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| 1 | The role of Src homology 2 containing protein tyrosine phosphatase 2 in vascular smooth muscle cell migration and proliferation显示文摘脉管的光滑的肌肉房间(VSMC ) 在生理、病理学的条件下面包括移植,区别和增长执行可收缩的必要光滑的肌肉和合成功能。响应病理学的刺激, VMSC 经历 phenotypic 变化导致反常移植和增长,它可以贡献鈥減a 象 thogenesis 一样鈥 ? 动脉粥样硬化。管理这个 phenotypic 开关的细胞内部的发信号机制不仅为动脉粥样硬化患者匾形成的更好的理解而且为为恰当的治疗学的疗法的策略意义大。(SHP2 ) Src 相同 2 包含的蛋白质酷氨酸磷酸酶 2 是包含响应各种各样的生长因素,荷尔蒙或 cytokines 玩主要生物函数的 Src 相同 2 域的无所不在的酷氨酸磷酸酶。特别地, SHP2 在表明控制房间周期前进,生长和移植的小径的房间被含有。在这评论,我们将主要讨论在 VSMC 移植和增长表明 SHP2 的角色的最近的文学。 | Machender R KANDADI Matthew S STRATION Jun REN | 2010 | Acta Pharmacologica Sinica2010，31，10： | 7 |
| 2 | Tween 80 containing lipid nanoemulsions for delivery of indinavir to brain显示文摘Indinavir is a protease inhibitor used in the treatment of HIV infection.However,it has limited efficacy in eradicating the virus in the brain due to efflux by P-glycoprotein(P-gp)expressed at the blood–brain barrier(BBB).The objective of this work was to develop an o/w lipid nanoemulsion(LNE)of indinavir using Tween 80 as co-emulsifier to improve its brain specific delivery.LNEs were prepared with different compositions and were characterized for globule size,polydispersity index,zeta potential and in vitro drug release.Five formulations were then evaluated for drug content,entrapment efficiency and stability after which brain uptake studies were carried out using fluorescent labeled LNEs and pharmacokinetic(PK)and tissue distribution studies were conducted after intravenous administration in mice.Brain uptake of indinavir was shown to be improved for a 1%Tween 80 containing formulation(F5)compared to a formulation containing 0.3%cholesterol(F2).In PK studies,the brain level of indinavir subsequent to administration of F5 was significantly(Po0.05)higher than produced by administration of a drug solution(2.44-fold)or a control nanoemulsion(F1)(1.48-fold)or formulation F2(1.6-fold).The increased brain specific accumulation of indinavir from F5 is probably due to enhanced low density lipoprotein-mediated endocytosis and P-gp inhibition by Tween 80 at the BBB.These results suggest Tween 80 containing LNEs could provide a simple but effective means of delivering indinavir to brain. | Kandadi Prabhakar Syed Muzammil Afzal Goparaboina Surender Veerabrahma Kishan | 2013 | Acta Pharmaceutica Sinica B2013，3，5： | 2 |
| 3 | Facilitated ethanol metabolism promotes cardiomyoeyte contractile dysfunction through autophagy in murine hearts显示文摘 | Guo R Hu N Kandadi MR | 2012 | Autophagy2012，8，4： | 1 |
| 4 | Chromium Alleviates Glucose Intolerance Insulin Resistance and Hepatic ER Stress in Obese Mice显示文摘 | Sreejayan N Dong F Kandadi MR | 2008 | Obesity (Silver Spring)2008，16，6： | 1 |
| 5 | Antidiabetic effect of Dodonaea viscosa aerial parts in high fat diet and low dose streptozotocin-induced type 2 diabetic rats : a mech- anistic approach显示文摘 | VEERAPUR VP PRABHAKAR KR KANDADI MR | 2010 | Pharm Biol2010，48，10： | 1 |
| 6 | Chromi- um (D--Phenylalanine) (3)alleviates high fat--induced in- sulin resistance and lipid abnormalities 显示文摘 | Kandadi M Unnikrishnan MK Warrier AS | 2011 | J Inorg Bio- chem2011，105，1： | 1 |
| 7 | Chromium al- leviates glucose intolerance, insulin resistance, and he- patic ER stress in obese mice 显示文摘 | Sreejayan N Dong F Kandadi MR | 2008 | Obesity (Silver Spring)2008，16，6： | 1 |
| 8 | Chromium (D-phenylalanine) 3 supplementation alters glucose disposal, insulin signaling, and glucose transporter-4 membrane translocation in insulin-resistant mice 显示文摘 | DONG F KANDADI M R REN J | 2008 | The Journal of Nutrition2008，138，10： | 1 |
| 9 | Chromium (D-Phenylalanine) 3 alleviates high fat-induced insulin resistance and lipid abnormalities显示文摘 | Kandadi M R Unnikrishnan M K Warrier A K | 2011 | J Inorg Biochem2011，105，1： | 1 |
| 10 | Tauroursodeoxycholic acid attenuates lipid accumulation in endoplasmic reticulum-stressed macrophages 显示文摘 | Hua Y Kandadi MR Zhu M | 2010 | J Cardiovasc Pharmacol2010，55，1： | 1 |
| 11 | Apelin adminis- tration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunetion显示文摘 | Ceylan-Isik AF Kandadi MR Xu X | 2013 | J Mol Cell Cardiol2013，63，： | 1 |
| 12 | Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pinkl-AMPK signaling and autophagy显示文摘 | Roe ND Xu X Kandadi MR | 2015 | Biochim Biophys Acta2015，1852，2： | 1 |
| 13 | Facilitated ethanol metabolism promotes cardiomyocyte contractile dysfunction through autophagy in murine hearts显示文摘 | Guo R Hu N Kandadi MR | 2012 | A utophagy2012，8，4： | 1 |
| 14 | Chromium Alleviates Glucose Intolerance Insulin Resistance and Hepatic ER Stress in Obese Mice显示文摘 | Sreejayan N Dong E Kandadi MR | 2008 | Obesity(Silver Spring)2008，16，6： | 1 |
| 15 | Toll-like receptor 4 knockout protects against anthrax lethal toxin-induced cardiac contractile dysfunction:Role of autophagy显示文摘 | Kandadi M R Frankel A E Ren J | 2012 | British Journal of Pharmacology2012，167，3： | 1 |
| 16 | Taurour- sodeoxycholic acid attenuates lipid accumulation in endoplasmic reticulum - stressed macrophages 显示文摘 | Hua Y Kandadi MR Zhu M | 2010 | J Cardiovasc Pharmacol2010，55，1： | 1 |
| 17 | Facilitated ethanol metabolismpromotes cardiomyocyte contractile dysfunction through autoph-agy in murine hearts显示文摘 | Guo R Hu N Kandadi MR | 2012 | Autophagy2012，8，4： | 1 |
| 18 | Chromium alleviates glucose intolerance,insulin resistance, and hepatic ER stress in obese mice显示文摘 | Sreejayan N Dong F Kandadi MR | 2008 | Obesity (Silver Spring)2008，16，： | 1 |
| 19 | Biochemical,Molecular,and Genetic Mechanisms Chromium(D-phenylalanine)3 Supplementation Alters Glucose Disposal,Insulin Signaling,and Glucose Transporter-4 Membrane Translocationin Insulin-Resistant Mice1-3 J显示文摘 | Feng Dong Machender Reddy Kandadi | | 0，，： | 1 |
| 20 | Chromium(Dphenylalanine)supplementation alters glucose disposal,insulin signaling,and glucose transporter-4 membrane translocation in insulin-resistant mice显示文摘 | Dong F Kandadi M R Ren J | 2008 | J Nutr2008，138，： | 1 |
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