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| 1 | Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date显示文摘Chronic lymphocytic leukemia(CLL) is the most common leukemia in the western world. Despite significantadvances in therapy over the last decade CLL remains incurable. Current front-line therapy often consists of chemoimmunotherapy-based regimens, most commonly the fludarabine, cyclophosphamide plus rituximab combination, but rates of relapse and refractory disease are high among these patients. Several key signaling pathways are now known to mediate the survival and proliferation of CLL cells in vivo, the most notable of which are the pathways mediated by the B-cell receptor(BCR) and cytokine receptors. A better understanding of the pathogenesis of the disease, the underlying biology of the CLL-cell and the roles of the tumour microenvironment has provided the rationale for trials of a range of novel, more targeted therapeutic agents. In particular, clinical trials of ibrutinib and idelalisib, which target the Brutons tyrosine kinase and the delta isoform of phosphoinositol-3 kinase components of the BCR signaling pathway respectively, have shown extremely promising results. Here we review the current literature on the key signaling pathways and interactions of CLL cells that mediate the survival and proliferation of the leukemic cells. For each we describe the results of the recent clinical trials and in vitro studies of novel therapeutic agents. | Kyle Crassini Stephen P Mulligan O Giles Best | 2015 | World Journal of Clinical Cases2015，3，8： | 5 |
| 2 | International Myeloma Working Group guidelines for the management of muldple myeloma patients hleligible for standard high-dose chemotherapy with autologous stem cell transplantation显示文摘 | Palumbo A Sezer O Kyle R | 2009 | Leukemia2009，23，10： | 1 |
| 3 | Efficient genera- tion of transgenic rats through the male germline using lentiviral transduction and transplantation of spermatogonial stem cells 显示文摘 | BUOM Y R KYLE E O JON M O | 2007 | Journal of Andrology2007，28，2： | 1 |
| 4 | Using microsatellire analysis to vertify breeding records:A study of Honeycrisp and other cold-hardy apple cultivars显示文摘 | PAUL R C ANDREW B KYLE O JAMES J L DABID S B | 2005 | HortScience2005，40，1： | 1 |
| 5 | Polymorphism of the erythropoietin gene promotor and the development of myelodysplastic syndromes subsequent to multiple myeloma显示文摘 | Landgren O Ma W Kyle RA | 2012 | Leukemia2012，26，4： | 1 |
| 6 | Influence of reinforcement on RC short column lateral resistance显示文摘 | Kyle A W James O J | 1984 | Journal of Structural Engineering1984，110，1： | 1 |
| 7 | Storage water activity affects flavor fade in high and normal oleic peanuts显示文摘 | Kyle A Reed Charles A Sims Daniel W Gorbet S.F O’Keefe | 2002 | Food Research International2002，，8： | 1 |
| 8 | Using microsatellire analysis to vertify breeding records: A study of honey crisp and other cold-hardy apple cultivars 显示文摘 | Paul R C Andrew B Kyle O | 2005 | Hort Science2005，40，1： | 1 |
| 9 | Retrovirus-mediated modification of male germline stem cells in rats 显示文摘 | Kyle E O Mary R A Ralph L B | 2002 | Biology of Reproduction2002，67，3： | 1 |
| 10 | Measuring aircraft carrier flexure in support of autonomous aircraft landings显示文摘 | MARK G PETOVELLO KYLE O' KEEFE G LACHA- PELLE | 2009 | IEEE Transactions on Aerospace and Electronic Systems2009，45，2： | 1 |
| 11 | Monoclonal gammopathies of undetermined significance(MGUS) consistently precedes multiple myeloma:a prospective study 显示文摘 | Landgren O Kyle R A Pfeiffer R M | 2009 | Blood2009，113，114： | 1 |
| 12 | The Basic Principles of an Electrode Regulation System 显示文摘 | LUCA O FRANCESCO M KYLE S | 2010 | Industrial Heating2010，，8： | 1 |
| 13 | Monoclonal gammopathy of undetermined significance(MGUS)consistently precedes multiple myeloma:a prospective study显示文摘 | Landgren O Kyle RA Pfeiffer RM | 2009 | Blood2009，113，22： | 1 |
| 14 | Constraints to art museum attendance显示文摘 | Jun J Kyle G O' Leary J T | 2008 | Journal of Park and Recreation Administration2008，26，1： | 1 |
| 15 | Mean power frequency and amplitude of the mechanomyographic and electromyographic signals during incremental cycle ergometry显示文摘 | Sharon R Perry Terry J Housh Joseph P Weir Glen O Johnson Anthony J Bull Kyle T Ebersole | 2001 | Journal of Electromyography and Kinesiology2001，，4： | 1 |
| 16 | Alloimmunization in sickle cell anemia in the era of extended red cell typing显示文摘 | Chibuzo O’Suoji Robert I. Liem A. Kyle Mack Paris Kingsberry Glenn Ramsey Alexis. A. Thompson | 2013 | Pediatr Blood Cancer2013，，： | 1 |
| 17 | Incidence of multiple myeloma in Olmsted County, Minnesota:1978 through 1990, with a review of the trend since 1945显示文摘 | Kyle R A Beard C M O' Fallon W M | 1999 | Clin Onco11999，12，： | 1 |
| 18 | Influence of reinforcement on RC short column lateral resistance 显示文摘 | Kyle A Woodward James O Jirsa | 1984 | Journal of Structural Engineering1984，110，1： | 1 |
| 19 | Polymorphism of the erythropoietin gene promotor and the development of myelodysplastic syndromes subsequent to multiple myeloma显示文摘 | Landgren O Ma W Kyle RA | 2012 | Leukemia2012，26，4： | 1 |
| 20 | Internation?al Myeloma Working Group guidelines for the man?agement of multiple myeloma patients ineligible for standard high-dose chemotherapy with autologous stem cell transplantation显示文摘 | PALUMBO A SEZER O KYLE Rv | 2009 | Leukemia2009，23，： | 1 |
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