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| 1 | Evolutionary trace analysis of eukaryotic DNA topoisomerase I superfamily: Identification of novel antitumor drug binding site显示文摘The studies of novel inhibitors of DNA topoisomerase I (Topo I) have already be-come very promising in cancer chemotherapy. Identifying the new drug-binding residues is playing an important role in the design and optimization of Topo I inhibitors. The designed com-pounds may have novel scaffolds, thus will be helpful to overcome the toxicities of current camptothecin (CPT) drugs and may provide a solution to cross resistance with these drugs. Mul-tiple sequence alignments were performed on eukaryotic DNA topoisomerase I superfamily and thus the evolutionary tree was constructed. The Evolutionary Trace method was applied to iden-tify functionally important residues of human Topo I. It has been demonstrated that class-specific hydrophobic residues Ala351, Met428, Pro431 are located around the 7,9-position of CPT, indi-cating suitable substitution of hydrophobic group on CPT will increase antitumor activity. The conservative residue Lys436 in the superfamily is of particular interest and new CPT derivatives designed based on this residue may greatly increase water solubility of such drugs. It has also been demonstrated that the residues Asn352 and Arg364 were conservative in the superfamily, whose mutation will render CPT resistance. As our molecular docking studies demonstrated they did not make any direct interaction with CPT, they are important drug-binding site residues for future design of novel non-camptothecin lead compounds. This work provided a strong basis for the design and synthesis of novel highly potent CPT derivatives and virtual screening for novel lead compounds. | SONG Yunlong QI Yunpeng ZHANG Wannian SHENG Chunquan ZHANG Min YAO Jianzhong YU Jianxin MIAO Zhenyuan ZHOU Youjun ZHU Ju L(U) Jiaguo | 2005 | Science China(Life Sciences)2005，48，4： | 5 |
| 2 | Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease显示文摘Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferroptosis,a novel form of regulated cell death characterized by iron-driven lipid peroxidation,was comprehensively activated in liver tissues from MAFLD patients.The canonical-GPX4(cGPX4),which is the most important negative controller of ferroptosis,is downregulated at protein but not mRNA level.Interestingly,a non-canonical GPX4 transcript-variant is induced(inducible-GPX4,iGPX4)in MAFLD condition.The high fat-fructose/sucrose diet(HFFD)and methionine/choline-deficient diet(MCD)-induced MAFLD pathologies,including hepatocellular ballooning,steatohepatitis andfibrosis,were attenuated and aggravated,respectively,in cGPX4-and iGPX4-knockin mice.cGPX4 and iGPX4 isoforms also displayed opposing effects on oxidative stress and ferroptosis in hepatocytes.Knockdown of iGPX4 by siRNA alleviated lipid stress,ferroptosis and cell injury.Mechanistically,the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic-active monomer to enzymatic-inactive oligomers upon lipid stress,and thus promotes ferroptosis.Co-immunoprecipitation and nano LC–MS/MS analyses confirmed the interaction between iGPX4 and cGPX4.Our results reveal a detrimental role of non-canonical GPX4 isoform in ferroptosis,and indicate selectively targeting iGPX4 may be a promising therapeutic strategy for MAFLD. | Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 3 |
| 3 | Trifluoromethyl-promoted homocamptothecins:synthesis and biological activity显示文摘 | Zhu LingJian Miao ZhenYuan Sheng ChunQuan | 2010 | Eur J Med Chem2010，45，7： | 1 |
| 4 | Study on Key Technologies of Internet of Things Perceiving Mine显示文摘 | WEI Qiupinga ZHU Shunbing DU Chunquan | 2011 | Procedia Engineering2011，，26： | 1 |
| 5 | Research on Urban Public Safety Emergency Management Early Warning System Based on Technologies for the Internet of Things显示文摘 | DU CHUNQUAN ZHU SHUNBING | | 0，，45： | 1 |
| 6 | Effects of rare earths on the microstructure, properties and fracture behavior of Mg-Al alloys 显示文摘 | Lu Yizhen Wang Qudong Zeng Xiaoqin Ding Wenjiang Zhai Chunquan Zhu Yanping | 2000 | Materials Science and Engineering A2000，278，： | 1 |
| 7 | The effect of Ca and rare earth elements on the microstructure, mechanical properties and corrosion behavior of AZ91D 显示文摘 | Wu Guohua Fan Yu Gao Hongtao Zhai Chunquan Zhu Yanping | 2005 | Materials Science and Engineering A2005，408，： | 1 |
| 8 | Salt stress response of membrane proteome of sugar beet monosomic addition line M14显示文摘 | Haiying Li Yu Pan Yongxue Zhang Chuan Wu Chunquan Ma Bing Yu Ning Zhu Jin Koh Sixue Chen | 2015 | Journal of Proteomics2015，，： | 1 |
| 9 | Synthesis and acrosin inhibitory activity of substituted 4-amino- N -(diaminomethylene) benzenesulfonamide derivatives显示文摘 | Lili Ding Ju Zhu Canhui Zheng Chunquan Sheng Jingjing Qi Xuefei Liu Guangqian Han Juntao Zhao Jiaguo Lv Youjun Zhou | 2011 | Bioorganic & Medicinal Chemistry Letters2011，，22： | 1 |
| 10 | Integrating climate,biodiversity,and sustainable land-use strategies:innovations from China显示文摘To reverse the accelerating degradation of biodiversity and ecosystem services(‘nature')and climate[1,2],the Convention on Biological Diversity(CBD)and the UN Framework Convention on Climate Change(UNFCCC)will hold major meetings in 2021.We argue that,as a critical priority,countries need to design and implement integrated national strategies to achieve the goals of the three Rio Conventions(including the UN Convention to Combat Desertification-UNCCD)using spatially explicit analyses and policies.This integration can maximize co-benefits and help manage trade-offs to meet the Sustainable Development Goals(SDGs). | Guido Schmidt-Traub Harvey Locke Jixi Gao Zhiyun Ouyang Justin Adams Lin Li Enric Sala M.Rebecca Shaw Sebastian Troëng Jing Xu Chunquan Zhu Changxin Zou Tianxiao Ma Fuwen Wei | 2021 | National Science Review2021，8，7： | 1 |
| 11 | The effect of Ca and rare earth elements on the microstructure, mechanical properties and corrosion behavior of AZ91D显示文摘 | Guohua Wu Yu Fan Hongtao Gao Chunquan Zhai Yan Ping Zhu | 2005 | Materials Science & Engineering A2005，，1： | 1 |
| 12 | Physiological and Proteomic Analyses Reveal Effects of Putrescine-Alleviated Aluminum Toxicity in Rice Roots显示文摘The effects of putrescine on improving rice growth under aluminum(Al)toxicity conditions have been previously demonstrated,however,the underlying mechanism remains unclear.In this study,treatment with 50 pmol/L Al significantly decreased rice root growth and whole rice dry weight,inhibited Ca2+uptake,decreased ATP syn thesis,and in creased Al,H2O2 and malon dialdehyde(MDA)con tents,whereas the application of putrescine mitigated these negative effects.Putrescine increased root growth and total dry weight of rice,reduced total Al content,decreased H2O2 and MDA contents by increasing antioxidant enzyme(superoxide dismutase,peroxidase,catalase and glutathione S・transferase)activities,increased Ca2+uptake and energy product!oru Proteomic analyses using data-independent acquisition successfully identified 7934 proteins,and 59 representative proteins exhibiting fold-change values higher than 1.5 were randomly selected.From the results of the proteomic and biochemical analyses,we found that putrescine significantly inhibited ethylene biosynthesis and phosphorus uptake in rice roots,increased pectin methylation,decreased pectin content and apoplastic Al deposit!on in rice roots.Putrescine also alleviated Al toxicity by repairing damaged DNA and increasing the proteins involved in maintaining plasma membra ne integrity and normal cell proliferation.These fin dings improve our understanding of how putrescine affects the rice response to Al toxicity,which will facilitate further studies on environmental protection,crop safety,in novations in rice performance and real-world producti on. | ZHU Chunquan HU Wenjun CAO Xiaochuang ZHU Lianfeng KONG Yali JIN Qianyu SHEN Guoxin WANG Weipeng ZHANG Hui ZHANG Junhua | 2021 | Rice science2021，28，6： | 0 |
| 13 | Hydrogen Sulfide Improves Rice Seed Germination by Regulating Aluminum Absorption,Internal Antioxidant Enzyme System and Osmotic Balance under Aluminum Toxicity Conditions显示文摘Uncovering the mechanism of hydrogen sulfide(H2S)in improving rice seed germination under aluminum(Al)toxicity conditions is important for rice production in acidic soil.In the present study,an Al sensitive rice variety Kasalath was used.Pretreatment with 0.1 mmol/L sodium hydrosulfide(NaHS,H2S donor)under 70 mmol/L AlCl3(indicated as Al+NaHS treatment)increased rice seed germination by 27.95%,germination potential by 474.16%,and the germination index by 43.44%,compared with Al treatment.The treatment of Al+NaHS reduced the Al content in rice seeds by 16.31%and 32.11%and increased the internal H2S content by 3.82%and 8.90%at 3 and 5 d of treatment,respectively,compared with Al treatment.Al+NaHS treatment significantly increased the activities of superoxide dismutase(SOD)。 | WEI Qianqian KONG Yali XIANG Xingjia ZHU Lianfeng LIU Jia TIAN Wenhao JIN Qianyu YU Yijun ZHANG Junhua ZHU Chunquan | 2023 | Rice science2023，30，4： | 0 |
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