosphoserine/threonine residues of TWIST1,SNAI1,and YAP1,leading to accumulation of these master regulators of EMT.Animals with genetic inhibition of PTEN^K27-polyUb,by a single nucleotide mutation generated using CRISPR/Cas9(Pten^K80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing processes.Our findings illustrate an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development. | Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang | 2019 | Cell Research2019，29，4： | 8 |
| 2 | Photoluminescence enhancement of red-emitting GdVO_4:Eu and YVO_4:Eu phosphors by adding zinc显示文摘We synthesized the rare-earth activated R0.94-xEu0.06ZnxVO4 (R: Gd and Y; 0≤x≤0.08) phosphors with a spherical morphology and a smooth surface by the ultrasonic spray pyrolysis. The annealed R0.94-xEu0.06ZnxVO4 crystallized in the tetragonal zircon type structure, belonging to the space group of I41/amd. The incorporation of a small amount of Zn to R0.94Eu0.06VO4 improved the emission characteristics. The emission intensities of the Gd0.88Eu0.06Zn0.06VO4 and Y0.9Eu0.06Zn0.04VO4 phosphors at 619 nm were 72% and 21% stronger than those of the Gd0.94Eu0.06VO4 and Y0.94Eu0.06VO4 phosphors, respectively. We demonstrated that the addition of Zn to R0.94Eu0.06VO4 was quite effective for improving the photoluminescent properties. | K.Park J.Kim K.Y.Kim J.Y.Kim Y.Kim S.J.Dhoble | 2013 | Journal of Rare Earths2013，31，1： | 3 |
| 3 | Prognostic significance of glycaemic control in patients with HBV and HCV‐related cirrhosis and diabetes mellitus显示文摘 | S. Y.Kwon S. S.Kim O. S.Kwon K. A.Kwon M. G.Chung D. K.Park Y. S.Kim Y. S.Koo Y. K.Kim D. J.Choi J. H.Kim | 2005 | Diabetic Medicine2005，，11： | 2 |
| 4 | 肝细胞癌的经皮射频消融:80例病人连续2期治疗分析显示文摘本研究探讨了一些病人需要连续2期经皮射频(RF)消融治疗肝细胞癌(HCC)的原因。回顾6a内1179例(1624次治疗)超声(US)引导下经皮RF消融治疗HCC的资料,对第1期治疗后需要第2期治疗的80例病人进行分析,研究其病案与CT随访的资料。评估了第2期治疗的理由及其结果。1642次经皮RF消融治疗HCC中需要第2期治疗的共80例(4.8%)。需第2期治疗的原因包括:由于病人或操作原因的技术性失败(n=26),因肿瘤残余造成的技术性失败(n=40), | H.Rhim Y.S.Kim D.Ghoi H.K.Lim K.Park 唐光健 | 2008 | 国际医学放射学杂志2008，31，5： | 2 |
| 5 | Equity or Debt Financing: Does Good Corporate Governance Matter?显示文摘 | VivekMande Young K.Park MyungsooSon | 2012 | Corporate Governance: An International Review2012，，： | 1 |
| 6 | 环境保护与亚洲经济发展显示文摘生态上高效的公司管理的演变可以划分为五个阶段:1)总体上冷漠;2)公众意义曙光;3)公司开始采取超出法律要求范围的举措;4)生态李成为公司决策中主要因素的阶段;和5)环境成本内化于公司会计学之中的阶段(目前仍只是理论上的).大多数东亚国家处于第二阶段,但对于尽快向第三和第四阶段推进的重要性有广泛的意识. | Ungush K.Park | 1997 | 产业与环境1997，19，3： | 1 |
| 7 | Differences in breast carcinoma characteristics in newly diagnosed African–American and Caucasian patients显示文摘 | Gloria J.Morris SashiNaidu Allan K.Topham FranGuiles YihuanXu PeterMcCue Gordon F.Schwartz Pauline K.Park Anne L.Rosenberg KristinBrill Edith P.Mitchell | 2007 | Cancer2007，，4： | 1 |
| 8 | Effect‐site concentration of propofol for reduction of remifentanil‐induced cough显示文摘 | J. Y.Kim S. Y.Lee D. H.Kim S. K.Park S. K.Min | 2010 | Anaesthesia2010，，7： | 1 |
| 9 | Design of integrated chassis control logics for AFS and ESP显示文摘 | T.H.HWANG K.PARK S.-J.HEO | | 0，，1： | 1 |
| 10 | Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus)显示文摘 | B.‐K.PARK J.‐H.LIM M.‐S.KIM H.‐I.YUN | 2006 | Journal of Veterinary Pharmacology and Therapeutics2006，，1： | 1 |
| 11 | Effects of HNO3 treatment of TiO2 nanoparticles on the photovoltaic properties of dye-sensitized solar cells显示文摘 | K.Park E.M.Jin H.B.Gu S.E.Shim C.K.Hong | | 0，，： | 1 |
| 12 | Coinfection of hepatitis B and C viruses and risk of hepatocellular carcinoma: Systematic review and meta‐analysis显示文摘 | Lisa Y.Cho Jae JeongYang Kwang‐PilKo BoyoungPark AesunShin Min KyungLim Jin‐KyoungOh SoheePark Yoon JunKim Hai‐RimShin Keun‐YoungYoo Sue K.Park | 2010 | Int J Cancer2010，，1： | 1 |
| 13 | Effect of Synthesis Method on Photoluminescence Properties of Na_2Sr_2Al_2PO_4Cl_9:Ce^(3+) Nanophosphor显示文摘We have synthesized a series of single-composition emission Na_2Sr_2Al_2PO_4Cl_9:Ce^(3+) phosphor by traditional solid state reactions and novel combustion method. Formation of compound was confirmed by X-ray diffraction analysis. The photoluminescence(PL) emission spectra were observed at 376 nm when excited around 322 nm for the various concentrations in both cases. The PL emission spectra of phosphors showed strong Ce^(3+)emission due to the 5d → 4f transition of Ce^(3+)ions. The Ce^(3+)emission intensity in Na_2Sr_2Al_2PO_4Cl_9:Ce^(3+) prepared by combustion was higher than that of solid state reactions. | K.N.Shinde S.J.Dhoble K.Park | 2012 | Nano-Micro Letters2012，4，2： | 1 |
| 14 | Effect of monovalent charge compensators on the photoluminescence properties of Ca_(3)(PO_(4))_(2):Tb^(3+),A^(+)(A=Li,Na,K)phosphors显示文摘Ca_(3-x)(PO_(4))_(2):xTb^(3+)(0.2≤x≤0.4),Ca_(2.3)(PO_(4))_(2):0.35 Tb^(3+),0.35 A^(+)(A=Li,Na,K),and Ca_(2.3)(PO_(4))_(2):0.35 Tb^(3+),yLi^(+)(0.35≤y≤0.455)phosphors were prepared by solid-state reaction.All the prepared phosphors formed a rhombohedral unit cell with the R3c space group.To improve the photoluminescence(PL)properties of the Ca_(2.65)(PO_(4))_(2):0.35 Tb^(3+)phosphor,monovalent charge compensators such as Li^(+),NA^(+),and K^(+)were added to the Ca_(2.65)(PO_(4))_(2):0.35 Tb^(3+)phosphor.The charge compensators acted as fluxes,so they improved the crystallinity.The excitation and emission properties were significantly improved through the incorporation of charge compensators.In particular,among the charge compensators,Li^(+)ion substantially enhanced the emission intensity and color purity.Furthermore,considering the evaporation of Li_(2)CO_(3)during the annealing process,we optimized the concentration of Li^(+)charge compensator to enhance its PL performance.Impressively,the green emission intensity of the Ca_(2.3)(PO_(4))_(2):0.35 Tb^(3+),0.385 Li^(+)phosphor was 260%higher than that of the Ca_(2.65)(PO_(4))_(2):0.35 Tb^(3+)phosphor.We believe that the effect of charge compensators on the PL properties and the optimum concentration of Li^(+)cha rge compensator are useful for the design of phosphors in light-emitting diodes. | G.W.Jung K.Park | 2021 | Journal of Materials Science & Technology2021，，23： | 1 |
| 15 | 查看详情显示文摘 | L.Huang Y.C.Lai K.Park X.G.Wang C.H.Lai and R.A.Gatenby | | 0，，： | 1 |
| 16 | Enhanced thermoelectric performance of spark plasma sintered p-type Ca_(3-x)Y_(x)Co_(4)O_(9+δ)systems显示文摘Highly textured dense Ca3-xYxCo4 O9+δ(0≤x≤0.3)samples were fabricated by combining sol-gel process with spark plasma sintering(SPS).Y^3+substitution for Ca^2+simultaneously increased the Seebeck coefficient and reduced the thermal conductivity.The latter was attributed to the increase in lattice anharmonicity,structural distortion,and grain boundary area,which enhanced the phonon scattering.Ca2.7Y0.3Co4 O9+δshowed the largest dimensionless figure-of-merit(ZT=0.194)at 1073 K because it had the largest Seebeck coefficient and the lowest thermal conductivity.This ZT value was 55%larger than that of undoped Ca3 Co4 O9(0.125 at 1073 K).Therefore,Y^3+substitution,sol-gel powder synthesis,and SPS are highly effective for enhancing the thermoelectric prope rties of Ca_(3)Co_(4)O_(9). | J.S.Cha D.H.Kim H.Y.Hong K.Park | 2020 | Journal of Materials Science & Technology2020，52，20： | 0 |
| 17 | Behavioral evidence for contextual olfactory-mediated avoidance of the ubiquitous phytopathogen Botrytis cinerea by Drosophila suzukii显示文摘Herbivorous insects may benefit from avoiding the smell produced by phytopathogens infecting plant host tissue if the infected tissue reduces insect fitness.However,in many cases the same species of phytopathogen can also infect host plant tissues that do not directly affect herbivore fitness.Thus,insects may benefit from differentiating between pathogen odors emanating from food and nonfood tissues.This is based on the hypothesis that unecessarily staying attentive to pathogen odor from nonfood tissue may incur opportunity costs associated with not responding to other important survival functions.In this study adults of Drosophila suzukii Matsumura,an invasive larval frugivore,showed reduced attraction to the odor of raspberry fruit,a food tissue,when infected with Botrytis cinerea Pers.,a ubiquitous phytopathogen,in favor of odors of uninfected raspberry fruit.Moreover,D.suzukii oviposited fewer eggs on infected raspberry fruit relative to uninfected raspberry fruit.Larval survival and adult size after eclosion were significantly reduced when reared on B.cinerea-infected raspberry relative to uninfected fruit.Interestingly,when the behavioral choice experiment was repeated using Botrytis-infected vsuninfected strawberry leaves,a nonfood tissue,in combination with fresh raspberry fruit,odor from B.cinerea-infected leaves did not reduce D.suzukii attraction to raspberries rel-ative to raspberries with uninfected leaves.These behavioral results illustrate the important role context can play in odor-mediated interactions between insects,plants and microbes.We discuss implications of our findings for developing a repellent that can be useful for the management of D.suzukii. | Dong H.Cha Stephen P.Hesler Gabrielle Brind'Amour Karen S.Wentworth Sara Villani Kerik D.Cox Matthew T.Boucher Anna Wallingford Shinyoung K.Park Jan Nyrop Gregory M.Loeb | 2020 | Insect Science2020，27，4： | 0 |
| 18 | From capture to transport:A review of engineered surfaces for fog collection显示文摘Collecting microscale water droplets suspended in the wind,that is,fog,using permeable surfaces is a promising solution to the worldwide problem of water scarcity and is of great interest to industries,such as mist elimination and recapturing water in cooling towers.In the past few decades,this topic has attracted a drastically increasing number of researchers across a wide range of subjects.However,many aspects remain unclear,such as the definition and process of fog collection,fog collection determined from the perspectives of both the fog capture process and the liquid transport process,and how surface characteristics affect fog collection performance.In this review,we introduce and discuss fog collection from the perspectives of aerodynamics-governed fog-capturing processes and interfacial-phenomena-determined liquid transport processes.Then,an emphasis is given to the design and engineering of permeable surfaces at different length scales to optimize the fog collection performance,including the dimension,morphology,and arrangement of wires at the millimetric scale,unidirectional spreading,and Laplace pressure gradient induced by asymmetric surface geometry and nano-/microstructures.At last,a brief outlook of future research directions is provided. | Youhua Jiang Christian Machado Kyoo-Chul K.Park | 2023 | Droplet2023，2，2： | 0 |
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