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| 1 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 4 | 蒙古南部新金斯特地区下泥盆统洛霍考夫阶察甘安布拉格组牙形刺的新记录(英文)显示文摘蒙古南部新金斯特地区萨克黑尔剖面察甘安布拉格组上部发现的牙形刺, 包括Caudicriodusneowos chmidtisp. nov., Caudicriodussp. A, Kimognathussp., “Ozarkodina”planilingua, Pandorinellinaoptima, Ozarkodinaexcavata, 清楚地表明察甘安布拉格组上部应当归到中洛霍考夫阶(泥盆系)而不是像以往那样归到中-上志留统。海相温洛克统和罗德洛统地层在蒙古南部是否存在还需要寻找证据。文章描写了一个新种Caudicriodusneowos chmidtisp. nov.和一个未定种Caudicriodussp. A。 | 王成源 Karsten W EDDIGE Willi ZIEGLER Ch MINJIN | 2005 | 古生物学报2005，44，1： | 2 |
| 5 | Oligoindenopyrenes:A New Class of Polycyclic Aromatics显示文摘 | Hermann A W Helge R Karsten R | 2006 | J Org Chem2006，71，： | 1 |
| 6 | A Recent Polyploidy Superim-posed on Older Large-Scale Duplications in the Arabidopsis Genome 显示文摘 | GUILLAUME B KARSTEN H KENNETH H W | 2003 | Genome Research2003，13，2： | 1 |
| 7 | Dynamic window-constrained scheduling of real-time streams in media servers显示文摘 | Richard W Yuting Z Karsten S Christian P | 2004 | IEEE Transactions on Computers2004，53，6： | 1 |
| 8 | Effect of drought on growth,carbohydrates,and soil water use by perennial ryegrass,tall rescue,and white clover显示文摘 | Karsten H D MacAdam J W | 2001 | Crop Science2001，41，1： | 1 |
| 9 | 显示文摘 | Smith D Y Inokuti M Karstens W | 2001 | J Phys:Condens Matter2001，13，： | 1 |
| 10 | Chemical and kinetic mechanism of as- partate-b-semialdehyde dehydrogenase from Escherichia coil 显示文摘 | Karsten W E Viola R E | 1991 | Biochim Biophys Acta1991，1077，： | 1 |
| 11 | Expression of Thomsen-Friednreich related antigens in primary and metastatic colorectal carcinomas显示文摘 | Cao Y Karsten UR Liebrich W | 1995 | Cancer1995，76，： | 1 |
| 12 | 3D video: acquisition, coding, and display 显示文摘 | Philipp M Karsten M Thomas W | 2010 | IEEE Transactions on Consumer Electronics2010，56，2： | 1 |
| 13 | Estrogen Modulates Estrogen Receptor a and b Expression, Osteogenic Activity,and Apoptosis in Mesenchymal Stem Cells (MSCs) of Osteoporotic Mice 显示文摘 | Shuanhu Z Yoram Z Karsten W | 2001 | Cellular Biochemistry Supplement2001，36，： | 1 |
| 14 | Isolation and characterization of P-type H+-ATPase genes from potato显示文摘 | Karsten Harms Rosa V. W?hner Burkhard Schulz Wolf B. Frommer | 1994 | Plant Molecular Biology1994，，3： | 1 |
| 15 | Softening of nanocrystalline metals at very small grain sizes 显示文摘 | Schiotz J Francesco D Di Tolla Jacobsen Karsten W | 1995 | Nature1995，391，： | 1 |
| 16 | Role of radiotherapy in the treatment of motor dysfunction due to metastatic spinal cord compression: Comparison of three different fractionation schedules显示文摘 | Rades D Karstens JH Alberti W | 2002 | Int J Radiat Oncol Biol Phys2002，54，： | 1 |
| 17 | Plant communities of the Gobi Gurvan Sayhan National park (South Gobi Aymak, Mongolia)显示文摘 | KARSTEN W SABINE M GEORG M | 2005 | Candollea2005，60，1： | 1 |
| 18 | Anastomotic leakage as an outcome measure for quality of colorectal cancer surgery显示文摘 | H S Snijders D Henneman N L van Leersum M ten Berge M Fiocco T M Karsten K Havenga T Wiggers J W Dekker R A E M Tollenaar M W J M Wouters | 2013 | BMJ Quality & Safety2013，，9： | 1 |
| 19 | Expression of Thomsen-Friedenreich-related antigens in primary and metastatic colorectal carcinomas显示文摘 | Karsten UR Liebrich W | 1995 | A Reevaluation Cancer1995，76，： | 1 |
| 20 | Hyperthermia-induced nuclear translocation of transcription factor YB-1 leads to enhanced expression of muhidrug resistance-related ABC transporters 显示文摘 | Ulrike S Karsten JR Wolfgang W | 2001 | J Biol Chem2001，276，28： | 1 |
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