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| 1 | A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review显示文摘Androgens have an intense consequence on the human scalp and body hair.Scalp hair sprouts fundamentally in awol of androgens whereas the body hair hike is vulnerable to the activity of androgens.Androgenetic alopecia(AGA)invoked as males emulate Alopecia due to the cause of the dynamic reduction of scalp hair.Androgens are medium of terminus growth of hair although the body.Local and system androgens convert the extensive terminal follicles into lesser vellus like structure.The out start of this type of alopecia is intensely irregular and the reason behind this existence of enough circulating steroidal hormones androgens and due to genetic predisposition.Effective treatments are available in the market as well as under clinical and preclinical testing.Many herbal formulations are also available but not FDA approved.Different conventional and NDDS formulations are already available in the market.To avoid various systemic side effects of both Finasteride and Minoxidil,topical formulations and natural products(nutrients,minerals,vitamins)now a days are being widely used to treat Androgenic alopecia.CAM(complementary and alternative medicine)provides the option to elect favorable,low-risk,adjuvant and alternative therapies.Herein,we offer a widespread review of topical marketed formulations,natural products,and CAM treatment options for AGA. | Sumel Ashique Navjot Kaur Sandhu Sk.Niyamul Haque Kartick Koley | 2020 | Natural Products and Bioprospecting2020，10，6： | 3 |
| 2 | Acanthus ilicifolius plant extract prevents DNA alterations in a transplantable Ehrlich ascites carcinoma-bearing murine model显示文摘AIM: To investigate the chemopreventive efficacy of the Indian medicinal plant Acanthus ilicifolius L Acanthaceae in a transplantable Ehrlich ascites carcinoma (EAC)- bearing murine model. METHODS: Male Swiss albino mice were divided into four groups: Group A was the untreated normal control; Group B was the EAC control mice group that received serial, intraperitoneal (ip) inoculations of rapidly proliferating 2 x 105 viable EAC cells in 0.2 mL of sterile phosphate buffered saline; Group C was the plant extract-treated group that received the aqueous leaf extract (ALE) of the plant at a dose of 2.5 mg/kg body weight by single ip injections, once daily for 10, 20 and 30 consecutive days following tumour inoculation (ALE control); and Group D was the EAC + ALE- treatment group. The chemopreventive potential of the ALE was evaluated in a murine model by studying various biological parameters and genotoxic markers, such as tumour cell count, mean survival of the animals, haematological indices, hepatocellular histology, immunohistochemical expression of liver metallothionein (MT) protein, sister-chromatid exchanges (SCEs), and DNA alterations.RESULTS: Treatment of the EAC-bearing mice with the ALE significantly (P < 0.001) reduced viable tumour cell count by 68.34% (228.7 x 106 ± 0.53) when compared to EAC control mice (72.4 x 106 ± 0.49), and restored body and organ weights almost to the normal values. ALE administration also increased (P < 0.001) mean survival of the hosts from 35 ± 3.46 d in EAC control mice to 83 ± 2.69 d in EAC + ALE-treated mice. Haematological indices also showed marked improvement with administration of ALE in EAC-bearing animals. There was a significant increase in RBC count (P < 0.001), hemoglobin percent (P < 0.001), and haematocrit value (P < 0.001) from 4.3 ± 0.12, 6.4 ± 0.93, and 17.63 ± 0.72 respectively in EAC control mice to 7.1 ± 0.13, 12.1 ± 0.77, and 30.23 ± 0.57 respectively in EAC + ALE-treated group, along with concurrent decrement (P < 0.001) in WBC count from 18.8 ± 0.54 in EAC control to 8.4 ± 0.71 in EAC + ALE. Furthermore, treatment with ALE substantially improved hepatocellular architecture and no noticeable neoplastic lesions or foci of cellular alteration were observed. Daily administration of the ALE was found to limit liver MT expression, an important marker of cell proliferation with concomitant reduction in MT immunoreactivity (62.25 ± 2.58 vs 86.24 ± 5.69, P < 0.01). ALE was also potentially effective in reducing (P < 0.001) the frequency of SCEs from 14.94 ± 2.14 in EAC control to 5.12 ± 1.16 in EAC + ALE-treated group. Finally, in comparison to the EAC control, ALE was able to suppress in vivo DNA damage by abating the generations of ‘tailed’ DNA by 53.59% (98.65 ± 2.31 vs 45.06 ± 1.14, P < 0.001), and DNA single-strand breaks (SSBs) by 38.53% (3.14 ± 0.31 vs 1.93 ± 0.23, P < 0.01) in EAC-bearing murine liver. CONCLUSION: Our data indicate that, ALE is beneficial in restoring haematological and hepatic histological profiles and in lengthening the survival of the animals against the proliferation of ascites tumour in vivo. Finally, the chemopreventive efficacy of the ALE is manifested in limiting MT expression and in preventing DNA alterations in murine liver. The promising results of this study suggest further investigation into the chemopreventive mechanisms of the medicinal plant A. ilicifolius in vivo and in vitro. | Tridib Chakraborty Dipak Bhuniya Mary Chatterjee Mosiur Rahaman Dipak Singha Baidya Nath Chatterjee Subrata Datta Ajay Rana Kartick Samanta Sunil Srivastawa Sankar K Maitra Malay Chatterjee | 2007 | World Journal of Gastroenterology2007，13，48： | 2 |
| 3 | Improvement in water and oil absorbency of textile substrate by atmospheric pressure cold plasma treatment显示文摘 | Kartick Kumar Samanta Manjeet Jassal Ashwini K. Agrawal | 2008 | Surface & Coatings Technology2008，，10： | 2 |
| 4 | Supply-Side Investments: An International Analysis of the Return and Risk Relation-ship in the Travel & Leisure Sector显示文摘 | Jenny Cave Kartick Gupta Stuart Locke | 2009 | Tourism Management2009，30，5： | 1 |
| 5 | Supply-Side Investments: An International Analysis of the Return and Risk Relationship in the Travel & Leisure Sector 显示文摘 | Jenny Cave Kartick Gupta Stuart Locke | 2009 | Tourism Management2009，30，5： | 1 |
| 6 | Preparation of NaA Zeolite Membranes Using Poly (Ethylenei- mine) as Buffer Layer, and Study of Their Permeation Behav- ior 显示文摘 | Kartick P Dey Debtosh Kundu Minati Chatterjee | 2013 | Journal J Am Ceram Soc2013，96，1： | 1 |
| 7 | Performance Evaluation of a Simple and General Space Vector Pulse- Width Modulation-based M-Level inverter Including Over-modulation Operation显示文摘 | Kartick Chandra Jana Sujit K Biswas Suparna Kar Chowdhury | 2013 | lET Power Electronics2013，6，4： | 1 |
| 8 | Performance Evaluation of a Simple and General Space Vector Pulse-Width Modulation-Based M-Level Inverter Including Over-Modulation Operation 显示文摘 | KARTICK CHANDRA JANA SUJIT K BISWAS SUPARNA KAR CHOWDHURY | 2013 | IET Power Electronics2013，6，4： | 1 |
| 9 | Supply-side investments:An international analysis of the return and risk relationship in the Travel&Leisure sector显示文摘 | Jenny Cave Kartick Gupta Stuart Locke | 2009 | Tourism Management2009，30，5： | 1 |
| 10 | CO 2 reforming of methane combined with steam reforming or partial oxidation of methane to syngas over NdCoO 3 perovskite-type mixed metal-oxide catalyst显示文摘 | Vasant R. Choudhary Kartick C. Mondal | 2005 | Applied Energy2005，，9： | 1 |
| 11 | Controlled drug release of 5-amino salicylic acid by poly(2- hydroxyethylmethacrylate) grafted agar显示文摘利用(2-hydroxyethylmethacrylate ) poly, grafted 琼脂(Ag-g-P (HEMA )) 作为为 5-aminosalicylic 酸的控制版本的一个矩阵被调查。2-hydroxyethylmethacrylate (HEMA ) 的 Grafted 共聚物琼脂上的单体被微波综合帮助方法。在 vitro,药版本研究在 2 和 7 的 pH 价值被执行以便调查为冒号的版本指向了药交货的触发的 pH 的可能性。进一步,百分比 grafting 对 t < 潜水艇 class= “ a-plus-plus ” > 50 ( 为 50% 围住的药的版本花的时间) 价值被学习,结果显示基于 grafted 开发一个可编程的药版本矩阵可能是可能的多糖。Ag-g-P (HEMA ) 看起来是为控制版本的一个有用矩阵。 | G. Usha RANI Kartick Prasad DEY Srijita BHARTI Sumit MISHRA | 2014 | Frontiers of Chemical Science and Engineering2014，8，4： | 0 |
| 12 | Targeting the complement system in pancreatic cancer drug resistance:a novel therapeutic approach显示文摘Pancreatic cancer is ranked as the fourth leading cause of cancer-related mortality and is predicted to become the second leading cause of cancer-related death by 2030.The cause of this high mortality rate is due to pancreatic ductal adenocarcinoma’s rapid progression and metastasis,and development of drug resistance.Today,cancer immunotherapy is becoming a strong candidate to not only treat various cancers but also to combat against chemoresistance.Studies have suggested that complement system pathways play an important role in cancer progression and chemoresistance,especially in pancreatic cancer.A recent report also suggested that several signaling pathways play an important role in causing chemoresistance in pancreatic cancer,major ones including nuclear factor kappa B,signal transducer and activator of transcription 3,c-mesenchymal-epithelial transition factor,and phosphoinositide-3-kinase/protein kinase B.In addition,it has also been proven that the complement system has a very active role in establishing the tumor microenvironment,which would aid in promoting tumorigenesis,progression,metastasis,and recurrence.Interestingly,it has been shown that the downstream products of the complement system directly upregulate inflammatory mediators,which in turn activate these chemo-resistant pathways.Therefore,targeting complement pathways could be an innovative approach to combat against pancreatic cancer drugs resistance.In this review,we have discussed the role of complement system pathways in pancreatic cancer drug resistance and a special focus on the complement as a therapeutic target in pancreatic cancer. | Naushair Hussain Deea Das Atreyi Pramanik Manoj K Pandey Vivek Joshi Kartick C.Pramanik | 2022 | Cancer Drug Resistance2022，5，2： | 0 |
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