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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Orientation to learning context modulates retrieval processing for unrecognized words显示文摘Explicit memory errors may occur when individuals fail to retrieve information about items previously studied (item memory) or about the learning context (source memory). We examined electrophysiological measures during recognition failure in order to determine the influence of retrieval orientation for item versus source information. Recognition failure was associated with brain potentials distinct from those associated with success. Furthermore, source-memory failures were associated with earlier-onset brain potentials with a more anterior distribution compared to item-memory failures. Neurocognitive processing was thus modulated by retrieval orientation so as to differentially influence neural correlates of successful versus unsuccessful retrieval. | GUO ChunYan CHEN WenJun TIAN Tian Ken A PALLER Joel L VOSS | 2010 | Chinese Science Bulletin2010，55，26： | 6 |
| 3 | Clinical use of bone-targeting radiopharmaceuticals with focus on alpha-emitters显示文摘Various single or multi-modality therapeutic options are available to treat pain of bone metastasis in patients with prostate cancer.Different radionuclides that emitβ-rays such as 153Samarium and 89Strontium and achieve palliation are commercially available.In contrast toβ-emitters,223Radium as a a-emitter has a short path-length.The advantage of the a-emitter is thus a highly localized biological effect that is caused by radiation induced DNA double-strand breaks and subsequent cell killing and/or limited effectiveness of cellular repair mechanisms.Due to the limited range of the a-particles the bone surface to red bone marrow dose ratio is also lower for 223Radium which is expressed in a lower myelotoxicity.The a emitter 223Radium dichloride is the first radiopharmaceutical that significantly prolongslife in castrate resistant prostate cancer patients with wide-spread bone metastatic disease.In a phaseⅢ,randomized,double-blind,placebo-controlled study 921patients with castration-resistant prostate cancer and bone metastases were randomly assigned.The analysis confirmed the 223Radium survival benefit compared to the placebo(median,14.9 mo vs 11.3 mo;P<0.001).In addition,the treatment results in pain palliation and thus,improved quality of life and a delay of skeletal related events.At the same time the toxicity profile of223Radium was favourable.Since May 2013,223Radium dichloride(Xofigo?)is approved by the US Food and Drug Administration. | Hinrich A Wieder Michael Lassmann Martin S Allen-Auerbach Johannes Czernin Ken Herrmann | 2014 | World Journal of Radiology2014，6，7： | 4 |
| 4 | Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells显示文摘AIM:To investigate the effects of four probiotic bacteria and their combination on human mast cell gene expression using microarray analysis.METHODS:Human peripheral-blood-derived mast cells were stimulated with Lactobacillus rhamnosus (L.rhamnosus) GG (LGG),L.rhamnosus Lc705 (Lc705),Propionibacterium freudenreichii ssp.shermanii JS (PJS) and Bifidobacterium animalis ssp.lactis Bb12 (Bb12) and their combination for 3 or 24 h,and were subjected to global microarray analysis using an Affymetrix GeneChip Human Genome U133 Plus 2.0 Array.The gene expression differences between unstimulated and bacteria-stimulated samples were further analyzed with GOrilla Gene Enrichment Analysis and Visualization Tool and MeV Multiexperiment Viewer-tool.RESULTS:LGG and Lc705 were observed to suppress genes that encoded allergy-related high-affinity IgE receptor subunits α and γ (FCER1A and FCER1G,respectively) and histamine H4 receptor.LGG,Lc705 and the combination of four probiotics had the strongest effect on the expression of genes involved in mast cell immune system regulation,and on several genes that encoded proteins with a pro-inflammatory impact,such as interleukin (IL)-8 and tumour necrosis factor alpha.Also genes that encoded proteins with anti-inflammatory functions,such as IL-10,were upregulated.CONCLUSION:Certain probiotic bacteria might diminish mast cell allergy-related activation by downregulation of the expression of high-affinity IgE and histamine receptor genes,and by inducing a pro-inflammatory response. | Anna Oksaharju Matti Kankainen Riina A Kekkonen Ken A Lindstedtt Petri T Kovanen Riitta Korpela Minja Miettinen | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 5 | Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target显示文摘 | Ashfaq Shuaib Ken Butcher Askar A Mohammad Maher Saqqur David S Liebeskind | 2011 | Lancet Neurology2011，，10： | 3 |
| 6 | DNA Repair by ERCC1 in non small-cell lung cancer and cisplatin-based adjuvant chemotherapy显示文摘 | KEN A OLAUSSEN RIANE D | 2006 | NewEngland J Med2006，355，10： | 1 |
| 7 | Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical-size defects of sheep long bones 显示文摘 | KEN E MURAGLIA A CORSI A | 2000 | J Bi- omed Mater Res2000，49，3： | 1 |
| 8 | The somatotropic axis in a short children born small for gestational age: Relation to insulin resistance显示文摘 | Kale A Maria V Ken KL | 2002 | Pediatric Research2002，51，： | 1 |
| 9 | Heat Shock Protein 72: Enhances Manganese Superoxide Dismutase Activity during Myocardial Ischemia-reperfusion Injury Associated with Mitochondrial Protection and Apoptosis Reduction 显示文摘 | Ken S Bari M Iran A S | 2002 | Circulation2002，106，12： | 1 |
| 10 | Complex N-glycan number and degree of branching ~te to regulate cell proliferation and differentiation 显示文摘 | Ken S Emilu A Partride | 2007 | Cell2007，129，1： | 1 |
| 11 | Global association of air pollution and heart failure: a systematic review and meta-analysis显示文摘 | Anoop SV Shah Jeremy P Langrish Harish Nair David A McAllister Amanda L Hunter Ken Donaldson David E Newby Nicholas L Mills | 2013 | The Lancet2013，，： | 1 |
| 12 | A polymorphism regulates CYP4A11 transcriptional activity and is associated with hypertension in a Japanese population显示文摘 | Ken S Hiroshi A Tomohiro K et a l | 2008 | Hypertension2008，52，6： | 1 |
| 13 | Soil seed bank of an upland calcareous grassland after 6 years of climate and management manipulations显示文摘 | Olatunde A M ken Thompson Saraha M B | 1998 | Journal of Applied Ecology1998，35，54： | 1 |
| 14 | Differential geometrical conditions between geodesic curves and ruled surfaces显示文摘 | Ayyildiz N A Cken C Yucesan A | 2002 | Balkan Journal of Geometry and Its Applications2002，7，1： | 1 |
| 15 | Strengthening Biomedicine's Roots 显示文摘 | Dill Ken A | 1999 | Nature1999，400，： | 1 |
| 16 | Analysis of K- ras mutation in pancreatic tissue after fine needle aspirates 显示文摘 | Brigitte P Sonke A Ken B | 1999 | Anticancer Res1999，19，10： | 1 |
| 17 | Genotoxic ; stress abrogates renewalolMelanoc; yte stem cells by triggering their differentiation显示文摘 | Ken I Takahiro A Nguyen TB | 2009 | CELL2009，137，： | 1 |
| 18 | A robust fuzzy autonomous underwater vehicle (AUV) docking approach for unknown current disturbances 显示文摘 | KEN T EDGAR A PIERRE-PHILIPPE J B | 2012 | IEEE Journal of Oceanic Engineering2012，37，2： | 1 |
| 19 | Quantitative Contrast-EnhancedUltrasound Parameters inCrohn Disease: Their Role inDisease Activity DeterminationWith U1trasound显示文摘 | Mede11in-Kowalewski A Wi 1 kens R Wilson A | 2016 | AJR Am JRoentgenol2016，206，1： | 1 |
| 20 | Spray cooling of enhanced surfaces : Impact of structured surface geometry and spray axis in- clination显示文摘 | Eric A Silk Jungho Kim Ken Kiger | 2006 | International Journal of Heat and Mass Transfer2006，49，： | 1 |
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