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| 1 | Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018显示文摘There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars. | Rei Ogawa Sadanori Akita Satoshi Akaishi Noriko Aramaki-Hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura Gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi | 2019 | Burns & Trauma2019，7，1： | 31 |
| 2 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 3 | Significance of serum and hepatic micro RNA ‐122 levels in patients with non‐alcoholic fatty liver disease显示文摘 | Hisamitsu Miyaaki Tatsuki Ichikawa Yasuhiro Kamo Naota Taura Takuya Honda Hidetaka Shibata Maddalena Milazzo Francesca Fornari Laura Gramantieri Luigi Bolondi Kazuhiko Nakao | 2014 | Liver Int2014，，7： | 4 |
| 4 | The application of SHRIMP to Phanerozoic geochronology: a critical appraisal of four zircon standards显示文摘 | Lance P Black Sandra L Kamo lan S Williams | 2003 | Chemical Geology2003，200，： | 1 |
| 5 | Comparison of leak point pressure methods in an animal model of stress uri nary incontinence 显示文摘 | Conway DA Kamo I Yoshimura N | 2005 | Int Urogynecol J2005，16，5： | 1 |
| 6 | Isolation and characterization ofalginate-derived oligosaccharides with root growth-promotion activities 显示文摘 | Natsume M Kamo Y Hirayama M | 1994 | Carbohydr Res1994，258，： | 1 |
| 7 | First isolation of natural cyanamide as a possible allelochemical from hairy vetch显示文摘 | Kamo T Hiradate S Fujii Y | 2003 | Journal of Chemical Ecology2003，29，2： | 1 |
| 8 | Incremental value ofT2-we i gh t ed and d i f f us i on-weighted MRI for predictionof biochemical recurrenceafter radical prostatectomy inclinically localized prostatecancer 显示文摘 | N i sh ida K Yuen S Kamo i K et a 1 | 2011 | Acta Radiol2011，52，2： | 1 |
| 9 | PTEN-mediated Akt/13-cate- nin/Foxol signaling regulates innate immune responses in mouse liver ischemia/reperfusion injury 显示文摘 | Kamo N Ke B Busuttil RW | 2013 | Hepatology2013，57，1： | 1 |
| 10 | The promoting effect of eucommiol from eucommiae cortex on collagen synthesis 显示文摘 | LI Y Kamo S Metori K | 2000 | Biol Pharm Bull2000，23，1： | 1 |
| 11 | FIEN-mediated Akt/15-Catenin/ Foxol signaling regulates innate immune responses in mouse liver is- chemia/reperfusion injury 显示文摘 | Kamo N Ke B Busuttil RW | 2013 | Hepatology2013，57，1： | 1 |
| 12 | TEMORA 1 :A New Zircon Standard for Phanerozoic U-Pb Geochronology 显示文摘 | Black L P Kamo S L Allen C M | 2003 | Chemical Geology2003，200，12： | 1 |
| 13 | Late Archaean to early Pro- terozoic granitoid magmatism and high-grade metamorphism in the central Limpopo belt, South Africa显示文摘 | Jaeckel P Kr/Sner A Kamo S L | 1997 | JourrtaI of the Geological Society of London1997，154，： | 1 |
| 14 | A minimum U-Pb age for Siberian flood-basalt volcanism 显示文摘 | Kamo L Czamanske G K Krogh T E | 1996 | Geochimiea et Cosmo- chimica Acta1996，60，18： | 1 |
| 15 | Wound-induced ethylene synthesis in stem tissue of harvested broccoli and its effect on senescence and ethylene synthesis in broccoli florets 显示文摘 | Kato M Kamo T Wang R | 2002 | Postharvest biology and technology2002，24，1： | 1 |
| 16 | Intermittent weekly administration of human parathyroid hormone(1-34) improves bone-hydroxyapatite block bonding in ovariectomized rats显示文摘 | Kamo K Miyakoshi N Kasukawa Y | 2010 | J Bone Miner Metab2010，28，6： | 1 |
| 17 | Guanine nucleotide exchange factor Tiam1,directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts显示文摘 | Otsuki Y Tanaka M Kamo T | 2003 | J Biol Chem2003，278，7： | 1 |
| 18 | Bisphenol A induces en- doplasmic reticulum stress-associated apoptosis in mouse non-parenchymal hepatocytes 显示文摘 | Asahi J Kamo H Baba R | 2010 | Life Sci2010，87，： | 1 |
| 19 | Effective resistance to potyvirus infection conferred by expression of antisense RNA in transgenic plants显示文摘 | KAMO K K | 1995 | MPMI1995，8，： | 1 |
| 20 | Longer Life in RH With Oxygen Top Blowing System显示文摘 | Kamo M Adachi K Nambu M | 1997 | Steelmaking Conference Pro ceedings1997，80，： | 1 |
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