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| 1 | Combined remediation of DDT congeners and cadmium in soil by Sphingobacterium sp.D-6 and Sedum alfredii Hance显示文摘Combined pollution of 1,1,1-trichloro-2,2-bis (4-chlorophenyl) ethane (DDT) and cadmium (Cd) in agricultural soils is of great concern because they present serious risk to food security and human health.In order to develop a cost-effective and safe method for the removal of DDTs and Cd in soil,combined remediation of DDTs and Cd in soil by Sphingobacterium sp.D-6 and the hyperaccumulator,Sedum alfredii Hance was investigated.After treatment for 210 days,the degradation half-lives of DDTs in soils treated by strain D-6 decreased by 8.1% to 68.0% compared with those in the controls.The inoculation of strain D-6 into soil decreased the uptake of DDTs by pak choi and S.alfredii.The shoots/roots ratios of S.alfredii for the Cd accumulation ranged from 12.32 to 21.75.The Cd concentration in soil decreased to 65.8%-71.8% for S.alfredii treatment and 14.1%-58.2% for S.alfredii and strain D-6 combined treatment,respectively,compared with that in the control.The population size of the DDTs-degrading strain,Simpson index (1/D) and soil respiratory rate decreased in the early stage of treatment and then gradually increased,ultimately recovering to or exceeding the initial level.The results indicated that synchronous incorporation of strain D-6 and S.alfredii into soil was found to significantly (p 0.05) enhance the degradation of DDTs in soil and the hyperaccumulation of Cd in S.alfredii.It was concluded that strain D-6 and S.alfredii could be used successfully to control DDTs and Cd in contaminated soil. | Hua Fang Wei Zhou Zhengya Cao Feifan Tang Dandan Wang Kailin Liu Xiangwei Wu Xiao'e Yang Yongge Sun Yunlong Yu | 2012 | Journal of Environmental Sciences2012，24，6： | 5 |
| 2 | Comparison of different partial least-squares methods in quantitative structure-activity relationships显示文摘 | Kailin Tang Tonghua Li | 2003 | Analytica Chimica Acta2003，，1： | 1 |
| 3 | An InDel-based linkage map of hot pepper ( Capsicum annuum )显示文摘 | Weipeng Li Jiaowen Cheng Zhiming Wu Cheng Qin Shu Tan Xin Tang Junjie Cui Li Zhang Kailin Hu | 2015 | Molecular Breeding2015，，1： | 1 |
| 4 | Comparison of different partialleast-squares methods in quantitative structure-activity rela-tionships 显示文摘 | Kailin Tang and Tonghua Li | 2003 | Analytica Chimica Acta2003，，1： | 1 |
| 5 | Ovarian cancer classification based on dimensionality reduction for SELDI-TOF data显示文摘 | TANG Kailin LI T0nghua XIONG Wenwei | 2010 | BMC Bioinformatics2010，11，： | 1 |
| 6 | Comparison of different squares methods inquantitative strueture-aetivity partial leash relationships 显示文摘 | Tang Kailin Li Tonghua | 2003 | Analytieal Chimiea Aeta2003，，1： | 1 |
| 7 | Pathway-pathway network-based study of the therapeutic mechanisms by which salvianolic acid B regulates cardiovascular diseases显示文摘Investigation of the potential therapeutic mechanisms of drug candidates is an essential step in the process of new drug discovery.With the rapid development of systems biology,recent network analyses of proteins,drugs,and diseases have enabled great progress in delineating the molecule mechanisms of drug candidates.However,most analyses perform a direct association between gene/protein and disease levels without considering the intermediate biological pathways regulated by the drugs.Given that a protein performs its biological roles through pathways,we propose using a novel pathway-pathway network analysis to investigate the potential therapeutic functions of the drug candidates.Many studies have demonstrated that salvianolic acid B(SalB) of Salvia miltiorrhiza is an effective therapy for cardiovascular diseases(CVD).Using molecular docking methods to identify direct interacting targets of Sal B,we collected all Sal B-regulated proteins with supporting experimental evidence in PubMed abstracts.FDA-approved CVD drugs and their corresponding targets were also collected.From a traditional drug-protein network analysis,we found that Sal B could affect ACE and REN of the renin-angiotensin-aldosterone system to relax vessels and alleviate hypertension.Subsequent pathway-pathway network analysis was attempted to study the mechanisms of Sal B in treating CVD,and demonstrated that Sal B regulates immunity/inflammation,apoptosis,ion transport and basic metabolism processes in the treatment of CVD.Regulating the immune/inflammation process may be the major mechanism of Sal B.We believe that pathwaypathway network analysis is a novel method for studying the therapeutic mechanisms of herbal ingredients. | YE Li HE Yuan YE Hao LIU XuePing YANG LinLin CAO ZhiWei TANG KaiLin | 2012 | Chinese Science Bulletin2012，57，14： | 1 |
| 8 | Comparison of different partial leastsquares methods in quantitative structure-activity relationships显示文摘 | Kailin Tang Tonghua Li | 2003 | Analytica Chimica Acta2003，，1： | 1 |
| 9 | Comparison of different squares methods in quantitative structure-activity partial leash relationships 显示文摘 | Tang Kailin Li Tonghua | 2003 | Analytical Chimiea Acta2003，，1： | 1 |
| 10 | Comparison of different partial least - squares methods in quantitative structure - activity relationships 显示文摘 | Kailin Tang Tonghua Li | 2003 | Analytica Chimica Acta2003，，1： | 1 |
| 11 | Developmental Exposure to Bisphenol A Degrades Auditory Cortical Processing in Rats显示文摘Developmental exposure to bisphenol A(BPA),an endocrine-disrupting contaminant,impairs cognitive function in both animals and humans.However,whether BPA affects the development of primary sensory systems,which are the first to mature in the cortex,remains largely unclear.Using the rat as a model,we aimed to record the physiological and structural changes in the primary auditory cortex(A1)following lactational BPA exposure and their possible effects on behavioral outcomes.We found that BPA-exposed rats showed significant behavioral impairments when performing a sound temporal rate discrimination test.A significant alteration in spectral and temporal processing was also recorded in their A1,manifested as degraded frequency selectivity and diminished stimulus rate-following by neurons.These post-exposure effects were accompanied by changes in the density and maturity of dendritic spines in A1.Our findings demonstrated developmental impacts of BPA on auditory cortical processing and auditory-related discrimination,particularly in the temporal domain.Thus,the health implications for humans associated with early exposure to endocrine disruptors such as BPA merit more careful examination. | Binliang Tang Kailin Li Yuan Cheng Guimin Zhang Pengying An Yutian Sun Yue Fang Hui Liu Yang Shen Yifan Zhang Ye Shan E´tienne de Villers-Sidani Xiaoming Zhou | 2022 | Neuroscience Bulletin2022，38，11： | 0 |
| 12 | A pathway profile-based method for drug repositioning显示文摘Finding new applications for existing pharmaceuticals,known as drug repositioning,is a validated strategy for resolving the problem of high expenditure but low productivity in drug discovery.Currently,the prevalent computational methods for drug repositioning are focused mainly on the similarity or relevance between known drugs based on their 'features',including chemical structure,side effects,gene expression profile,and/or chemical-protein interactome.However,such drug-oriented methods may constrain the newly predicted functions to the pharmacological functional space of the existing drugs.Clinically,many drugs have been found to bind 'off-target'(i.e.to receptors other than their primary targets),which can lead to undesirable effects.In this study,which integrates known drug target information,we propose a disease-oriented strategy for evaluating the relationship between drugs and disease based on their pathway profile.The basic hypothesis of this method is that drugs exerting a therapeutic effect may not only directly target the disease-related proteins but also modulate the pathways involved in the pathological process.Upon testing eight of the global best-selling drugs in 2010(each with more than three targets),the FDA(Food and Drug Administration,USA)-approved therapeutic function of each was included in the top 10 predicted indications.On average,60% of predicted results made using our method are proved by literature.This approach could be used to complement existing methods and may provide a new perspective in drug repositioning and side effect evaluation. | YE Hao YANG LinLin CAO ZhiWei TANG KaiLin LI YiXue | 2012 | Chinese Science Bulletin2012，57，17： | 0 |
| 13 | Study of drug function based on similarity of pathway fingerprint显示文摘Drugs sharing similar therapeutic function may not bind to the same group of targets.However,their targets may be involved in similar pathway profiles which are associated with certain pathological process.In this study,pathway fingerprint was introduced to indicate the profile of significant pathways being influenced by the targets of drugs.Then drug−drug network was further constructed based on significant similarity of pathway fingerprints.In this way,the functions of a drug may be hinted by the enriched therapeutic functions of its neighboring drugs.In the test of 911 FDA approved drugs with more than one known target,471 drugs could be connected into networks.760 significant associations of drug−therapeutic function were generated,among which around 60%of them were supported by scientific literatures or ATC codes of drug functional classification.Therefore,pathway fingerprints may be useful to further study on the potential function of known drugs,or the unknown function of new drugs. | Hao Ye Kailin Tang Linlin Yang Zhiwei Cao Yixue Li | 2012 | Protein & Cell2012，3，2： | 0 |
| 14 | Nonylphenol photodegradation by novel ternary MIL-100(Fe)/ZnFe_(2)O_(4)/PCN composite under visible light irradiation via double charge transfer process显示文摘Nonylphenol(NP)residues,as a typical endocrine disrupting chemical(EDC),frequently exist in sewage,surface water,groundwater and even drinking water,which poses a serious threat to human health due to its bioaccumulation.In order to remove NP,a series of MIL-100(Fe)/Zn Fe_(2)O_(4)/flake-like porous carbon nitride(MIL/ZC)was synthesized through in-situ synthesis at room temperature.High performance of ternary MIL/ZC is used to degrade NP under visible light irradiation.The results show that 30MIL/ZC2(20 wt.%Zn Fe_(2)O_(4))ternary composite had the best photocatalytic activity(99.84%)when the dosage was 30 mg.Further mechanism analysis shows that the excellent photocatalytic activity of 30MIL/ZC2could be ascribed to the double charge transfer process between flake-like porous carbon nitride(PCN)and other catalysts in the ternary heterojunction,and the separation of photogenerated electron-hole pairs was more effective.In addition,the 30MIL/ZC2 also showed high stability after five cycles of the photodegradation reaction.Furthermore,the active substance(·O_(2)^(-))was considered to be the main active substance in the NP degradation process.Based on the research results,the possible photocatalytic reaction mechanism of 30MIL/ZC2ternary composite was proposed and discussed in detail. | Kailin Xu Li Jiao Chuqiao Wang Yiming Bu Yuling Tang Liwei Qiu Qiuya Zhang Liping Wang | 2022 | Journal of Environmental Sciences2022，34，1： | 0 |
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