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| 1 | Ge-Gen Decoction attenuates oxytocin-induced uterine contraction and writhing response: potential application in primary dysmenorrhea therapy显示文摘The uterine tetanic contraction and uterine artery blood flow reduction are possible reasons for primary dysmenorrhea(PD). In the present study, we aimed to evaluate the uterine relaxant effect and the influence on uterine artery blood velocity of Ge-Gen Decoction(GGD), a well-known Chinese herbal formula. In female ICR mice, uterine contraction was induced by oxytocin exposure following estradiol benzoate pretreatment, and the uterine artery blood velocity was detected by Doppler ultrasound. Histopathological examination of the uterine tissue samples were performed by H&E staining. Ex vivo studies demonstrated that oxytocin, posterior pituitary, or acetylcholine induced contractions in isolated mouse uterus. GGD inhibited both spontaneous and stimulated contractions. In vivo study demonstrated that GGD significantly reduced oxytocin-induced writhing responses with a maximal inhibition of 87%. Further study demonstrated that GGD normalized oxytocin-induced abnormalities of prostaglandins F_2 alpha(PGF_(2α)) and Ca^(2+) in mice. In addition, injection of oxytocin induced a decrease in uterine artery blood flow velocity. Pretreatment with GGD reversed the oxytocin response on blood flow velocity. Histopathological examination showed pretreatment with GGD alleviated inflammation and edema in the uterus when compared with the model group. Both ex vivo and in vivo results indicated that GGD possessed a significant spasmolytic effect on uterine tetanic contraction as well as improvement on uterine artery blood velocity which may involve PGF_(2α) and Ca^(2+) signaling, suggesting that GGD may have a clinic potential in PD therapy. | YANG Lu CHAI Cheng-Zhi YUE Xin-Yi YAN Yan KOU Jun-Ping CAO Zheng-Yu YU Bo-Yang | 2016 | Chinese Journal of Natural Medicines2016，14，2： | 17 |
| 2 | K-wire and tension band wire fixation in treating sternoclavicular joint dislocation显示文摘目的将评估可行性和由 K 电线和紧张乐队电线固定对待 sternoclavicular 关节脱臼的治疗学的效果,并且改进这种技术的安全和稳定性。这研究与平均数由 9 个盒子, 6 男性和 3 女性组成了的方法 25 年变老(范围, 9-62 年) 。原因是在 7 种情况中的交通事故,掉在在 1 种情况中的 1 种情况和战斗里。到操作的从损害的持续时间是到 7 天的 2 个小时。有 5 左脱臼和 4 正确脱臼;8 前面的脱臼和 1 以后的脱臼,包括一个与左 olecranon 骨折与左肩胛骨折和破裂结合了。用 K 电线和紧张乐队电线的开的减小和内部固定被执行对待脱臼。结果所有病人被跟随在上面为 6 ~ 24 个月, 10 个月平均。根据 Rockwood 手术后的 sternoclavicular 关节上的等级规模, 8 个盒子与 13.88 的一个平均分数完成了优秀结果,并且剩余的盒子与 12 的分数完成了好结果。解剖减小在所有情况中被获得。象严重感染没有如此的手术后的复杂并发症,对血容器和神经的损害,固定的失败,等等。病人们都对解剖减小和功能的恢复满意。K 电线和紧张乐队电线固定的技术是保险箱的结论,简单,有效,不太侵略并且成功地在矫形外科被使用了。它在尽管它有一些劣势,对待 sternoclavicular 关节脱臼是有效的。 | CHEN Qing-yu CHENG Shao-wen WANG Wei LIN Zhong-qin ZHANG Wei KOU Dong-quan SHEN Yue YING Xiao-zhou CHENG Xiao-jie LU Chuan-zhu PENG Lei | 2011 | Chinese Journal of Traumatology2011，14，1： | 7 |
| 3 | Neuropeptide Y and leptin receptor expression in the hypothalamus of rats with chronic immobilization stress显示文摘In this study, Sprague-Dawley rats were immobilized to a frame for 3 hours a day for 21 days to establish a model of chronic immobilization stress. The body weight and food intake of rats subjected to chronic immobilization stress were significantly decreased compared with the control group. Dual-labeling immunofluorescence revealed that the expression of leptin receptor and the co-localization coeffient in these leptic receptor neurons in the arcuate nucleus of the hypothalamus were both upregulated, while the number of neuropeptide Y neurons was decreased. Chronic immobilization stress induced high expression of leptin receptor in the arcuate nucleus and suppressed the synthesis and secretion of neuropeptide Y, thereby disrupting the pathways in the arcuate nucleus that regulate feeding behavior, resulting in diminished food intake and reduced body weight. | Shaoxian Wang Jiaxu Chen Guangxin Yue Minghua Bai Meijing Kou Zhongye Jin | 2013 | Neural Regeneration Research2013，8，18： | 6 |
| 4 | Hierarchically porous carbon foams for electric double layer capacitors显示文摘对便携式的电子设备的成长要求意味着力量采购的那个无足轻重的人逐渐地被寻求在以后。电的双层电容器(EDLC ) 正在答应候选人因为使用尽最大努力由于他们的高力量密度和突出的控告 / 解除骑车稳定性采购原料。三维(3D ) 自食其力基于碳的材料广泛地在小 EDLC 为使用被学习了。然而,为 3D 碳电极的主要挑战是在他们的内部空格的有限离子散开率。探讨这限制,为内部离子散开提供另外的隧道的层次地多孔的 3D 结构被建议了。此处,我们为 ultralight 的合成报导一个新化学方法(9.92 mg/cm 3) 3D 面对钾碳酸盐包含连接 glutaraldehydecross 的 chitosan aerogel 的碳化的多孔的碳泡沫(PCF ) 。电子显微镜学图象表明碳泡沫是包含一致地驱散的 macropores 的碳表的一个互连的网络。另外, Brunauer-Emmett-Teller 大小证实层次地多孔的结构。PCF 电极能完成的电气化学的数据表演当当前的密度从 0.5 ~ 100 A/g 被增加时,在 0.5 A/g 的当前的密度的 246.5 F/g 的一个突出的 gravimetric 电容,和 67.5% 的显著电容保留被观察。伪固态的对称的 supercapacitor 经由二的汇编被制作新 PCF 并且被发现交付一超离频在 2.8 Wh/kg 的精力密度的 25 kW/kg 的力量密度。这研究与高电容的性能表明 ultralight 和层次地多孔的碳泡沫的合成。 | Feng Zhan Tianyu Liu Guihua Hou Tianyi Kou Lu Yue Rongfeng Guan Yat Li | 2016 | Nano Research2016，9，10： | 5 |
| 5 | Linear Strain-Gradient Effect on the Energy Bandgap in Bent CdS Nanowires显示文摘尽管在半导体的可能的非同类的紧张效果被调查了因为在一半上世纪和紧张坡度能每在灵活 nanostructures 的测微计是超过 1% ,我们仍然缺乏他们对精力乐队的影响的理解。这里,我们进行紧张坡度的系统的阴极射线发光光谱学研究在在低温度的有弹性地弄弯的 CdS nanowires 的导致的激子精力移动,并且发现在弄弯的 nanowires 的激子精力红移动与紧张坡度成正比,格子失真的一个索引。密度功能的计算在弄弯的 nanostructures 显示出乐队差距减小的一样的趋势并且揭示内在的机制。半导体的乐队差距上的重要线性紧张坡度效果应该在在 nanoelectronics 调节光电子的性质的方法上打开新灯。 | Qiang Fu Zi Yue Zhang Liangzhi KOU Peicai Wu Xiaobing Han Xinli Zhu Jingyun Gao Jun Xu Qing Zhao Wanlin Guo Dapeng Yu | 2011 | Nano Research2011，4，3： | 5 |
| 6 | Clinical observations of osteoporotic vertebral compression fractures by using mineralized collagen modified polymethylmethacrylate bone cement显示文摘To investigate the clinical outcomes of the treatment of osteoporotic vertebral compression fractures(OVCFs)by using mineralized collagen(MC)modified polymethylmethacrylate(PMMA)bone cement.52 cases(52 vertebras)who sustained OVCF treated with MC modified PMMA bone cement from July 2014 to December 2015 were reviewed retrospectively.All the cases(52 patients,52 vertebras)included 8 males and 44 females with an average age of 74.83(ranging from 57-to 90-years old).The visual analogue scale(VAS),vertebral body height,Cobb angle,CT values preand post-operation as well as incidence of complications were used to be observed.All the patients underwent the surgery were successfully followed-up with an average period of 13.54 months(ranging from 6 to 23 months).The patients can ambulate at the second day after the operation.The VAS scores 2 days after the operation and during the last follow-up were significantly decreased compared with that before the operation(P<0.05);the average vertebral height and local Cobb angle had significant recovery(P<0.05);the CT value of the treated vertebra significantly increased compared with that before the operation(P<0.05).MC with good osteogenic activity and degradation properties can effectively improve the mechanical properties and biocompatibility of the PMMA bone cement,thus obtain better clinical results. | XiWang Jian-Ming Kou Yang Yue An-Ze Shao Xue-Jun Jia Jian-Wen Hou Chong Gao Zhi-Ye Qiu Xiu-Mei Wang Xi-Sheng Weng | 2017 | Regenerative Biomaterials2017，4，2： | 5 |
| 7 | Intramedullary nailing of clavicular midshaft fractures in adults using titanium elastic nail显示文摘ObjectiveStudies 证明代替的 midclavicular 破裂的钉的有弹性的稳定的 intramedullary (ESIN ) 有优秀结果,以及高复杂并发症率和特定的问题。目的 fractures.MethodsTotally 是讨论 midshaft 的 ESIN 锁骨的 60 个合格病人(年老的 18-63 年) 被使随机化到在 2007 年 1 月和 2008 年 5 月之间的 ESIN 组或非起作用的组。锁骨的弄短在损伤和骨状的巩固以后被测量。X 光线照相术的联合和复杂并发症被估计。包括经常的肩膀分数和手臂,肩膀和手(破折号) 的残疾的功能分析得分在 15 月的 follow-up.ResultsESIN 导致了一 signifcantly 更短的时间到联合以后,被执行,特别为简单破裂。在 ESIN 组,所有病人得到了骨折联合, 5 个盒子有中间的皮激怒,因为, 1 个病人需要修订外科植入失败。在 nonoperative 组,有 3 个不属于工会的盒子, 2 征兆的 malunions 发展了要求校正截骨术。在在 intramedullary 稳定以后的 15 个月,在 ESIN 组的病人是对肩膀和全面结果的外观满意的更多,并且他们从 traumatic 以后的大改进有益于很多锁骨的弄短。而且,破折号分数更低,经常的分数与非起作用的 group.ConclusionESIN 相对照是显著地更高的是有更低的复杂并发症率,到每日的活动的更快的回来,优秀化妆品和更好功能的结果的一种安全最低限度地侵略的外科的技术,为对待中间柄的锁骨的破裂的锁骨的长度的恢复,导致高全面的满足,它能作为板固定或 mid-shaf 的 nonoperative | CHEN Qing-yu KOU Dong-quan CHENG Xiao-jie ZHANG Wei WANG Wei LIN Zhang-qin CHENG Shao-wen SHEN Yue YING Xiao-zhou PENG Lei LU Chuan-zhu | 2011 | Chinese Journal of Traumatology2011，14，5： | 4 |
| 8 | Hashtag Recommendation Based on Multi-Features of Microblogs显示文摘 | Fei-Fei Kou Jun-Ping Du Cong-Xian Yang Yan-Song Shi Wan-Qiu Cui Mei-Yu Liang Yue Geng | 2018 | Journal of Computer Science & Technology2018，33，4： | 4 |
| 9 | Association of XPG rs2094258 polymorphism with gastric cancer prognosis显示文摘BACKGROUND The xeroderma pigmentosum group G(XPG)gene at chromosome 13q33 consists of 15 exons,which may be related to the occurrence and development of gastric cancer(GC).AIM To examine the association of several common single nucleotide polymorphisms(SNPs)of the XPG gene with GC risk and survival.METHODS Five SNPs of XPG(rs2094258,rs751402,rs873601,rs2296147,and rs1047768)were genotyped by PCR restriction fragment length polymorphism in 956 histologically confirmed GC cases and 1012 controls in North China.GC patients were followed for survival status and,if deceased,cause of death.Logistic regression and Cox regression were used for analysing associations of XPG SNPs with risk of GC and prognosis,respectively.For rs2094258,heterozygous model(CT vs CC),homozygous model(TT vs CC),recessive model(TT vs CT+CC),and dominant model(TT+CT vs CC)were analyzed.RESULTS None of the examined loci were statistically associated with GC risk,although rs2296147 was marginally associated with GC risk(P=0.050).GC patients with the rs2094258 CT+CC genotype showed worse survival than those with the TT genotype(log-rank test,P=0.028),and patients with the CC genotype had a tendency of unfavourable prognosis compared with those with the TT+CT genotype(log-rank test,P=0.039).The increase in C alleles of rs2094258[hazard ratio(HR)=1.19,95%confidence interval(CI):1.02-1.45,P=0.037]were associated with the long-term survival of GC cases.Other risk factors for survival included tumor differentiation(HR=4.51,95%CI:1.99-8.23,P<0.001),lymphovascular invasion(HR=1.97,95%CI:1.44-3.01,P<0.001),and use of chemotherapy(HR=0.81,95%CI:0.63-0.98,P=0.041).CONCLUSION The XPG rs2094258 polymorphism may be associated with overall survival in GC patients. | Xiao-Qin Wang Paul D Terry Yang Li Yue Zhang Wen-Jing Kou Ming-Xu Wang | 2019 | World Journal of Gastroenterology2019，25，34： | 4 |
| 10 | Effect of calcium citrate on bone integration in a rabbit femur defect model显示文摘Objective:To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological and histological study. Methods:Twenty-four male Japanese white rabbits were randomly divided into three groups (Group A.B.C)in this study.Under anesthesia,defects of four sizes(1.2,1.5,2.0 and 2.5 mm) were created in each of the rabbits.Commercially pure calcium citrate powder was placed inside the medullary compartment of the femur(Experimental),while in the contralateral femur(Control) nothing was implanted.The defects were analyzed using radiography and histological analysis by using Imagepro-Plus 6.0 software after animal was sacrificed at 4th(Group A),6th(Group B) and 8th(Group C) weeks postoperatively.Four samples were analyzed for each size of defect and each healing period.Results:The histological and the radiologic evaluation were performed after sacrification of all rabbits on postoperative 4th and 6th weeks,It showed significant difference between the experimental group and the control group when these defects were less than or equal to 2.0 mm.No statistical difference was observed when these defects were larger than 2.0 mm at all healing periods except at the 4th week.Conclusions:Calcium citrate affects the early periods of hone defects healing mechanism in Japanese white rabbits positively,especially when the defect is not too large,We suggest further studies on calcium citrate to determine the effects of various dosages,administration ways and the experimental time on the bone defects. | Wei Zhang Wei Wang Qing-Yu Chen Zhong-Qin Lin Shao-Wen Cheng Dong-Quan Kou Xiao-Zhou Ying Yue Shen Xiao-Jie Cheng Peng-Fei Nie Xiu-Cui Li Ferdinand An Rompis Hang Huang Hua Zhang Zhong-Lin Mu Lei Peng | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 3 |
| 11 | Strongly connected components based efficient computation of page rank显示文摘In this paper,an efficient page rank (PR)exact algorithm is proposed,which can improve the computation efficiency without sacrificing results accuracy.The existing exact algorithms are generally based on the original power method (PM).In order to reduce the number of I/Os required to improve efficiency,they partition the big graph into multiple smaller ones that can be totally fitted in memory.The algorithm proposed in this paper can further reduce the required number of I/Os.Instead of partitioning the graph into the general subgraphs,our algorithm partitions graph into a special kind of subgraphs:SCCs (strongly connected components), the nodes in which are reachable to each other.By exploiting the property of SCC,some theories are proposed,based on which the computation iterations can be constrained on these SCC subgraphs.Our algorithm can reduce lots of I/Os and save a large amount of computations,as well as keeping the results accuracy.In a word,our algorithm is more efficient among the existing exact algorithms.The experiments demonstrate that the algorithms proposed in this paper can make an obvious efficiency improvement and can attain high accurate results. | Hongguo YANG Derong SHEN Yue KOU Tiezheng NIE Ge YU | 2018 | Frontiers of Computer Science2018，12，6： | 2 |
| 12 | Imaging-Based Characterization of Perthite in the Upper Triassic Yanchang Formation Tight Sandstone of the Ordos Basin,China显示文摘This work investigated the element distribution of perthite from the Upper Triassic Yanchang Formation tight sandstone in the Ordos Basin of northern China by field emission scanning electron microscopy(FE-SEM) and energy dispersive spectrometer(EDS). FE-SEM results indicate significant differences in the morphology of Na-rich feldspar when K-rich feldspar is the main component of the perthite. EDS results show that different types of perthite have clearly defined differences on different element indexes. Additionally, indexes such as average-weight-K(K-rich)/Na(Na-rich), maximumweight-K(Na-rich)/Na(Na-rich) and average-atomic-K(K-rich)/Na(Na-rich) might be the most effective ones to identify perthite types. Perthite is divided into six main types, i.e., perthite with thick parallel stripe distribution, with thin parallel stripe distribution, with lumpy stripe distribution, with dendritic stripe distribution, with encircling stripe distribution, and with mixed stripe distribution. | DU Shuheng SHI Guoxin YUE Xinjian KOU Gen ZHOU Bo SHI Yongmin | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 2 |
| 13 | Osteogenic capability of autologous rabbit adipose-derived stromal cells in repairing calvarial defects显示文摘ObjectiveTo 评估在里面 vitro 并且在脂肪质导出 stromal 房间(ASC ) 的 vivo osteogenic 能力, .MethodASCs 从新西兰白兔子被孤立并且由染色的碱的磷酸酶(高山) 决定了, von Kossa 染色并且茜素红染色。osteogenic 区别的一些特定的标记包括高山, osteocalcin (OCN ) , osteopontin (OPN ) 被反向的抄写聚合酶链反应(RT-PCR ) 检验。在 vivo, demineralized 骨头矩阵(DBM )-ASCs composites 被植入进在纵的中线的每个方面创造的兔子 calvarial 缺点。在 6 个星期以后, transplants 的 histo 逻辑性质是 analyzed.ResultsASCs 成功地被导致进成骨。染色的高山, von Kossa 染色和茜素红染色显示出积极结果。高山, OCN 和 OPN 的表情在 osteogenic 媒介在耕作以后在 ASC 被检测。广泛的新骨头在与 DBM-ASCs composites.ConclusionASCs 移植的缺点被观察有潜力区分进 osteogenic 系和 DBM-ASCs 构造是为在骨头缺点的新生的一个有希望的方法。 | CHENG Shao-wen LIN Zhong-qin WANG Wei ZHANG Wei KOU Dong-quan YING Xiao-zhou CHEN Qing-yu SHEN Yue CHENG Xiao-jie PENG Lei LU Chuan-zhu | 2011 | Chinese Journal of Traumatology2011，14，5： | 2 |
| 14 | An Efficient Grid Service Discovery Mechanism Based on the Locality Principle显示文摘With the explosion of services in grid environment, it’s necessary to develop a mechanism which has the ability of discovering suitable grid services efficiently. This paper attempts to establish a layered resource management model based on the locality principle which classifies services into different domains and virtual organizations (VOs) according to their shared purposes. We propose an ontology-based search method applying the ontology theory for characterizing semantic information. In addition, we extend the UDDI in querying, storing, and so on. Simulation experiments have shown that our mechanism achieves higher performance in precision, recall and query response time. | KOU Yue YU Ge SHEN De-rong NIE Tie-zheng LIU Jian CAO Yu | 2006 | Wuhan University Journal of Natural Sciences2006，11，1： | 2 |
| 15 | Association between interleukin-21 gene rs907715 polymorphism and gastric precancerous lesions in a Chinese population显示文摘BACKGROUND The single nucleotide polymorphisms of interleukin-21(IL-21)gene were confirmed to be related to various diseases,but no studies have examined the possible role of IL-21 single nucleotide polymorphisms(SNPs)(rs907715,rs2221903,and rs12508721)in gastric precancerous lesions.AIM To explore the associations between SNPs of IL-21 gene(rs907715,rs2221903,and rs12508721)and gastric precancerous lesions in a Chinese population.METHODS Three SNPs of IL-21 were genotyped using polymerase chain reaction–ligase detection reaction in 588 cases and 290 healthy controls from May 2013 to December 2016 in northwestern China.Gastric precancerous lesions were confirmed by endoscopic examination and categorized as non-atrophic gastritis,atrophic gastritis,and intestinal metaplasia.Descriptive statistic and logistic regression were used for data analyses.RESULTS IL-21 rs907715 genotype CC and C frequencies were higher in in patients with gastric precancerous lesions than in the controls(OR=1.59,95%CI:1.06-2.38,P=0.013;OR=1.28,95%CI:1.01-2.22,P=0.044,respectively)after adjusting for confounding factors.For SNP rs907715 in intestinal metaplasia patients,significant differences between cases and controls were observed in the frequencies of genotype CC and C(OR=1.92,95%CI:1.24-2.98,P=0.004;OR=1.53,95%CI:1.04-2.24,P=0.028,respectively);for non-atrophic gastritis and atrophic gastritis patients,the CC and C genotypes showed no significant association with risk in all models.No association between either rs2221903 or rs12508721 and gastric precancerous lesions was found in the present study.In the haplotype analysis,the TC haplotype(rs907715 and rs12508721)and TT haplotype(rs2221903 and rs907715)were more frequent in the case group than control group(P<0.05).CONCLUSION Our findings indicate that SNP rs907715 of IL-21 gene is associated with gastric precancerous lesions.The TC haplotype(rs907715 and rs12508721)and TT haplotype(rs2221903 and rs907715)increased the risk of gastric precancerous lesions.If confirmed,these findings will shed light on the etiology of precancerous lesions. | Xiao-Qin Wang Yang Li Paul D Terry Wen-Jing Kou Yue Zhang Zhao-Zhao Hui Xiao-Han Ren Ming-Xu Wang | 2020 | World Journal of Gastrointestinal Oncology2020，12，3： | 2 |
| 16 | Discovering context-aware conditional functional dependencies显示文摘有条件的功能的相关性(CFD ) 是为数据一致性的重要技术。然而, CFD 被限制到 1 ) 为一致性修理提供合理价值并且 2 ) 检测潜在的错误。这篇论文论述贡献的上下文知道的有条件的功能的相关性(CCFD ) 提供合理价值并且检测潜在的错误。特别,我们集中于自动地发现最小的 CCFD。在这篇论文,我们测量 CFD 的关系的现在的上下文相关性。相关 CFD 的重叠能提供导致修理的更多的精确性一致性的合理价值,并且一些相关 CFD 被合为 CCFDs.Moreover,我们证明发现最小的 CCFD 是 NP 完全的,我们设计精确方法和启发式的方法。我们也介绍统治价值在精确方法和启发式的方法便于这个过程。另外, CFD 的上下文相关性影响清洗结果。我们将为建议根据数据分发给上下文相关性的近似阀值。修理结果是 approvedmore 精确性,甚至由我们的实验评估证实了。 | Yuefeng DU Derong SHEN Tiezheng NIE Yue KOU Ge YU | 2017 | Frontiers of Computer Science2017，11，4： | 1 |
| 17 | An improved model and method of calculating the VLSI critical area 显示文摘 | MA Pei-jun HAO Yue KOU Yun | 2001 | Chin J Semicond2001，22，9： | 1 |
| 18 | Short-termeffects of conservation management practices on soillabile organic carbon fractions under a rape - rice ro-tation in central China显示文摘 | LI C F YUE L X KOU Z K | 2012 | Soil & Tillage Research2012，119，： | 1 |
| 19 | Short -term effects of conservationmanagement practices on soil labile organic carbon fractions under arape-rice rotation in central China显示文摘 | Li C F Yue L X Kou Z K | 2012 | Soil Tillage Research2012，119，： | 1 |
| 20 | Short-term effects of conservation management practices on soil labile organic carbon fractions under a rape-rice rotation in central China显示文摘 | Li C F Yue L X Kou Z K | 2012 | Soil and Tillage Research2012，119，： | 1 |
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