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| 1 | Larvicidal and repellent activity of medicinal plant extracts from Eastern Ghats of South India against malaria and filariasis vectors显示文摘Objective:To evaluate the larvicidal and repellent activities of ethyl acetate and methanol extracts of Acacia concinna(A.concinna),Cassia siamea(C.siamea).Conundrum sativum(C. sativum),Cuminum cyminum(C.cyminum),Lantana camma(L.camara),Nelumbo nucifera (N.nucifera) Phyllanlhus amarus(P.amarus).Piper nigrum(P.nigrum) and Trachyspermum ammi(T.ammi) against Anopheles stephensi(An.stephensi) and Culex quinquefasciatus(Cx. quinquefasciatus).Methods:The larvicidal activity of medicinal plant extracts were tested against earl) fourth-instar larvae of malaria and filariasis vectors.The mortality was observed 24 h and 48 h after treatment,data were subjected to probit analysis to determine the lethal concentrations(LC50 and LC90) to kill 50 and 90 per cent of the treated larvae of the tested species. The repellent efficacy was determined against two mosquito species at five concentrations(31.25. 62.50.125.00.250.00,and 500.00 ppm) under the laboratory conditions.Results:All plant extracts showed moderate effects after 24 h and 48 h of exposure;however,the highest activity was observed after 24 h in the leaf methanol extract ol N.nucifera.seed ethyl acetate and methanol extract of P.nigrum against the larvae of An.Stephensi(LC50 = 34.76.24.54 and 30.20 ppm) and against Cx.quinquefasciatus(LC50= 37.49.43.94 and 57.39 ppm),respectively.The toxic effect of leaf methanol extract of C.siamea,seed methanol extract of C.cyminum,leaf ethyl acetate extract of N.nucifera.leaf ethyl acetate and methanol extract of P.amarus and seed methanol extract of T.ammi were showed 100%mortality against An.stephensi and Cx.quinquefasciatus alter 48 h exposer.The maximum repellent activity was observed at 500 ppm in methanol extracts of N. nucifera.ethyl acetate and methanol extract of P.nigrum and methanol extract of T.ammi and the mean complete protection time ranged from 30 to 150 min with the different extracts tested. Conclusions:These results suggest that the leaf and seed extracts of C.siamea.N.nucifera.P. amarus.P.nigrum and T.ammi have the potential to be used as an ideal ecofriendly approach for the control of the An.stephensi and Cx.quinquefasciatus. | Chinnaperumal Kamaraj Abdul Abdul Rahuman Asokan Bagavan Gandhi Elango Abdul Abduz Zahir Thirunavukkarasu Santhoshkumar | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 5 |
| 2 | Larvicidal potential of medicinal plant extracts against Anopheles subpictus Grassi and Culex tritaeniorhynchus Giles (Diptera: Culicidae)显示文摘 | C. Kamaraj A. Bagavan A. Abdul Rahuman A. Abduz Zahir G. Elango G. Pandiyan | 2009 | Parasitology Research2009，，5： | 3 |
| 3 | Larvicidal activity of green synthesized silver nanoparticles using bark aqueous extract of Ficus racemosa against Culex quinquefasciatus and Culex gelidus显示文摘Objective:To investigate the larvicidal activity of synthesized silver nanoparticles(Ag NPs) utilizing aqueous bark extract of Ficus racemosa(F.racemosa) was tested against fourth instar larvae of filariasis vector,Culex quinquefasciatus(Cx.quinquefasciatus) and japanese encephalitis vectors,Culex gelidus(Cx.gelidus).Methods:The synthesized Ag NPs was characterized by UV-vis spectrum,X-ray diffraction(XRD),Scanning electron microscopy(SEM) and Fourier transform infrared(FTIR).The larvicidal activities were assessed for 24 h against the larvae of Cx.quinquefasciatus and Cx.gelidus with varying concentrations of aqueous bark extract off.racemosa and synthesized Ag NPs.LC50 and r2 values were calculated.Results:The maximum efficacy was observed in crude aqueous extract of F.racemosa against the larvae of Cx.quinquefasciatus and Cx.gelidus(LC50=67.72 and 63.70 mg/L;r2=0.995 and 0.985) and the synthesized Ag NPs(LC50=12.00 and 11.21 mg/L;r2=0.997 and 0.990).respectively.Synthesized Ag NPs showed the XRD peaks at 2θvalues of 27.61,29.60,35.48,43.48 and 79.68 were identified as (210),(121),(220),(200) and(311) reflections,respectively.The FTIR spectra of Ag NPs exhibited prominent peaks at 3 425,2 878,1 627 and 1 382 in the region 500-3 000 cm-1.The peaks correspond to the presence of a stretching vibration of(NH) C=O group.SEM analysis showed shape in cylindrical,uniform and rod with the average size of 250.60 nm.Conclusions:The biosynthesis of silver nanoparticles using bark aqueous extract of F.racemosa and its larvicidal activity against the larvae of disease spreading vectors.The maximum larvicidal efficacy was observed in the synthesized Ag NPs. | Kanayairam Velayutham Abdul Abdul Rahuman Govindasamy Rajakumar Selvaraj Mohana Roopan Gandhi Elango Chinnaperumal Kamaraj Sampath Marimuthu Thirunavukkarasu Santhoshkumar Moorthy Iyappan Chinnadurai Siva | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，2： | 2 |
| 4 | Effect of angiotensin converting enzyme gene I/D polymorphism in South Indian children with nephrotic syndrome显示文摘Nephrotic syndrome is one of the most common childhood kidney diseases. It is mostly found in the age group of 2 to 8 years. Around 10%-15% of nephrotic syndrome cases are non-responders of steroid treatment(SRNS).Angiotensin converting enzyme(ACE)(I/D) gene association studies are important for detecting kidney disease and herein we assessed the association of ACE(I/D) polymorphism with nephrotic syndrome in South Indian children. We recruited 260 nephrotic syndrome(162 boys and 98 girls) and 218(140 boys and 78 girls) control subjects. ACE I/D polymorphism was analyzed by PCR using genotype allele specific primers. In ACE(I/D), we did not find significant association for the ungrouped data of nephrotic syndrome children and the control subjects. Kidney biopsies were done in 86 nephrotic syndrome cases(minimal change disease, n = 51;focal segmental glomerulosclerosis, n = 27;diffuse mesangial proliferation, n = 8). We segregated them into the minimal change disease/focal segmental glomerulosclerosis groups and observed that the ACE’D’ allele was identified with borderline significance in cases of focal segmental glomerulosclerosis and the ’Ⅰ’ allele was assessed as having very weak association in cases of minimal change disease. ’Ⅱ’ genotype was weakly associated with minimal change disease. Gender specific analysis revealed weak association of’ID’ genotype with female nephrotic syndrome in females. Dominant expression of DD genotype was observed in males with nephrotic syndrome. Our finding indicated that ACE(I/D) has moderate association with focal segmental glomerulosclerosis. However, due to the limited number of biopsy proven focal segmental glomerulosclerosis subjects enrolled, further studies are required to confirm these results. | Aravind Selvin Kumar Ramanathan Balakrishnan Karuppiah Murali Vijayan Kamaraj Raju Dhivakar Mani Rathika Chinniah Manikandan Thirunavukkarasu Padma Malini Ravi Jeyaram Illiayaraja Krishnan Prabha Senguttuvan | 2019 | The Journal of Biomedical Research2019，33，3： | 2 |
| 5 | Larvicidal potential of selected indigenous lichens against three mosquito species–Culex quinquefasciatus, Aedes aegypti and Anopheles stephensi显示文摘Objective:Mosquitoes are the major transmitting vectors of serious human diseases,causing millions of deaths every year with undesirable effects,including toxicity to non-target organisms.Some plants with insecticidal properties have been used in recent years for the control of a variety of pest insects and vectors.In the quest for alternative natural biological control agents against mosquito larvae lichens were selected.Method:Larvicidal activity was assessed with methanolic extracts of Parmotrema reticulatum,Parmotrema kamatti,Parmotrema tinctorum,Parmelia erumpens,Leptogium papilosum,and Roccella montagnei against Aedes aegypti,Anopheles stephensi,and Culex quinquefasciatus.The standard WHO protocols with minor modifications were adopted and the bioassay was evaluated at the concentrations of 100–500μg/m L for each lichen.Since all the lichen extracts showed complete mortality against C.quinquefasciatus in100μg/m L,the concentrations were decreased to 100,50,25,12.5,and 6.25μg/m L for C.quinquefasciatus.Larval mortality was observed for 24 h after treatment.Results:All the lichen extracts exhibited activity against third instar larvae of A.aegypti and A.stephensi at 100μg/m L,and 100%mortality was observed against the vector C.quinquefasciatus at 100μg/m L.The highest larvicidal activity was found with L.papilosum against A.aegypti(81.127μg/m L)and A.stephensi(89.10μg/m L).Similarly,P.tinctorum and R.montagnei when tested against C.quinquefasciatus with minimum concentration<100μg/m L exhibited significant activity withof 5.32and 6.97μg/m L.Conclusion:The bioassay results revealed larvicidal potential of lichens especially against C.quinquefasciatus with high mortality even at lower concentration.Hence,lichens can be used as an ideal sustainable approach for the control of lymphatic filariasis caused by vector C.quinquefasciatus. | Syed Zameer Ahmed Khader Sidhra Syed Zameer Ahmed Kisore Perundurai Venkatesh Kamaraj Chinnaperumal Sanjeeva Nayaka | 2018 | Chinese Herbal Medicines2018，10，2： | 2 |
| 6 | Laboratory study on larvicidal activity of indigenous plant extracts against Anopheles subpictus and Culex tritaeniorhynchus显示文摘 | G. Elango A. Abdul Rahuman A. Bagavan C. Kamaraj A. Abduz Zahir C. Venkatesan | 2009 | Parasitology Research2009，，6： | 2 |
| 7 | Efficacy of larvicidal botanical extracts against Culex quinquefasciatus Say (Diptera: Culicidae)显示文摘 | A. A. Rahuman A. Bagavan C. Kamaraj E. Saravanan A. A. Zahir G. Elango | 2009 | Parasitology Research2009，，6： | 2 |
| 8 | Acaricidal activity of synthesized titanium dioxide nanoparticles using Calotropis gigantea against Rhipicephalus microplus and Haemaphysalis bispinosa显示文摘Objective:To assess the acaricidal activity of titanium dioxide nanoparticles(TiO_2 NPs)synthesized from flower aqueous extract of Calotropis gigantea(C.gigantea)against the larvae of Rhipicephalus(Boophilus)microplus[R.(B.)microplus]and the adult of Haemaphrysalis bispinosa(H.bispinosa).Methods:The lyophilized C.gigantea flower aqueous extract of 50 mg was added with 100 mL of TiO(OH_2)(10 mM)and magnetically stirred for 6 h.Synthesized TiO_2 NPs were characterized by X-ray diffraction(XRD).Fourier transform infrared spectroscopy(FTIR),Scanning electron microscopy(SEM),and Energy dispersive X-ray spectroscopy(EDX).The synthesised TiO_2 NPs were tested against the larvae of R(B.)microplus and adult of H.bispinosa were exposed to filter paper impregnated method.Results:XRD confirmed the crystalline nature of the nanoparticles with the mean size of 10.52 nm.The functional groups for synthesized TiO_2NPs were 1405.19,and 1053.45 cm^(-1)for-NH_2 bending,primary amines and amides and 1053.84and 1078.45 cm^(-1)for C-O.SEM micrographs of the synthesized TiO_2 NPs showed the aggregated and spherical in shape.The maximum efficacy was observed in the aqueous flower extract of C.gigantea and synthesized TiO_2 NPs against R.(B.)microplus(LC_(50)=24.63 and 5.43 mg/L and r^2=0.960 and 0.988)and against H.bispinosa(LC_(50)=35.22 and 9.15 mg/L and r^2=0.969 and 0.969).respectively.Conclusions:The synthesized TiO_2 NPs were highly stable and had significant acaricidal activity against the larvae of R.(B.)microplus and adult of H.bispinosa.This study provides the first report of synthesized TiO_2 NPs and possessed excellent anti-parasitic activity. | Sampath Marimuthu Abdul Abdul Rahuman Chidambaram Jayaseelan Arivarasan Vishnu Kirthi Thirunavukkarasu Santhoshkumar Kanayairam Velayutham Asokan Bagavan Chinnaperumal Kamaraj Gandhi Elango Moorthy Iyappan Chinnadurai Siva Loganathan Karthik Kokati Venkata Bhaskara Rao | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，9： | 2 |
| 9 | Biosynthesis of titanium dioxide nanoparticles using bacterium Bacillus subtilis显示文摘 | A.Vishnu Kirthi A. Abdul Rahuman G. Rajakumar S. Marimuthu T. Santhoshkumar C. Jayaseelan G. Elango A. Abduz Zahir C. Kamaraj A. Bagavan | 2011 | Materials Letters2011，，17： | 2 |
| 10 | Oviposition-deterrent, ovicidal, and repellent activities of indigenous plant extracts against Anopheles subpictus Grassi (Diptera: Culicidae)显示文摘 | G. Elango A. Bagavan C. Kamaraj A. Abduz Zahir A. Abdul Rahuman | 2009 | Parasitology Research2009，，6： | 2 |
| 11 | Antiplasmodial potential of medicinal plant extracts from Malaiyur and Javadhu hills of South India显示文摘 | Chinnaperumal Kamaraj Naveen Kumar Kaushik Dinesh Mohanakrishnan Gandhi Elango Asokan Bagavan Abdul Abduz Zahir Abdul Abdul Rahuman Dinkar Sahal | 2012 | Parasitology Research2012，，2： | 2 |
| 12 | Lysosomal abnor- malities during benzo (a)pyrene-induced experimental lung car- cinogenesis-defensive role of capsaicin 显示文摘 | Anandakumar P Kamaraj S Jagan S | 2009 | Fund Clin Pharma- col2009，23，1： | 1 |
| 13 | Electropolymerised polyaniline films as effective replacement of carcinogenic chromate treatments for corrosion protection of aluminium alloys 显示文摘 | KAMARAJ K KARPAKAM V AZIM S S | 2012 | Synthetic Metals2012，162，56： | 1 |
| 14 | Processing and proper- ties of nanocrystalline CuNiCoZnA1Ti high entropy alloys by mechanical alloying显示文摘 | Varalakshmi S Kamaraj M Murty B S | 2010 | Materials Science and Engineering: A2010，527，4： | 1 |
| 15 | Electropolymer- ised polyaniline films as effective replacement of carcinogen- ic chromate treatments for corrosion protection of aluminium alloys显示文摘 | Kamaraj K Kappakam V Azim S S | 2012 | Synthetic Metals2012，162，56： | 1 |
| 16 | Evolving Decision Tree Rule Based System for Audio Stego Anomalies Detection Based on Hausdorff Distance Statistics显示文摘 | Geetha S Ishwarya N Kamaraj N | 2010 | Information Sciences2010，180，13： | 1 |
| 17 | Detection of odoriferous subgingival and tongue microbiota in diabetic and nondiabetic patients with oral malodor using polymerase chain reaction显示文摘 | Kamaraj DR Bhushan KS Laxman VK | 2011 | Indian J Dent Res2011，22，2： | 1 |
| 18 | Review of solar cooling methods and thermal storage options 显示文摘 | Chidambaram LA Ramana AS Kamaraj G | 2011 | Energy Reviews2011，15，6： | 1 |
| 19 | Sulphonate Doped Polyaniline Containing Coatings for Corrosion Protection of Iron 显示文摘 | SATHIYANARAYANAN S KARPAKAM V KAMARAJ K | 2010 | Surface & Coatings Tech- nology2010，204，： | 1 |
| 20 | Mechanical and wear behavior of alloyed gray cast iron in the quenched and tempered and austempered conditions 显示文摘 | Balachandran G Vadiraj A Kamaraj M | 2011 | Materials and Design2011，32，7： | 1 |
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