|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 植物代谢组学研究进展(英文)显示文摘代谢组学是继基因组学、转录组学和蛋白质组学之后发展起来的一门学科,通过对细胞内的基因表达最终代谢产物的定性和定量分析以及定义细胞或器官的生化表现类型来解释功能基因的表达过程.文中就代谢组学的发展历史、主要研究内容、技术特点、数据处理过程及在植物领域中的应用的最新进展几方面进行阐述,以供读者参考. | 高敏 Praveen K.Saxena 刘春朝 | 2005 | 西北植物学报2005，25，2： | 6 |
| 2 | Melatonin improves the survival of cryopreserved callus of Rhodiola crenulata显示文摘 | YanZhao Li‐WangQi Wei‐MingWang Praveen K.Saxena Chun‐ZhaoLiu | 2010 | Journal of Pineal Research2010，，1： | 1 |
| 3 | Adiponectin activation of AMPK disrupts leptin‐mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS‐3)显示文摘 | Jeffrey A.Handy Neeraj K.Saxena PingpingFu SongbaiLin Jamie E.Mells Nitika A.Gupta Frank A.Anania | 2010 | J Cell Biochem2010，，5： | 1 |
| 4 | A rapid plate assay for screening l‐asparaginase producing micro‐organisms显示文摘 | R.Gulati R. K.Saxena R.Gupta | 2003 | Letters in Applied Microbiology2003，，1： | 1 |
| 5 | Essential oil composition of Mentha pulegium L. growing wild in the north‐western Himalayas India显示文摘 | V. K.Agnihotri P. L.Dhar R. K.Thappa Baleshwar B. K.Kapahi R. K.Saxena G. N.Qazi | 2005 | Flavour Fragr. J2005，，6： | 1 |
| 6 | Synthesis and cytotoxic evaluation of substituted 3-(3'-indolyl-/3'-pyridyl)-isoxazolidines and bis-indoles显示文摘Regio-and stereoselective 1,3-dipolar cycloadditions of C-(3-indolyl)-N-phenylnitrone(10)were carried out with different mono-substituted,disubstituted and cyclic dipolarophiles under mono-mode microwave irradiation to obtain substituted 3-(indol-30-yl)-N-phenyl-isoxazolidines(16–22).Reactions of nitrone(10)with allenic esters under similar conditions afforded,via a domino process,bis-indole derivatives(23a–c)along with compounds 24 and 25.Similarly,reactions of C-(3-pyridyl)-N-phenylnitrone(26)with mono-substituted,disubstituted and cyclic dipolarophiles were carried out in refluxing dry toluene to obtain substituted 3-(30-pyridyl)-Nphenylisoxazolidines(27–34).Some of the compounds(16f,18b,23a,23c,27c and 29f)display significant cytotoxicity against a number of human cancer cell lines. | Vishal Sharma Raman Kalia Tilak Raj Vivek K.Gupta Nitasha Suri Ajit K.Saxena Deepak Sharma Surinderjit S.Bhella Gurpinder Singh Mohan Paul S.Ishar | 2012 | Acta Pharmaceutica Sinica B2012，2，1： | 0 |
| 7 | Calcarea carbonica treatment rescues lipopolysaccharide-induced inflammatory response in human mononuclear cells via downregulation of inducible cyclooxygenase pathway显示文摘Objective: Prolonged use of nonsteroidal anti-inflammatory drugs is associated with severe side effects and toxicity. Therefore, we studied the anti-inflammatory role of Calcarea carbonica which had minimal toxicity at the low doses.Methods: THP-1 human mononuclear cells were treated with C. carbonica to evaluate the 50% cytotoxicity concentration(CC_(50)) and 50% effective concentration(EC_(50)). Cell survival was evaluated in lipopolysaccharide-stimulated C. carbonica-treated cells. Nitric oxide(NO) and tumor necrosis factor-a(TNF-a) were measured to evaluate the anti-inflammatory activity of C. carbonica. Cyclooxygenase-2(COX-2) protein expression was determined by Western blotting analysis, and the interaction of C. carbonica with the COX-2 protein was evaluated using molecular docking simulation.Results: The CC_(50) and EC_(50) of C. carbonica were found to be 43.26 and 11.99 mg/mL, respectively. The cell survival assay showed a 1.192-fold(P = 0.0129), 1.443-fold(P = 0.0009) and 1.605-fold(P = 0.0004)increase in cell survival at 24, 48 and 72 h after initiating C. carbonica treatment, respectively. C. carbonica-treated cells showed a reduction in NO levels by 2.355 folds(P = 0.0001), 2.181 folds(P = 0.0001) and 2.071 folds(P = 0.0001) at 24, 48 and 72 h, respectively. The treated cells also showed a reduction in TNFa levels by 1.395 folds(P = 0.0013), 1.541 folds(P = 0.0005) and 1.550 folds(P = 0.0005) at 24, 48 and72 h, respectively. In addition, a 1.193-fold reduction(P = 0.0126) in COX-2 protein expression was found in C. carbonica-treated cells. The molecular docking showed interaction of C. carbonica with the phenylalanine 367 residue present in active site of Cox-2.Conclusion: C. carbonica exhibited anti-inflammatory properties in lipopolysaccharide-stimulated cells by significantly reducing NO production and TNF-a level through downregulation of the COX-2 protein. This effect is probably mediated through interaction of C. carbonica with the phenylalanine 367 residue present in active site of Cox-2. | Swatantra Kumar Vimal KMaurya Debadatta Nayak Anil Khurana Raj KManchanda Srinivasulu Gadugu Madan LBBhatt Shailendra K.Saxena | 2020 | Journal of Integrative Medicine2020，18，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员