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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Patterns of handwashing behavior and visits to patients on a general medical ward of healtheare workers显示文摘 | Refik S Kurt W | 2004 | Infection Control and Hospital Epidemiology2004，25，： | 1 |
| 3 | Antimicrobial activities of the essential oils of various plants against tomato late blight disease agent Phytophthora infestans显示文摘 | SOYLU E M SOYLU S KURT S | 2006 | Mycopathologia2006，161，： | 1 |
| 4 | Metabolic monitoring of postischemic myocardium during intermittent warm-blood cardioplegic administration显示文摘 | Borowski A Kurt M Calvo S | 2010 | Tex Heart Inst J2010，37，2： | 1 |
| 5 | Oligomerization of Anthrax Toxin Protective Antigen and Binding of Lethal Factor during Endocytic Uptake into Mammalian Cells显示文摘 | Yogendra S Kurt RK Seema G | 1999 | J Infection and Immunity1999，67，3： | 1 |
| 6 | The role of ultrasound examination in the first trimester and at 16 weeks’ gestation to predict fetal complications in monochorionic diamniotic twin pregnancies显示文摘 | Liesbeth Lewi Paul Lewi Anke Diemert Jacques Jani Leonardo Gucciardo Tim Van Mieghem Elisa Doné Eduardo Gratacós Agnes Huber Kurt Hecher Jan Deprest | 2008 | American Journal of Obstetrics and Gynecology2008，，5： | 1 |
| 7 | Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis 显示文摘 | Kurt Jones EA Chan M Zhou S etal | 2004 | Proc Natl Acad Sc USA2004，101，5： | 1 |
| 8 | In-fluence of molding conditions on the shrinkage and roundness of injection molded parts显示文摘 | MUSTAFA KURT YUSUF KAYNAK OMER S | | 0，，46： | 1 |
| 9 | The protectiveness of the treatment of vitamin D insufficiency in the development of diabetes显示文摘 | Kurt O Balta S Cakar M | 2013 | Arq Bras Endocrinol Metabol2013，57，： | 1 |
| 10 | Cell therapy for human ischemic heart diseases: Critical review and summary of the clinical experiences显示文摘 | Noemi Pavo Silvia Charwat Noemi Nyolczas András Jakab Zsolt Murlasits Jutta Bergler-Klein Mariam Nikfardjam Imre Benedek Teodora Benedek Imre J. Pavo Bernard J. Gersh Kurt Huber Gerald Maurer Mariann Gy?ngy?si | 2014 | Journal of Molecular and Cellular Cardiology2014，，： | 1 |
| 11 | Patters of handwashing behavior and visits to patients on a general medical ward of healthcare workers显示文摘 | Janet R Refik S Kurt W etal | 2004 | Infect Control and Hosp Epidemiol2004，25，： | 1 |
| 12 | An examination of the influence of CPA firm type,size,and MAS provision on loan officer decisions and perceptions显示文摘 | Mckinley S Kurt K Reckers P | 1985 | Journal of Accounting Research1985，，： | 1 |
| 13 | Regulatable atrial natri- uretic peptide gene therapy for hypertension 显示文摘 | Kurt J S Sophia Y T George E T | 2005 | Proc Natl Acad Sci LI S A2005，102，13： | 1 |
| 14 | Two Measures of Sample En- mpy 显示文摘 | Nader Ebrahimi Kurt Ptlughoet Ehsan S Soofi | 1994 | Statistics & Probabilityh Letters1994，，20： | 1 |
| 15 | Patterns of hand-washing be-havior and visits to patients on a general medical ward of health care workers显示文摘 | Janet R Refik S Kurt W | 2004 | Infect Control and Hosp-Epidemiol2004，，25： | 1 |
| 16 | A multi-criteria intuitionistic fuzzy group decision making for supplier selection with TOPSIS method显示文摘 | F E BORAN S GENC M KURT | | 0，，07： | 1 |
| 17 | The classification and importance of E- S-Qual quality attributes: an evaluation of online shoppers 显示文摘 | KURT S D ATREK B | 2012 | Managing Service Quality2012，22，6： | 1 |
| 18 | Relation of peritoneal fluid and serum vascular endothelial growth factor levels to endometriosis stage 显示文摘 | Kopuz A Kurt S Demirtas O | 2014 | Clin Exp Obstet Gynecol2014，41，5： | 1 |
| 19 | Annular photonic crystals显示文摘 | KURT H CITRIN D S | 2005 | Opt Express2005，13，10： | 1 |
| 20 | Identifying the concepts contained in outcome measures of clinical trials on stroke using the International Classification of Functioning, Disability and Health as a reference显示文摘 | Geyh S Kurt T Brockow T | 2004 | J Rehabil Med2004，44，： | 1 |
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