|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Changes in lipid metabolism in chronic hepatitis C显示文摘AIM: To investigate the relationship between certain biochemical parameters of lipid metabolism in the serum and steatosis in the liver.METHODS: The grade of steatosis (0-3) and histological activity index (HAI, 0-18) in liver biopsy specimens were correlated with serum alanine aminotransferase (ALT), total cholesterol and triglyceride levels in 142 patients with chronic hepatitis C (CH-C), and 28 patients with non-alcoholic fatty liver disease (NAFLD) without hepatitis C virus (HCV) infection. The serum parameters were further correlated with 1 797 age and sex matched control patients without any liver diseases.RESULTS: Steatosis was detected in 90 out of 142 specimens (63%) with CH-C. The ALT levels correlated with the grade of steatosis, both in patients with CH-C and NAFLD (P<0.01). Inserting the score values of steatosis as part of the HAI, correlation with the ALT level (P<0.00001) was found. The triglyceride and cholesterol levels were significantly lower in patients with CH-C (with and without steatosis), compared to the NAFLD group and to the virus-free control groups.CONCLUSION: Our study confirms the importance of liver steatosis in CH-C which correlates with lower lipid levels in the sera. Inclusion of the score of steatosis into HAI, in case of CH-C might reflect the alterations in the liver tissue more precisely, while correlating with the ALT enzyme elevation. | Katalin Jármay Gizella Karácsony András Nagy Zsuzsa Schaff | 2005 | World Journal of Gastroenterology2005，11，41： | 22 |
| 2 | Evaluation of immunogenicity and reactogenicity of recombinant DNA hepatitis B vaccine produced in India显示文摘AIM: (1) To gain information on immune responses to an accelerated schedule of 0, 1, and 2 mo in paramedical staff and BDS students who are at an increased risk of getting hepatitis B infection and come under high risk groups. (2) To assess the efficacy and safety of EnivacHB in different age groups, using genetically modified yeast strain Pichia pastoris, a new recombinant hepatitis B vaccine developed and manufactured in India.METHODS: A prospective, comparative, and single blinded trial of rapid (0, 1, and 2 mo) hepatitis B immunization schedulewas reported. A total of three hundred and seven (212 females and 95 males) healthy volunteers divided into three age groups (18-29, 30-39,and 40-49) were enrolled after screening for markers of hepatitis B. All the volunteers received 20 mg of the vaccine intramuscularly at 0, 1, and 2 mo.RESULTS: Geometric mean titers were calculated pre and post vaccination. Before immunization the GMT was 0.0124 mIU/mL. One month after the administration of the third dose of recombinant vaccine 296/307 (96.5%)subjects achieved seroprotective levels of anti-HBs. The geometric mean anti-HBs titers achieved after one month of the third dose was 2 560.0 mIU/mL. The geometric mean anti-HBs titer of males was 2 029.0 mIU/mL, while that of the females was 2 759.0 mIU/mL. In the age group of 18-29 years, anti-HBs titer was 3 025.0 mIU/mL, while that in the age group of 30-39 years was 2096.0 mIU/mL. In third age group of 40-49 years, antiHBs titer was 1 592.0 mIU/mL. Hyper-responses (antiHBs≥100 mIU/mL) were shown in 88.0% (271/307) of subjects. Eleven (3.5%) subjects responded poorly to the vaccine in the age group of 40-49 years. There was only mild pain at the site of injection otherwise there were no other adverse drug reactions (ADRs).CONCLUSION: This vaccine (Enivac-HB) is safe and efficacious, providing significant protection after the third dose and rapid hepatitis B immunization schedule of 0, 1, and 2 mo can be recommended whenever rapid protection is the goal. | Zahid Hussain Syed S Ali Syed A Husain Mohammad Raish Deepika R Sharma Premashis Kar | 2005 | World Journal of Gastroenterology2005，11，45： | 3 |
| 3 | Elevated miR-33a and miR-224 in steatotic chronic hepatitis Cliver biopsies显示文摘AIM:To assess the expression of selected microRNAs(miRNA) in hepatitis C,steatotic hepatitis C,noninfected steatotic and normal liver tissues.METHODS:The relative expression levels of miR-21,miR-33 a,miR-96,miR-122,miR-125 b,miR-221 and miR-224 were determined in 76 RNA samples isolated from 18 non-steatotic and 28 steatotic chronic hepatitis C(CHC and CHC-Steatosis,respectively) cases,18 non-infected,steatotic liver biopsies of metabolic origin(Steatosis) and 12 normal formalin-fixed paraffin-embedded liver tissues using TaqMan MicroRNA Assays.All CHC biopsy samples were obtained prior to initiating therapy.Patients' serum biochemical values,which included glucose,triglyceride,cholesterol,alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl-transferase(GGT),alkaline phosphatase(AP),were obtained and correlated with relative miRNA expression.RESULTS:When compared with control non-infected liver samples,miR-122 and miR-221 levels were reduced in CHC-Steatosis(P < 0.03) and in CHC,CHCSteatosis and Steatosis(P < 0.01).Alternatively,the expression of miR-33 a and miR-224 were elevated in CHC-Steatosis and Steatosis in comparison to control tissue(P < 0.01).The levels of miR-33 a and miR-224 in CHC-Steatosis(P < 0.02) and miR-224 in Steatosis(P < 0.001) were increased in comparison to CHC samples.By contrast,the expression of miR-21 did not differ statistically between diseased and normal liver samples.Levels of miR-33 a correlated negatively with serum AST and AP levels in Steatosis as well as with necroinflammatory grade in CHC,whereas miR-21 correlated positively with AST in Steatosis and displayed negative correlation with triglyceride level in CHC-Steatosis.In contrast,miRNA levels were not correlated with ALT,GGT,cholesterol levels or fibrosis stage.CONCLUSION:Differences in miRNA expression were observed between CHC and steatotic CHC,CHC and steatotic liver,but not between steatotic CHC and steatotic liver of metabolic origin. | Gabor Lendvai Katalin Jármay Gizella Karácsony Tünde Halász Ilona Kovalszky Kornélia Baghy Tibor Wittmann Zsuzsa Schaff András Kiss | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 4 | 在肝的 G6PT-H6PDH-11HSD1 三个一组和它在新陈代谢的症候群的 pathomechanism 的含意显示文摘 The metabolic syndrome, one of the most common clinical conditions in recent times, represents a combination of cardiometabolic risk determinants, including central obesity, glucose intolerance, insulin resistance, dyslipidemia, non-alcoholic fatty liver disease and hypertension. Prevalence of the metabolic syndrome is rapidly increasing worldwide as a consequence of common overnutrition and consequent obesity. Although a unifying picture of the pathomechanism is still missing, the key role of the pre-receptor glucocorticoid activation has emerged recently. Local glucocorticoid activation is catalyzed by a triad composed of glucose-6-phosphate-transporter, hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum. The elements of this system can be found in various cell types, including adipocytes and hepatocytes. While the contribution of glucocorticoid activation in adipose tissue to the pathomechanism of the metabolic syndrome has been well established, the relative importance of the hepatic process is less understood. This review summarizes the available data on the role of the hepatic triad and its role in the metabolic syndrome, by confronting experimental findings with clinical observations. | Ibolya Czegle Miklós Csala József Mandl Angelo Benedetti István Karádi Gábor Bánhegyi | 2012 | World Journal of Hepatology2012，4，4： | 2 |
| 5 | Evolution of microstructure and mechanical properties during annealing of cold-rolled AA8011 alloy显示文摘 | Roy R K Kar S Das S | 2009 | J Alloys Compd2009，468，12： | 1 |
| 6 | Methylglyoxal increase in uremia with special reference to snakebite-mediated acute renal failure 显示文摘 | Mukhopadhyay S Ghosh A Kar M | 2008 | Clin Chim Acta2008，391，12： | 1 |
| 7 | New attachment following surgical treatment of human periodontal disease显示文摘 | LINDHE J KARRING T | 1982 | J Clin Periodontol1982，9，4： | 1 |
| 8 | Theoretical study of Si impurities in BN nanotubes显示文摘 | Guerini S Kar T Piquini P | 2004 | The European Physical Journal B-Condensed Matter and Complex Systems2004，38，3： | 1 |
| 9 | Amine terminated poly(ethylene glycol)benzoate modified epoxy networks显示文摘 | Samanta B C Maity T Kar S | 2005 | Pigment & Resin Technology2005，34，1： | 1 |
| 10 | Comparative analysis of the nail xenografts with cartilage autografts in eyelid reconstruction显示文摘 | (O)zkaya (O) Kar(s)idag S Egemen O | | 0，，： | 1 |
| 11 | Beta-amyloid-related peptides inhibit potassium-evoked acetylcholine release from rat hippocampal slices显示文摘 | Kar S Seto D Gaudreau P | 1996 | J Neurosci1996，16，3： | 1 |
| 12 | Convex fuzzy mappings显示文摘 | NANDA S KAR K | 1992 | Fuzzy Sets and Systems1992，48，1： | 1 |
| 13 | Watchman left atrial appendage closure in atrial fibrillation patients 75 years or greater;a sub-analysis of the protect at study显示文摘 | Kar S Doshi S Holmes D | | Journal of the American College of Cardiology0，，： | 1 |
| 14 | Relativistically correct hole-boring and ion acceleration by circularly polarized laser pulses显示文摘 | A P L Robinson P Gibbon M Zepf S Kar R G Evans C Bellei | 2009 | Plasma Physics and Controlled Fusion2009，，2： | 1 |
| 15 | Testing of MEMS capacitive accelerometer structure through electro-static actuation 显示文摘 | KAR S K SWAMY K B M MUKHERJEE B | 2013 | Microsystem Tech- nologies2013，19，1： | 1 |
| 16 | Quality of life assessment in therandomized PROTECT AF (Percutaneous Closure of the LeftAtrial Appendage Versus Warfarin Therapy for Prevention ofStroke in Patients With Atrial Fibrillation) trial of patients atrisk for stroke with nonvalvular atrial fibrillation显示文摘 | Alii 0 Doshi S Kar S | 2013 | J Am CollCardiol2013，61，17： | 1 |
| 17 | Methane hydrate formation and dissociation in oil-in-water emulsion显示文摘 | KAKATI H KAR S MANDALA | 2014 | Energy&Fuels2014，28，7： | 1 |
| 18 | New attachment following surgical treatment of human periodontal disease 显示文摘 | Nyman S Lindhe J Karring T | 1982 | J Clin Periodontol1982，9，4： | 1 |
| 19 | Use of acrylate-based liquid rubbers as toughening agents and adhesive property modifiers of epoxy resin 显示文摘 | Kar S Banthia A K | 2004 | Journal of Applied Polymer Science2004，92，6： | 1 |
| 20 | Percutaneous mitral repair with the Mitr- aClip system : safety and midterm durability in the initial EVEREST ( Endovas- cular Valve Edge-to-Edge REpair Study ) cohort 显示文摘 | Feldman T Kar S Rinaldi M | 2009 | J Am Coll Cardiol2009，54，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员