|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of ascites adenosine deaminase in differentiating between tuberculous peritonitis and peritoneal carcinomatosis显示文摘AIM: To investigate the usefulness of tumor markers and adenosine deaminase in differentiating between tuberculous peritonitis (TBP) and peritoneal carcinoma- tosis (PC). METHODS: A retrospective analysis of data was performed on consecutive patients who underwent perito-neoscopic and abdominal computed tomography (CT) evaluations. Among 75 patients at the Seoul National University Hospital from January 2000 to June 2010 who underwent both tests, 27 patients (36.0%) and 25 patients (33.3%) were diagnosed with TBP and PC, respectively. Diagnosis was confirmed by peritoneoscopic biopsy. RESULTS: Serum c-reactive protein (7.88 ± 6.62 mg/ dL vs 3.12 ± 2.69 mg/dL, P = 0.01), ascites adenosine deaminase (66.76 ± 32.09 IU/L vs 13.89 ± 8.95 IU/L, P < 0.01), ascites lymphocyte proportion (67.77 ± 23.41% vs 48.36 ± 18.78%, P < 0.01), and serumascites albumin gradient (0.72 ± 0.49 g/dL vs 1.05 ± 0.50 g/dL, P = 0.03) were significantly different between the two groups. Among tumor markers, serum and ascites carcinoembryonic antigen, serum carbohydrate antigen 19-9 showed significant difference between two groups. Abdominal CT examinations showed that smooth involvement of the parietal peritoneum was more common in the TBP group (77.8% vs 40.7%) whereas nodular involvement was more common in the PC group (14.8% vs 40.7%, P = 0.04). From receiver operating characteristic (ROC) curves ascites adenosines deaminase (ADA) showed better discriminative capability than tumor markers. An ADA cut-off level of 21 IU/L was found to yield the best results of differential diagnosis; sensitivity, specificity, positive predictive value, and negative predictive value were 92.0%, 85.0%, 88.5% and 89.5%, respectively. CONCLUSION: Besides clinical and radiologic findings, ascitic fluid ADA measurement is helpful in the differential diagnosis of TBP and PC. | Seung Joo Kang Ji Won Kim Jee Hyun Baek Se Hyung Kim Byeong Gwan Kim Kook Lae Lee Ji Bong Jeong Yong Jin Jung Joo Sung Kim Hyun Chae Jung In Sung Song | 2012 | World Journal of Gastroenterology2012，18，22： | 15 |
| 2 | Retrospective analysis of extra-gastrointestinal stromal tumors显示文摘AIM:To investigate the clinicopathologic features of patients with extra-gastrointestinal stromal tumors(EGISTs)in South Korea.METHODS:A total of 51 patients with an EGIST were identified.The clinicopathologic features,including sex,age,location,tumor size,histology,mitotic rate,immunohistochemical features,genetic status and survival data,were analyzed.RESULTS:The median age was 55 years(range:29-80years),and male:female ratio was 1:1.04.The most common site was in the mesentery(n=15)followed by the retroperitoneum(n=13)and omentum(n=8).The median tumor size was 9.0 cm(range:2.6-30.0cm)and the median mitotic rate was 5.0/50HPF.(1/50-185/50).KIT was analyzed in 16,which revealed 10cases with wild-type KIT and 6 cases with an exon 11mutation.Among 51 patients,31 patients had undergone surgery,and 10 had unresectable disease and had taken palliative imatinib,which resulted in 22.7 mo of progression-free survival.Of the patients who had undergone surgery,18 did not take adjuvant imatinib,and 8 of these were categorized as'high risk'according to the risk criteria.However,the relapse-free survival was not different(P=0.157)between two groups.CONCLUSION:Because the biologic behaviors of GISTs differ according to the location of the tumor,a more stratified strategy is required for managing EGISTs including incorporation of molecular features. | Jun Ho Yi Byeong-Bae Park Jung Hun Kang In Gyu Hwang Dong Bok Shin Sun Jin Sym Hee Kyung Ahn Soon Il Lee Do Hyoung Lim Keon Woo Park Young-Woong Won Sung Hee Lim Se Hoon Park | 2015 | World Journal of Gastroenterology2015，21，6： | 9 |
| 3 | Five-year major clinical outcomes between first-generation ana second- generation drug-eluting stents in acute myocardial infarction patients underwent percutaneous coronary intervention显示文摘 | Yong Hoon Kim Ae-Young Her Seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Ju Yeol Baek Woong Gil Choi Tae Soo Kang Ji Hoon Ahn Sang-Ho Park Ahmed Mashaly Jin Oh Na Cheol Ung Choi Hong Euy Lim Eung Ju Kim Chang Gyu Park Hong Seog Seo Dong Joo Oh | 2018 | Journal of Geriatric Cardiology2018，15，8： | 8 |
| 4 | Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels显示文摘Brachydactyly 打 A1 (BDA1 ) ,第一在人记录了孟德尔的正染色体的主导的混乱,被弄短或中间的指骨的缺席描绘。在印度刺猬(IHH ) 基因的异质接合的错误感觉变化作为 BDA1 的一个原因被识别了;然而,这些变化的生物化学的后果是不清楚的。在这份报纸,我们在印度刺猬(IhhN ) 的 N 终端碎片分析了三个 BDA1 变化(E95K, D100E,和 E131K ) 。结构的分析证明 E95K 变化在一条钙绑定沟把一个否定地控告的区域改变到一个断然控告的区域,并且 D100E 变化改变本地第三级的结构。而且,我们证明 E95K 和 D100E 变化导致了一温度敏感并且 IhhN 的钙依赖者不稳定性,它可能经由 lysosome 贡献变异的蛋白质的提高的细胞内部的降级。尤其是,所有三个变化影响了对受体 Patched1 (PTC1 ) 有约束力的 Hh,减少它的能力导致细胞的区别。我们建议这些是引起 BDA1 的变化的普通特征,影响 Hh 第三级的结构,细胞内部的命运,到受体 / 搭挡的绑定,和到细胞外的部件的绑定。这些特征的联合改变发信号的能力和范围,但是影响是可能的是变量和变化依赖者。在发信号的范围的潜在的变化被和 heparan 硫酸盐的一个提高的相互作用与 E95K 变化,然而并非 E131K 变化为 IHH 描绘。一起拿,我们的结果建议这些 IHH 变化影响在多重层次,引起的反常骨头发展和反常的位形成发信号的 Hh。 | Gang Ma Jiang Yu Yue Xiao Danny Chan Bo Gao Jianxin Hu Yongxing He Shengzhen Guo Jian Zhou Lingling Zhang Linghan Gao Wenjuan Zhang Yan Kang Kathryn SE Cheah Guoyin Feng Xizhi Guo Yujiong Wang Cong-zhao Zhou Lin He | 2011 | Cell Research2011，21，9： | 6 |
| 5 | Risk factors for tuberculosis after gastrectomy in gastric cancer显示文摘AIM: To examine incidence of tuberculosis(TB) in gastrectomy patients and investigate the risk factors for developing TB after gastrectomy in patients with gastric cancer.METHODS: A retrospective cohort study of gastrectomy patients with gastric cancer was performed at a university-affiliated hospital in Seoul, South Korea between January 2007 and December 2009. We reviewed patient medical records and collected data associated with the risk of TB, surgery, and gastric cancer. Standardized incidence ratios(SIRs) of TB were calculated to compare the incidence of TB in gastrectomy patients with that in the general Korean population, and risk factors for TB after gastrectomies were analyzed.RESULTS: Among the 1776 gastrectomy patients, 0.9%(16/1776) developed post-gastrectomy TB, with an incidence of 223.7 cases per 100000 patients per year. The overall incidence of TB in gastrectomy patients, adjusted by sex and age, was significantly higher thanthat in the general population(SIR = 2.22, 95%CI: 1.27-3.60). Previous TB infection [odds ratio(OR) = 7.1, P < 0.001], lower body mass index(BMI)(kg/m2; OR = 1.21, P = 0.043) and gastrectomy extent(total gastrectomy vs subtotal gastrectomy)(OR = 3.48, P = 0.017) were significant risk factors for TB after gastrectomy in a multivariate analysis.CONCLUSION: TB incidence after gastrectomy is higher than that in the general population. Previous TB infection, lower BMI, and total gastrectomy are risk factors for TB after gastrectomy in patients with gastric cancer. | Won Jai Jung Young Mok Park Joo Han Song Kyung Soo Chung Song Yee Kim Eun Young Kim Ji Ye Jung Moo Suk Park Young Sam Kim Se Kyu Kim Joon Chang Sung Hoon Noh Ji Yeong An Young Ae Kang | 2016 | World Journal of Gastroenterology2016，22，8： | 3 |
| 6 | Calcium channel blocker monotherapy versus combination with reninangiotensin system inhibitors on the development of new-onset diabetes mellitus in hypertensive Korean patients显示文摘Background In real practice, two or more antihypertensive drugs are needed to achieve target blood pressure. We investigated the comparative beneficial actions of combination therapy of renin-angiotensin system inhibitors (RASI), with calcium channel blockers (CCB) over CCB monotherapy on the development of new-onset diabetes mellitus (NODM) in Korean patients during four-year follow-up periods. Methods A total of 3208 consecutive hypertensive patients without a history of diabetes mellitus who had been prescribed CCB were retrospectively enrolled from January 2004 to December 2012. These patients were divided into the two groups according to the additional use of RASI (the RASI group, n = 1221 and the no RASI group, n = 1987). Primary endpoint was NODM, defined as a fasting blood glucose ≥ 126 mg/dL or hemoglobin A1c ≥ 6.5%. Secondary endpoint was major adverse cardiac events (MACE) defined as total death, myocardial infarction (MI) and percutaneous coronary intervention (PCI). Results After propensity score-matched (PSM) analysis, two propensity- matched groups (939 pairs, n = 1878, C-statistic = 0.743) were generated. The incidences of NODM (HR = 1.009, 95% CI: 0.700–1.452, P = 0.962), MACE (HR = 0.877, 95% CI: 0.544–1.413, P = 0.589), total death, MI, PCI were similar between the two groups after PSM during four years. Conclusions The use of RASI in addition to CCB showed comparable incidences of NODM and MACE compared to CCB monotherapy in non-diabetic hypertensive Korean patients during four-year follow-up period. However, large-scaled randomized controlled clinical trials will be required for a more definitive conclusion. | Yong Hoon Kim Ae-Young Her Seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Yoonjee Park Dong Oh Kang Won Young Jang Woohyeun Kim Woong Gil Choi Tae Soo Kang Jihun Ahn Sang-Ho Park Ji Young Park Min-Ho Lee Cheol Ung Choi Chang Gyu Park Hong Seog Seo | 2019 | Journal of Geriatric Cardiology2019，16，6： | 3 |
| 7 | Short-term overlap lamivudine treatment with adefovir dipivoxil in patients with lamivudine-resistant chronic hepatitis B显示文摘AIM:To evaluate the efficacy of short-term overlap lamivudine therapy with adefovir in patients with lamivudine-resistant and nave chronic hepatitis B,we compared patients receiving overlap therapy with those receiving adefovir alone. METHODS:Eighty patients who had received lamivudine treatment for various periods and had a lamivudine- resistant liver function abnormality were enrolled.Forty of these patients received adefovir treatment combined with lamivudine treatment for≥2 mo,while the other 40 received adefovir alone.We assessed the levels of hepatitis B virus(HBV)DNA at 0,12 and 48 wk and serum alanine aminotransferase(ALT)levels after 0,12, 24 and 48 wk of adefovir treatment in each group. RESULTS:We found serum ALT became normalized in 72(87.5%)of the 80 patients,and HBV DNA decreased by≥2 log10 copies/mL in 60(75%)of the 80 patients at the end of a 48-wk treatment.HBV DNA levels were not significantly different between the groups.The improvements in serum ALT were also not significantly different between the two groups. CONCLUSION:These findings suggest short-term overlap lamivudine treatment results in no better virological and biological outcomes than non-overlap adefovir monotherapy. | Soon Woo Nam Si Hyun Bae Seung Woo Lee Yeon Soo Kim Sang Bum Kang Jong Young Choi Se Hyun Cho Seung Kew Yoon Joon-Yeol Han Jin Mo Yang Young Suk Lee | 2008 | World Journal of Gastroenterology2008，14，11： | 3 |
| 8 | Clinicopathologic significance of GLUT1 expression and its correlation with Apaf-1 in colorectal adenocarcinomas显示文摘AIM:To investigate the role of glucose transporter 1 (GLUT1) expression in colorectal carcinogenesis and evaluate the correlation with clinicopathological parameters and apoptosis-activating factor-1 (Apaf-1) expression in colorectal adenocarcinomas. METHODS:We used tissue microarrays consisting of 26 normal mucosa,50 adenomas,515 adenocarcinomas,and 127 metastatic lesions. Medical records were reviewed and clinicopathological analysis was performed. RESULTS:GLUT1 expression was absent in normal mucosa and low or moderately apparent in 19 cases (38.0%) of 50 adenomas. However,GLUT1 expression was detected in 423 (82.1%) of 515 adenocarcinomas and in 96 (75.6%) of 127 metastatic lesions. GLUT1 expression was significantly correlated with female gender (P = 0.009),non-mucinous tumor type (P = 0.045),poorer differentiation (P = 0.001),lymph node metastasis (P < 0.001),higher AJCC and Dukes stage (P < 0.001 and P < 0.001,respectively). There was a significant inverse correlation between GLUT1 expression and Apaf-1 expression (P = 0.001). In univariate survival analysis,patients with GLUT1 expression demonstrated poor overall survival and disease-free survival (P = 0.047 and P = 0.021,respectively,log-rank test). CONCLUSION:GLUT1 expression was frequently increased in adenocarcinomas and metastatic lesions. GLUT1 expression was significantly correlated with poorer clinicopathologic phenotypes and survival of patients with colorectal adenocarcinomas. | Young Jin Jun Se Min Jang Hu lin Han Ki-Seok Jang Seung Sam Paik Kang Hong Lee | 2011 | World Journal of Gastroenterology2011，17，14： | 2 |
| 9 | A phase II study of sunitinib as a second-line treatment in advanced biliary tract carcinoma: A multicentre, multinational study显示文摘 | Jun Ho Yi Sumitra Thongprasert Jeeyun Lee D.C. Doval Se Hoon Park Joon Oh Park Young Suk Park Won Ki Kang Ho Yeong Lim | 2011 | European Journal of Cancer2011，，2： | 2 |
| 10 | Sinkihwan-gamibang ameliorates puromycin amino nucleoside-induced nephrotic syndrome显示文摘Nephrotic syndrome(NS)is a kidney disease characterized by hypertriglyceridemia,massive proteinuria,hypo-albuminemia and peripheral edema.Sinkihwan-gamibang(SKHGMB)was recorded in a traditional Chinese medical book named“Bangyakhappyeon(方藥合編)”and its three prescriptions Sinkihwan,Geumgwe-sinkihwan,and Jesaeng-sinkihwan belong to Gamibang.This study confirmed the effect of SKHGMB on renal dysfunction in an NS model induced by puromycin aminonucleoside(PAN).The experimental NS model was induced in male Sprague Dawley(SD)rats through injection of PAN(50 mg·kg^(-1))via the femoral vein.SKHGMB not only reduced the size of the kidneys increased due to PAN-induced NS,but also decreased proteinuria and ascites.In addition,SKHGMB significantly ameliorated creatinine clearance,creatinine,and blood urea nitrogen.SKHGMB relieved glomeruli dilation and tubules fibrosis in the glomeruli of the NS model.SKHGMB inhibited the protein and mRNA levels of the NLRP3 inflammasome including NLRP3,ASC,and pro-caspase-1 in NS rats.SKHGMB reduced the protein and mRNA levels of fibrosis regulators in NS rats.The results indicated that SKHGMB exerts protective effects against renal dysfunction by inhibiting of renal inflammation and fibrosis in NS rats. | Lee Hyeon Kyoung Jang Youn Jae Na Se Won Kim Hye Yoom Han Bywig Hyuk Lee Yun Jung Lee Ho Sub Yoon Jung Joo Kang Dae Gill | 2022 | Chinese Journal of Natural Medicines2022，20，3： | 2 |
| 11 | Effect of sitagliptin plus metformin on beta-cell function, islet integrity and islet gene expression in Zucker diabetic fatty rats显示文摘 | Hart S J Choi SE Kang Y | 2011 | Diabetes Res Clin Pract2011，92，2： | 1 |
| 12 | Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention显示文摘Background There are limited data comparing long-term clinical outcomes between first-generation (1G) and second-generation (2G) drug-eluting stents (DESs) in patients who underwent successful percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) lesion. Methods A total of 840 consecutive patients who underwent PCI with DESs for CTO lesion from January 2004 to November 2015 were enrolled. Finally, a total of 324 eligible CTO patients received 1G-DES (Paclitaxel-eluting stent or Sirolimus-eluting stent, n = 157) or 2G-DES (Zotarolimus-eluting stent or Everolimus-eluting stent, n = 167) were enrolled. The clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), total repeat revascularization [target lesion revascularization (TLR), target vessel revascularization (TVR), and non-TVR]. We investigated the 5-year major clinical outcomes between 1G-DES and 2G-DES in patient who underwent successful CTO PCI. Results After propensity score matched (PSM) analysis, two well-balanced groups (111 pairs, n = 222, C-statistic = 0.718) were generated. Up to the 5-year follow-up period, the cumulative incidence of all-cause death, re-MI, TLR, TVR and non-TVR were not significantly different between the two groups. Finally, MACE was also similar between the two groups (HR = 1.557, 95% CI: 0.820–2.959, P = 0.176) after PSM. Conclusions In this study, 2G-DES was not associated with reduced long-term MACE compared with 1G-DES following successful CTO revascularization up to five years. | Yong Hoon Kim Ae-Young Her Seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Yoonjee Park Dong Oh Kang Won Young Jang Woohyeun Kim Ju Yeol Baek Woong Gil Choi Tae Soo Kang Jihun Ahn Sang-Ho Park Ji Young Park Min-Ho Lee Cheol Ung Choi Chang Gyu Park Hong Seog Seo | 2019 | Journal of Geriatric Cardiology2019，16，8： | 1 |
| 13 | Antenna mask design for SAR performance optimization显示文摘 | Se Young Kim Noh Hoon Myung Min Jeong Kang | 2009 | IEEE Geo- o science and Remote Sensing Letters2009，6，3： | 1 |
| 14 | Pre - procedural platelet reac- tivity 'after clopidogrel loading in korean patients undergoing sched- uled percutaneous coronary intervention 显示文摘 | Kang MK Jeong YH Yoon SE | 2010 | J Atheroscler Thromb2010，17，11： | 1 |
| 15 | Expression of hMLH1 is inactivated in thegastric adenomas with enhaned microsatllite instability显示文摘 | BAEK MJ KANG H KIM SE | 2001 | Br J Cancer2001，85，8： | 1 |
| 16 | A developmental mechanism of spontaneous reattachment in rhegmatogenous retinal detach- ment 显示文摘 | Chung SE Kang SW Yi CH | 2012 | Korean J Ophthalmol2012，26，： | 1 |
| 17 | Choroidal thickness in polypoidal choroidal vaseulopathy and exudative age-related macular degeneration 显示文摘 | Chung SE Kang SE | 2011 | Ophthalmology2011，118，9： | 1 |
| 18 | Compara- tive study of patients with central serous chorioretinopathy undergoing focal laser photocoagulation or photodynmnic therapy 显示文摘 | LIM JW KANG SW KIM YT CHUNG SE LEE SW | 2011 | Br J Ophthahnol2011，95，4： | 1 |
| 19 | The analgesic and anti-inflammatory effects of Litsea japonica fruit are mediated via suppression of NF-κB and JNK/p38 MAPK activation显示文摘 | Hyun Jung Koo Weon-Jong Yoon Eun-Hwa Sohn Young-Min Ham Seon-A Jang Jung-Eun Kwon Yong Joon Jeong Jong Hwan Kwak Eunsoo Sohn Soo-Young Park Ki-Hyo Jang Seung Namkoong Hyo-Sang Han Yong-Hwan Jung Se Chan Kang | 2014 | International Immunopharmacology2014，，： | 1 |
| 20 | Postoperative Changes in Pelvic Parameters and Sagittal Balance in Adult Isthmic Spondylolisthesis显示文摘 | Se Jun Park Chong Suh Lee Sung Soo Chung Kyung Chung Kang Seong Kee Shin | 2011 | Neurosurgery2011，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员