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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Significant Reduction of Interfacial Thermal Resistance and Phonon Scattering in Graphene/Polyimide Thermally Conductive Composite Films for Thermal Management显示文摘The developing flexible electronic equipment are greatly affected by the rapid accumulation of heat,which is urgent to be solved by thermally conductive polymer composite films.However,the interfacial thermal resistance(ITR)and the phonon scattering at the interfaces are the main bottlenecks limiting the rapid and efficient improvement of thermal conductivity coefficients(λ)of the polymer composite films.Moreover,few researches were focused on characterizing ITR and phonon scattering in thermally conductive polymer composite films.In this paper,graphene oxide(GO)was aminated(NH_(2)-GO)and reduced(NH_(2)-rGO),then NH_(2)-rGO/polyimide(NH_(2)-rGO/PI)thermally conductive composite films were fabricated.Raman spectroscopy was utilized to innovatively characterize phonon scattering and ITR at the interfaces in NH_(2)-rGO/PI thermally conductive composite films,revealing the interfacial thermal conduction mechanism,proving that the amination optimized the interfaces between NH_(2)-rGO and PI,reduced phonon scattering and ITR,and ultimately improved the interfacial thermal conduction.The in-planeλ(λ∥)and through-planeλ(λ_(⊥))of 15 wt%NH_(2)-rGO/PI thermally conductive composite films at room temperature were,respectively,7.13 W/mK and 0.74 W/mK,8.2 timesλ∥(0.87 W/mK)and 3.5 timesλ_(⊥)(0.21 W/mK)of pure PI film,also significantly higher thanλ∥(5.50 W/mK)andλ_(⊥)(0.62 W/mK)of 15 wt%rGO/PI thermally conductive composite films.Calculation based on the effective medium theory model proved that ITR was reduced via the amination of rGO.Infrared thermal imaging and finite element simulation showed that NH_(2)-rGO/PI thermally conductive composite films obtained excellent heat dissipation and efficient thermal management capabilities on the light-emitting diodes bulbs,5G high-power chips,and other electronic equipment,which are easy to generate heat severely. | Kunpeng Ruan Yongqiang Guo Chuyao Lu Xuetao Shi Tengbo Ma Yali Zhang Jie Kong Junwei Gu | 2021 | Research2021，，1： | 14 |
| 3 | Numerical Simulation of a Class of Nonlinear Wave Equations by Lattice Boltzmann Method显示文摘In this paper,we develop a lattice Boltzmann model for a class ofone-dimensional nonlinear wave equations,including the second-order hyperbolictelegraph equation,the nonlinear Klein-Gordon equation,the damped and undampedsine-Gordon equation and double sine-Gordon equation.By choosing properly theconservation condition between the macroscopic quantity u,and the distributionfunctions and applying the Chapman-Enskog expansion,the governing equation isrecovered correctly from the lattice Boltzmann equation.Moreover,the local equilib-rium distribution function is obtained.The results of numerical examples have beencompared with the analytical solutions to confirm the good accuracy and the applica-bility of our scheme. | Yali Duan Linghua Kong Min Guo | 2017 | Communications in Mathematics and Statistics2017，5，1： | 4 |
| 4 | Multisymplectic Fourier pseudo-spectral integrators for Klein-Gordon-Schrdinger equations显示文摘A multisymplectic Fourier pseudo-spectral scheme,which exactly preserves the discrete multisymplectic conservation law,is presented to solve the Klein-Gordon-Schrdinger equations.The scheme is of spectral accuracy in space and of second order in time.The scheme preserves the discrete multisymplectic conservation law and the charge conservation law.Moreover,the residuals of some other conservation laws are derived for the geometric numerical integrator.Extensive numerical simulations illustrate the numerical behavior of the multisymplectic scheme,and demonstrate the correctness of the theoretical analysis. | KONG LingHua WANG Lan JIANG ShanShan DUAN YaLi | 2013 | Science China Mathematics2013，56，5： | 3 |
| 5 | Spectral-like resolution compact ADI finite difference method for the multi-dimensional Schrodinger equations 显示文摘 | Kong Linghua Duan Yali Wang Lan | 2012 | Math Com- put Model2012，55，89： | 1 |
| 6 | Overexpression of Aurora-A contributes to malignant development of human esophageal squamous cell carcinoma显示文摘 | Tong Tong Yali Zhong jianping kong | 2004 | Clin Cancer Res2004，10，1： | 1 |
| 7 | Super-assembly of integrated gold magnetic assay with loopmediated isothermal amplification for point-of-care testing显示文摘With the increasing global threat of various diseases and infections,it is essential to develop a fast,low-cost,and easy-to-use point-of-care testing(POCT)system for inspections at all levels of medical institutions and self-examination at home.In this work,gold magnetic nanoparticles(GMNPs)are used as the key material,and a rapid visual detection method is designed through integrating loop-mediated isothermal amplification(LAMP)and lateral flow assay(LFA)biosensor for detecting a variety of analytes which includes whole blood,buccal swabs,and DNA.It is worth to note that the proposed method does not need DNA extraction.Furthermore,uracil DNA glycosylase(UDG)is employed to eliminate carrier contamination for preventing false positive results.The whole detection process can be finished within 25 min.The accuracy of detection is measured by assessing the polymorphisms of the methylenetetrahydrofolate reductase(MTHFR)C677T.The detection limit of the newly developed extraction-free detection system for MTHFR C677T is 0.16 ng/μL.A preliminary clinical study of the proposed method is carried out by analyzing 600 clinical samples(including 200 whole blood samples,100 buccal swabs,and 300 genomic DNA samples).The results indicate that the proposed method is 100%consistent with the sequencing results which provides a new choice for POCT and shows a broad application prospect in all levels of medical clinics and at home. | Jianping Liang Jie Zeng Xiaojuan Huang Tengteng Zhu Yonglong Gong Chen Dong Xiangrong Wang Lingzhi Zhao Lei Xie Kang Liang Qiongxiang Tan Yali Cui Biao Kong Wenli Hui | 2023 | Nano Research2023，16，1： | 0 |
| 8 | Physiological and Proteomic Analyses Reveal Effects of Putrescine-Alleviated Aluminum Toxicity in Rice Roots显示文摘The effects of putrescine on improving rice growth under aluminum(Al)toxicity conditions have been previously demonstrated,however,the underlying mechanism remains unclear.In this study,treatment with 50 pmol/L Al significantly decreased rice root growth and whole rice dry weight,inhibited Ca2+uptake,decreased ATP syn thesis,and in creased Al,H2O2 and malon dialdehyde(MDA)con tents,whereas the application of putrescine mitigated these negative effects.Putrescine increased root growth and total dry weight of rice,reduced total Al content,decreased H2O2 and MDA contents by increasing antioxidant enzyme(superoxide dismutase,peroxidase,catalase and glutathione S・transferase)activities,increased Ca2+uptake and energy product!oru Proteomic analyses using data-independent acquisition successfully identified 7934 proteins,and 59 representative proteins exhibiting fold-change values higher than 1.5 were randomly selected.From the results of the proteomic and biochemical analyses,we found that putrescine significantly inhibited ethylene biosynthesis and phosphorus uptake in rice roots,increased pectin methylation,decreased pectin content and apoplastic Al deposit!on in rice roots.Putrescine also alleviated Al toxicity by repairing damaged DNA and increasing the proteins involved in maintaining plasma membra ne integrity and normal cell proliferation.These fin dings improve our understanding of how putrescine affects the rice response to Al toxicity,which will facilitate further studies on environmental protection,crop safety,in novations in rice performance and real-world producti on. | ZHU Chunquan HU Wenjun CAO Xiaochuang ZHU Lianfeng KONG Yali JIN Qianyu SHEN Guoxin WANG Weipeng ZHANG Hui ZHANG Junhua | 2021 | Rice science2021，28，6： | 0 |
| 9 | Hydrogen Sulfide Improves Rice Seed Germination by Regulating Aluminum Absorption,Internal Antioxidant Enzyme System and Osmotic Balance under Aluminum Toxicity Conditions显示文摘Uncovering the mechanism of hydrogen sulfide(H2S)in improving rice seed germination under aluminum(Al)toxicity conditions is important for rice production in acidic soil.In the present study,an Al sensitive rice variety Kasalath was used.Pretreatment with 0.1 mmol/L sodium hydrosulfide(NaHS,H2S donor)under 70 mmol/L AlCl3(indicated as Al+NaHS treatment)increased rice seed germination by 27.95%,germination potential by 474.16%,and the germination index by 43.44%,compared with Al treatment.The treatment of Al+NaHS reduced the Al content in rice seeds by 16.31%and 32.11%and increased the internal H2S content by 3.82%and 8.90%at 3 and 5 d of treatment,respectively,compared with Al treatment.Al+NaHS treatment significantly increased the activities of superoxide dismutase(SOD)。 | WEI Qianqian KONG Yali XIANG Xingjia ZHU Lianfeng LIU Jia TIAN Wenhao JIN Qianyu YU Yijun ZHANG Junhua ZHU Chunquan | 2023 | Rice science2023，30，4： | 0 |
| 10 | LncRNA-AP006284.1 promotes prostate cancer cell growth and motility by forming RNA-DNA triplexes and recruiting GNL3/SFPQ complex to facilitate RASSF7 transcription显示文摘Long noncoding RNAs(lncRNAs)are known to be involved in transcriptional regulation and their deregulation is associated with the development of human diseases such as cancer.1,2 LncRNA can directly bind to purine-rich double-stranded DNA sequences through Hoogsteen base pairing to form an RNA-DNA triplex motifs and regulate gene expression.3,4,5 However,its regulatory mechanisms and functions in tumors remain unclear.Here,we report that the LMNTD2 antisense RNA 1(LMNTD2-AS1,also known as AP006284.1)is highly expressed in prostate cancer(PCa)and positively correlated with the expression of its adjacent coding gene N-terminal Ras-association domain family 7(RASSF7).Mechanistically,AP006284.1 tethers to the RASSF7 promoter via RNA-DNA triplexes in cis-acting manner,which enhances chromatin accessibility and recruits the transcription factor complex GNL3/SFPQ to activate the expression of RASSF7,a repressor of the Hippo signaling pathway.Consistently,overexpression of either AP006284.1 or RASSF7 inactivated the Hippo signaling and malignant proliferation of PCa cells. | Yali Lu Yan Lin Xiaoyang Zhang Jun Yan Zhe Kong Lu Zhang Chenji Wang Yan Huang Shimin Zhao Yao Li | 2023 | Genes & Diseases2023，10，2： | 0 |
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