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您的检索式：作者名="Kangying Yu"
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| 1 | Therapeutic potential of gasotransmitters for cold stress-related cardiovascular disease显示文摘Growing evidence has shown that exposure to low ambient temperature poses a huge challenge to human health globally.Actually,cold stress is closely associated with a higher incidence of cardiovascular morbidity and mortality in winter or in cold regions.Cellular and molecular mechanisms underlying cardiovascular complications in response to cold exposure have yet to be fully clarified.Considering that cold exposure is an important risk of cardiovascular complications,it is necessary to clarify the molecular mechanism of cold stress-induced cardiovascular diseases and to develop effective intervention strategies.Hydrogen sulfide(H2S),nitric oxide(NO),and carbon monoxide(CO)are well-known gasotransmitters that are endogenously produced in many biological systems.Accumulating studies have demonstrated that these gasotransmitters play a critical role in a wide spectrum of physiological and/or pathophysiological processes by regulating numerous signaling pathways.These gas signal molecules are emerging as important players in cardiovascular homeostasis,and disruption of these gasotransmitters is critically implicated in cardiovascular anomalies,such as hypertension,atherosclerosis,myocardial ischemia,heart failure,and stroke.Also,evidence is emerging that H2S,NO,and CO may be involved in the pathologies of cold stress-induced cardiovascular ailments.In this review,we aim to highlight and discuss the recent advances towards the development of gasotransmitters-based therapeutics for cold stress-related cardiovascular pathogenesis.We believe that the effects of H2S,NO,and CO on cardiovascular regulation under cold environment will attract tremendous interest in the near future as they serve as novel regulators of cardiovascular biology in cold environment. | Haijian Sun Xiaowei Nie Kangying Yu Jinsong Bian | 2022 | Frigid Zone Medicine2022，2，1： | 1 |
| 2 | Synthesis of a ternary amide LixKy(NH2)x+y and a novel Li3K(NH2)4–xMgH2 combination system for hydrogen storage显示文摘The ternary amides LiK2(NH2)3, LiK(NH2)2, and Li3 K(NH2)4 are successfully synthesized by ball milling mixtures of LiNH2 and KNH2, and the hydrogen storage properties of Li3K(NH2)4–xMgH2(x = 1, 2, 3,4) are systematically investigated. The Li3K(NH2)4–2 Mg H2 sample displays optimized hydrogen storage properties, releasing 6.37 wt% of hydrogen in a two-stage reaction with an onset temperature of 60 °C.The first dehydrogenation stage exhibits good reaction kinetics and thermodynamic properties because of a lower activation energy and appropriate enthalpy change. After full dehydrogenation at 130 °C, the Li3K(NH2)4–2 MgH2 sample absorbs 3.80 wt% of H2 below 160 °C in a variable temperature hydrogenation mode. Mechanistic investigations indicate that Li3 K(NH2)4 reacts with Mg H2 to produce Mg(NH2)2, LiH,and KH during ball milling. In the heating process, Mg(NH2)2 first reacts with Li H to form Li2 Mg2 N3 H3 and Li NH2, while KH works as a catalyst, and then, KH reacts with Li2Mg2N3H3 and Li NH2 to generate a new K-containing compound. | Chao Li Changlong Li Meiqiang Fan Haichao Chen Kangying Shu Yu Zhang Mingxia Gao Yongfeng Liu Hongge Pan | 2019 | Journal of Energy Chemistry2019，28，8： | 0 |
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