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| 1 | The Development of Protein Microarrays and Their Applications in DNA-Protein and Protein-Protein Interaction Analyses of Arabidopsis Transcription Factors显示文摘 | Wei Gong Kun He Mike Covington S. R Dinesh-Kumar Michael Snyder Stacey L. Harmer Yu-Xian Zhu Xing Wang Denga | 2008 | Molecular Plant2008，1，1： | 7 |
| 2 | Targeting Tumor-Associated Macrophages by Anti-tumor Chinese Materia Medica显示文摘Tumor-associated macrophages(TAMs) play a key role in all stages of tumorigenesis and tumor progression. TAMs secrete different kinds of cytokines, chemokines, and enzymes to affect the progression, metastasis, and resistance to therapy depending on their state of reprogramming. Therapeutic benefit in targeting TAMs suggests that macrophages are attractive targets for cancer treatment. Chinese materia medica(CMM) is an important approach for treating cancer in China and in the Asian region. According to the theory of Chinese medicine(CM) and its practice, some prescriptions of CM regulate the body's internal environment possibly including the remodeling the tumor microenvironment(TME). Here we briefly summarize the pivotal effects of TAMs in shaping the TME and promoting tumorigenesis, invasion, metastasisand immunosuppression. Furthermore, we illustrate the effects and mechanisms of CMM targeting TAMs in antitumor therapy. Finally, we reveal the CMM's dual-regulatory and multi-targeting functions on regulating TAMs, and hopefully, provide the theoretical basis for CMM clinical practice related to cancer therapy. | PU Wei-ling SUN Li-kang GAO Xiu-mei Curzio Rüegg Muriel Cuendet Micheal O.Hottiger ZHOU Kun MIAO Lin ZHANG Yun-sha Margaret Gebauer | 2017 | Chinese Journal of Integrative Medicine2017，23，10： | 3 |
| 3 | Heterostructured ZnFe_2O_4/Fe_2TiO_5/TiO_2 Composite Nanotube Arrays with an Improved Photocatalysis Degradation Efficiency Under Simulated Sunlight Irradiation显示文摘To improve the visible light absorption and photocatalytic activity of titanium dioxide nanotube arrays(TONTAs), ZnFe_2O_4(ZFO) nanocrystals were perfused into pristine TONTA pipelines using a novel bias voltageassisted perfusion method. ZFO nanocrystals were well anchored on the inner walls of the pristine TONTAs when the ZFO suspensions(0.025 mg m L^(-1)) were kept under a60 V bias voltage for 1 h. After annealing at 750 °C for2 h, the heterostructured ZFO/Fe_2 TiO_5(FTO)/TiO_2 composite nanotube arrays were successfully obtained. Furthermore, Fe^(3+)was reduced to Fe^(2+)when solid solution reactions occurred at the interface of ZFO and the pristine TONTAs. Introducing ZFO significantly enhanced thevisible light absorption of the ZFO/FTO/TONTAs relative to that of the annealed TONTAs. The coexistence of type I and staggered type II band alignment in the ZFO/FTO/TONTAs facilitated the separation of photogenerated electrons and holes, thereby improving the efficiency of the ZFO/FTO/TONTAs for photocatalytic degradation of methylene blue when irradiated with simulated sunlight. | Kun Xiong Kunzhou Wang Lin Chen Xinqing Wang Qingbo Fan Jérémie Courtois Yuliang Liu Xianguo Tuo Minhao Yan | 2018 | Nano-Micro Letters2018，10，1： | 2 |
| 4 | Rare case of Helicobacter pylori-positive multiorgan Ig G4-related disease and gastric cancer显示文摘A 61-year-old male from Northeast China presented with a 2-mo history of abdominal distension,pruritus and jaundice.Laboratory testing revealed an elevated serum Ig G4 level.A computed tomography scan showed a typical feature of autoimmune pancreatitis(AIP) and cholecystocholangitis.Early gastric cancer was incidentally discovered when endoscopic untrasound-guided fine needle aspiration(EUSFNA) of the pancreas was carried out.The patient underwent radical subtotal gastrectomy for gastric cancer combined with cholecystectomy.Helicobacter pylori(H.pylori) and Ig G4-positive plasmacytes were detected in gastric cancer tissue,pancreatic EUSFNA sample and resected gallbladder specimen by immunohistochemistry.The patient was diagnosed with H.pylori-positive Ig G4-related AIP and sclerosing cholecystocholangitis as well as H.pylori-positive gastric cancer.He responded well to steroid therapy and remains healthy with no signs of recurrence at one year follow-up.We speculate that H.pylori might act as a trigger via direct or indirect action in the initiation of onset of gastric cancer and multiorgan Ig G4-related disease. | Min Li Qiang Zhou Kun Yang David R Brigstock Lu Zhang Ming Xiu Li Sun Run-Ping Gao | 2015 | World Journal of Gastroenterology2015，21，11： | 2 |
| 5 | Deoxynivalenol accumulation and detoxification in cereals and its potential role in wheat-Fusarium graminearum interactions显示文摘Deoxynivalenol(DON)is a prominent mycotoxin showing significant accumulation in cereal plants during infection by the phytopathogen Fusarium graminearum.It is a virulence factor that is important in the spread of F.graminearum within cereal heads,and it causes serious yield losses and significant contamination of cereal grains.In recent decades,genetic and genomic studies have facilitated the characterization of the molecular pathways of DON biosynthesis in F.graminearum and the environmental factors that influence DON accumulation.In addition,diverse scab resistance traits related to the repression of DON accumulation in plants have been identified,and experimental studies of wheat–pathogen interactions have contributed to understanding detoxification mechanisms in host plants.The present review illustrates and summarizes the molecular networks of DON mycotoxin production in F.graminearum and the methods of DON detoxification in plants based on the current literature,which provides molecular targets for crop improvement programs.This review also comprehensively discusses recent advances and challenges related to genetic engineering-mediated cultivar improvements to strengthen scab resistance.Furthermore,ongoing advancements in genetic engineering will enable the application of these molecular targets to develop more scab-resistant wheat cultivars with DON detoxification traits. | Kun Luo Jiao Guo Dejia He Guangwei Li Thérèse Ouellet | 2023 | aBIOTECH2023，4，2： | 2 |
| 6 | An innovative for packaging power electronics building blocks using metal posts interconnected parallel plate structures显示文摘 | Kun X Lin R L | 1999 | IEEE Transactions on Advanced Packaging1999，22，2： | 1 |
| 7 | Bursts in a fiber bundle model with continuous damage显示文摘 | Hidalgo R C Kun F Herrmann H J | 2001 | Physical Review E2001，64，6： | 1 |
| 8 | A study on mRNA expressions of fibrenectin in dermal and cerebral wound healing for wound age estimation显示文摘 | Takamiya M KunⅢgai R Nakayashiki N | 2006 | Leg Med(Tokyo)2006，8，4： | 1 |
| 9 | Maternal socio-economic indices for prenatal care research in rural China显示文摘 | Nwaru B I Klemetti R Kun H | 2012 | The European Journal of Public Health2012，22，6： | 1 |
| 10 | Prolyl isomerase PIN1:a catalyst for oncogenesis and a potential therapeutic target in cancer显示文摘 | AKIHIDE R YIH-CHERNG L KUN P L | 2003 | J Cell Science2003，116，： | 1 |
| 11 | Reduced electromigration of Cu wires by surface coating显示文摘 | Hu Chin Kun Gigna C L Rosenberg R | 2002 | Appl Phys Lett2002，81，10： | 1 |
| 12 | CD44 mediates constitutive type I receptor signaling in cervical carcinoma cells 显示文摘 | Wobus M Kuns R Wolf C | 2001 | Gynecol Oncol2001，83，2： | 1 |
| 13 | Specific Associanon of Human Telomerase Activity with Immortal Cells and Cancer显示文摘 | KUN N W PRATYSZEK M A PROWSE K R | 1994 | Science1994，266，5193： | 1 |
| 14 | Development of integral hydro-bulge forming (IHBF) process and its numerical simulation显示文摘 | Wang Z R Dai Kun Yuan Shijian | 2000 | Journal of Materials Processing Technology2000，102，13： | 1 |
| 15 | Synthesis and struc- tural and photocatalytic properties of TiO2/montmorillonite nanocomposites显示文摘 | KUN R MOGYOROSI K DEKANY I | 2006 | Applied Clay Science2006，32，12： | 1 |
| 16 | Bursts in a fiber bundle model with continuous damage 显示文摘 | Hidalgo R C Kun F Herrmann H J | 2001 | Physical Review(E)2001，64，6： | 1 |
| 17 | Titania-sepiolite nanocomposites prepared by a surfactant templating colloidal route显示文摘 | ARANDA P KUN R MARTIN-LUENGO M A | 2008 | Chem Mater2008，20，1： | 1 |
| 18 | Separation and characterization of aconitase hydrate isoenymes from pig tissues显示文摘 | Eanes R Z Kun E | 1971 | Biochim Biophys Acta1971，227，： | 1 |
| 19 | Sewer pipe deformation assessment by image analysis of video surveys 显示文摘 | Xu Kun Luxmoore A R Davies T | 1998 | Pattern Recognition1998，31，2： | 1 |
| 20 | CNC incremental sheet forming of an axially symmetric specimen and the locus of optimization 显示文摘 | Dai Kun Wang Z R Fang Yi | 2000 | Materials Processing Technology2000，102，1： | 1 |
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